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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang Pan Yihuang Chen Qiong liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Free radical reactions

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王有鹏教授治疗寒地儿童耳鸣的经验

中国医药导报 2023年第34期20卷 172-175页

作者：史梦迪王超刘璐佳王有鹏黑龙江中医药大学研究生院黑龙江哈尔滨150036 黑龙江中医药大学附属第二医院儿科黑龙江哈尔滨150001

耳鸣是临床上常见的疾病与并发症,多见于成年人。近年来随着生活方式的改变与学习压力的增大,越来越多的儿童被诊断为耳鸣,尤其是对于不会正确表达病情的儿童,常常导致病情延误,给临床诊断及治疗带来困难,所以耳鸣一病在儿科应当被予以... 详细信息

耳鸣是临床上常见的疾病与并发症,多见于成年人。近年来随着生活方式的改变与学习压力的增大,越来越多的儿童被诊断为耳鸣,尤其是对于不会正确表达病情的儿童,常常导致病情延误,给临床诊断及治疗带来困难,所以耳鸣一病在儿科应当被予以重视。本文总结了名老中医王有鹏教授治疗耳鸣的临床经验,归纳寒地儿童具有易感外邪、脾胃湿热、心肝火旺的患病特点,将其病因病机分为风寒外袭、痰浊湿困、肝气郁结、肾元亏损4个方面,在治疗上注重标本兼顾,扶正祛邪,以求耳鸣止,耳窍通,同时调节儿童心理问题,以求心身同治。文后附验案一则详细说明佐证。

关键词：王有鹏寒地儿科耳鸣名医经验

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宣白承气汤治疗支气管哮喘的网络药理学分析

中药新药与临床药理 2022年第10期33卷 1386-1393页

作者：孙明月兰明月杨阳刘璐佳王有鹏景伟超李志军黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001

目的运用网络药理学方法探讨宣白承气汤治疗支气管哮喘的作用机制。方法通过TCMSP数据库筛选宣白承气汤的活性成分及作用靶点,通过GeneCards数据库筛选支气管哮喘的疾病相关靶点,获取二者交集靶点,即宣白承气汤治疗支气管哮喘的潜在... 详细信息

目的运用网络药理学方法探讨宣白承气汤治疗支气管哮喘的作用机制。方法通过TCMSP数据库筛选宣白承气汤的活性成分及作用靶点,通过GeneCards数据库筛选支气管哮喘的疾病相关靶点,获取二者交集靶点,即宣白承气汤治疗支气管哮喘的潜在作用靶点。使用Cytoscape 3.7.2软件构建“疾病-药物-活性成分-靶点”网络,并分析网络中的核心活性成分;将交集靶点导入STRING数据库进行蛋白互作(PPI)网络分析,筛选出潜在核心靶点;运用R语言软件包对交集靶点进行GO功能和KEGG通路富集分析。结果共筛选得到34个活性成分及64个潜在作用靶点(交集靶点);获得香叶木素、羟基芫花素、泽兰黄醇素、α-菠菜甾醇等核心活性化合物,IL-6、MAPK3、MMP-9、PPARG和ICAM1等核心靶点;共筛选得到67条信号通路,关键通路包括神经活性配体-受体相互作用信号通路、c AMP信号通路、钙信号通路、TNF信号通路、Th17细胞分化、Th1/Th2细胞分化等。结论宣白承气汤可能是通过香叶木素、羟基芫花素等关键活性成分,作用于IL-6、MAPK3、MMP-9等潜在核心靶点,调控神经活性配体-受体相互作用、cAMP等信号通路,从而发挥治疗支气管哮喘的作用。

关键词：宣白承气汤支气管哮喘网络药理学作用机制香叶木素羟基芫花素

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王有鹏应用柴桂温胆汤治疗心悸合并郁证经验

中医药临床杂志 2018年第11期30卷 2012-2014页

作者：宋奇霖杨阳刘璐佳王有鹏黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001

心悸是指患者心中悸动不安不能自主的一类病证,一般多呈阵发性,病机多为虚实夹杂。然心悸常常与情志因素相关,或伴随其他精神神经系统症状,故在心悸患者的治疗当中应注意分辨情志因素,做到病郁同治。现详细记录王有鹏教授应用自拟柴桂... 详细信息

心悸是指患者心中悸动不安不能自主的一类病证,一般多呈阵发性,病机多为虚实夹杂。然心悸常常与情志因素相关,或伴随其他精神神经系统症状,故在心悸患者的治疗当中应注意分辨情志因素,做到病郁同治。现详细记录王有鹏教授应用自拟柴桂温胆汤,以分消走泄法治疗心悸合并郁证之经验,其用药精妙,疗效显著,值得同道探讨。

关键词：医案柴桂温胆汤王有鹏分消走泄

Emerging trends in the selective production of value-added aromatics

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Science China Chemistry 2025年第1期68卷 15-20页

作者： Yuchao Wu Houliang Dai Weisheng Yang Yaxing Li Lichen liu Petrochemical Research Institute Company Limited China National Petroleum Corporation Engineering Research Center of Advanced Rare Earth Materials Department of Chemistry Tsinghua University

1 Introduction Aromatics (mainly benzene, toluene, and xylenes, BTX) are essential intermediates in the chemical industry. They are employed in the synthesis of a broad spectrum of chemicals and materials, e.g., various polymers, plastics, resins, solvents, dyes, pharmaceuticals [1]. The manufacturing pathway of BTX mainly includes petroleum reforming of naphtha, coal-to-aromatics, methanol-to-aromatics [2].

关键词：

Si-C Foam Porous-Medium Combustion Power-Generation System for Low-Calorific-Value Biomass Syngas

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Journal of Thermal Science 2025年第1期34卷 206-222页

作者： YANG Jianwen CHEN Wei CAO Bingwei liu Xinhui LI Hang College of Mechanical and Aerospace Engineering Jilin University School of Mechanical and Vehicle Engineering Changchun University

Syngas produced from the gasification of organic feedstocks from biomass is one of the clean and sustainable sources of *** advantages of simple access and renewability of biomass energy can meet the energy needs of temporary power *** study presents a biomass power-generation system for vehicular *** biomass and a free-piston Stirling engine generator（FPSEG） as the primary material and prime mover,respectively,biomass energy is converted into electricity by combusting the syngas to heat the *** and key parameter design for biomass gasification and thermoelectric conversion systems within a power generation system were performed.A porous medium area was constructed using Si-C foam ceramics to obtain an energy-conversion experimental *** effects of bed height,porosity,porous-region diameter,and air-intake conditions on the power-generation performance were investigated,and optimisations were performed for the thermoelectric conversion *** rate of increase during FPSEG power generation first increased and then decreased with increasing bed height,peaking at a bed height of 40 *** increasing porous-region diameter accelerated FPSEG power generation,whereas porosity changes in the porous media did not significantly affect the rate of change during FPSEG power *** increasing air intake,the rate of increase during power generation first increased and then *** maximum change rate and the highest thermoelectric conversion efficiency of the power-generation system occurred at 9.5 m3/h and 6.5 m3/h（～45.1%）air intakes,*** the thermal inertia and combustion structure of the thermoelectric conversion system significantly increased the power-generation rate of the system,with 1.8 W/s being observed at a 9.7 m3/h air intake.

关键词： biomass combined heat and power (CHP) gasification porous media combustion power generation

Preparation of Modified Composite Nanofiltration Membrane Synergistically Using Carboxylic Multi- walled Carbon Nanotube and β-cyclodextrin

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 232-239页

作者： liu Peng MAO Junpeng FANG Yanfeng YU Yunwu CHEN Changxiu TANG Ning WAN Ye GU Yaxin liu Yunxue WANG Lihua School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new modified blend ultrafiltration(UF)membrane with good hydrophilicity,high porosity and excellent anti-fouling performance was developed by using carboxylic multi-walled carbon nanotube(CMWCNT)as casting solution ***,a composite nanofiltration(NF)membrane with large water flux and good retention rate was fabricated by using the PVDF/CMWCNT blend UF membrane as the substrate,and polyvinyl alcohol(PVA),β-cyclodextrin(β-CD)and polyethylenimine(PEI)as the coating *** results show that with the appropriate addition of CMWCNT in the casting solution,the surface roughness,porosity and recovery rate of the PVDF/CMWCNT blend UF membrane is obviously *** water flux of blend UF membrane is significantly improved when the CMWCNT content increases from 0 wt%to 0.2 wt%.The water flux of blend UF membrane with 0.2 wt%CMWCNT is 162.7 L/(m^(2)·h),which is 44.3%higher than that of the pure PVDF ***β-CD content is 0.8 wt%,the retention rate of Congo red by PVDF/CMWCNT/β-CD composite NF membrane reaches 98.7%,which is 28.3%higher than that of single PVA/PEI modified *** research will provide a new idea and simple method for developing novel high-performance composite NF membranes.

关键词： CMWCNT cyclodextrin nanofiltration membrane

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从“风”“湿”论治小儿咳嗽变异性哮喘概述

辽宁中医杂志 2022年第7期49卷 58-61页

作者：司秀影梁嫄刘洋刘璐佳王有鹏黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001

咳嗽变异性哮喘是一种特殊类型的哮喘,咳嗽是其唯一或主要临床表现,无明显喘息、气促等重要体征,但有气道高反应性。对于本病病因病机的认识大多集中在风、痰、瘀、虚及脏腑功能不调等方面,现根据查阅相关文献及导师多年的临床实践经验... 详细信息

咳嗽变异性哮喘是一种特殊类型的哮喘,咳嗽是其唯一或主要临床表现,无明显喘息、气促等重要体征,但有气道高反应性。对于本病病因病机的认识大多集中在风、痰、瘀、虚及脏腑功能不调等方面,现根据查阅相关文献及导师多年的临床实践经验,认为风、湿是本病重要的病理因素,风邪主要包括内风与外风,湿邪主要由体质特点和脏腑功能失常,水液运化不及产生的病理产物。故在治疗时针对“风”、“湿”的特点,及肺、肝、脾、肾脏腑的功能进行论治,通过论述小儿CVA因风、湿致咳的理论来源、病因病机、临床表现等,提出风邪、湿邪是小儿CVA发病及缠绵难愈的重要病理基础。根据病理因素在不同的脏腑,可发展为不同的病因病机,故提出祛风散寒、清热利湿、健脾化湿、温肾化气除湿、活血化瘀等治疗方法,以期在治疗与预防儿童CVA上提供新思路,防止迁延,发展为难治的典型支气管哮喘。

关键词：风湿咳嗽变异性哮喘病因病机

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Loading Localization by Small-Diameter Optical Fiber Sensors

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第2期35卷 275-281页

作者： liu Rongmei Zhu lujia Lu Jiyun Liang Dakai College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Structural health monitoring(SHM)in service has attracted increasing attention for *** localization on a structure is studied *** algorithms,i.e.,support vector machine(SVM)method and back propagation neural network(BPNN)algorithm,are proposed to identify the loading positions *** feasibility of the suggested methods is evaluated through an experimental program on a carbon fiber reinforced plastic *** experimental tests involve in application of four optical fiber-based sensors for strain measurement at discrete *** sensors are specially designed fiber Bragg grating(FBG)in small *** small-diameter FBG sensors are arrayed in 2-D on the laminate *** testing results indicate that the loading position could be detected by the proposed *** SVM method,the 2-D FBG sensors can approximate the loading location with maximum error less than 14 ***,the maximum localization error could be limited to about 1 mm by applying the BPNN *** is mainly because the convergence conditions(mean square error)can be set in advance,while SVM cannot.

关键词： small diameter optical fiber sensor structural health monitoring loading localization back propagation neural network support vector machine

Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期68卷 103-115页

作者： Xizi Luo Nan Zhang Yuntao liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词： SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition