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Frontiers of Chemical Science and Engineering 2021年第2期15卷 399-409,F0004页

作者： Fernando F.rivera Berenice Miranda-Alcantara German Orozco Carlos Ponce de Leon luis F.Arenas National Council of Science and Technology(CONACYT) Mexico City 03940Mexico Center of Research and Technological Development in Electrochemistry(CIDETEQ) Queretaro 76703Mexico Electrochemical Engineering Laboratory Energy Technology Research GroupFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries(RFBs)and other electrochemical *** order to determine their predictive capability,turbulent Reynolds-averaged Navier-Stokes(RANS)and free flow plus porous media(Brinkman)models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RFB for laboratory *** different platinized titanium electrodes were considered,a plate plus a turbulence promoter and an expanded metal *** pressure drop was validated against experimental data obtained with typical cerium *** was found that the pressure drop values were better described by the RANS approach,whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

关键词： CFD simulation porous media porous electrode pressure drop redox flow battery

Chilaiditi syndrome in pediatric patients - Symptomatic hepatodiaphragmatic interposition of colon: A case report and review of literature

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World Journal of Clinical Pediatrics 2021年第3期10卷 40-47页

作者： luis Caicedo Paul Wasuwanich Andrés rivera Maria S Lopez Wikrom Karnsakul Division of Pediatric Gastroenterology Hepatologyand NutritionNicklaus Children’s HospitalMiamiFL 33155United States Department of Medicine University of Florida College of MedicineGainesvilleFL 32610United States Department of Pediatrics Icahn School of Medicine at Mount SinaiNew YorkNY 10092United States Department of Pediatrics Nicklaus Children’s HospitalMiamiFL 33155United States Division of Pediatric Gastroenterology Hepatologyand NutritionDepartment of PediatricsJohns Hopkins University School of MedicineBaltimoreMD 21287United States

BACKGROUND Chilaiditi syndrome is a rare disorder characterized by the hepatodiaphragmatic interposition of the *** SUMMARY Here we report a case of a 12-year-old male who was admitted to the pediatric intensive care unit secondary to abdominal pain and severe respiratory *** was treated conservatively but the symptoms persisted requiring a surgical *** there have been several cases of Chilaiditi syndrome reported in adults,there is a scarcity of cases reported in the pediatric *** review of the literature found only 30 pediatric cases,including our reported case,with Chilaiditi syndrome,19(63%)of which were *** median age of diagnosis was 4.5 years old with an interquartile range of 2.0-10.0 *** our review,we found that the most common predisposing factors in children are aerophagia(12/30 cases)and constipation(13/30 cases).Ninety percent of the cases presented with complete intestinal interposition,in 100%of which,the colon was *** of the 30 cases were associated with *** In the pediatric population,conservative(21/30 cases)and surgical(8/30 cases)treatment approaches have produced satisfactory outcomes for all the patients,regardless of approach.

关键词： Abdominal pain Dyspnea Constipation Rare diseases Respiratory insufficiency Colon Case report

Near-UV light assisted green reduction of graphene oxide films through l-ascorbic acid

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International Journal of Smart and Nano Materials 2021年第1期12卷 20-35页

作者： Jaime Regis Sebastian Vargas Andrea Irigoyen Elsa Bramasco-rivera Jose L.Bañuelos luis C.Delfin Anabel Renteria Ulises Martinez Tommy RockwardYirong Lin Department of Mechanical Engineering The University of Texas at El PasoEl PasoTX USA W.M.Keck Center for 3D Innovation the University of Texas at El PasoEl PasoTX USA Department of Physics The University of Texas at El PasoEl PasoTX USA Materials Physics and Applications Los Alamos National LaboratoryLos AlamosNM USA Department of Mechanical Engineering The University of Texas At El Paso 500 W.University Ave.El Paso TX 79968United States

Recent studies have highlighted the effects of various stimuli on the chemical reduction of graphene oxide(GO)through green reductant L-ascorbic acid(L-AA);however,the combination of near ultraviolet(NUV)light to increase the reduction rate has yet to be thoroughly *** this study,drop-casted GO films were subjected to chemical reduction through L-AA with various levels of exposure under 405 nm NUV *** structure and uniformity of GO stackings that form the film were characterized through scanning electron microscopy(SEM)and wide-angle x-ray scattering(WAXS).Additionally,WAXS was used to track the removal of oxygen-containing functional groups along with Fourier-transform infrared(FT-IR)spectroscopy and x-ray photoelectron spectroscopy(XPS)as a function of L-AA and NUV light exposure *** results demonstrated that the interaction between L-AA and NUV exposure has a significant effect on the reduction of ***,the results that yielded the highest reduction(C-C bond concentration of 60.7%)were the longest L-AA and NUV light exposure times(48 hours and 3 hours,respectively).This report provides a study on the effects of NUV on the green reduction of GO films through L-AA with potential application in solar energy and chemical sensing applications.

关键词： Graphene Oxide Films Green Reduction Near Ultraviolet Light L-Ascorbic Acid Wide-Angle X-Ray Scattering

A novel heterozygous SF1/NR5A1 gene variant causes 46,XY DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency

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Genes & Diseases 2024年第4期11卷 128-130页

作者： luis Ramos Department of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic factor 1(SF1/NR5A1;nuclear receptor subfamily 5 group A member 1)is an essential orphan protein involved in gonadal embryogenesis,sex determination,and reproductive endocrinology.

关键词： insufficiency determination gonadal

New frontiers on open standards for geo-spatial science

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Geo-Spatial Information Science 2017年第2期20卷 126-133页

作者： luis Bermudez Open Geospatial Consortium WaylandMAUSA

The process of sharing of data has become easier than ever with the advancement of cloud computing and software ***,big challenges remain such as efficient handling of big geospatial data,supporting and sharing of crowd sourced/citizen science data,integration with semantic heterogeneity,and inclusion of agile processes for continuous improvement of geospatial *** paper discusses the new frontiers regarding these challenges and the related work performed by the Open Geospatial Consortium,the world leading organization focused on developing open geospatial standards that“geo-enable”the Web,wireless,and location-based services and mainstream IT.

关键词： Open Geospatial Consortium(OGC) big data cloud computing open standards semantics linked data

Evaluation and Improvement of an Organizational Resource Applying Strategy Patterns

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Journal of Software Engineering and Applications 2016年第4期9卷 128-146页

作者： Maria Fernanda Papa Belen rivera Pablo Becker luis Olsina GIDIS Web School of Engineering National University of La Pampa General Pico Argentina

For any software company that frequently performs quality assurance activities devoted to measurement, evaluation (ME) and change/improvement (MEC) projects, ME and MEC strategies can be valuable organizational assets. In this paper, we analyze the improvement of a ME strategy, which can be considered an organizational resource to be applied to quality assurance activities. This resource is called the GOCAME (Goal-Oriented Context-Aware Measurement and Evaluation) strategy. AME/MEC strategy embraces the next three integrated capabilities: 1) the ME/MEC domain conceptual base and framework;2) the process perspective specifications;and, 3) the method specifications. The improvement of GOCAME was performed instantiating two strategy patterns. A strategy pattern is a reusable solution to recurrent problems in ME/MEC projects. For an improvement goal, the selected MEC strategy pattern allows instantiating in a project a set of tailored activities and methods for measurement, evaluation, analysis and change. Particularly, we instantiate the GoME_1QV (Goal-oriented Measurement and Evaluation for One Quality View) strategy pattern to understand the GOCAME current quality state and compare it with the so-called GQM+ Strategies. First, this evaluation and analysis allows us to know the GOCAME strengths and weaknesses with regard to the quality of the three capabilities. Second, we instantiate the GoMEC_1QV (Goal-oriented Measurement, Evaluation and Change for One Quality View) strategy pattern to improve the GOCAME current state, producing as result a new version of the GOCAME strategy.

关键词： Strategy Pattern Quality View Evaluation Change Improvement

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Celiac disease

World Journal of Gastroenterology 2006年第41期12卷 6585-6593页

作者： luis Rodrigo Gastroenterology Service University Hospital Central AsturiasOviedoSpain

Celiac disease （CD） is a common autoimmune disorder, induced by the intake of gluten proteins present in wheat, barley and rye. Contrary to common belief, this disorder is a protean systemic disease, rather than merely a pure digestive alteration. CD is closely associated with genes that code HLA-Ⅱ antigens, mainly of DQ2 and DQ8 classes. Previously, it was considered to be a rare childhood disorder, but is actually considered a frequent condition, present at any age, which may have multiple complications. Tissue transglutaminase-2 （tTG）, appears to be an important component of this disease, both, in its pathogenesis and diagnosis. Active CD is characterized by intestinal and/or extra-intestinal symptoms, villous atrophy and crypt hyperplasia, and strongly positive tTG auto-antibodies. The duodenal biopsy is considered to be the ＂gold standard＂ for diagnosis, but its practice has significant limitations in its interpretation, especially in adults. Occasionally, it results in a false-negative because of patchy mucosal changes and the presence of mucosal villous atrophy is often more severe in the proximal jejunum, usually not reached by endoscopic biopsies. CD is associated with increased rates of several diseases, such as iron deficiency anemia, osteoporosis, dermatitis herpetiformis, several neurologic and endocrine diseases, persistent chronic hypertransami-nasemia of unknown origin, various types of cancer and other autoimmune disorders. Treatment of CD dictates a strict, life-long gluten-free diet, which results in remission for most individuals, although its effect on some associated extraintestinal manifestations remains to be established.

关键词： Celiac disease Tissue transglutaminase antibodies Autoimmune disorders Gluten-free diet

Pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： luis Alexandre Pedro de Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

关键词： Coating Drying Granulation Inclusion Microencapsulation

Dynamics of air transport networks：A review from a complex systems perspective

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Chinese Journal of Aeronautics 2017年第2期30卷 469-478页

作者： luis E.C.Rocha Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Mathematics University of Namur 5000 Belgium

Air transport systems are highly dynamic at temporal scales from minutes to *** dynamic behavior not only characterizes the evolution of the system but also affect the system＇s *** the evolutionary mechanisms is thus fundamental in order to better design optimal air transport networks that benefits companies,passengers and the *** this review,we briefly present and discuss the state-of-the-art on time-evolving air transport *** distinguish the structural analysis of sequences of network snapshots,ideal for long-term network evolution（*** evolution）,and temporal paths,preferred for short-term dynamics（*** evolution）.We emphasize that most previous research focused on the first modeling approach（***-term） whereas only a few studies look at high-resolution temporal *** conclude the review highlighting that much research remains to be done,both to apply already available methods and to develop new measures for temporal paths on air transport *** particular,we identify that the study of delays,network resilience and optimization of resources（aircraft and crew） are critical topics.

关键词： Air transport Airport network Complex network Dynamic network Temporal network

Performance assessment of two-dimensional hydraulic models for generation of flood inundation maps in mountain river basins

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Water Science and Engineering 2019年第1期12卷 11-18页

作者： Juan Pinos luis Timbe Department of Water Resources and Environmental Sciences University of Cuenca

Hydraulic models for the generation of flood inundation maps are not commonly applied in mountain river basins because of the difficulty in modeling the hydraulic behavior and the complex topography. This paper presents a comparative analysis of the performance of four twodimensional hydraulic models (HEC-RAS 2D, Iber 2D, Flood Modeller 2D, and PCSWMM 2D) with respect to the generation of flood inundation maps. The study area covers a 5-km reach of the Santa B-arbara River located in the Ecuadorian Andes, at 2330 masl, in Gualaceo. The model's performance was evaluated based on the water surface elevation and flood extent, in terms of the mean absolute difference and measure of fit. The analysis revealed that, for a given case, Iber 2D has the best performance in simulating the water level and inundation for flood events with 20- and 50-year return periods, respectively, followed by Flood Modeller 2D, HEC-RAS 2D, and PCSWMM 2D in terms of their performance. Grid resolution, the way in which hydraulic structures are mimicked, the model code, and the default value of the parameters are considered the main sources of prediction uncertainty.

关键词： Two-dimensional hydraulic models Flood modeling Flood extent Water surface elevation High mountain river Ecuador