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Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2020年第42期26卷 6658-6668页

作者： Marta Hernández-Conde Elba Llop Carlos Fernández Carrillo Beatriz Tormo Javier Abad luis Rodriguez Christie Perelló Marta López gomez Joséluis Martínez-Porras Natalia Fernández Puga Maria Trapero-Marugan Enrique Fraga Carlos Ferre Aracil Joséluis Calleja Panero Gastroenterology and Hepatology Department IDIPHISAHospital Universitario Puerta de Hierro-MajadahondaMadrid 28222Spain Centro de Investigación Biomédica en Red en elÁrea temática de Enfermedades Hepáticas Instituto de Salud Carlos IIIMadrid 28029Spain

BACKGROUND Obesity is a risk factor for non-alcoholic fatty liver disease(NAFLD),although obese patients with NAFLD do not always develop significant *** distribution of body fat could predict the risk of NAFLD *** To investigate the role of bioelectrical impedance-estimated visceral fat(VF)in assessing NAFLD *** In this cross-sectional study,patients with biopsy-proven NAFLD were prospectively *** patients underwent anthropometric evaluation,blood tests and bioelectrical impedance *** Between 2017 and 2020,119 patients were included[66.4%male,56 years(SD 10.7),62.2%obese,61.3%with metabolic syndrome].Sixty of them(50.4%)showed significant fibrosis(≥F2)in liver ***,VF and metabolic syndrome were associated with significant fibrosis(61 years vs 52 years,16.4 vs 13.1,73.3%vs 49.2%,respectively;P<0.001 for all).In the multivariate analysis,VF and age were independently associated with significant fibrosis(VF,OR:1.11,95%CI:1.02-1.22,P=0.02;age,OR:1.08,95%CI:1.03-1.12,P<0.01).A model including these variables showed and area under the receiver operating characteristic curve(AUROC)of 0.75,which was not inferior to transient elastography or NAFLD fibrosis score *** developed a nomogram including age and VF for assessing significant fibrosis in routine *** VF is a surrogate marker of liver fibrosis in patients with *** impedance analysis is an inexpensive and simple method that can be combined with age to guide patient referral when other resources may be unavailable.

关键词： Non-alcoholic fatty liver disease Visceral fat Liver fibrosis Bioimpedanciometry Metabolic syndrome Obesity

Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease

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World Journal of Gastroenterology 2009年第22期15卷 2768-2777页

作者： Eduardo Vilar gomez luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez Department of Hepatology National Institute of Gastroenterology Department of Pathology National Institute of Gastroenterology Department of Gastroenterology National Institute of Gastroenterology Deparment of Gastroenterology The"Calixto Garcia"Hospital Department of Biostatistics National Institute of Gastroenterology

AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic ***:We prospectively evaluated the survival of 172 cirrhotic *** model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards *** was applied to estimate 12-,52-and 104-wk *** model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation ***,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was *** proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,*** addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.

关键词： Liver cirrhosis Prognosis Statistical models Prognostic factors Model for end-stage liver disease score Child-Pugh score Survival

Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C

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World Journal of Gastroenterology 2010年第21期16卷 2638-2647页

作者： Eduardo Vilar gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian Department of Hepatology National Institute of GastroenterologyHavana 10400Cuba Department of Gastroenterology National Institute of GastroenterologyHavana 10400Cuba Department of Immunology National Institute of GastroenterologyHavana 10400Cuba Department of Oxidative Stress National Genetic CenterHavana 10400Cuba Department of Biostatistics National Institute of GastroenterologyHavana 10400Cuba Department of Pathology Institute of GastroenterologyHavana 10400Cuba

AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis ***:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 *** primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well ***:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C.

关键词： Antioxidant therapy Chronic hepatitis C Cytokines Immunomodulatory therapy Nutritional supplement Oxidative stress

Synthesis and characterization of nano-hydroxyapatite added with magnesium obtained by wet chemical precipitation

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Progress in Natural Science:Materials International 2021年第4期31卷 575-582页

作者： Brandon A.Correa-Pi?a Omar M.gomez-Vazquez Sandra M.Londo?o-Restrepo luis F.Zubieta-Otero Beatriz M.Millan-Malo Mario E.Rodriguez-García Posgrado en Ciencia e Ingeniería de Materiales Centro de Física Aplicada y Tecnología Avanzada Universidad Nacional Autónoma de México Campus Juriquilla Departamento de Nanotecnología Centro de Física Aplicada y Tecnología Avanzada Universidad Nacional Autónoma de México Campus Juriquilla

Biogenic hydroxyapatites from mammalian bones naturally contain traces of ions, like Mg, which play a vital role in the bone remodeling process. In this way, synthetic hydroxyapatites should include this kind of mineral. In this work, hydroxyapatite added with Mg was synthesized by wet precipitation using（NH;）H;PO;, Ca（NO;）;.4 H;O,and Mg（NO;）;.6 H;O（0, 0.032, 0.061, and 0.123 M）. Inductively coupled plasma and X-ray diffraction evidenced the Mg inclusion in the hydroxyapatite lattice in the same levels reported for natural hydroxyapatites. The calcination at 600℃ was performed to remove the reaction by-products, but it also gave rise to physicochemical changes as the coalescence and crystals recrystallization. It produced, in turn, an improvement in the crystalline quality, according to Raman analysis. Despite those physicochemical changes, all the samples remained nanometric according to scanning electron microscopy imaging.

关键词： Magnesium Physicochemical properties Calcination Nanometric crystal size Coalescence Recrystallization

Identification of Arceuthobium globosum using unmanned aerial vehicle images in a high mountain forest of central Mexico

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Journal of Forestry Research 2020年第5期31卷 1759-1771页

作者： luis A.Leon-Banuelos Angel R.Endara-Agramont William gomez-Demetrio Carlos G.Martınez-Garcıa E.Gabino Nava-Bernal 50000 TolucaMexicoMexico

The identification of forests infested by parasitic plants is important for the design of appropriate control and prevention *** images and geographic information systems are commonly used to analyze the presence of pest and parasitic plants in the *** there is a need for finer *** the last decade,the use of unmanned aerial vehicles has become increasingly common for capturing aerial images(<10 cm per pixel).The objective of the study was to obtain RGB values(Red,Green and Blue)through the colorimetric ranges for use in identification of Yellow Dwarf Mistletoe(YDM)(Arceuthobium globosum)in aerial images taken in a forest of central Mexico via a programmed *** tonalities of YDM were classified according to its phenological stages,***(young stage),yellow(adult stage),and brown(senescence stage),considering two light intensities,sunny and ***-parametric tests were used in statistical *** Spearman test showed significant negative correlation(p<0.001)between phenological stage and colour,indicating that lower RGB values were associated with greater *** differences between groups were analysed using Kruskal–Wallis(p<0.01)and Mann–Whitney tests(p<0.01).The applied algorithm identified the presence and predominant colours of YDM according to its phenological stage.

关键词： Colorimetric analysis RGB Pinus hartweggi Parasitic plants Remote sensing

Software Package Evaluation for Lyapunov Exponent and Others Features of Signals Evaluating Condition Monitoring Performance of Nonlinear Dynamic Systems

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Journal of Energy and Power Engineering 2015年第5期9卷 443-451页

作者： Julio Cesar gomez-Mancilla luis Manuel Palacios-Pineda Valeriy Nosov Vibrations & Rotordynamies Laboratory ESIME (Superior School of Mechanical and Electrical Engineering) IPN (National Polytechnic Institute) Zaeateneo Professional Center Mexieo D. F. 07738 Mexieo Graduated and Research Department Technological Institute of Pachuca Pachuca 42083 Mexico

Efficient use of industrial equipment, increase its availability, safety and economic issues spur strong research on maintenance programs based on their operating conditions. Machines normally operate in a linear range, but when malfunctions occur, nonlinear behavior might set in. By studying and comparing five nonlinear features, which listed in decreasing order by their damage detection capability are： LLE （largest Lyapunov exponent）, embedded dimension, Kappa determinism, time delay and cross error values; i.e., LLE performs best. Using somewhat similar ideas from Chaos control, i.e., vary the ＂mass imbalance＂ forcing parameters, we aim to stabilize the Lorenz equation. Quite interestingly, for certain imbalance excitation values, the system is stabilized. The previous even when paradigmatically chaotic parameters for Lorenz system are used （plus our forcing terms）. This quasi-control approach is validated studying signals obtained from the previously mentioned lab test. Finally, it is concluded that analyzing and comparing nonlinear features extracted from baseline vs. malfunction condition （test acquired）, one might increase the efficiency and the performance of machine condition monitoring.

关键词： Modified Lorenz equation largest Lyapunov exponent nonlinear features chaos control test validation.

Management : people, performance, change 2nd ed.

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Management : people, performance, change

Sensitivity,specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis

2005年

作者： gomez-Mejia luis R.

来源：畅想之星图书光盘版（南... 评论

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Eye and Vision 2017年第1期4卷 100-105页

作者： Carl Sjoholm-gomez de Liano Vidal F.Soberon-Ventura Guillermo Salcedo-Villanueva Abril Santos-Palacios Jose luis Guerrero-Naranjo Jans Fromow-Guerra Gerardo García-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Retina Department Asociación para Evitar la Ceguera en MexicoHospital“Dr.Luis Sanchez Bulnes”IAPMexico CityMexico Universidad Popular Autonoma del Estado de Puebla PueblaMexico Ophthalmology Department Macula Retina ConsultantsMexico CityMexico

Background:To assess the sensitivity,specificity,positive predictive value and negative predictive value of anterior chamber tap for the diagnosis of bacterial endophthalmitis on a population with high ***:Retrospective,single centre,case series *** reviewed all medical records with clinical diagnosis of bacterial endophthalmitis in our hospital from January 1st,2000 to December 31st *** each record,we documented general demographic data,best corrected visual acuity and vitreous and aqueous tap microbiological *** cases were further divided according to the endophthalmitis aetiology to perform individual calculations of sensitivity,specificity,positive predictive value,negative predictive value,accuracy and *** used the results of the vitreous tap as the gold standard for diagnosis of bacterial *** excluded those records in which the aqueous and vitreous samples were not taken simultaneously or had an incomplete microbiological *** were assessed with chi squared statistics,with an alpha value of 0.05 for statistical ***:A total of 190 cases fulfilled the inclusion/exclusion *** culture rate from vitreous samples was 64.74%.Positive culture rate from aqueous sample was 32.11%.Bacteria isolated from aqueous samples matched those isolated from vitreous samples 78.68%of the *** overall sensitivity was 38.21%,specificity:75.51%,positive predictive value:79.66%,negative predictive value:32.74%(p=0.08).Subgroup analysis showed that anterior chamber taps in cases of post-surgical endophthalmitis had a moderate to low sensitivity(37.73%),high specificity(93%)and high positive predictive value(95%)(p<0.04).Conclusion:The sensitivity and specificity of anterior chamber tap are low and should not be used for critical therapeutic decisions in patients with suspected bacterial *** cases of post-surgical endophthalmitis,the result of an anterior chamber tap

关键词： Aqueous humour Endophthalmitis Anterior chamber tap Diagnostic test Vitreous tap Aqueous sampling Sensibility Sensitivity

Rheological Characterization of a Mixed Fruit/Vegetable Puree Feedstock for Hydrogen Production by Dark Fermentation

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Advances in Chemical Engineering and Science 2014年第1期4卷 81-88页

作者： Jacob gomez-Romero Inés Garcia-Pena Jorge Ramirez-Munoz luis G.Torres Bioprocess and Bioengineering Departments UPIBI-Instituto Politecnico NacionalMexico CityMexico Energy Department Universidad Autónoma Metropolitana-AzcapotzalcoMexico CityMexico

Bio-hydrogen (Bio-H2) production from the organic fraction of solid waste, as fruit and vegetable wastes, constitutes an interesting and feasible technology to obtain clean energy. In spite of the feasibility to produce Bio-H2 from fruit/vegetable wastes (FVW), data about its rheological characterization are scarce. This information is useful to establish the hydrodynamic behavior, which controls the overall mixing process when the feedstock for Bio-H2 production process is a mixture of FVW. In this work, the rheological behavior of a vegetable/fruit waste mixture was characterized. The effect of the solids content (%, w/w), temperature, time (tyxotropy effects) and shear rate over the apparent viscosity of the mixture was evaluated. Most of the mixtures showed non-Newtonian behavior. The curves are typical rheofluidizing fluids. The rheological curves were different at increasing solids contents (80%, 60%, 40% and 30%), independent from the temperature. Rheological data were fitted to the power law model. Correlation factors R2 for the different mixtures were 0.991-0.995 for 80%, 0.961 -0.986 for 60%, 0.890 -0.925 for 40%. In the case of 30% of solids, the R2 value was not acceptable, and it was also found that this mixture was very near to the Newtonian behavior. Calculated activation energies (Ea) values were 15.98, 14.89 and 20.96 kJ/mol for the 80%, 60%, 40% mixtures, respectively. FVW purees rheological behavior was well characterized by Carbopol solutions at given concentrations and pH values. This fluid can be used as a model for other studies, e.g. LDA (Laser Doppler Anemometry) and PIV (Particle Image Velocimetry).

关键词： Bio-Hydrogen Mixing Rheology Rheofluidizing Materials Fruit/Vegetable Waste Mixture