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Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease

World Journal of Gastroenterology 2023年第23期29卷 3688-3702页

作者： mielle michaux Justin m Chan Luke Bergmann luis F Chaves Brian Klinkenberg Kevan Jacobson Department of Pediatrics Division of GastroenterologyHepatology and NutritionFaculty of MedicineBritish Columbia Children’s HospitalUniversity of British ColumbiaVancouver V6H 3V4British ColumbiaCanada British Columbia Children’s Hospital Research Institute British Columbia Children’s HospitalVancouver V5Z 4H4British ColumbiaCanada Department of Geography University of British ColumbiaVancouver V6T 1Z2British ColumbiaCanada Department of Environmental and Occupational Health School of Public HealthIndiana UniversityBloomingtonIN 47405United States Department of Cellular and Physiological Sciences University of British ColumbiaVancouver V6T 1Z3British ColumbiaCanada

BACKGROUND Geographical(geospatial)clusters have been observed in inflammatory bowel disease(IBD)incidence and linked to environmental determinants of disease,but pediatric spatial patterns in North America are *** hypothesized that we would identify geospatial clusters in the pediatric IBD(PIBD)population of British Columbia(BC),Canada and associate incidence with ethnicity and environmental *** To identify PIBD clusters and model how spatial patterns are associated with population ethnicity and environmental *** One thousand one hundred eighty-three patients were included from a BC Children’s Hospital clinical registry who met the criteria of diagnosis with IBD≤age 16.9 from 2001–2016 with a valid postal code on file.A spatial cluster detection routine was used to identify areas with similar *** ecological analysis employed Poisson rate models of IBD,Crohn’s disease(CD),and ulcerative colitis(UC)cases as functions of areal population ethnicity,rurality,average family size and income,average population exposure to green space,air pollution,and vitamin-D weighted ultraviolet light from the Canadian Environmental Health Research Consortium,and pesticide *** Hot spots(high incidence)were identified in metro Vancouver(IBD,CD,UC),southern Okanagan regions(IBD,CD),and Vancouver Island(CD).Cold spots(low incidence)were identified in Southeastern BC(IBD,CD,UC),Northern BC(IBD,CD),and on BC’s coast(UC).No high incidence hot spots were detected in the densest urban *** results were represented as incidence rate ratios(IRR)with 95%*** risk factors for PIBD included fine particulate matter(Pm2.5)pollution(IRR=1.294,CI=1.113-1.507,Pm oil to orchards and grapes(IRR=1.135,CI=1.007-1.270,P=0.033).South Asian population(IRR=1.020,CI=1.011-1.028,Pmily size(IRR=0.467,CI=0.268-0.81

关键词： Inflammatory bowel diseases Crohn disease Ulcerative colitis Pesticides Air pollution South Asian people

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Symmetrization for Fractional Elliptic and Parabolic Equations and an Isoperimetric Application(Dedicated to Haim Brezis,great master of analysis,on his 70th birthday)

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Chinese Annals of mathematics,Series B 2017年第2期38卷 661-686页

作者： Yannick SIRE Juan luis VAZQUEZ Bruno VOLZONE johns hopkins university Krieger Hall3401 N.Charles StBaltimoreM D21218USA. departamento de matemticas universidad autnoma de madrid28049 M adridSpain dipartimento di ingegneria universit degli studi di napoli"parthenope"80143 Italia.

This paper develops further the theory of symmetrization of fractional Laplacian operators contained in recent works of two of the authors. This theory leads to optimal estimates in the form of concentration comparison inequalities for both elliptic and parabolic equations. The authors extend the theory for the so-called restricted fractional Laplacian defined on a bounded domain Ω of R^N with zero Dirichlet conditions outside of Ω. As an application, an original proof of the corresponding fractional Faber-Krahn inequality is derived. A more classical variational proof of the inequality is also provided.

关键词： Symmetrization, Fractional Laplacian, Nonlocal elliptic and parabolicequations, Faber-Krahn inequality

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Evolutionary modifications of Astyanax larval prey capture (LPC) in a dark environment

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Zoological Research 2023年第4期44卷 750-760页

作者： luis Espinasa Ruth Diamant Ehud Vinepinsky monika Espinasa School of Science Marist CollegePoughkeepsieNY 12601USA Depto.de Física Universidad Autónoma Metropolitana-IztapalapaCiudad de México C.P.09310México Institut de Biologie de l’ENS(IBENS) Département de BiologieÉcole Normale SupérieureCNRSINSERMUniversitéPSL75005 ParisFrance SUNY Ulster Stone RidgeNY 12484USA

Feeding strategies of an organism depend on the multimodal sensory processing that most efficiently integrates available visual,chemosensory,and/or mechanoreceptive cues as part of their environmental *** blind cavefish morph of Astyanax mexicanus has developed sensory-dependent behaviors to find food more efficiently than their eyed,surface-morph counterparts while in *** the absence of light,adult cavefish have evolved enhanced behaviors,such as vibration attraction behavior(VAB),and changes in feeding ***,we identified evolved differences in cavefish larval prey capture(LPC)*** the dark,LPC is more efficient in cavefish than in surface ***,different cave populations express laterality in their LPC and strike towards prey preferentially located on their left or right *** suggests the occurrence,to some extent,of divergent LPC evolution among cave *** LPC can be triggered exclusively by a vibration stimulus in both surface and cavefish,we provide evidence that LPC is,at least partially,a multimodal sensory process different from adult *** also found that a lack of food may exacerbate the laterality of ***,we proposed a mathematical model for explaining laterality based on a balance between:(1)enlarged range of foraging field(behavioral or perceptive)due to asymmetry,(2)food abundance,and(3)disadvantages caused by laterality(unequal lateral hydrodynamic resistance when swimming,allocation of resources for the brain and receptors,and predator escape).

关键词： Astyanax Cave Troglobite Neuromast Prey Asymmetry

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Sintering study of Ti6Al4V powders with different particle sizes and their mechanical properties

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International Journal of minerals,metallurgy and materials 2018年第12期25卷 1389-1401页

作者： Joséluis Cabezas-Villa JoséLemus-Ruiz Didier Bouvard Omar Jiménez Héctor Javier Vergara-Hernández luis Olmos University michoacana of San Nicolás of Hidalgo IIMMMorelia 58060México University Grenoble Alpes CNRSSIMaPGrenoble 38000France University of Guadalajara Departamento de Ingeniería de ProyectosZapopan 45100México National Technological Institute of mexico I.T.MoreliaMorelia 58120México University michoacana of San Nicolás of Hidalgo INICITMorelia 58060México

Ti6Al4V powders with three different particle size distributions(0–20, 20–45, and 45–75 μm) were used to evaluate the effect of the particle size distribution on the solid-state sintering and their mechanical properties. The sintering kinetics was determined by dilatometry at temperatures from 900 to 1260°C. The mechanical properties of the sintered samples were evaluated by microhardness and compression tests. The sintering kinetics indicated that the predominant mechanism depends on the relative density irrespective of the particle size used. The mechanical properties of the sintered samples are adversely affected by increasing pore volume fraction. The elastic Young's modulus and yield stress follow a power law function of the relative density. The fracture behavior after compression is linked to the neck size developed during sintering, exhibiting two different mechanisms of failure: interparticle neck breaking and intergranular cracking in samples with relative densities below and above of 90%, respectively. The main conclusion is that relative density is responsible for the kinetics, mechanical properties, and failure behavior of Ti6 Al4 V powders.

关键词： Ti6Al4V powders dilatometry microhardness sintering kinetics compression failure behavior

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Plasmonic metal‐organic frameworks

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Smartmat 2021年第4期2卷 446-465页

作者： Guangchao Zheng Isabel Pastoriza‐Santos Jorge Pérez‐Juste luis m.Liz‐marzán School of Physics and microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouChina CINBIO Universidade de VigoDepartamento de Química FísicaVigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS‐UVIGOVigoSpain CIC biomaGUNE Basque Research and Technology Alliance(BRTA)Donostia‐San SebastianSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain Centro de Investigación Biomédica en Red BioingenieríaBiomateriales y NanomedicinaCIBER‐BBNDonostia‐San SebastiánSpain

Plasmonic metal‐organic frameworks are composite nanoparticles comprising plasmonic metal nanoparticles(NPs)embedded within a metalorganic framework(mOF)*** a result,not only the functionalities of the individual components are retained,but synergistic effects additionally provide improved chemical and physical *** progress in plasmonic mOFs has demonstrated the potential for nanofabrication and various nanotechnology *** challenges toward plasmonic mOFs have been recently addressed,resulting in new opportunities toward practical applications,such as surface‐enhanced Raman scattering,therapy,and *** impact of key parameters(thermodynamic ***)on the synthetic pathways of plasmonic mOFs is reviewed,while providing insight into related progress toward structure‐derived applications.

关键词： catalysis drug delivery metal‐organic frameworks nanocomposites plasmonic metal nanoparticles plasmonic mOFs surface‐enhanced Raman scattering

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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco m Jesús Fernández Aceñero luis Ortega medina Department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA molecular

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CsPbBr_(x)I_(3-x)thin films with multiple ammonium ligands for low turn-on pure-red perovskite light-emitting diodes

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Nano Research 2021年第1期14卷 191-197页

作者： maowei Jiang Zhanhao Hu luis K.Ono Yabing Qi Energy materials and Surface Sciences Unit(EmSSU) Okinawa Institute of Science and Technology Graduate University(OIST)1919-1 TanchaOnna-sonOkinawa 904-0495Japan

All-inorganic α-CsPbBr_(x)I_(3-x)perovskites featuring nano-sized crystallites show great potential for pure-red light-emitting diode(LED)***,the CsPbBr_(x)I_(3-x)LEDs based on nano-sized α-CsPbBr_(x)I_(3-x)crystallites have been fabricated mainly via the classical colloidal route including a tedious procedure of nanocrystal synthesis,purification,ligand or anion exchange,film casting,*** the usually adopted conventional LED device structure,only high turn-on voltages(>2.7)have been achieved for CsPbBrxl3-x ***,this mix-halide system may suffer from severe spectra-shift under *** this report,CsPbBr_(x)I_(3-x)thin films featuring nano-sized crystallites are prepared by incorporating multiple ammonium ligands in a one-step spin-coating *** multiple ammonium ligands constrain the growth of CsPbBr_(x)I_(3-x)*** CsPbBr_(x)I_(3-x)thin films benefit from quantum *** corresponding CsPbBr_(x)I_(3-x)LEDs,adopting a conventional LED structure of indium-doped tin oxide(ITO)/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)/CsPbBr_(x)I_(3-x)/[6,6]-phenyl C61 butyric acid methyl ester(PCBm)/bathocuproine(BCP)/AI,emit pure-red color at Commission Internationale de I'eclairage(CIE)coordinates of(0.709,0.290),(0.711,0.289),etc.,which represent the highest color-purity for reported pure-red perovskite LEDs and meet the Rec.2020 requirement at CIE(0.708,0.292)very *** CsPbBr_(x)I_(3-x)LED shows a low turn-on voltage of 1.6 V,maximum external quantum efficiency of 8.94%,high luminance of 2,859 cd·m^(-2),and good color stability under bias.

关键词： CsPbBr_(x)I_(3-x)thin film nano-sized crystallites surface termination pure-red color perovskite light-emitting diode low turn-on voltage

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Experimental evaluation and simulation of volumetric shrinkage and warpage on polymeric composite reinforced with short natural fibers

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Frontiers of mechanical Engineering 2015年第3期10卷 287-293页

作者： Jonnathan D. SANTOS Jorge I. FAJARDO Alvaro R. CUJI Jaime A. GARCIA luis E. GARZON luis m. LOPEZ Department of mechanical Engineering Universidad Polit6cnicaSalesiana Elia Liut Ecuador Department of mechanical Engineering Universidad PontificiaBolivariana Medellin Columbia

A polymeric natural fiber-reinforced composite is developed by extrusion and injection molding process. The shrinkage and warpage of high-density polyethylene reinforced with short natural fibers of Guadua angustifolia Kunth are analyzed by experimental measure- ments and computer simulations. Autodesk moldflow and Solid Works are employed to simulate both volumetric shrinkage and warpage of injected parts at different configurations： 0wt.%, 20wt.%, 30wt.% and 40 wt.% reinforcing on shrinkage and warpage behavior of polymer composite. Become evident the restrictive effect of reinforcing on the volumetric shrinkage and warpage of injected parts. The results indicate that volumetric shrinkage of natural composite is reduced up to 58% with fiber increasing, whereas the warpage shows a reduction form 79% to 86% with major fiber content. These results suggest that it is a highly beneficial use of natural fibers to improve the assembly properties of polymeric natural fiber-reinforced composites.

关键词： biocomposite natural fiber shrinkage,simulation warpage

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Hepatic hemangioma:What internists need to know

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World Journal of Gastroenterology 2020年第1期26卷 11-20页

作者： monica Leon luis Chavez Salim Surani Centro medico ABC Ciudad de MexicoCDMX 01120Mexico Department of Internal medicine Texas Tech University Health Sciences CenterEl PasoTX 79905United States Texas A&m University Corpus ChristiTX 78405United States

Hepatic hemangioma(HH)is the most common benign liver tumor and it is usually found incidentally during radiological *** tumor arises from a vascular malformation;however,the pathophysiology has not been clearly *** usually correlate with the size and location of the *** commonly the presence of a large HH may cause life-threatening *** diagnosis can be established by the identification of HH hallmarks in several imaging *** patients that present with abdominal symptoms other etiologies should be excluded first before attributing HH as the *** asymptomatic patient’s treatment is not required and follow up is usually reserved for HH of more than 5 *** patients can be managed surgically or with other non-surgical modalities such as transcatheter arterial embolization or radiofrequency *** surgery has shown to have fewer complications as compared to hepatectomy or other surgical *** of the tumor is seen in less than 40%.Hormone stimulation may play a role in HH growth;however,there are no contraindications for hormonal therapy in patients with HH due to the lack of concrete *** clinicians encounter this condition,they should discern between observation and surgical or non-surgical management based on the clinical presentation.

关键词： Hepatic hemangioma Liver masses Liver Vascular lesion

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Convergence in leaf phenology traits of two understorey ferns in the northwestern Iberian Peninsula

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Journal of Plant Ecology 2018年第1期11卷 92-102页

作者： luis G.Quintanilla Beatriz Pías Department of Biology and Geology Physics and Inorganic ChemistrySchool of Environmental Sciences and TechnologyRey Juan Carlos Universityc/Tulipán s/n28933 MóstolesMóstolesSpain Department of Plant Sciences Faculty of BiologyComplutense of Madrid UniversityMadridSpain

Aims Plants control leaf phenology to maximize annual photosynthetic *** ferns play an important ecological role in many habitats,especially forests,their phenology traits have been poorly ***,we investigate the leaf phenology of two ferns of the forest understorey and analyse the relationship between the timing of leaf emergence and spore dispersal and the effect of between-year climatic *** We compared the leafing and sporing phenologies of two ferns with very large(>2 m),overwintering leaves:Culcita macrocarpa and Woodwardia *** regularly monitored individuals of six popu-lations in the northwestern Iberian Peninsula during a 3-year *** studied eight phenology variables:leafing start date,leafing end date,leaf expansion time,number of new leaves per individual,between-individual synchrony,within-individual synchrony,percentage of fertile leaves and spore release *** also determined leaf mass per area(LmA)and gathered data on air temperature and *** findings Both *** and *** produce few leaves(~2 leaves individual−1 year−1),which expand simultaneously for a very long period(from midwinter to early summer),are retained for more than 1 year(37 and 19 months,respectively)and have relatively high *** traits,together with large leaf size,have also been found in seed plants from the forest understorey and represent adap-tations to this light-limited *** of both study ferns are simultaneously released in late winter,with little between-year variation caused by differences in air *** remarkable similarity between species suggests that the convergence in tim-ing of leaf emergence favours the convergence in timing of spore dispersal.

关键词： Culcita macrocarpa leaf phenology spore dispersal temperate forest Woodwardia radicans

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