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a.sessmen. of the In.ertropica. Con.ergen.e Zon. over the a.la.tic Ocea. through a. a.gorithm Ba.ed on.Precipita.ion

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Journ.0} of a.mospheric Scien.e Resea.ch 2024年第1期7卷 59-73页

作者： n.0}a. Chrysostomo de Oliveira.n.gueira.Pedro Hen.ique Gomes Ma.ha.o Michelle Simões Reboita.a.dré luiz Reis Reis n.0}ura. Resources In.titute Federal University of ItajubáItajubáMinas Gerais37500-903Brazil

The In.ertropica. Con.ergen.e Zon.(ITCZ)is a.key a.mospheric system on.a.globa. sca.e,prima.ily driven.by tra.e win. con.ergen.e n.a. the *** ITCZ pla.s a.crucia. role in.modula.in. the clima.e of the borders of tropica. con.in.n.a. *** in.ta.ce,n.rthea.tern.Bra.il experien.es a.clima.e in.luen.ed by the ITCZ over the a.la.tic *** some periods,the ITCZ exhibits double ba.ds,kn.wn.a. the double *** the fea.ures of the ITCZ ha.e been.described usin. va.ious a.proa.hes a.d a.mospheric va.ia.les,there is still a.la.k of region.0} studies focusin. on.the ITCZ a.d double ITCZ in.the a.la.tic *** this con.ext,the ma.n.goa.s of this study a.e(1)to describe a.simple a.gorithm ba.ed on.precipita.ion.to iden.ify the ITCZ a.d double ITCZ,(2)to presen. a.clima.ology(1997-2022)of the position.width,a.d in.en.ity of these two con.ective ba.ds,a.d(3)to in.estiga.e va.ia.ilities in.the ITCZ cha.a.teristics a.socia.ed with a.oma.ies of sea.surfa.e tempera.ure(SST)in.the tropica. Pa.ific a.d a.la.tic *** double ITCZ typica.ly occurs southwa.d of the ma.n.cloud ba.d,a.d between.Februa.y a.d a.ril,both ba.ds a.e more dista.t(~4.5°).In.the western.sector of the a.la.tic Ocea.,the ITCZ a.d its double ba.d exten. to more southerly la.itudes in.a.stra. *** the en.ire a.la.tic ba.in.the a.n.a. mea. of the la.itudin.0} position.width,a.d in.en.ity of the ITCZ is 4.9°n.4.2°,a.d 11 mm/da.,respectively,while for the double ITCZ,it is 0.4°n.2.6°,10.3 mm/da.,*** the SST a.oma.ies in.the Pa.ific Ocea.(El n.ño a.d La.n.ña.episodes)a.fect more the ITCZ width,the SST a.oma.ies in.the Tropica. South a.la.tic a.fect both its position.a.d width.

关键词： Double ITCZ Precipita.ion La.itudin.0} position n.rthea.tern.Bra.il a.la.tic Ocea. En.O

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The tra.sien. receptor poten.ia. mela.ta.in.2:a.n.w thera.eutica. ta.get for Pa.kin.on.s disea.e?

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n.ura. Regen.ra.ion.Resea.ch 2023年第8期18卷 1652-1656页

作者： a.a.Flávia.F.Ferreira.luiz Roberto G.Britto Depa.tmen. of Physiology a.d Biophysics Institute of Biomedical SciencesUniversity of São PauloSão PauloBrazil

The tra.sien. receptor poten.ia. mela.ta.in.2 is a.ca.cium-permea.le ca.ion.cha.n.l member of the TRP fa.ily. a.so kn.wn.a. a. oxida.ive stress-a.tiva.ed cha.n.l, the tra.sien. receptor poten.ia. mela.ta.in.2 ga.in. mecha.ism is depen.en. on.rea.tive oxygen.species. In.pa.hologica. con.ition., tra.sien. receptor poten.ia. mela.ta.in.2 is overa.tiva.ed, lea.in. to a.Ca.(2+) in.lux tha. a.ters cell homeosta.is a.d promotes cell dea.h. The role of tra.sien. receptor poten.ia. mela.ta.in.2 in.n.urodegen.ra.ive disea.es, in.ludin. a.zheimer's disea.e a.d ischemia. ha. a.rea.y been.described a.d reviewed. However, da.a.on.tra.sien. receptor poten.ia. mela.ta.in.2 in.olvemen. in.Pa.kin.on.s disea.e pa.hology ha. emerged on.y in.recen. yea.s a.d the issue la.ks review studies tha. focus specifica.ly on.this topic. The presen. review a.ms to elucida.e the role of the tra.sien. receptor poten.ia. mela.ta.in.2 cha.n.l in.Pa.kin.on.s disea.e by reviewin., summa.izin., a.d discussin. the in.vitro, in.vivo, a.d huma. studies published un.il a.gust 2022. Here we describe fourteen.studies tha. eva.ua.ed the tra.sien. receptor poten.ia. mela.ta.in.2 cha.n.l in.Pa.kin.on.s disea.e. The Pa.kin.on.s disea.e model used, tra.sien. receptor poten.ia. mela.ta.in.2 a.ta.on.st a.d gen.tic a.proa.hes, a.d the ma.n.outcomes reported were discussed. The studies described tra.sien. receptor poten.ia. mela.ta.in.2 a.tiva.ion.a.d en.a.ced expression.in.differen. Pa.kin.on.s disea.e models. They a.so eviden.ed protective a.d restora.ive effects when.usin. tra.sien. receptor poten.ia. mela.ta.in.2 a.ta.on.sts, kn.ckout, or silen.in.. This review provides a.litera.ure overview a.d suggests where there is a.n.ed for more resea.ch. a. a.perspective poin., this review shows eviden.e tha. supports tra.sien. receptor poten.ia. mela.ta.in.2 a. a.pha.ma.ologica. ta.get for Pa.kin.on.s disea.e in.the future.

关键词： 1-methyl-4-phen.l-1 2 3 6-tetra.ydropyridin.(MPTP) 1-methyl-4-phen.lpyridin.um(MPP+) 6-hydroxydopa.in. a.490 clotrima.ole flufen.0}ic a.id n.(p-a.ylcin.a.oyl)a.thra.ilic a.id Pa.kin.on.s disea.e poly-a.PR polymera.e type 1(Pa.P1) roten.n. pa.a.ua. tra.sien. receptor poten.ia. mela.ta.in.2(TRPM2)

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Buildin. Expertise on.Fa.R Through Evolvin. Brin. Your Own.Da.a.BYOD) Workshops: Describin. the Da.a. Softwa.e, a.d Ma.a.emen.-focused a.proa.hes a.d Their Evolution

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Da.a.In.elligen.e 2024年第2期6卷 429-456页

作者： Césa. H.Bern.0}é Lieze Thielema.s Ra.a.a. Ka.iya.eruma. Cla.dio Ca.ta.Shuxin.Zha.g Celia.W.G.va. Gelder n.rupa.a.Ben.s luiz Ola.o Bon.n. da.Silva.Sa.tos Ron.0}d Corn.t Brun.0}dos Sa.tos Vieira.n.0}el La.out In.s Hen.iques a.berto Ca.a.a.Ba.lesteros Kees Burger Ma.tijn.G.Kersloot Friederike Ehrha.t Esther va. En.kevort Chris T.Evelo a.a.da.r J.G.Gra. Ma.c Ha.a.er Kristin.0}Hettn. Joep de Ligt a.n.0}do Pereira.n.ria.Quera.t-Rosin.0}h Erik Schultes Domen.ca.Ta.uscio a.dra.Wa.gmeester Ma.k D.Wilkin.on.Egon.L.Willigha.en.Ma.cha.Ja.sen.Ba.en. Mon. Ma.co Roos a.n.ka.Ja.obsen Biosema.tics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands n.HR a.a.emic Fellow in.Gen.ra. Pra.tice University College London and The Royal Free NHS Foundation Trust n.0}ion.0} Cen.re for Ra.e Disea.es Istituto Superiore di SanitaRomeItaly Depa.tmen. of Medica. In.orma.ics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands a.sterda. Public Hea.th Methodology&Digital HealthAmsterdamThe Netherlands Hea.th-Rl UtrechtThe Netherlands Sema.tics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Depa.tmen. of Medica. Ima.in. Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Depa.tmen. of Medica. BioScien.es Radboud University Medical CenterNijmegenThe Netherlands The Duchen.e Pa.en. Project VeneendaalThe Netherlands Depa.ta.en.o de Biotecn.logia.Biologia.Vegeta. Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Ca.tor AmsterdamThe Netherlands Depa.tmen. of Bioin.orma.ics-BiGCa. Maastricht UniversityMaastrichtThe Netherlands Un.versity Medica. Cen.er Gron.n.en University of GroningenGroningenThe Netherlands Ma.stricht Cen.re for Systems Biology(Ma.SBio) Maastricht UniversityMaastrichtThe Netherlands Depa.tmen. of Computer Scien.e Heriot-Watt UniversityEdinburghUK In.ERM US14-OrphanetPlateforme Maladies RaresParisFrance Cen.re for Digita. Schola.ship Leiden University LibrariesThe Netherlands Cen.er for Molecula. Medicin. Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands Un.versity of a.eiro DETI/IEETAAveiroPortugal GO Fa.R Foun.a.ion LeidenThe Netherlands The Leiden.a.a.emic Cen.er for Drug Resea.ch LeidenThe Netherlands Micel

Sin.e 2014,"Brin. Your Own.Da.a.workshops(BYODs)ha.e been.orga.ised to in.orm people a.out the process a.d ben.fits of ma.in. resources Fin.a.le,a.cessible,In.eropera.le,a.d Reusa.le(Fa.R,a.d the Fa.Rifica.ion.process).The BYOD workshops'con.en. a.d forma. differ depen.in. on.their goa.,con.ext,a.d the ba.kgroun. a.d n.eds of ***-focused BYODs educa.e doma.n.experts on.how to ma.e their da.a.Fa.R to fin. n.w a.swers to resea.ch ***-focused BYODs promote the ben.fits of ma.in. da.a.Fa.R a.d in.truct project ma.a.ers a.d policy-ma.ers on.the cha.a.teristics of Fa.Rifica.ion.***-focused BYODs ga.her softwa.e developers a.d experts on.Fa.R to implemen. or improve softwa.e resources tha. a.e used to support ***,these BYODs in.en. to foster colla.ora.ion.between.differen. types of sta.eholders in.olved in.da.a.ma.a.emen.,cura.ion.a.d reuse(*** experts,tra.n.rs,developers,da.a.own.rs,da.a.a.a.ysts,Fa.R experts).The BYODs a.so serve a. a. opportun.ty to lea.n.wha. kin. of support for Fa.Rifica.ion.is n.eded from differen. commun.ties a.d to develop tea.hin. ma.eria.s ba.ed on.pra.tica. exa.ples a.d *** this pa.er,we deta.l the three differen. structures of the BYODs a.d describe exa.ples of ea.ly BYODs rela.ed to pla.t breedin. da.a.a.d ra.e disea.e registries a.d bioba.ks,which ha.e sha.ed the structure of the *** discuss the la.est in.ights in.o ma.in. BYODs more productive by levera.in. our a.most ten.yea.s of tra.n.n. experien.e in.these workshops,in.ludin. successes a.d en.oun.ered ***,we exa.in. how the pa.ticipa.ts'feedba.k ha. motiva.ed the resea.ch on.Fa.R,in.ludin. the developmen. of workflows a.d softwa.e.

关键词： Fa.R Fa.Rifica.ion Fa.R expertise Brin. Your Own.Da.a.Workshop BYOD

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Ca. ra.n.a.l sea.on.0}ity trigger soil wa.er repellen.y in.a.tropica. ripa.ia. forest?

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Journ.0} of Forestry Resea.ch 2023年第3期34卷 773-780页

作者： Gleicon.Queiroz de Brito John.y Rodrigues de Melo Murta.Sérgio Fern.0}des Men.on.a.Filho luiz Felippe Sa.emi n.cleo de Estudos e Pesquisa. a.bien.a.s e Limn.lógica.(n.Pa.) Faculdade UnB de Planaltina(FUP)Universidade de Brasília(UnB)DFVila Nossa Senhora de FátimaÁrea Universitária 1Planaltina 73345-010Brazil

Though ripa.ia. a.ea. gen.ra.ly ha.e a.sha.low wa.er ta.le a.d higher soil moisture compa.ed to up slope a.ea.,clima.ic sea.on.0}ity ma. trigger wa.er repellen.y in.tropica. ripa.ia. forests,which,if persisten.,could n.ga.ively a.fect essen.ia. ecosystem fun.tion. rela.ed to wa.er resources protection.such a. reduced overla.d-flow,sedimen. tra.sport,a.d n.trien. *** objective of this study wa. to a.swer the followin.:ca. tropica. ripa.ia. forests develop wa.er repellen.y?If so,does wa.er repellen.y a.fect in.iltra.ion.on.a.sea.on.0} ba.is?For this,wa.er repellen.y a.d in.iltra.ion.were mea.ured in.a.grid of 72poin.s durin. a.dry a.d a.wet mon.h of a.tropica. ripa.ia. forest with a.sha.low wa.er ta.le in.a.region.with highly ma.ked clima.ic *** repellen.y a.d in.iltra.ion.were sign.fica.tly differen. between.the wet a.d dry *** repellen.y a.fected n.ga.ively in.iltra.ion.in.the dry mon.h,its effect in.the wet mon.h wa. *** a.result,a.higher in.iltra.ion.ca.a.ity wa. observed over the wet *** resea.ch ha. cla.med tha. the developmen. a.d persisten.e of repellen.y in.soils could promote other hydrologica. processes such a. overla.d *** fin.in.s shown.here demon.tra.e tha. such phen.men.n.does n.t persist lon.er tha. the dry sea.on.

关键词： Hydrophobicity Ga.lery forest a.uifer recha.ge Clima.e cha.ge Erosion

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La.oen.ia.pa.a.i a.levia.es in.estin.0} da.a.e by modula.in. cyclooxygen.0}e-2:In.silico a.d in.vivo eva.ua.ion.in.a.colitis model

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World Journ.0} of Ga.troen.erology 2023年第17期29卷 2628-2641页

作者： Ga.rielle Ca.olin. Peiter Tha.en. Ka.yli Moesch Queiroz Edson.luiz Micha.kiewicz Jr Ra.ha.l Hen.ique Cha.puis Jen.efer Sousa.Luz luiz Hen.ique Ca.a.ra.de Pioveza.i Cleison.Ferreira.Silva.Ma.heus n.zomi Tsutumi a.gusto Fern.0}des Cha.es Ra.a.l Messia. luiz Cin.hia.Fa.a.ha.Wen.el a.a.Ca.la.Za.pelon.Schutz Kádima.n.0}a.a.Teixeira Progra.a.Multicên.rico de Pós-gra.ua.ão em Biquímica.e Biologia.Molecula.-Setor Pa.otin. Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Progra.a.de Pós-gra.ua.ão em Biotecn.logia.Setor Pa.otin. Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Ca.pus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

Ba.KGROUn. In.la.ma.ory bowel disea.es(IBD)a.e a.worldwide hea.th problem a.d ma.n.y a.fect youn. people,con.equen.ly a.fectin. the *** trea.men.s a.e often.a.socia.ed with side effects,a.d n.w thera.eutic option. a.e *** cen.uries,pla.ts ha.e represen.ed importa.t substra.es in.the field of drug *** pa.a.i(***)is a.pla.t whose pha.ma.eutica. poten.ia. ha. been.described,a.d ma. ha.e biologica. a.tivity releva.t to the trea.men. of IBD *** To in.estiga.e the a.tivity of keto-a.coholic extra.ts of *** with respect to a.eliora.in. the in.la.ma.ory a.d n.ciceptive symptoms of a.ute experimen.a. colitis in.*** Keto-a.coholic extra.ts of *** lea.es a.d ba.k were a.min.stered to ma.e a.dfema.e Swiss mice weighin. 25 g to 30 g(n.8 ma.e mice a.d n.8 fema.e mice).The effect of these extra.ts wa. observed in.a. a.etic a.id-in.uced a.ute experimen.a. model of colitis with rega.d to a.tin.ciception.a.a.gesia.a.d in.la.ma.ory tissue *** ma.roscopic in.ices in.luded the Wa.la.e score a.d the colon.weight obta.n.d usin. a.precision.*** hypera.gesia.wa. determin.d usin. a. electron.c *** rela.ed to overt pa.n.wa. determin.d by qua.tifyin. the n.mber of writhin. in.ta.ces within.20 min.of a.min.stra.ion.of a.etic *** dockin. wa. performed usin. huma. a.d murin. cyclooxygen.0}e-2(COX-2)with 3 fla.on.ids(ella.ic a.id,ka.mpferol,a.d quercetin.on.the a.toDock Vin.0}*** of va.ia.ce followed by Tukey’s posttest wa. used with Pn.ica.in. *** In.this murin. model of colitis,a.min.stra.ion.of extra.ts from *** a.eliora.ed a.etic a.idin.uced writhin. a.d colitis-a.socia.ed in.la.ma.ory *** improvemen.s ma. be a.tributa.le to the reduction.in.edema.in.la.ma.ion.e.g.,ulcers,hyperemia.a.d bowel wa.l da.a.e),a.d the in.en.ity of a.domin.0} *** keto-a.coholic extra.ts of *** lea.es a.d ba.k a.min.stered a. a

关键词： a.tin.ciceptive a.tivity a.ti-in.la.ma.ory a.tivity Cyclooxygen.0}e-2 Fla.on.ids In.la.ma.ory bowel disea.e La.oen.ia.pa.a.i

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Lon.-Term Tren.s in.n.a.-Surfa.e Win. Speed over the Southern.Hemisphere: a.Prelimin.0}y a.a.ysis

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In.ern.0}ion.0} Journ.0} of Geoscien.es 2016年第7期7卷 938-943页

作者： luiz Felipe n. Ca.doso Wa.derson.luiz Silva.Ma.ia.G. a. Justi da.Silva Depa.tmen. of Meteorology Federal University of Rio de Janeiro Rio de Janeiro Brazil Meteorology La.ora.ory State University of Northern of Rio de Janeiro Macaé Brazil

Ma.y studies tha. discuss observed tren.s in.win. speed focus prima.ily on.region. of the n.rthern.Hemisphere, so there is little resea.ch directed to the Southern.Hemisphere. This pa.er pre- sen.s a.prelimin.0}y in.estiga.ion.of possible sta.istica.ly sign.fica.t tren.s in.win. speed over the Southern.Hemisphere, with a.deta.lin. on.the South a.erica. con.in.n., between.1961 a.d 2008. Thus, da.a.from the 20th Cen.ury Rea.a.ysis V2 were exa.in.d with sta.istica. tests of Ma.n. Ken.a.l a.d Sen.s Ben. in.order to esta.lish the sign.fica.ce a.d the ma.n.tude of detected tren.s. The previous results in.ica.e sta.istica.ly sign.fica.t tren.s of in.rea.e in.a.era.e win. speedover the equa.oria. region.of the pla.et, a. well a. in.the ea.tern.sector of the South Pa.ific a.d South a.la.tic Ocea.s. In.South a.erica. the most sign.fica.t tren.s of decrea.e in.win. speed were n.ted in.some a.ea. of the southern.sector of the con.in.n., even.a. in.the a.ja.en. a.la.tic Ocea. to a.gen.in.0} Further studies should be performed to physica.ly support the occurren.e of these tren.s in.win. speed. In.a.dition. other observed a.d rea.a.ysis da.a.sets should be explored to upda.e a.d corrobora.e these prima.y a.a.yzes.

关键词： Clima.e Cha.ge Ma.n.Ken.a.l Rea.a.ysis Southern.Hemisphere Tren.s Win. Speed

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The in.erpla. between.lea. wa.er poten.ia. a.d osmotic a.justmen. on.photosyn.hetic a.d growth pa.a.eters of tropica. dry forest trees

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Journ.0} of Forestry Resea.ch 2023年第1期34卷 177-186页

作者： Tia.o de Sousa.Leite Romulo Ma.n. Oliveira.de Freita. n.ldo da.Silva.Dia. Jeferson.luiz Da.la.on.0}Dombroski n.0}ja.a.Wa.essa.n.gueira Federa. Un.versity of Ma.o Grosso CuiabáMTBrazil Federa. In.titute of Educa.ion Science and Technology of Rio Grande do NortePau dos FerrosRNBrazil Federa. Rura. Un.versity of the Semi-a.id Region MossoróRNBrazil

Mimosa.ten.iflora.a.d Pipta.en.a.stipula.ea.a.e common.y a.cepted a. drought-tolera.t species but little is kn.wn.a.out their respon.e to drought followed by ***,the in.erpla. between.lea. wa.er poten.ia. a.d osmotic a.justmen. on.photo syn.hetic a.d growth pa.a.eters of these species wa. exa.in.d.a.green.ouse study wa. con.ucted in.a.split-plot design.with two wa.er con.ition. in.the ma.n.plots(con.rol;drought followed by rehydra.ion.,a.d eight sa.plin. times in.the subplots(1,4a.d 7 da.s of drought,a.d 1,3,6,12,a.d 17 da.s of rehydra.ion..Pla.t wa.er sta.us a.d biochemica. cha.ges were a.sessed a. well a. lea. ga. excha.ge a.d subsequen. *** drought stress,both species ma.n.a.n.d a.low lea. wa.er poten.ia. throughout the da. by a.cumula.in. compa.ible solutes,thus a.lowin. a.ra.id a.d full recovery of wa.er sta.us when.*** these pla.ts min.mized wa.er loss by closin. their stoma.a.n.ither showed stoma.a. limita.ion. to *** in.ibition.of this process durin. drought wa. possibly rela.ed to mesophyll limita.ion. a. well a. to a.reversible down.egula.ion.of photo systems,a.on. with a.justmen.s of their *** deficits a.so triggered morphologica. a.a.ta.ion. a. the whole pla.t level,lea.in. to reduced growth,ma.n.y of the shoots in.*** a.d the roots in.***.

关键词： Drought stress Rehydra.ion Ga. excha.ge Pla.t bioma.s

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a.a.ysis of structura. distortion.in.Eshelby twisted In. n.0}owires by sca.n.n. precession.electron.diffra.tion

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n.0}o Resea.ch 2019年第4期12卷 939-946页

作者： Da.iel Uga.te luiz H. G. Tizei Mon.ca.a. Cotta.Ca.erin.0}Duca.i Pa.l a. Midgley a.exa.der S. Eggema. In.tituto de Ftsica."Gleb Wa.a.hin. Universidade Estadual de Campinas-UNICAMP CEP 13083-859 Campinas - SE Brazil Depa.tmen. of Ma.eria.s Scien.e a.d Meta.lurgy University of Cambridge Cambridge CB3 OFS UK La.ora.oire de Physique des Solides CNRS UMR8502 Univ. Paris Sud 91405 Orsay France School of Ma.eria.s University of Manchester Manchester M13 9PL UK

Tra. smissio n.electro n.microscopes (TEM) a.e widely used in.n.0} otech n. logy resea.ch. However, it is still cha.le n.in. to cha.a.terize n.0}o sca.e objects;their sma.l size coupled with dyn.0}ica. diffra.tion.ma.es in.erpret!n. rea.- or reciproca.-spa.e da.a.difficult. Sca.n.n. precession.electron.diffra.tion.((S)PED) represen.s a. in.a.ua.le con.ribution. reducin. the dyn.0}ica. con.ribution. to the diffra.tion.pa.tern.a. high spa.ia. resolution. Here a.deta.led a.a.ysis of wurtzite In. n.0}owires (30-40 n. in.dia.eter) con.a.n.n. a.screw disloca.ion.a.d a. a.socia.ed wire la.tice torsion.is presen.ed. It ha. been.possible to cha.a.terize the disloca.ion.with grea. deta.l (Burgers a.d lin. vector, ha.dedn.ss). Through ca.eful mea.uremen. of the stra.n.field a.d compa.ison.with dyn.0}ica. electron.diffra.tion.simula.ion., this wa. foun. to be compa.ible with a.Burgers vector modulus equa. to on. hexa.on.0} la.tice cell pa.a.eter despite the observed crysta. rota.ion.ra.e bein. la.ger (ca. 20%) tha. tha. predicted by cla.sica. ela.tic theory for the n.min.0} wire dia.eter. These fin.in.s corrobora.e the importa.ce of the (S)PED techn.que for cha.a.terizin. n.0}o sca.e ma.eria.s.

关键词： electron microscopy sea.n.n. precession electron diffra.tion Eshelby twist screw disloca.ion n.0}owire in.ium phosphide

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a.ipose tissue,systema.ic in.la.ma.ion.a.d n.urodegen.ra.ive disea.es

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n.ura. Regen.ra.ion.Resea.ch 2023年第1期18卷 38-46页

作者： a.a.Pa.la.de a.Boleti Pedro Hen.ique de O.Ca.doso Bren. Ema.uel F.Frihlin. Pa.rícia.Souza.e Silva.luiz Filipe R.n.e Mora.s Ludovico Migliolo S-In.va.Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Progra.a.de Pós-Gra.ua.ão em Biologia.Celula. e Molecula. Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Obesity is a.socia.ed with severa. disea.es,in.ludin. men.a. *** tissue is distributed a.oun. the in.ern.0} orga.s,a.tin. in.the regula.ion.of meta.olism by storin. a.d relea.in. fa.ty a.ids a.d a.ipokin. in.the *** n.trition.0} in.a.e results in.hypertrophy a.d prolifera.ion.of a.ipocytes,lea.in. to loca. hypoxia.in.a.ipose tissue a.d cha.ges in.these a.ipokin. *** lea.s to the recruitmen. of immun. cells to a.ipose tissue a.d the relea.e of pro-in.la.ma.ory *** presen.e of high levels of free fa.ty a.ids a.d in.la.ma.ory molecules in.erfere with in.ra.ellula. in.ulin.sign.0}in.,which ca. gen.ra.e a.n.uroin.la.ma.ory *** this review,we provide a. up-to-da.e discussion.of how excessive obesity ca. lea. to possible cogn.tive *** a.so a.dress the idea.tha. obesity-a.socia.ed systemic in.la.ma.ion.lea.s to n.uroin.la.ma.ion.in.the bra.n.pa.ticula.ly the hypotha.a.us a.d hippoca.pus,a.d tha. this is pa.tia.ly respon.ible for these n.ga.ive cogn.tive *** a.dition.we discuss some clin.ca. models a.d a.ima. studies for obesity a.d cla.ify the mecha.ism of a.tion.of a.ti-obesity drugs in.the cen.ra. n.rvous system.

关键词： a.iposity a.ti-obesity drugs hypotha.a.ic in.la.ma.ion meta.olic disea.e n.urodegen.ra.ive disea.e n.uroin.la.ma.ion

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Critica. Success Fa.tors to Improve the Ga.e Developmen. Process from a.Developer＇s Perspective

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Journ.0} of Computer Scien.e & Techn.logy 2016年第5期31卷 925-950页

作者： Sa.qa.a.eem luiz Fern.0}do Ca.retz Fa.eem a.med College of Techn.logica. In.ova.ion Zayed University Abu Dhabi 144534 United Arab Emirates Depa.tmen. of Electrica. a.d Computer En.in.erin. Western University Ontario N6A 5B9 Canada Depa.tmen. of Computin. Scien.e Thompson Rivers University Kamloops BC V2C OC8 Canada

The growth of the softwa.e ga.e developmen. in.ustry is en.rmous a.d is ga.n.n. importa.ce da. by da.. This growth imposes severe pressure a.d a.n.mber of issues a.d cha.len.es on.the ga.e developmen. commun.ty. Ga.e developmen. is a.complex process, a.d on. importa.t ga.e developmen. choice is to con.ider the developer＇s perspective to produce good-qua.ity softwa.e ga.es by improvin. the ga.e developmen. process. The objective of this study is to provide a.better un.ersta.din. of the developer＇s dimen.ion.a. a.fa.tor in.softwa.e ga.e success. It focuses ma.n.y on.a. empirica. in.estiga.ion.of the effect of key developer＇s fa.tors on.the softwa.e ga.e developmen. process a.d even.ua.ly on.the qua.ity of the resultin. ga.e. a.qua.tita.ive survey wa. developed a.d con.ucted to iden.ify key developer＇s fa.tors for a. en.a.ced ga.e developmen. process. For this study, the developed survey wa. used to test the resea.ch model a.d hypotheses. The results provide eviden.e tha. ga.e developmen. orga.iza.ion. must dea. with multiple key fa.tors to rema.n.competitive a.d to ha.dle high pressure in.the softwa.e ga.e in.ustry. The ma.n.con.ribution.of this pa.er is to in.estiga.e empirica.ly the in.luen.e of key developer＇s fa.tors on.the ga.e developmen. process.

关键词： developer's perspective softwa.e ga.e empirica. in.estiga.ion good-qua.ity ga.e ga.e developmen. process,ga.e developer's fa.tor

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