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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Disaster Journalism in Print media:Analysis of the Top 10 Hydrogeomorphological Disaster Events in Portugal,1865–2015

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International Journal of Disaster Risk Science 2022年第4期13卷 521-535页

作者： michele Nacif antunes Susana da Silva Pereira Joséluis Zêzere Adauto Emmerich Oliveira Postgraduate Program in Public Health(PPGSC) Federal University of Espírito SantoVitoriaEspírito Santo 29047-105Brazil Centre for Geographical Studies Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Associate Laboratory TERRA 1349-017 LisbonPortugal

Disaster communication guidelines emphasize that journalists should be aware of past major disasters and draw lessons from the coverage of those *** press is an important source for the evolution of historical disaster and risk research paradigms over *** study explored the top 10 damaging hydrogeomorphological events in Portugal selected from the disaster database,which includes events that caused human damages(fatalities,injured,missing,evacuated,and displaced)reported over a period of 151years(1865–2015)by the Portuguese newspaper Diário de Notícias(DN).News analysis was guided by the news *** analysis of the news published in DN enabled us to identify textual marks that present interconnections in the journalistic coverage and produce discursive standards for these *** textual marks were associated with the hazard and risk *** discursive standards of DN did not clearly reflect the ruptures in the hazard *** a rule,the journalistic reports contributed to the naturalization of disasters and the gap in public understanding of risks,by presenting an approach focused on relief actions—ignoring social issues,vulnerability,and population resilience—reducing the discourse of preparedness for future disasters.

关键词： Disaster journalism Hydrogeomorphological events News protocol Portugal Print media

Auditory thalamus neurons contribute to the coding of surprise

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Auditory thalamus neurons contribute to the coding of surpri...

Biliary tract schwannoma:A rare cause of obstructive jaundice in a young patient

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Flora m.antunes manuel S.mALmIERCA Auditory Neurophysiology Unit Laboratory for the Neurobiology of HearingInstitute of Neuroscience of Castilla y LeonUniversity of SalamancaSpain

＜正＞Objective Neurons in the cat auditory cortex（AC;Ulanovsky et al.,2003） and in the rat inferior culliculus（IC;Perez-Gonzalez et al.,2005,malmierca et al.,2009）,show a reduced response to a repeated stimulus（deviant）,and briefly resume firing if a novel stimulus（oddball） is presented,i.e.,they show stimulus-specific adaptation（SSA）.To date,no study demonstrated high levels of SSA in the medial geniculate body（mGB） as those found in the AC and *** that the mGB receives its inputs from both the AC and IC it is unclear why mGB does not exhibit similar levels of SSA. Thus,our main goal is to examine if neurons in the mGB show a similar type of SSA as neurons in the AC and in the IC. methods We recorded single unit extracellular responses,in the mGB of urethane anaesthetized rats,using a similar stimulation paradigm as the one used in the AC and IC *** included the three main subdivisions of the *** Our data demonstrate that a high percentage of neurons in the mGB adapt to the standard stimulus but not to the oddball *** of the neurons in the dorsal and medial subdivisions exhibited extreme levels of SSA,firing almost entirely to the oddball tone,and behaving as surprise *** neurons maintained a high degree of SSA even at very extreme conditions,e.g.,at the combination of a frequency contrast as small as 0.14 octaves and an ISI as long as 2000 *** SSA neurons were mainly onset responders with short latency,but some neurons with tonic and also long latency responses showed high levels of *** We provide evidence for a very rapid and sensitive to the stimuli statistics type of adaptation,that may be mediated by diverse neuronal *** results taken together with those from the AC and the IC,demonstrate the ubiquity of this type of adaptation in neurons from the midbrain level up to the *** hypothesize that SSA may be shaped in a bottom-up process.

关键词： medial geniculate body stimulus-specific adaptation oddball paradigm surprise detectors

来源： cnki会议评论

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World Journal of Gastroenterology 2012年第37期18卷 5305-5308页

作者： Gilton marques Fonseca André luis montagnini manoel de Souza Rocha Rosely antunes Patzina mário Vinícius Angelete Alvarez Bernardes Ivan Cecconello José Jukemura Digestive Surgery Division Department of GastroenterologySchool of MedicineUniversity of So Paulo

Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastro-intestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumordid not recur in any of the resected cases.

关键词： Schwannoma Neurilemoma Biliary tract Hilar adenocarcinoma Computadorized tomography

A graph-based representation of knowledge for managing land administration data from distributed agencies–A case study of Colombia

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Geo-Spatial Information Science 2022年第2期25卷 259-277页

作者： luis m.Vilches-Blázquez Jhonny Saavedra Investigación en Computación Instituto Politécnico NacionalMexico CityMexico School of Land Surveying Geodesy and Mapping EngineeringUniversidad Politécnica de MadridMadridSpain

multiple efforts have been performed worldwide around diverse aspects of land ***,land administration data and systems’notorious heterogeneity remains a longstanding challenge to develop a harmonized *** this sense,the traditional Spatial Data Infrastructures adoption is not enough to overcome this challenge since data sources’heterogeneity implies needs related to harmonization interoperability,sharing,and integration in land administration *** paper proposes a graph-based represen-tation of knowledge for integrating multiple and heterogeneous data sources(tables,shape-files,geodatabases,and WFS services)belonging to two Colombian agencies within a decentralized land administration *** knowledge graphs are developed on an ontology-based knowledge representation using national and international standards for land *** approach aims to prevent data isolation,enable cross-datasets integration,accomplish machine-processable data,and facilitate the reuse and exploitation of multi-jurisdictional datasets in a single approach.A real case study demonstrates the applicability of the land administration data cycle deployed.

关键词： Land administration knowledge graph ontology heterogeneity data integration

A review on the synergism between corrosion and fatigue of magnesium alloys:mechanisms and processes on the micro-scale

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Journal of magnesium and Alloys 2024年第8期12卷 3062-3093页

作者： mara Cristina Lopes de Oliveira Rejane maria Pereira da Silva Ricardo m.Souto Renato Altobelli antunes Federal University of the ABC Center for EngineeringModeling and Applied Social SciencesAv.Dos Estados500109280-560 Santo AndréSPBrazil Department of Chemistry-PPGQ State University of PiauíUESPICampus Poeta Torquato NetoPirajáTeresina 64002-150 PIBrazil Institute of material Science and Nanotechnology University of La LagunaP.O.Box 45638200 La LagunaTenerifeSpain

Understanding the interaction between cyclic stresses and corrosion of magnesium(mg)and its alloys is increasingly in demand due to the continuous expansion of structural applications of these *** review is dedicated to exploring the corrosion-fatigue mechanisms of these materials,with an emphasis on microscale processes,and the possibility of expanding current knowledge on this topic using scanning electrochemical *** interaction between fatigue and corrosion of mg alloys is analyzed by considering the microstructural aspects(grain size,precipitates,deformation twins),as well as the formation of ***,in the case of coated alloys,the role of coating defects in these phenomena is also *** this context,the feasibility of using scanning electrochemical microscopy(SECm),scanning vibrating electrode technique(SVET),scanning ion-selective electrode technique(SIET),localized electrochemical impedance spectroscopy(LEIS)and scanning Kelvin probe(SKP)methods to study the corrosion-fatigue interaction of mg alloys is examined.A comprehensive review of the current literature in this field is presented,and the opportunities and limitations of consolidating the use of these techniques to study the microscale processes involved in mg corrosion-fatigue are discussed.

关键词： magnesium alloys Localized corrosion and protection Fatigue Scanning electrochemical microscopy Scanning vibrating electrode technique Scanning ion-selective electrode technique Scanning Kelvin probe Chemical imaging

Occurrence data may provide unreliable thermal preferences and breadth of species

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Current Zoology 2015年第6期61卷 972-982页

作者： Sara VILLEN-PEREZ luis m. CARRASCAL Department of Biogeography and Global Change National Museum of Natural Sciences MNCN-CSIC. C/José Gutiérrez Abascal 2 28006 Madrid Spain.

Accurate information on the thermal preference and specialization of species is needed to understand and predict spe- cies geographical range size and vulnerability to climate change. Here we estimate the position and breadth of species within thermal gradients based on the shape of the response curve of species abundance to temperature. The objective of the study is to compare the measurements of this approach based on abundance data with those of the classical approach using species＇ occur- rence data. The relationship between species＇ relative abundance and minimum winter temperature of 106 bird species wintering in the Iberian Peninsula is modeled at 100 Km2 resolution with quadratic logistic regressions. From these models we calculated the preferred temperature of species as the temperature at which the abundance is maximized, and the thermal breadth of species as the relative area under the temperature-abundance curve. We also estimated the thermal preferences and breadth of species as the average temperature and temperature range of the UTm cells in which the species are present. The abundance-temperature response curves reveal that birds prefer higher temperatures to overwinter, and are more thermally selective, than is measured by the classical approach. moreover, response curves detect a higher inter-specific variability in both thermal preferences and ther- mal breadth of species. As occurrence data gives the same weight to cells with one or many individuals, the average temperature of the cells in which the species is present roughly reflects the average temperature in the region of study and not the environ- mental preferences of species .

关键词： Abundance-temperature response curve Birds Species occurrence Thermal breadth Thermal preferences Winter

Woodland mediterranean birds can resist a dry extreme cold wave

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Current Zoology 2014年第4期60卷 429-437页

作者： Sara VILLEN-PEREZ luis m. CARRASCAL Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales (CSIC) C/Jos6 Guti6rrez Abascal 228006 Madrid Spain

The ecological consequences of climate extreme events are still poorly understood, especially those related to cold episodes. Winter cold spells might imperil the energy balance of small passerines, thus compromising their survivorship. Here we analyze how the abundance and habitat use of three tree-gleaning passerine species wintering in a montane oakwood of central Spain at ca. 1,300 m a.s.1, was influenced by the cold wave that hit Europe in February 2012. We monitored temperature, wind and the relative abundance of great tit Parus major, blue tit Cyanistes caeruleus and long-tailed tit Aegithalos caudatus in 15 plots throughout three periods： before, during and after the cold wave. Our results clearly rule out widespread mortality and temporal migration of the studied passerine populations, as the abundance of these species did not diminish during the cold wave. moreover, the species usually foraging higher in the tree canopy -and thus more exposed to windmoved to the less windy woodland plots （long-tailed tit） and reduced their foraging height above ground during the cold wave （long-tailed tit and blue tit）, probably to mitigate the deleterious effects of wind chill. Therefore, these forest birds were able to cope with a dry cold wave that was statistically extreme in terms of temperature and wind chill, according to the historic climate records of the region. It seems that, at least when foraging substrates are not heavily covered by snow or ice, mediterranean birds can resist an extreme cold wave [Current Zoology 60 （4）： 429-437, 2014].

关键词： Cold wave Harsh weather mediterranean oakwoods Temperature Tree-gleaning birds Wind chill

Investigating local corrosion processes of magnesium alloys with scanning probe electrochemical techniques: A review

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Journal of magnesium and Alloys 2022年第11期10卷 2997-3030页

作者： mara Cristina Lopes de Oliveira Rejane maria Pereira da Silva Ricardo m.Souto Renato Altobelli antunes Federal University of ABC Center for EngineeringModeling and Applied Social SciencesAv.Dos Estados500109210-580Santo AndréSP Brazil Instituto de Pesquisas Energéticas e Nucleares IPEN/CNENAv.Prof.Lineu Prestes2242São PauloBrazil Institute of material Science and Nanotechnology University of La LagunaP.O.Box 456La LagunaTenerife 38200Spain

The study of corrosion of magnesium and its alloys has emerged a hot topic in the applications of lightweight structural materials. The inherently high electrochemical activity of bare magnesium surfaces still lacks a convincing mechanism to describe the observed experimental characteristics, and it has prompted the development of various types of protective coatings with the aim of slowing metal dissolution. In recent years, new instruments and techniques have been developed to study with spatial resolution the local corrosion processes that occur in metallic materials in general, and for magnesium and its alloys in particular, both for bare surfaces and coated. Scanning microelectrochemical techniques, such as local electrochemical impedance spectroscopy(LEIS), scanning electrochemical microscopy(SECm), scanning vibrating electrode technique(SVET), scanning ion-selective electrode technique(SIET) and scanning Kelvin probe(SKP) can provide information about the local electrochemical activity of metallic surfaces. In the present work, the applications of these techniques in corrosion studies of magnesium and its alloys are reviewed. Assessment of corrosion mechanisms, barrier properties of conventional coatings and active corrosion behavior of self-healing coatings are examined. Limitations and future developments in this area are discussed.

关键词： magnesium alloys LEIS SECm SVET SIET SKP