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Minimally Invasive Surgery for Necrotizing Pancreatitis: A Case Report

Surgical Science 2024年第9期15卷 514-521页

作者： Néstor Veriel Méndez Huerta luis Fernando Zorrilla Núñez Noelia Obregón Gaxiola César Jair Treviño Arizmendi Gerardo Iván Muñoz Morales Marco Alejandro Arizmendi Villarreal Pamela Denisse Valdez Navarro Marco Antonio Hernández Guedea Gerardo enrique Muñoz Maldonado Service of General Surgery Hospital Universitario Dr. Jos Eleuterio Gonzlez Universidad Autnoma de Nuevo Len Monterrey Mxico

Introduction: Necrotizing pancreatitis management is complex and varies significantly among clinicians. Minimally invasive approaches like transgastric necrosectomy via laparoscopy are emerging as effective treatment options. This case report underscores the technique’s efficacy, clinical outcomes, and role in reducing complications. Clinical Observation: A 59-year-old male with a history of smoking and alcoholism presented with severe abdominal pain, nausea, and vomiting. Over the following weeks, he developed symptoms including asthenia, weight loss, and melena. Diagnostic workup revealed severe anemia and Balthazar e necrotizing pancreatitis, with significant intra-abdominal fluid collections and signs of infection. After initial conservative management, the patient underwent transgastric necrosectomy via laparoscopy due to deteriorating clinical status. The procedure involved removing necrotic tissue and performing a cystogastroanastomosis and jejunostomy. Postoperative care included fasting, parenteral nutrition, broad-spectrum antibiotics, and enzymatic replacement. The patient recovered well, with reduced necrotic tissue on follow-up imaging, and was discharged twelve days post-surgery [1]. Conclusion: Transgastric necrosectomy by laparoscopy is a valuable first-line surgical option for patients with symptomatic necrotizing pancreatitis, particularly in cases without prior interventions. This minimally invasive technique helps reduce major complications and mortality, offering a less invasive alternative to traditional open necrosectomy. The multidisciplinary approach and careful postoperative management were crucial to the patient’s favorable outcome. The case highlights the potential of transgastric necrosectomy as an effective treatment strategy in managing complex pancreatitis cases, including those with associated duodenal perforation [2].

关键词： Necrotizing Transgastric Pancreatic Necrosectomy Pancreatitis Case Report

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Reproductive seasonality of Astyanax mexicanus cavefish

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Zoological Research 2023年第4期44卷 698-700页

作者： luis espinasa Nicolas Rohner Sylvie Rétaux School of Science Marist CollegePoughkeepsieNY 12601USA Stowers Institute for Medical Research Kansas CityMO 64110USA Department of Molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160USA Paris-Saclay Institute of Neuroscience CNRS and UniversitéParis-SaclaySaclay 91400France

DeAR eDITOR,The characiform fish Astyanax is a well-studied model system for understanding evolutionary development and genomics in cave ***,considerable gaps remain in our understanding of its field ***,we conducted a fouryear field study and found that while cavefish spawned yearround,reproductive peaks occurred in January to February.

关键词： cave ecology fish

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A methodology for assessing the urban supply of on-street delivery bays

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Green energy and Intelligent Transportation 2022年第3期1卷 63-72页

作者： Antonio Comi Joséluis Moura Sara ezquerro University of Rome Tor Vergata RomeItaly University of Cantabria SantanderSpain

The loading and unloading operations carried out by transport and logistics operators have a strong impact on city mobility if they are not performed *** loading/unloading bays,i.e.,delivery bays(DB),are not available for freight vehicle operations,operators may opt to double park or park on the sidewalk where there is no strong enforcement of these laws,with significant impact on *** paper proposes a methodology for verifying and designing the number of delivery bays needed for freight vehicles for not interfere with cars or *** methodology consists of two stages:in the first stage,an initial estimation is made using queueing ***,in the second stage,using such tentative scenario,in order to take into account the system stochasticity involving different entities,a discrete event simulation is performed to more realistically verify and upgrade(if necessary)the number of delivery bays to obtain the expected *** methodology was applied in the inner area of Santander(Spain).The study area was subdivided into 29 zones where the methodology was applied *** results indicated that none of these zones currently have an optimal number of delivery bays to satisfy *** some zones,there is an excess of delivery bays,although in most of them,there is a deficit which can cause significant impacts on *** method proposed can be an effective tool to be used by city planners for improving freight operations in urban areas limiting the negative impacts produced in terms of internal and external costs.

关键词： Urban freight transportation On-street delivery bays Discrete event simulation City logistics Urban goods movements

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Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease

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Stroke & Vascular Neurology 2022年第3期7卷 251-257页

作者： Valentina Nardi John C Benson Anthony S Larson Waleed Brinjikji Luca Saba Fredric B Meyer Giuseppe Lanzino Amir Lerman luis e Savastano Department of Cardiovascular Diseases Mayo ClinicRochesterMinnesotaUSA Radiology Mayo ClinicRochesterMinnesotaUSA Radiology Azienda Ospedaliero UniversitariaCagliariItaly Neurosurgery Mayo ClinicRochesterMinnesotaUSA

Object We sought to determine the safety and efficacy in secondary stroke prevention of carotid endarterectomy(CeA)in patients with symptomatic non-stenotic carotid artery disease(SyNC).Methods This was a single-centre retrospective case *** patients who underwent CeA for unilateral anterior circulation cerebrovascular events with ipsilateralenosis from 2002 to 2020 were *** hallmarks including the degree of luminal stenosis and the presence of various vulnerable plaque characteristics(eg,intraplaque haemorrhage(IPH)on MR angiography,ulceration or low-density plaque on CT angiography)were *** presence of vulnerable plaque characteristics was compared between arteries ipsilateral to the ischaemic event and contralateral *** prevalence of perioperative/intraoperative complications,as well as recurrent ischaemic events at follow-up was *** Thirty-two patients were included in the analysis,of which 25.0%were *** arteries ipsilateral to an ischaemic event had a significantly higher prevalence of IPH when compared with contralateral arteries(80.0%vs 0.0%;pere were no intraoperative *** patient(3.1%)developed symptoms of transient ipsilateral ischaemia 1 day following CeA which resolved without *** a median follow-up of 18.0 months(IQR 5.0-36.0),only one patient(3.1%)experienced a transient neurologic deficit with complete resolution(annualised rate of recurrent stroke after CeA of 1.5%for a total follow-up of 788 patient-months following CeA).All other patients(31/32,96.9%)were free of recurrent ischaemic *** CeA appears to be safe and well-tolerated in patients with *** studies with larger cohorts and longer follow-up intervals are needed in order to determine the role of CeA in this patient population.

关键词： patients carotid prevention

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Mitochondrial Sulfide Detoxification Requires a Functional Isoform O-Acetylserine（thiol）lyase C in Arabidopsis thaliana

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Molecular Plant 2012年第6期5卷 1217-1226页

作者： Consolacien Alvarez Irene Garcia luis C Romero Cecilia Gotor Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas y Universidad de Sevilla Avda. Am~rico Vespucio 49 41092Sevilla Spain

In non-cyanogenic species, the main source of cyanide derives from ethylene and camalexin biosyntheses. In mitochondria, cyanide is a potent inhibitor of the cytochrome c oxidase and is metabolized by the β-cyanoalanine synthase CYS-C1, catalyzing the conversion of cysteine and cyanide to hydrogen sulfide and β-cyanoalanine. The hydrogen sulfide released also inhibits the cytochrome c oxidase and needs to be detoxified by the O-acetylserine（thiol）lyase mitochondrial isoform, OAS-C, which catalyzes the incorporation of sulfide to O-acetylserine to produce cysteine, thus generating a cyclic pathway in the mitochondria. The loss of functional OAS-C isoforms causes phenotypic characteristics very similar to the loss of the CYS-C1 enzyme, showing defects in root hair formation. Genetic complementation with the OAS-Cgene rescues the impairment of root hair elongation, restoring the wild-type phenotype. The mitochondria compromise their capacity to properly detoxify cyanide and the resulting sulfide because the latter cannot re-assimilate into cysteine in the oas-c null mutant. Consequently, we observe an accumulation of sulfide and cyanide and of the alternative oxidase, which is unable to prevent the production of reactive oxygen species probably due to the accumulation of both toxic molecules. Our results allow us to suggest that the significance of OAS-C is related to its role in the proper sulfide and cyanide detoxification in mitochondria.

关键词： alternative oxidase Arabidopsis thaliana cysteine cyanide β-cyanoalanine synthase O-acetylserine(thiol)-lyase reactive oxygen species root hair sulfide.

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The Use of Data Mining Techniques in Rockburst Risk Assessment

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engineering 2017年第4期3卷 552-558页

作者： luis Ribeiro e Sousa Tiago Miranda Rita Leal e Sousa Joaquim Tinoco State Key Laboratory for GeoMechanics and Deep Underground engineering China University of Mining and Technology (Beijing) Beijing 100083 China Institute for Sustainability and Innovation in Structural engineering Department of Civil Engineering University of Minho Campus de Azurem Guimaraes 4800-058 Portugal Masdar Institute of Science and Technology Musdar City Abu Dhabi UAE

Rockburst is an important phenomenon that has affected many deep underground mines around the world. An understanding of this phenomenon is relevant to the management of such events, which can lead to saving both costs and lives. Laboratory experiments are one way to obtain a deeper and better understanding of the mechanisms of rockburst. In a previous study by these authors, a database of rockburst laboratory tests was created; in addition, with the use of data mining （DM） techniques, models to predict rockburst maximum stress and rockburst risk indexes were developed. In this paper, we focus on the analysis of a database of in situ cases of rockburst in order to build influence diagrams, list the factors that interact in the occurrence of rockburst, and understand the relationships between these factors. The in situ rockburst database was further analyzed using different DM techniques ranging from artificial neural networks （ANNs） to naive Bayesian classifiers. The aim was to predict the type of rockburst-that is, the rockburst level-based on geologic and construction characteristics of the mine or tunnel. Conclusions are drawn at the end of the paper.

关键词： Rockburst Data mining Bayesian networks In situ database

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Yet Another Intelligent Code-Generating System： A Flexible and Low-Cost Solution

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Journal of Computer Science & Technology 2018年第5期33卷 940-965页

作者： Joao Fabricio Filho luis Gustavo Araujo Rodriguez Anderson Faustino da Silva Department of Informatics State University of Maringd Maringd-PR 87020-900 Brazil Federal University of Technology -- Parand Campo Mourao-PR 87301-899 Brazil

Modern compilers apply various code transformation algorithms to improve the quality of the target code. However, a complex problem is to determine which transformation algorithms must be utilized. This is difficult because of three reasons： a number of transformation algorithms, various combination possibilities, and several configuration possibil- ities. Over the last few years, various intelligent systems were presented in the literature. The goal of these systems is to search for transformation algorithms and thus apply them to a certain program. This paper proposes a flexible, low-cost and intelligent system capable of identifying transformation algorithms for an input program, considering the program＇s specific features. This system is flexible for parameterization selection and has a low-computational cost. In addition, it has the capability to maximize the exploration of available computational resources. The system was implemented under the Low Level Virtual Machine infrastructure and the results indicate that it is capable of exceeding, up to 21.36%, performance reached by other systems. In addition, it achieved an average improvement of up to 17.72% over the most aggressive compiler optimization level of the Low Level Virtual Machine infrastructure.

关键词： compiler code transformation iterative compilation knowledge representation machine learning

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Breeding effects on the genotype×environment interaction for yield of durum wheat grown after the Green Revolution:The case of Spain

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The Crop Journal 2020年第4期8卷 623-634页

作者： Fadia Chairi Nieves Aparicio Maria Dolores Serret José luis Araus Section of Plant Physiology University of BarcelonaBarcelonaSpain AGROTeCNIO(Center of Research in Agrotechnology) LleidaSpain Instituto de Tecnología Agraria de Castilla y León(ITACyL) ValladolidSpain

This study evaluates the changes caused by breeding in the genotype by environment(G×e)interaction of the durum wheat varieties most widely cultivated in Spain after the Green Revolution.A set of 12 cultivars was tested in 27 environments,which are understood as the combination of different sites,years,and treatments(water regime and planting dates),representative of the durum wheat growing conditions in Spain with average grain yields(GY)ranging between 2.8 and 9.1 Mg ha^-*** most important environmental factors affecting the G×e interaction for yield were themaximum and the mean temperature during the entire crop *** improvement in genetic yield was observed in warm environments and under optimal water conditions that resemble those where the germplasm originated(essentially as advanced lines)before its release in ***,the adaptation of semi-dwarf durum in Spain has shown a tendency to specific adaptation rather than large-scale *** different patterns of selection have been reported due the G×e interaction and changes in the ranking of genotypes:in the high yielding environments(GY>5 Mg ha^-1),plants favor increased water uptake,with higher levels of transpiration and more open stomata(more negative values of carbon isotope composition,δ^13 C,and higher canopy temperature depression,CTD),whereas,in low yielding environments(GYe their stomata and favor greater water use efficiency(less negativeδ^13 C values and lower CTD values).

关键词： breeding cultivar dwarf

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Feeding ecology of a highly aerial bird during its long breeding season

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Avian Research 2023年第1期14卷 62-69页

作者： Sandra Fernandes Vanessa A.Mata luis P.da Silva CIBIO Centro de Investigacão em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do Porto4485-661Vairão Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do Porto4099-002PortoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de Vairão4485-661VairãaoPortugal

Pallid Swifts(Apus pallidus),as other swifts,are birds extremely adapted to an aerial lifestyle,showing unique adaptations that allow them to fly almost *** diet of these non-stopping high-altitudinal aerial birds has been mostly studied through techniques that fail to produce highly resolved prey identifications,and for that have been replaced by molecular techniques,such as DNA *** samples of Pallid Swifts were monthly collected from a colony in the north of Portugal during the breeding *** from the faecal samples was used to sex the birds and to identify the arthropods present in the diet through DNA *** the detected prey items,74 families were identified belonging to 16 orders,with Hymenoptera and Hemiptera being the most frequently *** were seasonal variations in diet richness,composition and prey *** the diet of males and females,although no differences were found between the diet of males and females in terms of composition and richness,there were differences in the size of arthropods preyed by the different sexes,with males feeding on larger *** large seasonal variation in Pallid Swifts’diet during the breeding season is probably a result of spatiotemporal variation in aerial prey,of which swifts likely predate *** no significant differences were detected in diet richness and composition between sexes,the fact that males consumed larger prey may suggest the existence of sexual dietary segregation in this group of *** last,several pest species were found in these swifts’diet,which,if studied through DNA metabarcoding,can be used to monitor small arthropods,including airborne pests.

关键词： AMerial foraging Apus plius Dietary s-ssonal variation FReeding omlogy Metahercoding Opimel foraging theoary

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Human umbilical artery smooth muscle exhibits a 2-APBsensitive capacitative contractile response evoked by vasoactive substances and expresses mRNAs for STIM, Orai and TRPC channels

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BIOCeLL 2012年第2期36卷 73-81页

作者： ANA ROCÍO ROLDÁN PALOMO PeDRO MARTIN ALeJANDRO ReBOLLeDO NICOLÁS eNRIQUe luis e.FLOReS VeRÓNICA MILeSI GINFIV–Grupo de Investigación en Fisiología Vascular Facultad de Ciencias ExactasUniversidad Nacional de La Plata.Argentina CeNeXA–Centro de endocrinología experimental y Aplicada (UNLP-CONICET La PlataCentro Colaborador OPS/OMS)Facultad de Ciencias MédicasUniversidad Nacional de La Plata.Argentina

After depletion of intracellular Ca^(2+)stores the capacitative response triggers an extracellular Ca^(2+)influx through store-operated channels(SOCs)which refills these *** objective was to explore if human umbilical artery smooth muscle presented this response and if it was involved in the mechanism of serotonin-and histamine-induced *** Ca^(2+)depletion by a Ca^(2+)-free extracellular solution followed by Ca^(2+)readdition produced a contraction in artery rings which was inhibited by the blocker of Orai and TRPC channels 2-aminoethoxydiphenyl borate(2-APB),suggesting a capacitative *** presence of 2-APB the magnitude of a second paired contraction by serotonin or histamine was significantly less than a first one,likely because 2-APB inhibited store refilling by capacitative Ca^(2+)entry.2-APB inhibition of sarcoplasmic reticulum Ca^(2+)release was excluded because this blocker did not affect serotonin force development in a Ca^(2+)-free *** PCR technique showed the presence of mRNAs for STIM proteins(1 and 2),for Orai proteins(1,2 and 3)and for TRPC channels(subtypes 1,3,4 and 6)in the smooth muscle of the human umbilical ***,this artery presents a capacitative contractile response triggered by stimulation with physiological vasoconstrictors and expresses mRNAs for proteins and channels previously identified as SOCs.

关键词： human umbilical artery capacitative response TRPC channels serotonin histamine

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