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System control-mediated drug delivery towards complex systems via nanodiamond carriers

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International Journal of Smart and Nano Materials 2010年第1期1卷 69-81页

作者： Dean ho Chih-ming ho Department of Biomedical Engineering Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Robert H.Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL 60611USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLACA 90095USA Center for Cell Control A NIH Nanomedicine Development CenterLos AngelesCA 90095USA

Cells represent the basic units of life and contain an intertwined network of signaling and regulatory circuitries that drive the processes of *** processes include the mediation of mechano-sensation,onset of and protection against disease,inflammation,and *** the network of bio-complex systems,each pathway interacts nonlinearly with others through different molecular *** a result,specific functionalities can not be simply linked to the cellular molecules in isolation.A complex system generally possesses very rich information content that can be characterized by the following features:(i)they contain a large number of building blocks;(ii)their interactions among building blocks and with their environment;(iii)they display organization without an external organizing principle being applied;and(iv)they exhibit adaptability and *** properties account for the innate intelligence of biology and its ability to regulate its homeostatic ***,this same complexity underlies,in cancer for example,challenges towards disease management,as the addressing of singular pathways with therapeutic compounds is not ***,combinatorial therapy often serves as a key strategy towards tumor *** iterative searching for optimized therapeutic combinations is indeed a daunting,if not preclusive task,we introduce the feedback system control(FSC)scheme,which may serve as a clinically relevant approach,provided a translational approach towards drug delivery is *** to their innate biocompatibility,which has been comprehensively observed,as well as their ability to delivery virtually any type of therapeutic in a sustained fashion due to their unique surface properties,nanodiamonds may serve as a foundation for nanoenabled combinatorial therapy.

关键词： bio-complex system feedback system control drug delivery,nanodiamond combinatorial medicine signaling network nanomedicine

Pseudobacteremia with amoxycillin-clavulanic acid-resistant Escherichia coli traced to cross-contamination during blood culture processing

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Chinese Medical Journal 1998年第6期 90-96页

作者： ho Pak leung, luk Wei

Escherichia coli has seldom been reported to cause pseudobacteremia. The investigation of an outbreak of amoxycillin clavulanic acid resistant E. coli pseudobacteremia is described. Seventeen cases occurred over a five day period. The source of the E. coli was traced to the blood culture specimen of a patient (index patient) with genuine bacteremia as a result of urinary tract infection. The other 16 case patients had pseudobacteremia which was found to be the result of cross contamination during subculture of blood specimens. The E. coli strain was carried over from the culture bottle of the index patient, through the contaminated gloved hands of a technician to the culture bottles of the other 16 cases. Although the pseudobacteremia occurred over a five day period, they all resulted from cross contamination during blood culture processing within one day. An early outbreak investigation was prompted by the unusual finding of amoxycillin clavulanic acid resistance in the case E. coli isolates in a short period. The relatedness of the E. coli strains from the 17 cases was confirmed by arbitrary primed polymerase chain reaction. Clinicians should be alerted to the possibility of a blood E. coli isolate being a contaminant despite its predominant role as a true pathogen.

关键词： ang Wong Sai yin Samson Seto Wing hong Lo Yee chee Janice and Yuen Keywordsok yung

Animal models to study Mycobacterium tuberculosis and HIV co-infection

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Zoological Research 2014年第3期35卷 163-169页

作者： ming GUO Wen-Zhe ho Center for Animal Experiment/Animal Biosafety Level Ⅲ Laboratory Wuhan University

Mycobacterium tuberculosis(***) and human immunodeficiency virus(HIV) co-infection has become a public health issue worldwide. Up to now, there have been many unresolved issues either in the clinical diagnosis and treatment of ***/HIV coinfection or in the basic understanding of the mechanisms for the impairments to the immune system by interactions of these two pathogens. One important reason for these unsolved issues is the lack of appropriate animal models for the study of ***/HIV coinfection. This paper reviews the recent development of research on the animal models of ***/HIV co-infection, with a focus on the non-human primate models.

关键词： HIV Mycobacterium tuberculosis Co-infection Animal model

Research on interaction of innovation spillovers in the AI,Fin‑Tech,and IoT industries:considering structural changes accelerated by COVID‑19

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Financial Innovation 2023年第1期9卷 204-232页

作者： Chi‑ming ho Department of Finance Southern Taiwan University of Science and TechnologyTainanTaiwan

This paper aims to probe the influence of innovation spillovers in the artificial intelligence(AI)and financial technology(Fin-tech)industries on the value of the internet of things(IoT)*** was utilized to download public information from Yahoo Finance,and then the GARCH model was used to extract the fluctuations of cross-industry innovation ***,the Fama–French three-factor model was used to explore the interactive changes between *** panel data regression analysis indicates that the more firms accept innovation spillovers from other industries,the better the excess return;however,this effect differs because of industrial attributes and the environmental changes induced by ***,this study finds that investing in large-cap growth stocks of IoT firms is more likely to yield excess ***,the study yields lessons for policy leverage to accelerate the upgrading and transformation of innovation-interactive industries by referring to the practices of Singapore and South Korea.

关键词： AI Covid-19 Fin-Tech Innovation spillover IoT

Three-dimensional histology:new visual approaches to morphological changes during neural regeneration

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Neural Regeneration Research 2017年第1期12卷 53-55页

作者： Hei ming Lai ho Man Ng Wutian Wu School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Research Center of Reproduction Development and GrowthLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangdong-hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Three-dimensional（3D） histology utilizes tissue clearing techniques to turn intact tissues transparent,allowing rapid interrogation of tissue architecture in three *** this article,we summarized the available tissue clearing methods and classified them according to their physicochemical principles of operation,which provided a framework for one to choose the best techniques for various research *** attempts in addressing various questions regarding the degenerating and regenerating nervous system have been promising with the use of 3D histological techniques.

关键词： three-dimensional histology tissue clearing neuronal morphology neuronal network

On the first negative Hecke eigenvalue of an automorphic representation of GL_(2)(A_(Q))

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Science China Mathematics 2021年第11期64卷 2381-2394页

作者： Yuk-Kam Lau ming ho Ng Hengcai Tang Yingnan Wang Department of Mathematics The University of Hong KongHong KongChina Department of Mathematics The Chinese University of Hong KongHong KongChina Institute of Modern Mathematics School of Mathematics and StatisticsHenan UniversityKaifeng 475004China Shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and StatisticsShenzhen UniversityShenzhen 518060China

Letπbe a self-dual irreducible cuspidal automorphic representation of GL_(2)(A_(Q))with trivial central *** Hecke eigenvalue λπ(n)is a real multiplicative function in *** show that λπ(n)<0 for some n< 详细信息

关键词： automorphic representation Hecke eigenvalue Maass cusp form sign change

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Defect inspection of indoor components in buildings using deep learning object detection and augmented reality

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 41-54页

作者： Shun-Hsiang Hsu ho-Tin Hung Yu-Qi Lin Chia-ming Chang Department of Civil and Environmental Engineering University of Illinois at Urbana-ChampaignUSA Department of Civil Engineering Taiwan University(NTU)TaiwanChina

Visual inspection is commonly adopted for building operation,maintenance,and *** durability and defects of components or materials in buildings can be quickly assessed through visual ***,implementations of visual inspection are substantially time-consuming,labor-intensive,and error-prone because useful auxiliary tools that can instantly highlight defects or damage locations from images are not ***,an advanced building inspection framework is developed and implemented with augmented reality(AR)and real-time damage detection in this *** this framework,engineers should walk around and film every corner of the building interior to generate the three-dimensional(3D)environment through ***,a trained YOLOv5 model real-time detects defects during this process,even in a large-scale field,and the defect locations indicating the detected defects are then marked in this 3D *** defects areas can be measured with centimeter-level accuracy with the light detection and ranging(LiDAR)on *** required damage information,including defect positions and sizes,is collected at a time and can be rendered in the 2D and 3D ***,this visual inspection can be efficiently conducted,and the previously generated environment can also be loaded to re-localize existing defect marks for future maintenance and change ***,the proposed framework is also implemented and verified by an underground parking lot in a building to detect and quantify surface defects on concrete *** seen in the results,the conventional building inspection is significantly improved with the aid of the proposed framework in terms of damage localization,damage quantification,and inspection efficiency.

关键词： visual inspection damage detection augmented reality damage quantification deep learning

Xieite,a new mineral of high-pressure FeCr_2O_4 polymorph

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Chinese Science Bulletin 2008年第21期53卷 3341-3345页

作者： CHEN ming SHU JinFu MAO ho-kwang Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Geophysical Laboratory Carnegie Institution of Washington 5251 Broad Branch Road NW 20015 Washington DC USA

Xieite,a new mineral,occurs in the shock vein of the Suizhou *** mineral has an ortho-rhombic structure and its space group is *** cell parameters are a = 9.462(6),b = 9.562(9),c = 2.916(1).The crystal-chemical formula is(Fe0.87Mg0.13Mn0.01)1.01(Cr1.62Al0.25Ti0.08V0.02)1.97O4,or simply formula *** X-ray diffraction lines are [d(),I/Io]:(2.675,100),(2.389,20),(2.089,10),(1.953,90),(1.566,60),(1.439,15),(1.425,15),(1.337,40).Xieite is a high pressure polymorph of FeCr2O4 and formed by solid-state transformation of chromite under shock-induced high pressure and tem-perature,in association with other high-pressure minerals including ringwoodite,majorite,lingunite and *** P-T condition for the formation of xieite is estimated to be 18―23 GPa and 1800―1950℃,*** has recently been approved by the Commission on New Minerals,Nomenclature and Classification of the International Mineralogical Association(IMA 2007-056).The mineral name,xieite,is named after Xiande Xie.

关键词：络铁矿高压环境基因多态性矿物

Management of early hepatic artery occlusion after liver transplantation with failed rescue

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World Journal of Gastroenterology 2015年第44期21卷 12729-12734页

作者： Chih-Yang Hsiao Cheng-Maw ho Yao-ming Wu ming-Chih ho Rey-Heng Hu Po-Huang Lee Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine

Hepatic artery thrombosis is a serious complication after liver transplantation which often results in biliary complications, early graft loss, and patient death. It is generally thought that early hepatic artery thrombosis without urgent re-vascularization or retransplantation almost always leads to mortality, especially if the hepatic artery thrombosis occurs within a few days after transplantation. This series presents 3 cases of early hepatic artery thrombosis after living donor liver transplantation, in which surgical or endovascular attempts at arterial re-vascularization failed. Unexpectedly, these 3 patients survived with acceptable graft function after 32 mo, 11 mo, and 4 mo follow-up, respectively. The literatures on factors affecting this devastating complication were reviewed from an anatomical perspective. The collective evidence from survivors indicated that modified nonsurgical management after liver transplantation with failed revascularization may be sufficient to prevent mortality from early hepatic artery occlusion. Re-transplantation may be reserved for selected patients with unrecovered graft function.

关键词： Complication Hepatic artery Thrombosis Liver trans