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Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism

World Journal of Gastroenterology 2017年第28期23卷 5246-5252页

作者： Fernando Díaz-Fontenla Marta Castillo-Pradillo Arantxa Díaz-Gómez luis ibanez-samaniego Pilar Gancedo Juan Adan Guzmán-de-Villoria Pilar Fernández-García Rafael Banares-Canizares Rita García-Martínez Unidad de Hepatología Servicio de Aparato DigestivoHospital General Universitario Gregorio Maranón Instituto de Investigación Sanitaria Hospital Gregorio Maranón Servicio de Aparato Digestivo Hospital Santa Bárbara Servicio de Radiodiagnóstico Hospital General Universitario Gregorio Maranón Centro de Investigación Biomédica en Red de Salud Mental Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Facultad de Medicina Universidad San Pablo CEU

Hepatic encephalopathy(HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events(i.e.,portosystemic shunt) and alternative diagnosis. Hypothyroidism shares clinical manifestations with HE and is usually considered within the differential diagnosis of HE. Here,we describe a patient with refractory HE who presented a large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment,hyperammonaemia,electroencephalograph alterations,impaired neuropsychological performance,and magnetic resonance imaging and spectroscopy disturbances were highly suggestive of HE,paralleled the course of hypothyroidism and normalized after thyroid hormone replacement. There was no need for intervention over the portosystemic shunt. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. This case led us to consider hypothyroidism not only in the differential diagnosis but also as a precipitating factor of HE.

关键词： Hepatic encephalopathy Hypothyroidism Cognitive impairment Cirrhosis Portosystemic shunt Magnetic resonance spectroscopy

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Benthic Diatom Communities of a Large Mediterranean River under the Influence of a Thermal Effluent

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Open Journal of Ecology 2018年第2期8卷 104-125页

作者： luis Quevedo Carles ibanez Nuno Caiola Escuela Superior Politecnica de Chimborazo ESPOCHRiobambaEcuador IRTA Aquatic Ecosystems Carretera Poble NouCataloniaSpain

The influence of a thermal discharge caused by the cooling system of a nuclear power station on benthic diatom communities was assessed at the lower Ebro River (in Spain), and the information generated could be useful to understand the effects of increasing temperature on large Mediterranean rivers. Surveys conducted at sites before and after the effluent and collected from natural and artificial substrate were analyzed and, Non-metrical Multidimensional Scaling (NMDS), Similarity Percentage Analysis (SIMPER) and 1-way Analysis of Similarities (ANOSIM) were performed to assess changes in community structure. The relationship between diatom assemblages and environmental variables was assessed with a multivariate distance-based linear regression model (DISTLM) and the model was visualized through a redundancy analysis (dbRDA). NMDS ordination was obtained with a stress of 0.18 and 0.17 for natural and artificial substrates, respectively. ANOSIM showed significant differences between Control and Impacted sites (p 0.05). Simper analysis showed that the mean dissimilarity between Control and Impacted sites was of 42.22% for natural substrate and of 39.97% for artificial substrate. DISTLM selected a set of explanatory variables (dissolved oxygen, Tº?difference, total phosphorus, pH and chlorophyll) with a 67.24% of fitted variation. Diatoms showed sensitivity to thermal changes, even though when these did not exceed 3℃. The factors that seemed to influence benthic assemblages the most were seasonal variation and the thermal increase caused by the nuclear power station.

关键词： Diatoms Ebro River Thermal Pollution Nuclear

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Splenic rupture following colonoscopy

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World Journal of Gastroenterology 2008年第41期14卷 6410-6412页

作者： Juan Francisco Guerra Ignacio San Francisco Fernando Pimentel luis ibanez Departamento de Cirugía Digestiva Pontificia Universidad Católica de Chile Marcoleta 367

Colonoscopy is a safe and routinely performed diagnostic and therapeutic procedure for different colorectal diseases. Although the most common complications are bleeding and perforation, extracolonic or visceral injuries have also been described. Splenic rupture is a rare complication following colonoscopy, with few cases reported. We report a 60-year-old female who presented to surgical consultation 8 h after a diagnostic colonoscopy. Clinical, laboratory and imaging findings were suggestive for a massive hemoperitoneum. At surgery, an almost complete splenic disruption was evident, and an urgent splenectomy was performed. After an uneventful postoperative period, she was discharged home. Splenic injury following colonoscopy is considered infrequent. Direct trauma and excessive traction of the splenocolic ligament can explain the occurrence of this complication. Many times the diagnosis is delayed because the symptoms are due to colonic insuffl ation, so the most frequent treatment is an urgent splenectomy. A high index of suspicion needs an early diagnosis and adequate therapy.

关键词： Colonoscopy Splenic injury Splenic rupture Splenectomy

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The ITK Software Guide 2.4 2nd ed.

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2005年

作者： luis ibanez William Schroeder

ISBN: (纸本)9781930934153

Everything you need to install, use, and extend the Insight Segmentation and Registration Toolikit ITK. Includes detailed examples, installation procedures, and system overview for ITK version 2.4. (The included examples are taken directly from the ITK source code repository and are designed to demonstrate the essential features of the software.) The book comes with a CD-ROM that contains a complete hyperlinked version of the book plus ITK source code, data, Windows binaries, and extensive class documentation. Also includes CMake binaries for managing the ITK build process on a variety of compiler and operating system configurations. VolView 2.0, is a powerful image viewing and volume rendering application. A 30 day evaluation CD is included with your purchase. VolView offers a powerful free mode, supports collaborative network-based sessions, and ITK plug-ins. VolView is also available for a free 30 day trial download

关键词： guide software

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Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance:A randomized controlled trial

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World Journal of Gastroenterology 2020年第47期26卷 7568-7583页

作者： Agustin Seoane Xenia Font Juan C Perez Rocio Perez Carlos F Enriquez Miriam Parrilla Faust Riu Josep M Dedeu luis E Barranco Xavier Duran Ines A ibanez Marco A Alvarez Digestive Department Endoscopy UnitHospital del MarParc de Salut MarBarcelona 08003Spain Colorectal Cancer Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Consulting Service on Methodology for Biomedical Research IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain

BACKGROUND Colonoscopy attendance is a key quality parameter in colorectal cancer population screening *** these programmes,educative interventions with bidirectional contact carried out by trained personnel have been proved to be an important tool for colonoscopy attendance improvement,and because of its huge clinical and economic impact,they have been widely ***,outside of this population programmes,educative measures to improve colonoscopy attendance have been poorly studied and no navigation interventions are usually *** To investigate the clinical and economic impacts of an educational telephone intervention on colonoscopy attendance outside colorectal cancer screening *** This randomized controlled trial included consecutive patients referred to colonoscopy from primary care centres from November 2017 to May *** intervention group(IG)received a telephone intervention,while the control group(CG)did *** assigned to the IG received an educational telephone call 7 d before the colonoscopy *** intervention was carried out by two nurses with deep endoscopic knowledge who were previously trained for a telephone educational intervention for *** impact on patient compliance with preparedness protocols related to bowel cleansing,antithrombotic management,and sedation scheduling was also evaluated.A second call was conducted to assess patient ***-to-treat(ITT)and perprotocol(PP)analyses were *** A total of 738 and 746 patients were finally included in the IG and CG *** hundred thirteen(83%)patients were contacted in the *** non-attendance rate was lower in the IG,both in the ITT analysis(IG 8.4%vs CG 14.3%,P<0.001)and in the PP analysis(4.4%vs 14.3%,P<0.001).In a multivariable analysis,belonging to the control group increased the risk of nonattendance in both,the ITT analysis(OR 1.81,95%CI:1.27 to 2.58,P=0.001)and the PP analysis(O

关键词： Colonoscopy Quality improvement No-show patients Nursing education Patient compliance Telephone intervention

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Pathogenesis of occult chronic hepatitis B virus infection

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World Journal of Gastroenterology 2011年第12期17卷 1543-1548页

作者： Rocio Aller de la Fuente María L Gutiérrez Javier Garcia-samaniego Conrado Fernández-Rodriguez Jose luis Lledó Gregorio Castellano Gastroenterology Hospital Clinico Universitario Valladolid Institute of endocrinology and Nutrition Medical SchoolUniversity of Valladolid47003 ValladolidSpain Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain Gastroenterology Department Hospital Carlos IIIc/Sinesio Delgado28029 MadridSpain Hospital Universitario 12 de Octubre Av de Andalucia 2804128039 MadridSpain

Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological *** HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene *** is an entity with world-wide *** failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this"occult"HBV infection;although the mechanisms responsible for suppression of HBV are not well *** majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV *** evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma.

关键词： Occult hepatitis B virus infection Hepatitis B virus-DNA Anti-HBc alone Hepatitis B virus Hepadnaviral hepatitis Occult viral persistence Primary occult infection Secondary occult infection Virus reactivation

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Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study

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Journal of Sport and Health Science 2021年第3期10卷 360-367页

作者： Carlos Cristi-Montero Javier Courel-ibanez Francisco B.Ortega Jose Castro-Pinero Alba Santaliestra-Pasias Angela Polito Jeremy Vanhelst Ascension Marcos luis M.Moreno Jonatan R.Ruiz IRyS Group Physical Education SchoolPontificia Universidad Catolicade ValparaisoValparaisso 2530388Chile Department of Physical Activity and Sport Faculty of Sport SciencesUniversity of MurciaMurcia 30071Spain PROmoting FITness and Health through Physical Activity Research Group(PROFITH) Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18001Spain Department of Physical Education Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Department of Health and Human Performance School of Health SciencesUniversity of ZaragozaZaragoza 50001Spain Growth ExerciseNutrition and Development(GENUD)Research GroupZaragoza 50001Spain National Institute for Food and Nutrition Research Rome 80070Italy Lille Inflammation Research International Center University of LilleLille 59000France Immunonutrition Research Group Department Metabolism and NutritionInstitute of Food Science and Technology and Nutrition(ICTAN)Spanish National Research Council(CSIC)Madrid E-28040 Spain

Purpose:This study was aimed to analyze the mediation role of cardiorespiratory fitness(CRF)on the association between fatness and cardiometabolic risk scores(CMRs)in European ***:A cross-sectional study was conducted in adolescents(n=525;46%boys;14.1±1.1 years old,mean ±SD)from 10 European cities involved in the Healthy Lifestyle in Europe by Nutrition in Adolescence *** was measured by means of the shuttle run test,while fatness measures included body mass index(BMI),waist to height ratio,and fat mass index estimated from skinfold thicknesses.A clustered CMRs was computed by summing the standardized values of homeostasis model assessment,systolic blood pressure,triglycerides,total cholesterol/highdensity lipoprotein cholesterol ratio,and ***:Linear regression models indicated that CRF acted as an important and partial mediator in the association between fatness and CMRs in 1217-year-old adolescents(for BMI:coefficients of the indirect role b=0.058(95%confidence interval(95%CI):0.023-0.101),Sobel test z=3.11(10.0%mediation);for waist to height ratio:b=4.279(95%CI:2.242-7.059),z=3.86(11.5%mediation);and for fat mass index:b=0.060(95%CI:0.020-0.106),z=2.85(9.4%mediation);all p<0.01).Conclusion:In adolescents,the association between fatness and CMRs could be partially decreased with improvements to fitness levels;therefore,CRF contribution both in the clinical field and public health could be important to consider and promote in adolescents independently of their fatness levels.

关键词： Cardiovascular disease Children Fat mass Fitness Health Physical activity

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Evaluation of Effect of Eddy Currents in PLC Influenced by Atmospheric Corrosion in the Electronics Industry

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材料科学与工程（中英文B版） 2013年第5期3卷 314-321页

作者： Gustavo Lopez Badilla Elizabeth Romero samaniego Sandra Luz Toledo Perea Miriam Maleny Garcia Castrellon luis Alberto Gameros Rios Researcher-Academic Technological Institute of Mexicali (TIM) Mexicali Baja California M~xico Researcher-Academic Technological Institute of Ensenada (TIE) Ensenada Baja California Mexico Students of Electronic Engineering Technological Institute of Mexicali (TIM) Mexicali B.C. M~xico

Inductive proximity sensors contain an internal coil. When a current flow through it, a magnetic field is generated, which has the direction of the electric currents involved in it, as electrical flow in the input or output area. The coil or winding of the inductive sensor induces Foucault currents in the material to be detected, that are originated by eddy currents. These electrical flows generate a magnetic field, which opposes to the sensor coil, causing a reduction in the inductance of micro inductors of electronic devices. This reduction of the internal inductance originates bad function in the micro inductors used in the programming logic controller (PLC). This PLC is in the manufacturing processes of the electronics industry and reduces their operation yielding. Sometimes the actuators of these electronic systems not operate correctly, and causing stops in the activities of industrial equipments and machines, being a factor of economic losses. A study of micro evaluation of these inductors which are elements of the relays of PLC was made to determine the influence of corrosion in these components. The analysis showed micro corrosion in these devices with images obtained of the scanning electron microscopy (SEM) and also was made a correlation of the climatic factors as relative humidity (RH) and temperature with the corrosion rate (CR). The evaluation was made in indoor of an industrial plant which fabricate microelectronic components in Mexicali city. The major factors, which cause an adverse effect in the operation of PLC of this industrial plant was the humidity and sulfurs, which originates the deterioration of components of PLC. The study was made from 2010 to 2011.

关键词：大气腐蚀 PLC 电子工业影响评估涡流电感式传感器接近传感器相对湿度

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Heficobacter pylori Biofilm Formation and Gene Expression on Abiotic Surfaces Using a Cyanobacterial Extract

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Journal of Life Sciences 2012年第12期6卷 1317-1327页

作者： Alba E. Vega Fabio A. Persia Gabriel A. Salinas-ibanez Teresa Alarcon Stella M.C. Lucero Estrada Teresa I.Cortinas Humberto J. Silva Microbiology Laboratory Department of Biochemistry and Biological Sciences Faculty of Chemistry Biochemistry andPharmacy National University of San Luis San Luis 5700 Argentina Department of Microbiology University Hospital La Princesa Princess Health Research Institute (IP) Madrid 28006 Spain

The effects of a cyanobacterial extract （CE） on Helicobacter pylori biofilm formation onto hydrophobic and hydrophilic abiotic surfaces and the expression of luxS, flaA, omp18, lpxD and ureA genes associated to biofilm were studied. NCTC11638 reference strain and HP796, a resistant clinical isolate, were grown in Mueller-Hinton broth supplemented with 5% fetal calf serum （FCS） or 1% CE. The ability to form biofilm, viability, morphological changes and gene expression of adhered H. pylori cells were determined. The strains were able to form biofilm on both surfaces with the nutritional supplements analyzed. H. pylori conserved a characteristic bacillary morphology and viability with CE. Cells attachment was higher with CE than FCS regardless of strains and surfaces. The most remarkable increase in gene expression was observed with the ompl8 gene using the CE supplement, indicating the important participation of outer membrane proteins in biofilm establishment. The clinical isolate showed similar and even greater gene expression than the reference strain. The results obtained indicated that the nutrients provided by CE favored biofilm formation with retained pathogenicity that under certain conditions can occur in natural aquatic environments.

关键词： Helicobacterpylori biofilm cyanobacterial extract gene expression.

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