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Assessment of the Intertropical Convergence Zone over the Atlantic Ocean through an Algorithm Based on Precipitation

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Journal of Atmospheric Science Research 2024年第1期7卷 59-73页

作者： Natan Chrysostomo de Oliveira Nogueira Pedro Henrique gomes Machado Michelle Simões Reboita André luiz Reis Reis Natural Resources Institute Federal University of ItajubáItajubáMinas Gerais37500-903Brazil

The Intertropical Convergence Zone(ITCZ)is a key atmospheric system on a global scale,primarily driven by trade wind convergence near the *** ITCZ plays a crucial role in modulating the climate of the borders of tropical continental *** instance,Northeastern Brazil experiences a climate influenced by the ITCZ over the Atlantic *** some periods,the ITCZ exhibits double bands,known as the double *** the features of the ITCZ have been described using various approaches and atmospheric variables,there is still a lack of regional studies focusing on the ITCZ and double ITCZ in the Atlantic *** this context,the main goals of this study are(1)to describe a simple algorithm based on precipitation to identify the ITCZ and double ITCZ,(2)to present a climatology(1997-2022)of the position,width,and intensity of these two convective bands,and(3)to investigate variabilities in the ITCZ characteristics associated with anomalies of sea surface temperature(SST)in the tropical Pacific and Atlantic *** double ITCZ typically occurs southward of the main cloud band,and between February and April,both bands are more distant(~4.5°).In the western sector of the Atlantic Ocean,the ITCZ and its double band extend to more southerly latitudes in austral *** the entire Atlantic basin,the annual mean of the latitudinal position,width,and intensity of the ITCZ is 4.9°N,4.2°,and 11 mm/day,respectively,while for the double ITCZ,it is 0.4°N,2.6°,10.3 mm/day,*** the SST anomalies in the Pacific Ocean(El Niño and La Niña episodes)affect more the ITCZ width,the SST anomalies in the Tropical South Atlantic affect both its position and width.

关键词： Double ITCZ Precipitation Latitudinal position Northeastern Brazil Atlantic Ocean ENSO

Meningococcal disease, a clinical and epidemiological review

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1019-1029页

作者： Rodrigo Siqueira Batista Andreia Patricia gomes Jorge luiz Dutra Gazineo Paulo Sergio Balbino Miguel luiz Alberto Santana Lisa Oliveira Mauro Geller Laboratorio de Agentes Patogenicos Departamento de Medicina e Enfermagem Universidade Federal de VicosaVicosaMGBrazil Curso de Medicina Faculdade Dinamica do Vale do PirangaPonte NovaMGBrazil Hospital Universitario Clementino Fraga Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Curso de Medicina Centro Universitario Serra dos Orgaos (UNIFESO)TeresopolisRJBrazil School of Medicine New York University–NYUNew YorkUSA Departamento de Genetica Medica Universidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroRJBrazil

Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals.

关键词： Neisseria meningitidis Bacterial infection Meningococcal disease

Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael gomes da Silva luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum

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Journal of Integrative Medicine 2018年第6期16卷 404-410页

作者： Bruno Jose Martins Da Silva Sandro Wilson gomes Pereira Ana Paula Drummond Rodrigues Jose luiz Martins Do Nascimento Edilene Oliveira Silva Laboratory of Structural Biology Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging(INCT-INBEB) Rio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil Laboratory of Molecular and Cellular Neurochemistry Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Neuroimmunomodulation(INCT-NIM) Rio de Janeiro 21040-360Brazil

Objective： In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root （AEPa） on Leishmania infanturn proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages. Methods： I., infantum promastigotes were treated with 50 and 100 μg/mL AEPa for 72 h and then antipro- mastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal activity was detected. In addition, macrophages were infected with L. infantum and were used to evaluate anti-amastigote activity of AEPa and effects of AEPa on cytokine secretion after 72-hour treatment. Results： Treatment with AEPa reduced the numbers ofL infantum promastigotes （50% inhibitory concen- tration （ICso） = 65.9μg/mL; selectivity index （SI）= 22.1） and amastigotes （ICso = 37.9 μg/mL; SI = 38.5） compared with the untreated control. Amphotericin B reduced 100% of the promastigote numbers after 72 h of treatment （IC50 = 0.2μg/mL）. AEPa induced several morphological changes and increased the production of reactive oxygen species and apoptotic death in promastigotes after treating for 72 h. AEPa （100 μg/mL） promoted tumor necrosis factor-α secretion in macrophages infected with L. infantum after 72 h of treatment, but did not induce an increase in this cytokine in noninfected macrophages. In addition, AEPa showed no cytotoxic effect on J774-A1 cells （50% cytotoxic concentration 〉1000μg/mL）. Conclusion： AEPa presented antileishmanial activity against the promastigotes and amastigotes of I.. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis.

关键词： Leishmanicidal activity Leishmania infantum Reactive oxygen species Apoptosis Physalis angulata

Cyclone as a Sugar Cane Bagasse Dryer

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Chinese Journal of Chemical Engineering 2004年第6期12卷 826-830页

作者： Jefferson luiz gomes Correa Daniel Rezende Graminho Maria Aparecida Silva Silvia Azucena Nebra Faculty of Mechanical Engineering State University of Campinas P.O. Box 6122 Campinas/SP 13083-970 BrazilFaculty of Mechanical Engineering State University of Campinas P.O. Box 6122 Campinas/SP 13083-970 BrazilFaculty of Chemical Engineering State University of Campinas P.O. Box 6066 Campinas/SP 13083-970 BrazilFaculty of Mechanical Engineering State University of Campinas P.O. Box 6122 Campinas/SP 13083-970 Brazil

Drying of sugar cane bagasse was theoretically and experimentally studied ina cyclone. The experiments were carried out using hot air as drying agent. The influence of thecyclone conical part was studied. It was shown that the conical part has a great influence on theparticle residence time and, consequently, on moisture reduction. Experimental results were alikeindustrial ones. CFX 4.4 from AEA Technology was used to simulate some experiments. Simulated andexperimental results were close and showed that the presented model leads to a good prediction.

关键词： cyclone cyclonic dryer sugar cane bagasse particle residence time dryer energy

Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release

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Journal of Integrative Medicine 2022年第2期20卷 153-162页

作者： Célia Cristina Malaguti Figueiredo Amanda da Costa gomes Filipe Oliveira Granero Joao luiz Bronzel Junior Luciana Pereira Silva Valdecir Farias Ximenes Regildo Márcio Goncalves da Silva Institute of Chemistry São Paulo State UniversityAraraquaraSão Paulo 14800-060Brazil Educational Foundation of the City of Assis AssisSão Paulo 19807-130Brazil Department of Chemistry School of SciencesSão Paulo State UniversityBauruSão Paulo 17033-360Brazil Department of Biotechnology School of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão Paulo 19806-900Brazil

Objective:The present study investigated antiglycation and antioxidant activities of crude dry extract and saponin fraction of Tribulus *** also developed a method of microencapsulation and evaluated antiglycation and antioxidant activities of crude dry extract and saponin fraction before and after microcapsule ***:Antiglycation activity was determined by relative electrophoretic mobility(REM),free amino groups and inhibition of advanced glycation end-product(AGE)*** activity was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),ferric ion-reducing antioxidant power(FRAP),nitric oxide(NO)and thiobarbituric acid reactive species(TBARS)*** were prepared using maltodextrin as wall material and freeze-drying as encapsulation *** characterization of microcapsules was evaluated by scanning electron microscopy,and encapsulation efficiency and microcapsule release were determined by total saponins *** and antioxidant assays were performed using crude dry extract and saponin fraction of *** before and after ***:Saponin fraction showed an increase of 32.8%total ***-performance liquid chromatography-mass spectrometry analysis showed the presence of saponins in the obtained *** evaluation by REM demonstrated that samples before and after release presented antiglycation activity similar to bovine serum albumin treated with ***,samples inhibited AGE formation,highlighting treatment with saponin fraction after release(89.89%).Antioxidant tests demonstrated antioxidant activity of the *** dry extract before encapsulation presented the highest activities in DPPH(92.00%)and TBARS(32.49%)*** fraction before encapsulation in FRAP test(499μmol Trolox equivalent per gram of dry sample)and NO test(15.13μmol nitrite formed per gram of extract)presented the highest ***:This study presen

关键词： Glycation Microencapsulation Oxidative stress Saponins Tribulus terrestris

Genotype-environment interaction in Cordia trichotoma(Vell.)Arrá*** *** in two different soil conditions

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Journal of Forestry Research 2022年第1期33卷 309-319页

作者： Wanderley dos Santos Bruno Marchetti de Souza Daniele Fernanda Zulian Gilberto Terra Ribeiro Alves João Bosco Vasconcellos gomes Mário luiz Teixeira de Moraes Valderês Aparecida de Sousa Ananda Virginia de Aguiar Faculdade de Engenharia de Ilha Solteira Universidade Estadual Paulista“Júlio Mesquita Filho”Ilha Solteira 15385-000Brazil Sucupira Agroflorestas Fazenda SucupiraValença 45400-000Brazil EMBRAPA Florestas Empresa Brasileira de Pesquisa AgropecuáriaColombo 83411-000Brazil

Investment in silvicultural techniques is noticeably lacking,especially in breeding programs for non-conventional wood *** genotype×environment interaction(G×E)is essential to the development of breeding ***,this study aimed to estimate genetic diversity of and the effects of G×E interaction on two progeny tests of Cordia trichotoma,including the estimation of genetic gain and genetic diversity after *** the experiment,30 progenies of *** were tested at two sites with differing soil *** at breast height(1.30 m above soil surface,dbh-cm),total height,diameter at 30 cm from the soil,first branch height,and survival were all monitored for four *** deviance,best linear unbiased estimator,and harmonic mean of relative performance of genetic values(MHPRVG)were all calculated to predict breeding values,estimate genetic parameters,and analyze *** quantified traits varied significantly among progenies by soil type,with greatest variation recorded for genetic *** of the progenies led to predictions of genetic gain,ranging from 7.73 to 15.45%,for dbh at four years of *** calculated decrease in genetic diversity after selection showed that this parameter should be monitored in subsequent breeding cycles.G×E was low for all *** best-performing progenies proved most stable and best adapted to the different environmental conditions tested.

关键词： Effective population number Native species Productivity Stability and adaptability Tree improvement

GIS as a Decision Support Tool in the Area of Influence of the Nuclear Complex Angra dos Reis, Brazil

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Journal of Geographic Information System 2013年第1期5卷 13-23页

作者： Corbiniano Silva luiz Landau luiz Claudio gomes Pimentel Paulo Fernando Lavalle Heilbron Filho Civil Engineering Program Alberto Luiz Coimbra Institute of Post Graduate Studies and Research Federal University of Rio de Janeiro Rio de Janeiro Brazil Mechanical Engineering Program Alberto Luiz Coimbra Institute of Post Graduate Studies and Research Federal University of Rio de Janeiro Rio de Janeiro Brazil National Commission for Nuclear Energy Rio de Janeiro Brazil

The outlook concerning the occurrence of industrial accidents has led to the implementation of response systems based on geoprocessing tools, which are widely adopted in emergency for such ventures, since they have helped and served as a support for decision making, as well as for the preparation of guidelines aimed at managing emergencies. Nuclear power plants, because they constitute types of industrial activities that present dangerous conditions and attention regarding security are characterized as hazardous, especially due to consequences that occurred from large accidents— such as Chernobyl (1986) and Fukushima (2011)—highlighting the importance to its negative impacts, since the occurrence of accidents at nuclear power plants may affect surrounding areas, thus exposing a set of elements that are part of the environmental dynamics that integrates the catchment area where this type of plant is situated. In this way, through an integrated view of the region where the nuclear complex is located in Angra dos Reis City (Rio de Janeiro State) and, also, by aggregating information that portray the geobiophysical reality of its surroundings, several elements were incorporated into a database developed in a virtual environment, in which was produced a geographic information system (GIS) that presents a complex of variables that, once considered, can enhance various analysis in order to support emergency situations and planning, as well as guidelines that help define actions from the occurrence of accidental events at the nuclear plant.

关键词： Industrial Accidents Nuclear Power GIS Planning of Emergency Response Systems

Combined Training in the Treatment of Type 2 Diabetes Mellitus: A Review

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Health 2017年第12期9卷 1605-1617页

作者： Cláudia gomes Bracht Rodrigo Sudatti Delevatti luiz Fernando Martins Kruel Universidade Federal do Rio Grande do Sul Porto Alegre Brazil Universidade Federal de Santa Catarina Florianópolis Brazil

This study aimed to review combined training (CT) effects on HbA1c levels in patients with T2DM. Searches were conducted in PubMed via MEDLINE and Google Scholar. Of the 14 selected studies, 11 found reductions in HbA1c levels. The interventions that performed both aerobic and resistance training in the same sessions were highlighted. In aerobic training, the best results were in the interventions between 30 and 45 minutes per session, with intensities between 60 and 80% of maximal parameters. In resistance training, the interventions with sets from 8 to 12 repetitions with intensities of 80% and 60% of 1RM respectively, or prescribed by maximal repetitions, were highlighted. We conclude that CT can result in better glycaemic control than AT and RT conducted alone.

关键词： Diabetes Combined Training Glycaemic Control HbA1c