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A two-phase type-curve method with multiscale fluid transport mechanisms in hydraulically fractured shale reservoirs

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Petroleum Science 2023年第4期20卷 2253-2267页

作者： feng-Yuan Zhang Lin-Jun Zou Zhen-Hua Rui Hamid Emami-Meybodi luis.f.ayala Zheng-Xin Zhang College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Oil and Gas Technology Research Institute PetroChina Changqing Oilfield CompanyXi'an710000ShaanxiChina College of Carbon Neutrality future Technology China University of Petroleum(Beijing)Beijing102249China College of Petroleum China University of Petroleum(Beijing)at KaramayKaramay834000XinjiangChina College of Earth and Mineral Sciences The Pennsylvania State University(University Park)State CollegePA16802USA

The quantitative understanding of hydraulic fracture(Hf)properties guides accurate production forecasts and reserve *** curve is a powerful technique to characterize Hf and reservoir properties from flowback and long-term production ***,two-phase flow of water and hydrocarbon after an Hf stimulation together with the complex transport mechanisms in shale nanopores exacerbate the nonlinearity of the transport equation,causing errors in type-curve ***,we propose a new two-phase type-curve method to estimate Hf properties,such as Hf volume and permeability of fracture,through the analysis of flowback data of multi-fractured shale *** proposed type curve is based on a semianalytical solution that couples the two-phase flow from the matrix with the flow in Hf by incorporating matrix influx,slippage effect,stress dependence,and the spatial variation of fluid properties in inorganic and organic *** the first time,multiple fluid transport mechanisms are considered into two-phase type-curve analysis for shale *** analyze the flowback data from a multi-fractured horizontal well in a shale gas reservoir to verify the field application of the proposed *** results show that the fracture properties calculated by the type-curve method are in good agreement with the long-time production data.

关键词： Type curve Two-phase flow flowback analysis fluid transport mechanisms Shale reservoir

Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： luis A.Pesantes Ruben Hidalgo-León Johnny Rengifo Miguel Torres Jorge Aragundi JoséCordova-Garcia luis f.Ugarte facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to find solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. for the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: mathematical and modelling aspects of porous media

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frontiers of Chemical Science and Engineering 2021年第2期15卷 399-409,F0004页

作者： fernando f.Rivera Berenice Miranda-Alcantara German Orozco Carlos Ponce de Leon luis f.Arenas National Council of Science and Technology(CONACYT) Mexico City 03940Mexico Center of Research and Technological Development in Electrochemistry(CIDETEQ) Queretaro 76703Mexico Electrochemical Engineering Laboratory Energy Technology Research GroupFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries(RfBs)and other electrochemical *** order to determine their predictive capability,turbulent Reynolds-averaged Navier-Stokes(RANS)and free flow plus porous media(Brinkman)models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RfB for laboratory *** different platinized titanium electrodes were considered,a plate plus a turbulence promoter and an expanded metal *** pressure drop was validated against experimental data obtained with typical cerium *** was found that the pressure drop values were better described by the RANS approach,whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

关键词： CfD simulation porous media porous electrode pressure drop redox flow battery

Current and emerging therapies for alcohol-associated hepatitis

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Liver Research 2023年第1期7卷 35-46页

作者： francisco Idalsoaga Gustavo Ayares luis Antonio Díaz Jorge Arnold María ayala-Valverde David Hudson Marco Arrese Juan Pablo Arab Department of Gastroenterology School of MedicinePontificia Universidad Catolica de ChileSantiagoChile Internal Medicine Service Hospital El PinoCritical Patient UnitClinica DavilaSantiagoChile Division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonOntarioCanada Department of Epidemiology and Biostatistics Schulich School of MedicineWestern UniversityLondonOntarioCanada Alimentiv LondonOntarioCanada

Alcohol-related liver disease(ALD)encompasses a spectrum of diseases caused by excessive alcohol *** includes hepatic steatosis,steatohepatitis,variable degrees of fibrosis,cirrhosis,and alcohol-associated hepatitis(AH),the latter being the most severe acute form of the *** AH is associated with high mortality(reaching up to 30%e50%)at 90 *** cornerstone of ALD,and particularly AH,treatment continues to be abstinence,accompanied by support measures such as nutritional supplementation and management of alcohol withdrawal syndrome(AWS).In severe AH with model for end-stage liver disease(MELD)score21,corticosteroids can be used,especially MELD score between 25 and 39,where the highest benefit is *** key aspects of treatment include the early identification of infections and their associated management and the proper identification of potential candidates for liver *** development of new therapies based on the pathophysiology and mechanisms of liver injury are *** includes the modulation and management of the innate immune response,gut dysbiosis,bacterial translocation,and bacteria-derived products from the *** hold promise for the future of AH treatment.

关键词： Alcohol-associated hepatitis(AH) Alcohol-related liver disease(ALD) Alcohol use disorder(AUD) AUD treatment Nutritional therapy Steroids therapy Cirrhosis fibrosis

Introduction to the special issue on “COVID-19”

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Geoscience frontiers 2022年第6期13卷 208-209页

作者： luis f.O.Silva Weijun Li Teresa Moreno Department of Civil and Environmental Universidad de la CostaCUC Department of Atmospheric Sciences School of Earth SciencesZhejiang University Institute for Environmental Assessment and Water Research Consejo Superior de Investigaciones Científicas

COVID-19 pandemic is wreaking havoc and bringing the whole world into a standstill in an unprecedented fashion. Joint efforts from multiple sectors to address the various aspects of environment and public health through usage of green technologies have become essential. The application of cleaner and effective technologies can be expanded to management and control, pollution mitigation and valorization of waste. In this Special Issue of Geoscience frontiers, we present contributions addressing the interactions of COVID-19 in relation to environment and human health.

关键词： bringing expanded COV

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Comparative carbon emission assessments of recycled and natural aggregate concrete: Environmental influence of cement content

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Geoscience frontiers 2021年第6期12卷 66-75页

作者： Marian Sabǎu Dan V.Bompa luis f.O.Silva Department of Civil and Environmental Engineering Universidad de la Costa080020 BarranquillaColombia Department of Civil and Environmental Engineering University of SurreyGuildford GU27XHUK Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru

This work examines the environmental and geochemical impact of recycled aggregate concrete production with properties representative for structural *** environmental influence of cement content,aggregate production,transportation,and waste landfilling is analysed by undertaking a life cycle assessment and considering a life cycle inventory largely specific for the *** obtain a detailed insight into the optimum life cycle parameters,a sensitivity study is carried out in which supplementary cementitious materials,different values of natural-to-recycled aggregate content ratio and case-specific transportation distances were *** results show that carbon emissions were between 323 and 332 kgCO_(2)e per cubic metre of cement only natural aggregate *** values can be reduced by up to 17%by replacing 25%of the cement with fly *** contrast,carbon emissions can increase when natural coarse aggregates are replaced by recycled aggregates in proportions of 50%and 100%,and transportation is not included in ***,the concrete with 50%recycled aggregate presented lower increase,only 0.3%and 3.4%for normal and high strength concrete,*** some cases,the relative contribution of transportation to the total carbon emissions increased when cement was replaced by fly ash in proportions of 25%,and case-specific transportation distances were *** absolute values,the concrete mixes with 100%recycled aggregates and 25%fly ash had lower carbon emissions than concrete with cement and natural aggregates *** environmental benefits can be obtained when the transportation distances of fly ash are relatively short(15–25 km)and the cement replacement by fly ash is equal or higher than 25%,considering that the mechanical properties are adequate for practical *** observations from this paper show that recycled aggregate concrete with strength characteristics representative for structural members can have lowe

关键词： Life cycle assessment Recycled aggregate Natural aggregate Transportation distance OpenLCA

Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia

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World Journal of Gastroenterology 2016年第18期22卷 4567-4575页

作者： Roberto Herrera-Goepfert luis f Onate-Ocana José luis Mosqueda-Vargas luis A Herrera Clementina Castro Julia Mendoza Rodrigo González-Barrios Department of Pathology Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Clinical Research Division Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Unidad de Investigacion Biomedica en Cancer Instituto Nacional de Cancerologia (INCan)-Instituto de Investigaciones Biomedicas (IIB) Universidad Nacional Autonoma de Mexico (UNAM) 14080 Mexico DF Mexico

AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar ***: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by ***: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection.

关键词： DNA methylation Esophageal columnar metaplasia Thrombospondin-1 Death-associated protein kinase Helicobacter pylori cagA

An experimental validation of genomic selection in octoploid strawberry

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Horticulture Research 2017年第1期4卷 380-388页

作者： Salvador A Gezan luis f Osorio Sujeet Verma Vance M Whitaker School of forest Resources and Conservation University of Florida363 Newins-Ziegler HallPO Box 110410Gainesville32611-0410FLUSA Gulf Coast Research and Education Center University of Florida14625 CR 672Wimauma33598FLUSA

The primary goal of genomic selection is to increase genetic gains for complex traits by predicting performance of individuals for which phenotypic data are not *** objective of this study was to experimentally evaluate the potential of genomic selection in strawberry breeding and to define a strategy for its *** clonally replicated field trials,two in each of 2 years comprised of a total of 1628 individuals,were established in 2013–2014 and 2014–*** complex yield and fruit quality traits with moderate to low heritability were assessed in each ***-density genotyping was performed with the Affymetrix Axiom IStraw90 single-nucleotide polymorphism array,and 17479 polymorphic markers were chosen for *** methods were compared,including Genomic BLUP,Bayes B,Bayes C,Bayesian LASSO Regression,Bayesian Ridge Regression and Reproducing Kernel Hilbert ***-validation within training populations resulted in higher values than for true validations across *** true validations,Bayes B gave the highest predictive abilities on average and also the highest selection efficiencies,particularly for yield traits that were the lowest heritability *** efficiencies using Bayes B for parent selection ranged from 74%for average fruit weight to 34%for early marketable yield.A breeding strategy is proposed in which advanced selection trials are utilized as training populations and in which genomic selection can reduce the breeding cycle from 3 to 2 years for a subset of untested parents based on their predicted genomic breeding values.

关键词： breeding straw traits