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仅在永久性脑缺血后短暂出现的星形胶质细胞样NG2胶质细胞亚群

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神经损伤与功能重建 2021年第8期16卷 F0003-F0003页

作者： Denisa Kirdajova lukas Valihrach Martin Valny Jan Kriska Daniela Krocianova Sarka Benesova Pavel Abaffy Daniel Zucha Ruslan Klassen Denisa Kolenicova Pavel Honsa Mikael Kubista Miroslava Anderova 杜一星(编译) Department of Cellular Neurophysiology Institute of Experimental MedicineCzech Academy of SciencesPragueCzech Republic Second Faculty of Medicine Charles UniversityCzech Republic Laboratory of Gene Expression Institute of Biotechnology CASBIOCEVVestecCzech Republic Faculty of Chemical Technology Laboratory of Informatics and ChemistryUniversity of Chemistry and TechnologyPragueCzech Republic Faculty of Science Charles UniversityPragueCzech Republic 不详

NG2神经胶质细胞在生理和病理条件下显示出较强的增殖和分化潜力。本研究用3月龄Cspg4启动子下由tdTomato标记NG2神经胶质细胞的小鼠,在不同类型的脑疾病模型(局灶性脑缺血、皮质刺伤和脱髓鞘)中研究NG2细胞的增殖和分化潜力,研究首先... 详细信息

NG2神经胶质细胞在生理和病理条件下显示出较强的增殖和分化潜力。本研究用3月龄Cspg4启动子下由tdTomato标记NG2神经胶质细胞的小鼠,在不同类型的脑疾病模型(局灶性脑缺血、皮质刺伤和脱髓鞘)中研究NG2细胞的增殖和分化潜力,研究首先采用单细胞RT-qPCR和Kohonen自组织映射图分析从未损伤和特定损伤后的皮质/胼胝体分离的tdTomato阳性细胞,比较不同损伤后NG2神经胶质细胞表达概况。这种方法使我们能够区分NG2神经胶质细胞和少突胶质细胞,每个细胞群都包含4个不同的亚群。基因表达谱显示,表达GFAP(反应性星形胶质细胞的标志物)的NG2胶质细胞亚群仅在局灶性脑缺血后短暂出现。然而,在较轻的损伤后(皮质刺伤和脱髓鞘),反映少突胶质细胞成熟不同阶段的亚群明显占优势。免疫组织化学也证实了不同亚群的损伤依赖性发生率。本研究使用单细胞RNA测序分析这种独特的短暂星形胶质细胞样NG2胶质细胞亚群,并采用膜片钳技术揭示了其基本的细胞膜特性。综上所述,我们证明了星形胶质细胞样NG2神经胶质细胞是仅在局灶性脑缺血后短暂出现的NG2神经胶质细胞的特定亚群。这些位于缺血后神经胶质瘢痕中的细胞处于活跃的细胞周期,并显示出与皮质星形胶质细胞相似的电流模式,可能是缺血后胶质瘢痕形成和修复过程中的重要参与者。

关键词：星形胶质细胞脱髓鞘缺血 NG2胶质细胞少突胶质细胞刺伤

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深圳证券交易所

城市环境设计 2014年第6期 38-51页

作者： Kunle Adeyemi Ryann Aoukar Sebastian Appl Laura Baird Waichuen Chan Jan Dechow lukas Drasnar Matthew Engele Leo Ferretto Clarisa Garcia Fresco Alasdair Graham Jaitian Gu Matthew Haseltine Joo Ferreira Marques Jesus Matthew Jull Alexde Jong Santiago Hierro Kennedy Klaas Kresse Miranda Lee Anna Little Luxiang Liu David Eugin Moon Cristina Murphy Se Yoon Park Ferdjan Vander Pijl Franscesca Portesine Idrees Rasouli Korbinian Schneider Wolfgang Schwarzwalder Felix Schwimmer Richard Sharam lukasz Skalec Christine Svensson lukasz Szlachcic Ken Yang Tan Michela Tonus Miroslav Vavrina Na Wei Xinyuan Wang Leonie Wenz Su Xia Yunchao Xu Yang Yang Yun Zhang

股票市场的本质是投机买卖:基于资本,而非物质。深圳证券交易所可被设想为虚拟股票市场的具体实践:这一栋拥有悬浮基座的建筑物不但能发挥物理功能,为股票市场提供场地,更重要的是它象征了股票市场。一般来说,基座用以锚固结构,并将其... 详细信息

股票市场的本质是投机买卖:基于资本,而非物质。深圳证券交易所可被设想为虚拟股票市场的具体实践:这一栋拥有悬浮基座的建筑物不但能发挥物理功能,为股票市场提供场地,更重要的是它象征了股票市场。一般来说,基座用以锚固结构,并将其牢牢地与地面连接;然而,深圳证券交易所的基座却沿着塔楼从地面往高处攀升,投机买卖的热烈气氛在驱动交易市

关键词：深圳证券交易所深交所半钢化玻璃

西瓜基因组框架图谱绘制与20份代表性资源重测序研究

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中国瓜菜 2019年第8期32卷 193-195页

作者：郭绍贵(编译) 许勇(编译) 张建国孙宏贺 Jerome Salse William JLucas 张海英 Yi Zheng 毛林勇任毅王志文闵久梦郭晓森 Florent Murat Byung-Kook Ham 张召亮高山黄明云徐益民钟思林 Aureliano Bombarely lukas A Mueller 赵泓何洪巨张岩张忠华黄三文谭涛庞尔丽林魁胡群匡汉辉倪培相王博刘景安孔秋生侯文菊邹小花江姣宫国义 Kathrin Klee Heiko Schoof 黄莹胡雪松董珊珊梁德全王娟吴奎夏阳赵翔郑泽群邢淼梁新明黄邦清吕添王军一尹烨伊鸿平李瑞强吴明珠 Amnon Levil 张兴平 James J Giovannoni 王俊李云伏费章君北京市农林科学院蔬菜研究中心国家蔬菜工程技术研究中心·北京市农林科学院·农业部华北地区园艺作物生物学与种质创制重点实验室康奈尔大学博伊斯汤普逊研究所农业部基因组学重点实验室·深圳华大基因研究院北京农学院植物科学技术学院法国农业科学研究院联合研究中心谷类遗传学多样性和生态生理研究所加州大学生物科学学院植物生物学系(戴维斯) 中国农业科学院蔬菜花卉研究所北京师范大学生命科学学院华中农业大学园林学院波恩大学植物科学与资源保护研究所作物生物信息研究室新疆农业科学院北京诺禾致源生物信息科技有限公司美国农业部农业科学研究院蔬菜研究室美国农业部农业与健康罗伯特霍利研究中心哥本哈根大学生物系复旦大学理论生命科学研究中心

目的与意义:西瓜是一种重要的葫芦科作物,占全世界蔬菜生产面积的7%.经过长期人工选育,西瓜遗传多样性变的十分狭窄,已成为西瓜品种改良的瓶颈.本研究以东亚类型高品质西瓜品种‘97103’为材料进行西瓜全基因组序列分析,并开展20份代表... 详细信息

目的与意义:西瓜是一种重要的葫芦科作物,占全世界蔬菜生产面积的7%.经过长期人工选育,西瓜遗传多样性变的十分狭窄,已成为西瓜品种改良的瓶颈.本研究以东亚类型高品质西瓜品种‘97103’为材料进行西瓜全基因组序列分析,并开展20份代表性西瓜资源的基因组重测序分析,以明确西瓜基因组结构和进化历程,阐明果实品质和维管束信号传导等重要生物学过程的分子机制.

关键词：全基因组测序分析西瓜资源图谱框架品种改良果实品质

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宝马世界

城市环境设计 2020年第4期126卷 134-149页

作者：沃尔夫·狄·普瑞克斯 Paul Kath Tom Wiscombe Waltraut Hoheneder Mona Marbach Hans Aescht Beatrix Basting Guy Bebiè Chris Beccone Johannes Behrens Marcelo Bernardi Pawel Bodzak Verena Boyer Antja Bulthaup Claudia Buhmann Timo Carl Jan Chaldil Ing Tse Chen Tadeusz Chimiak Andrea Christmann Patrick Erhardt Stephan Exsternbrink Wolfgang Fiel Benedikt Frass Helmut Fr?tscher Volker Gessendorfer Andrea Graser lukas Haller Markus Henning Armin Hess Jens Hoff Tamas Horvath Robert Huebser Astrid Jagersberger Marin Jurycz Gregor Kassl Areta Keller Markus Klausecker Tobias Klein Martin Konrad Quirin Krumbholz Caroline Kufferath Marion Lattenmayer Stefan Laub Wolfgang Leitgeb Andreas Mieling Karin Miesenberger Dennis Milam Elke Müller Henrike Münker Claudia Nehammer Martin Oberascher Alexander Ott Stefan Pfefferle Florian Pfeifer Markus Pillhofer Ekkehard Rehfeld Goswin Rothenthal Wolfgang Ruthensteiner Jasmin Sauerbier Florian Schafschetzy Kristina Schinegger Karolin Schmidbaur Patrick Schneider Katharina Schneider Hubert Schoba Angus Schoenberger Andrea Sch?ning Anja Sorger Gernot Stangl Mark Steinmetz Sigrid Steinwender Martina Tippelskirch Dionicio Valdez Pascal Vauclair Akvile Rimantaite Andreas Weissenbach Heribert Wolfmayer Irina Zahler 2007 Ari Marcopoulos Gerald Zugmann Hélène Binet Duccio Malagamba Marcus Buck Christian Richters Richard Walch

项目大事记/CHRONOLOGY竞赛（一等奖）/Competition（1st Prize）:2001规划设计起始时间/Start of Planning:11/2001施工起始时间/Start of Construction:08/2003投入使用/Opening:20/10/2007-21/10/2007项目参数/PROJECT DATA用地面积/Site Area:约25 000m2/Approx. 25 000m2建筑毛面积/Gross Floor Area:约73 000m2（除坡道）=100%/Approx.73 000m2（excluding ramps）=100%地上建筑毛面积/Gross Floor Area above ground:约28 500m2=40%/Approx.28 500m2=40%地下建筑毛面积/Gross Floor Area underground:约44 500m2=60%/Approx.44 500m2=60%

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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