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Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

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World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz guilherme Costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM： To evaluate the safety and feasibility of bone marrow cell （BMC） transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS： Ten patients （eight males） with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS： The median age of the patients was 52 years （range 24-70 years）. All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 （2.19 ± 0.9） and 4 mo （2.10 ± 1.0） after cell transplantation that baseline levels （238 ± 1.2）. Albumin levels 4 mo after BMC infusion （3.73 ± 0.5） were higher than baseline levels （3.47 ± 0.5）. International normalized ratio （INR） decreased from 1.48 （SD = 0.23） to 1.43 （SD = 0.23） one month after cell transplantation. CONCLUSION： BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词： Bone marrow Cell transplantation Liverfailure Stem cell Cirrhosis

A Proof-of-Concept Assessment of the Safety and Efficacy of Intralesional Diclofenac in the Treatment of Cutaneous Neurofibromas

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International Journal of Clinical Medicine 2015年第12期6卷 975-983页

作者： Mauro Geller Aguinaldo Bonalumi Filho Lisa Oliveira Allan ERubenstein luiz guilherme Darrigo Jr David Azulay Allan Bernacchi Marcia Goncalves Ribeiro Karin Soares Goncalves Cunha Immunology Department Fundacao Educacional Serra dos Orgaos(UNIFESO)TeresopolisBrazil Clinical Immunology Instituto de Pos-Graduacao Medica Carlos Chagas(IPGMCC)Rio de JaneiroBrazil Medical Genetics Service IPPMG-Universidade Federal Rio de JaneiroRio de JaneiroBrazil Hospital Naval Marcilio Dias Rio de JaneiroBrazil Sociedade Evangelica Beneficiente de Curitiba Outpatient Unit CuritibaBrazil NYU Langone Medical Center New YorkNYUSA Bone Marrow Transplant Unit Hospital das Clinicas da Faculdade de Medicina de Ribeirao PretoUniversidade de Sao Paulo(USP)Ribeirao PretoBrazil Pontifica Universidade Catolica do Rio de Janeiro(PUC-RJ) Rio de JaneiroRJBrazil Plastic Surgery Post-Graduation PUC-RJRio de JaneiroBrazil 1 Universidade Federal Fluminense(UFF) Rio de JaneiroBrazil

The objectives of this study were to assess the safety and efficacy of intralesionally administered diclofenac in the treatment of cutaneous neurofibromas in patients with NF1. This was a proof-of-concept, prospective, safety and efficacy study of the effect of intralesionally administered diclofenac 25 mg/ml given once a week to 3 target cutaneous neurofibromas for 4 consecutive weeks. Overall, there was no significant change in neurofibroma size. During the study, some treated lesions developed signs of necrosis and fell off after a few weeks, but none of the control neurofibromas fell off. There were no significant changes in patient’s vital signs. A few adverse events occurred, mostly at the injection sites. During the study, some neurofibromas developed necrosis after the diclofenac injections and eventually detached from the patient. Overall, diclofenac was well tolerated, suggesting minimal systemic exposure, which required confirmation and further studies, including bioavailability analysis.

关键词： Neurofibromatosis Type 1 Cutaneous Neurofibromas Diclofenac Sodium

Chemical Composition of the Cashew Apple Bagasse and Potential Use for Ethanol Production

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Advances in Chemical Engineering and Science 2012年第4期2卷 519-523页

作者： Flávia Cristina dos Santos Lima Flávio luiz Honorato da Silva Josivanda Palmeira gomes José Mariano da Silva Neto Department of Chemical Engineering Center of Sciences and TechnologyFederal University of Campina GrandeCampina GrandeBrazil Department of Chemical Engineering Center of TechnologyFederal University of ParaibaJoao PessoaBrazil Department of Agricultural Engineering Center of Science and TechnologyFederal University of Campina GrandeCampina GrandeBrazil

On the world scene, the energy requirements are mainly based on fossil fuels, however, these compounds reserves are finite and their exploitation has caused serious environmental problems. As a consequence, the demand for alternative renewable sources has been intensified in substitution the rising demand for energy and raw materials. The biomass is emerging as one of the few sources that have potential to meet these challenges of sustainability, as is currently the largest energy resource in the world, and only carbon-rich material available on the planet, apart from fossils. Form, the cashew crop has great potential for technological development of alternative sources of energy, from its industrial waste processing cashew adding value to the product. In this sense, this paper aims to study the characterization of the cashew apple bagasse and to verify (by acid prehydrolysis) the potential of this material for ethanol production. Initially it was carried out physicochemical characterization of cashew bagasse used (pH, moisture content, soluble solids, sugars, cellulose, hemicellulose and lignin). Following it was carried prehydrolysis at 105℃ for 1h to obtain fermentable sugars. Analyses of the samples were carried out on HPLC the results showed the saccharification of biomass with glucose (1537.49 mg/L), xylose (3823.22 mg/L) and arabinose (7131.11 mg/L) as well as the capacity of the biomass for ethanol production.

关键词： Pre-Hydrolyze Ethanol Cashew Apple Bagasse

Complete Achilles Tenotomy:A New Improved Experimental Surgical Technique in Rats

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Open Journal of Animal Sciences 2018年第1期8卷 1-11页

作者： Kelly Biancardini gomes Barbato guilherme de Almeida Joao da Costa Libardo Rodriguez Clara Raposo Hanna Dias Renata Paiva Liszt Palmeira de Oliveira Jorge Carvalho Clinical and Experimental Pathophysiology Postgraduate Program School of MedicineState University of Rio de JaneiroRio de JaneiroBrazil Department of Surgical Specialties School of MedicineState University of Rio de JaneiroRio de JaneiroBrazil School of Medicine State University of Rio de JaneiroRio de JaneiroBrazil Department of Histology and Embriology Roberto Alcantara Gomes Institute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil

Rupture of the Achilles tendon is one of the most frequent tendon injuries in humans. However, there is no standard surgical technique thus far to reproduce complete rupture of this tendon in rats. Surgical procedures were performed in Wistar rats under light microscopy, with posterior longitudinal incision and preservation of the plantaris tendon. The animals were sacrificed on 2nd and 8th postoperative week and we used hematoxilin and eosin, picrosirius-red and Weigert’s resorcin-fuchsin to observe general tendon healing. The mean operative time was one minute and 24 seconds. Histological studies showed cellular proliferation and fibrillogenesis at two weeks, with decreased amounts of cellularity and elastic fibers at the 8th week, besides changes in structural organization of collagen fibers. The complete Achilles tenotomy in rats, was improved under light microscopy and sparing the plantaris tendon. This surgical technique was simple and quick, showed signs of normal healing process, could be easily reproducible, and triggered translational researches in this area.

关键词： Achilles Tendon Rupture Animal Experimentation Wound Healing Collagen Elastic Tissue

Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Uranium Metabolism Associated with Ontogenetic Growth of Birds—Case Studies with Broilers and Ducks

Advances in Molecular Imaging（分子影像学） 2024年第2期 7页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael gomes da Silva luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo

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Advances in Bioscience and Biotechnology 2014年第9期5卷 768-776页

作者： Joao Dias de Toledo Arruda-Neto Guacyara Tenorio Cavalcante guilherme de Paula Nogueira Tulio Eduardo Rodrigues luiz Eduardo Correa Fonseca Mitiko Saiki Godofredo Camara Genofre Physics Institute University of Sao PauloSao PauloBrazil CEPESq/UniItalo—Italy-Brazilian University Center Sao PauloBrazil School of Veterinary Medicine Sao Paulo State University/UNESPAracatubaBrazil Institute for Energy and Nuclear Research IPEN/CNEN-SPSao PauloBrazil Institute for Biomedical Sciences University of Sao PauloSao PauloBrazil

Cobb broilers and domestic ducks, both one-day-old, were treated using ration doped with 20 ppm of uranyl nitrate. Uranium concentrations in the tibia (μg-U/g-bone) were measured by neutron activation analysis as function of the animals’ age, from the neonatal period to maturity. Results show that Uranium and Calcium qualitatively follow the same metabolic pathway, and that adult ducks incorporate on average ten times more Uranium than broilers. Data interpretation shows that the Uranium clearance rate in broilers is substantially higher than that in ducks, suggesting that metabolic characteristics favoring Calcium retention in bone may hinder the elimination of Uranium in ducks. The need for further comparative biochemistry studies between Galliformes and Anseriformes is addressed.

关键词： Cobb Broilers Domestic Ducks Uranium-Doped-Ration Uranium-Content in Bones U/Ca Metabolism Uranium Residence Times

Diesel Consumption and CO2 Emissions in Agricultural Crops： An Estimation Model and a Forestry-Based Neutralization Proposal

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Journal of Agricultural Science and Technology(B) 2017年第1期7卷 34-48页

作者： luiz Carlos Sérvulo de Aquino Brunna Simōes Ungarelli guilherme Amatuzzi Teixeira Marcos Auré1io Vasconcelos de Freitas Aida Inirida Ortega Acosta International Virtual Institute for Global Climate Change (1VIG) Coordination of Research and Engineering Postgraduation(COPPE) Federal University of Rio de Janeiro (UFR I) RI 21941-485 Brazil Alcaldia de Bogotá Secretarla Distrital de Ambiente Bogotá 110231324 Colémbia

This research presented a mathematical model to calculate the consumption of diesel oil and the respective emissions of CO2from 41 agricultural crops （38 permanent and 3 temporary） in Brazil. It contains data obtained between 2000 and 2012, from accreditedbibliographic sources. In addition to spreadsheets containing diesel consumption, resulting from the analysis of the productive processes,this research presents data on energy conversion and forest development used to subsidize CO2 emissions and mitigation *** for C sequestration of the atmosphere, four options of forest projects were systematized：（1） reforestation with fast growingspecies; （2） forest protection projects, with enrichment plantations; （3） implementation of agroforestry systems （1 st cycle）; and （4） urbanafforestation projects （streets and parks）. Such alternatives are in line with the proposals of the ＂sectorial plan for mitigation andadaptation to climate change for the consolidation of a low C emission in agriculture＂, of the Brazilian Agricultural ResearchCorporation （EMBRAPA）. The results show that three temporary products （soybean, sugarcane and cotton） are responsible, for at least,85% of all CO2 emissions, comparatively the low consumption of diesel oil verified in the management of the 38 permanent productsstudied in this research. Therefore, in order to contribute to the reduction of the release of CO2 into the atmosphere, perennial crops andecologically rational extractivism should be more encouraged and more supported by the public authorities.

关键词： Agricultural crops, diesel consumption, CO2 emissions and C sequestration.

Alpha-Tomatin against Witches’Broom Disease

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American Journal of Plant Sciences 2014年第5期5卷 596-604页

作者： luiz Humberto gomes Keila Maria Roncato Duarte Felipe Gabriel Andrino Gildemberg Amorin Leal Jr Lia Matelli Garcia Antonio Figueira Simone Possedente de Lira Laboratory of Natural Products Environmental ChemistryDepartment of Exact SciencesEscola Superior de Agricultura“Luiz de Queiroz”Universidade de Sao PauloPiracicabaBrazil Institute of Animal Science and Pastures Nova OdessaBrazil Federal University of Alagoas MaceioBrazil Centro de Energia Nuclear na Agricultura Universidade de Sao PauloPiracicabaBrazil

Several plants use secondary metabolites against insects and pathogens attack. Among such metabolites known glycoalkaloids are the most studied. Plants from Solanaceae Family are the most abundant on those alkaloids. Despite alfa-tomatine is a known glycoalkaloid, its specific action against Moniliophthora perniciosa, fungi responsible for witches broom disease in cocoa plantations was obtained in this work. Alfa-tomatine was infusion-extracted from Solanum lycopersicum leaves, and its action against the fungi growth was shown on the bioassays. In these tests, M. perniciosa growth was totally inhibited but other fungus tested, the inhibition was not totally, or did not present effect on growth, showing in this way, the specificity of alfa-tomatine to M. perniciosa. The advantages of work with a natural molecule for the fungi control is the stability of the molecule, its resistance to high temperature and pressure and for its use, the simple method of extraction used. The confirmation of the alfa-tomatine molecule was done by High Performance Liquid Chromatography and Mass Spectrometry in comparison to the Sigma standard.

关键词： Cocoa Glycoalkaloids Solanaceae

Interface Recombination &Emission Applied to Explain Photosynthetic Mechanisms for (e–, h+) Charges’ Separation

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World Journal of Nano Science and Engineering 2012年第2期2卷 58-87页

作者： Marco Sacilotti Denis Chaumont Claudia Brainer Mota Thiago Vasconcelos Frederico Dias Nunes Marcelo Francisco Pompelli Sergio luiz Morelhao Anderson S. L. gomes Departament of Eletronics and Systems Federal University of Pernambuco Recife Brazil Department of Physics Federal University of Pernambuco Recife Brazil Institute of Physics University of Sao Paulo Sao Paulo Brazil Nanoform Group ICB & UFR Science and Technology University of Burgundy Dijon France Plant Physiology Laboratory Department of Botany Federal University of Pernambuco Recife Brazil

To copy natural photosynthesis process we need to understand and explain the physics underneath its first step mechanism, which is “how to separate electrical charges under attraction”. But this Nature’s nanotechnological creation is not yet available to the scientific community. We present a new interpretation for the artificial and natural photosynthetic mechanism, concerning the electrical charges separation and the spent energy to promote the process. Interface (e–, h+) recombination and emission is applied to explain the photosynthetic mechanisms. This interpretation is based on energy bands relative position, the staggered one, which under illumination promotes (e–, h+) charges separation through the action of an interface electric field and energy consumption at the interface of both A/B generic materials. Energy band bending is responsible by the interface electric field (and the driving force) for the charges separation. This electric field can be as high or above that for p-n semiconductor junctions (104 - 105 V/cm). This physical effect is not considered by most of the researches. Without an electric field and without spending energy to separate electrical charges, any other existing model violates physical laws. The staggered energy band type is the only energetic configuration that permits charges separation under illumination and energy loss to perform the process. Application to natural photosynthesis and artificial photovoltaic material and their energetic configurations are discussed. Examples for A/B being III-V/III-V, TiO2/materials and II-VI/II-VI staggered energy band gap pairs are presented. In the proposed quantum mechanism, plants are able to eliminate most of the 79% of the absorbed visible light, according to the published reflection and transmission data. Moreover, the proposed mechanism can be applied to explain green fluorescent protein - GFP, charge transfer states - CTS and Fluorescent Resonance Energy Transfer - FRET. As recent litera

关键词： Solar Energy Renewable Energy Photovoltaic Photosynthesis Type II Interfaces Staggered Interface Interface Emission Interface Recombination Quantum Photosynthesis Solar Cell FRET GFP