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Radiation therapy and chemotherapy-induced oral mucositis

中国口腔颌面外科杂志 2008年第B5期6卷 206-206页

作者： luiz E. R. Volpato Fabiano T. Borges Maria C. P. F. Volpato Maria A. A. M. machado Department of Dentistry for Special Care Patients University of Cuiaba. Cuiaba Mato Grosso Brazil Department of Dentistry Mato Grosso Cancer Hospital. Cuio54 Mato Grosso Brazil Department of Dentistry Mato Grosso Cancer Hospital. Cuiaba Mato Grosso Brazil Department of Pediatric Dentistry Orthodontics and Collective Health Bauru Dental School Silo Paulo University. Bauru Sao Paulo Brazil

Purpose: To establish a tumor marker that can be used for the early detection and follow-up of oral cancer patients。Methods: By employing the proteomic approach using MALDI TOF-MS, 2-D gel electrophoresis, sera of patients, and cell culture lines, the serum autoantibodies (autoAbs) were screened, and their serum levels were estimated by ELISA。Results: MRC-5 human fibroblasts were employed as target cells with the aim of targeting the tumor cell invasion into the surrounding stromal tissues, and a mitochondrial membrane protein, Sideroflexin3 (SFXN3), was identified。The serum anti-SFXN3-autoAb levels significantly increased in patients with oral squamous cell carcinoma, with 77% sensitivity and 89% specificity against control samples。The serum anti-SFXN3-autoAb levels slightly correlated with the primary tumor sizes; however, the levels were highly increased in T1 early cancer。An immunohistochemical analysis revealed that the SFXN3 antigen is expressed in the stromal fibroblasts between the caner nests and also in the basal layer of the squamous epithelium。The changes in the serum anti-SFXN3-autoAb levels after therapy correlated with the clinical tumor burden。Conclusion: The serum anti-SFXN3-autoAb is worthy of clinical evaluation as a potential novel tumor marker for the early detection of oral squamous cell carcinoma。

关键词：口腔粘膜炎治疗方法放射疗法化学疗法

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