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Haplotype phasing after joint estim.tion of recom.ination and linkage disequilibrium.in breeding populations

Journal of Anim.l Science and Biotechnology 2014年第1期5卷 38-52页

作者： luis Gom.z-Raya Am.nda m.Hulse David Thain Wendy m.Rauw Departam.nto de m.jora Genética Anim.l Instituto Nacional deInvestigación y Tecnología Agraria y Alimentaria (INIA) Interdisciplinary Program.in Genetics Texas A&M University College Station Departm.nt of Anim.l Biotechnology University of Nevada

A novel m.thod for haplotype phasing in fam.lies after joint estim.tion of recom.ination fraction and linkage disequilibrium.is developed. Results from.m.nte Carlo com.uter sim.lations show that the newly developed E.m. algorithm.is accurate if true recom.ination fraction is 0 even for single fam.lies of relatively sm.ll sizes. Estim.tes of recom.ination fraction and linkage disequilibrium.were 0.00 （SD 0.00） and 0.19 （SD 0.03） for sim.lated recom.ination fraction and linkage disequilibrium.of 0.00 and 0.20, respectively. A genom. fragm.ntation phasing strategy was developed and used for phasing haplotypes in a sire and 36 progeny using the 50 k Illum.na BeadChip by： a） estim.tion of the recom.ination fraction and LD in consecutive SNPs using fam.ly inform.tion, b） linkage analyses between fragm.nts, c） phasing of haplotypes in parents and progeny and in following generations. Hom.zygous SNPs in progeny allowed determ.nation of paternal fragm.nt inheritance, and deduction of SNP sequence inform.tion of haplotypes from.dam.. The strategy also allowed detection of genotyping errors. A total of 613 recom.ination events were detected after linkage analysis was carried out between fragm.nts. Hot and cold spots were identified at the individual （sire level）. SNPs for which the sire and calf were heterozygotes becam. inform.tive （over 90%） after the phasing of haplotypes. Average of regions of identity between half-sibs when com.aring its m.ternal inherited haplotypes （with at least 20 SNP） in com.on was 0.11 with a m.xim.m.of 0.29 and a m.nim.m.of 0.05. A m.nte-Carlo sim.lation of BTA1 with the sam. linkage disequilibrium.structure and genetic linkage as the cattle fam.ly yielded a 99.98 and 99.94% of correct phases for inform.tive SNPs in sire and calves, respectively.

关键词： Breeding Haplotype phasing Linkage disequilibrium SNP

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Local Em.eddings of Som. Fam.lies of Subgroups of Finite Groups

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Acta m.them.tica Sinica,English Series 2009年第6期25卷 869-882页

作者： A.BALLESTER-BOLINCHES luis m.EZQUERRO Alexander N.SKIBA Departam.nt d'lgebra Universitat de València Departam.nto Departm.nt of m.them.tics Gomel State University F.Skorina

In this paper we study the influence of the partial cover and avoidance property on the subgroups of som. relevant fam.lies of subgroups in a finite group.

关键词： Finite group cover-avoidance property p-supersoluble groups saturated form.tion

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Novel strategies to tailor the photocatalytic activity of m.tal–organic fram.works for hydrogen generation: a m.ni-review

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Frontiers in Energy 2022年第5期16卷 734-746页

作者： luis A.ALFONSO-HERRERA Leticia m.TORRES-m.RTINEZ J.m.nuel m.RA-HERNANDEZ Universidad Autónom. de Nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México Centro de Investigación en m.teriales Avanzados S.C.(CIMAV)Miguel de Cervantes No.120.Complejo Ind.ChihuahuaChihuahuaChih 31136México CONACYT-Universidad Autónom. de Nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México

This review provides a recom.ilation of the m.st im.ortant and recent strategies em.loyed to increase the efficiency of m.tal-organic fram.work(m.F)-based system. toward the photocatalytic hydrogen evolution(PHE)reaction through specific strategies:tailoring the photocatalytic activity of bare m.Fs and guest@m.F com.osites,form.tion of heterojunctions based on m.Fs and various photocatalysts,and inorganic photocatalysts derived from.*** to the data reported in this m.ni-review,the m.st effective strategy to im.rove the PHE of m.Fs relies on m.difying the linkers with new secondary building units(SBUs).Although several reviews have investigated the photocatalytic activity of m.Fs from.a general point of view,m.ny of these studies relate this activity to the physicochem.cal and catalytic properties of ***,they did not consider the interactions between the com.onents of the photocatalytic *** study highlights the effects of strength of the supram.lecular interactions on the photocatalytic perform.nce of bare and m.F-based m.terials during PHE.A thorough review and com.arison of the results established that m.tal-nanoparticle@m.F com.osites have weak van der Waals forces between com.onents,whereas heterostructures only interact with m.Fs at the surface of bare *** m.terial derivatives from.m.Fs,we found that pyrolysis destroyed som. beneficial properties of m.Fs for ***,we conclude that adding SBUs to organic linkers is the m.st efficient strategy to perform.the PHE because the SBUs added to the m.Fs prom.te synergy between the two m.terials through strong coordination bonds.

关键词： m.tal-organic fram.works(m.Fs) photocatalytic hydrogen evolution m.F heterojunctions m.terials derived from.m.Fs bandgap recom.ination

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A New m.m.er of the Thioredoxin Reductase Fam.ly from.Early Oxygenic Photosynthetic Organism.

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m.lecular Plant 2017年第1期10卷 212-215页

作者： Rubén m. Buey Sergio Galindo-Trigo luis López-m.ury Adrián Velázquez-Cam.oy José luis Revuelta F. Javier Florencio José m. de Pereda Peter Schürm.nn Bob B. Buchanan m.nica Balsera Departm.nt m.crobiología y Genética Universidad de Salamanca Salamanca 37007 Spain Instituto de Recursos Naturales y Agrobiología de Salam.nca (IRNASA-CSIC) Salamanca 37008 Spain Instituto de Bioquím.ca Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla) Seville 41092 Spain Institute of Biocom.utation and Physics of Com.lex System. (BIFI) University of Zaragoza Zaragoza 50018 Spain Instituto de Biología m.lecular y Celular del Cáncer (CSIC-Universidad de Salam.nca) Salamanca 37007 Spain Laboratoire de Biologie m.léculaire et Cellulaire Université de Neuchâtel Neuchâtel 2000 Switzerland Departm.nt of Plant and m.crobial Biology University of California Berkeley CA 94720 USA

Dear Editor,Thioredoxins （Trxs） are key com.onents of the redox system.that regulates the activity of a spectrum.of target proteins through dithiol-disulfide exchange reactions. Trxs are reduced by m.m. bers of the Trx reductase （TR） fam.ly （Jacquot et al., 2009）. NADP-dependent thioredoxin reductases （NTRs）, the m.st com.m.n type, belong to the fam.ly of dim.ric pyridine nucleotide disul-fide oxidoreductase flavoproteins that use NADPH as the source of reducing equivalents.

关键词： Thioredoxin Early Organism.

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A procedure to assess the spatial variability in the im.ortance of abiotic factors affecting distributions： the case of world freshwater fishes

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Current Zoology 2018年第5期64卷 549-557页

作者： Ana m. m.NJARRES-HERNANDEZ Castor GUISANDE Em.lio GARCiA-ROSELLO Patricia PELAYO-VILLAm.L Jacinto GONZALEZ-DAcOSTA Juirgen HEINE luis GONZALEZ VILAS Carlos GRANADO-LORENClO Santiago R. DUQUE Jorge m. LOBO alnstituto Am.zonico de Investigaciones-Im.NI Universidad Nacional de Colombia Leticia A.A. 215 Colombia 910001 Facultad de Ciencias del m.r Universidad de Vigo Vigo 36310 Spain Departam.nto de Inform.tica Edificio Fundicien Universidad de Vigo Vigo 36310 Spain Grupo de Iciologia Universidad de Antioquia Medellin Colombia 050010 eDepartamento de Biologia Vegetal y Ecologia Facultad de Biologia Universidad de Sevilla Sevilla 41080 Spain Departam.nto de Biogeografia y Cam.io Global Museo Nacional de Ciencias Naturales (CSIC) Calle de Jose Gutierrez Abascal 2 Madrid 28006 Spain

Understanding the factors shaping species＇ distributions is a key longstanding topic in ecology with unresolved issues. The aim. were to test whether the relative contribution of abiotic factors that set the geographical range of freshwater fish species m.y vary spatially and/or m.y depend on the geographical extent that is being considered. The relative contribution of factors, to discrim.nate between the conditions prevailing in the area where the species is present and those existing in the considered extent, was estim.ted with the instability index included in the R pack- age SPEDInstabR. We used 3 different extent sizes： 1） each river basin where the species is present （local）; 2） all river basins where the species is present （regional）; and 3） the whole Earth （global）. We used a data set of 16,543 freshwater fish species with a total of 845,764 geographical records, together with bioclim.tic and topographic variables. Factors associated with tem.era- ture and altitude show the highest relative contribution to explain the distribution of freshwater fishes at the sm.ller considered extent. Altitude and a m.x of factors associated with tem.erature and precipitation were m.re im.ortant when using the regional extent. Factors associated with precipitation show the highest contribution when using the global extent. There was also spatial variability in the im.ortance of factors, both between species and within species and from.region to region. Factors associated with precipitation show a clear latitudinal trend of decreasing in im.ortance toward the equator.

关键词： anisotropic predictors environm.ntal data selection geographical background non-stationary predictors

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Large-Scale Group Decision m.king:A System.tic Review and a Critical Analysis

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IEEE/CAA Journal of Autom.tica Sinica 2022年第6期9卷 949-966页

作者： Diego García-Zam.ra Alvaro Labella Weiping Ding Rosa m.Rodríguez luis m.rtínez Departm.nt of Com.uter Science University of JaénJaén 23071Spain IEEE School of Inform.tion Science and Technology Nantong UniversityNantong 226019China

The society in the digital transform.tion era dem.nds new decision schem.s such as e-dem.cracy or based on social *** novel decision schem.s require the participation of m.ny experts/decision m.kers/stakeholders in the decision *** a result,large-scale group decision m.king(LSGDm.has attracted the attention of m.ny researchers in the last decade and m.ny studies have been conducted in order to face the challenges associated with the ***,this paper aim. at reviewing the m.st relevant studies about LSGDm.identifying the m.st profitable research trends and analyzing them.from.a critical point of *** do so,the Web of Science database has been consulted by using different *** these results a total of 241 contributions were found and a selection process regarding language,type of contribution and actual relation with the studied topic was then carried *** 87 contributions finally selected for this review have been analyzed from.four points of view that have been highly rem.rked in the topic,such as the preference structure in which decision-m.kers’opinions are m.deled,the group decision rules used to define the decision m.king process,the techniques applied to verify the quality of these m.dels and their applications to real world problem. ***,a critical analysis of the m.in lim.tations of the existing proposals is ***,taking into account these lim.tations,new research lines for LSGDm.are proposed and the m.in challenges are stressed out.

关键词： Challenges large-scale consensus m.dels large-scale group decision m.king(LSGDm. system.tic review

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Substance use and inhalation injury in adult burn patients:retrospective study of the im.act on outcom.s

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Burns & Traum. 2019年第1期7卷 132-138页

作者： Kevin m.Klifto luis Quiroga C.Scott Hultm.n Departm.nt of Plastic and Reconstructive Surgery Johns Hopkins Burn CenterThe Johns Hopkins Hospital4940 Eastern AvenueBaltimore 21224USA

Background:Substance use,alcohol use,and sm.king use have all been associated with burn *** studies have investigated associations with substances,alcohol,sm.king,inhalational only burns,and patient *** purpose of the study was to identify risk factors for pulm.nary failure in patients suffering inhalation injury,focusing on the im.act of substance,alcohol,and cigarette ***:This is a single-center retrospective analysis of 115 patients adm.tted to the Johns Hopkins Bayview Burn Center with inhalational injury from.January 1,2010,through Septem.er 30,*** were excluded if they were under the age of 18 years or had burn involvem.nt of the skin>5%.Prim.ry outcom. variables m.asured were if patients were intubated,length of total tim. intubated,substance use,alcohol use,and sm.king *** outcom. variables m.asured were types of substances used(am.hetam.nes,barbiturates,benzodiazepines,cannabinoids,cocaine,m.thadone,codeine/m.rphine),total num.er of substances used,intensive care unit(ICU)length of stay(LOS),hospital LOS,secondary com.lications,and patient *** was perform.d with Fisher’s exact test and the m.nn-Whitney U test.A sub-group analysis for each substance,alcohol,sm.king,and control subgroup was com.ared to its respective sub-group without substance,alcohol,sm.king,and control within the no intubation and intubation group.A sub-group analysis of substance use,alcohol use,sm.king use,and control was further analyzed with binom.al logistic regression within the intubation ***:Following inhalation injury,50/115(43%)patients required ***-two of the 50(84%)patients intubated had substance use(pm.king(p=0.038).Am.ng the specific substances used,26/50(52%)patients intubated were using benzodiazepines(p<0.001)and 7/50(14%)patients were using cocaine(p=0.022).The lengths of intubation,ICU LOS,and hospital LOS with no substanc

关键词： Intubation Sm.king Burn Risk factors Cocaine Benzodiazepines m.rphine Inhalation

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m.ize forage aptitude: Com.ining ability of inbred lines and stability of hybrids

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The Crop Journal 2014年第6期2卷 407-418页

作者： luis m.xim. Bertoia m.nica Beatriz Aulicino Departm.nt of Plant Production Faculty of Agrosciences National University of Lomas de Zamora Camino de Cintura km 21832 Lomas de Zamora Buenos Aires Argentina Departm.nt of Genetics Faculty of Agrosciences National University of Lomas de Zamora Camino de Cintura km 2 1832 Lomas de ZamoraBuenos Aires Argentina Santa Catalina Plant Breeding Institute National University of La Plata CC 4 1836 Llavallol Buenos Aires Argentina

Breeding of forage m.ize should com.ine im.rovem.nt achieved for grain with the specific needs of forage hybrids. Production stability is im.ortant when m.ize is used for silage if the planting area is not in the ideal agronom.c environm.nt. The objectives of the present research were:(i) to quantify environm.ntal and genetic and their interaction effects on m.ize silage traits;(ii) to identify possible heterotic groups for forage aptitude and suggest the form.tion of potential heterotic patterns, and(iii) to identify suitable inbred line com.inations for producing hybrids with forage aptitude. Forty-five hybrids derived from.diallelic crosses(without reciprocals) am.ng ten inbred lines of m.ize were evaluated in this study. Com.ined ANOVA over environm.nts showed differences between genotypes(G), environm.nts(E), and their interactions(GEI). Heritability(H2), and genotypic and phenotypic correlations were estim.ted to evaluate the variation in and relationships between forage traits. Postdictive and predictive Am.I m.dels were fitted to determ.ne the im.ortance of each source of variation, G, E, and GEI, and to select genotypes sim.ltaneously on yield, quality and stability. A predom.nance of additive effects was found in the evaluated traits. The heterotic pattern Reid-BSSS × Argentine flint was confirm.d for ear yield(EY) and harvest index(HI). High and broad genetic variation was found for stover and whole plant traits. Som. inbred lines had genes with differential breeding aptitude for ear and stover. Stover and ear yield should be the m.in breeding objectives in m.ize forage breeding.

关键词： Zea m.ys L. Forage m.ize Com.ining ability GEI interaction Stover and ear digestibility

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Endoscopic ultrasound-guided gastroenterostom. for gastric outlet obstruction in m.xico

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World Journal of Surgical Procedures 2024年第3期14卷 15-20页

作者： m.ssiel m.delin Rosario-m.rel Rodrigo Soto-Solis Katia Picazo-Ferrera m.riam.Idalia Torres-Ruiz JoséAlberto Estradas-Trujillo m.rio Alberto Gallardo-Ram.rez Gerardo Akram.Darwich-del m.ral luis Ariel Waller-González Departm.nt of Endoscopy Centro Médico Nacional“20 de Noviembre”ISSSTEMexico City 03229Mexico Departm.nt of Gastroenterology HospitalÁngeles PedregalMexico City 10700Mexico Departm.nt of Endoscopy Centro Médico ABCMexico City 01120Mexico Departm.nt of Endoscopy Hospital General de México“Dr.Eduardo Liceaga”Mexico City 06720Mexico

BACKGROUND Endoscopic ultrasound-guided gastroenterostom.(EUS-GE)has recently em.rged as an alternative treatm.nt for gastric outlet obstruction(GOO)in selected *** To report the initial experience of EUS-GE in patients with *** This study was a retrospective,observational,m.lticenter study in which the data from.10 patients who underwent EUS-GE due to GOO between Septem.er 2021 and m.y 2023 were *** analyzed technical success,clinical success,adverse events,and *** success was defined as adequate positioning and deploym.nt of the *** success was defined as the patient’s ability to tolerate oral intake without vom.ting 7 d after the *** adverse events were *** Eleven procedures in 10 patients with GOO were *** m.an age of the patients was 67.5 years(range:56-77 years).m.lignant GOO was present in 9 *** success was achieved in 9/11 procedures(82%).Am.ng them.clinical success was achieved in 9 patients(100%).Adverse events occurred in 1 patient(9%).The m.dian survival was 3 m.nths(n=7;range:1-8 m.nths).CONCLUSION EUS-GE is a feasible therapeutic option in the treatm.nt of GOO.

关键词： Endoscopic ultrasound-guided gastroenterostom. Gastric outlet obstruction Lum.n apposing m.tal stent Interventional endoscopic ultrasound Gastrojejunostom. Duodenal stenting

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Integrating geographical inform.tion in the Linked Digital Earth

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International Journal of Digital Earth 2014年第7期7卷 554-575页

作者： luis m.Vilches-Blazquez Boris Villazon-Terrazas Oscar Corcho Asuncion Gom.z-Perez Ontology Engineering Group Departamento de Inteligencia ArtificialFacultad de InformaticaUniversidad Politecnica de MadridMadridSpain

m.ny progresses have been m.de since the Digital Earth notion was envisioned thirteen years ***,the m.chanism.for integrating geographic inform.-tion into the Digital Earth is still quite *** this context,we have developed a process to generate,integrate and publish geospatial Linked Data from.several Spanish National *** data-sets are related to four Infrastructure for Spatial Inform.tion in the European Com.unity(INSPIRE)them.s,specifically with Adm.nistrative units,Hydrography,Statistical units,and *** m.in goal is to com.ine different sources(heterogeneous,m.ltidisciplinary,m.ltitem.oral,m.ltiresolution,and m.ltilingual)using Linked Data *** goal allows the overcom.ng of current problem. of inform.tion integration and driving geographical inform.tion toward the next decade scenario,that is,‘Linked Digital Earth’.

关键词： geographical inform.tion integration Digital Earth Linked Data

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