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Preliminary Study on Taxonomic Review Using Histological Sections of Some Iberian Species from the Genus <i>Quercus</i>L. (Fagaceae)

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American Journal of Plant Sciences 2014年第18期5卷 2773-2784页

作者： Sara del Río Rafael álvarez Adoración Candelas Silvia González-Sierra luis herrero Angel Penas Departamento de Biología Molecular-área de Biología Celular Facultad de Ciencias Biológicas y Ambientales Universidad de León León Spain Department of Biodiversity and Environmental Management (Botany) Faculty of Biology and Environmental Sciences Mountain Livestock Institute (CSIC-University of León) University of León León Spain Laboratorio de Microscopía Centro Nacional de Investigación sobre la Evolución Humana (CENIEH) Burgos Spain

The taxonomy of the genus Quercus is the subject of ongoing scientific interest at the present time. Classically the scanning electron microscope is and has been used for the study of leaf surfaces, particularly to characterise the trichomes, stomata and epicuticular waxes. In the present work, in addition to using the SEM, histological sections from a group of taxa from the northern Iberian Peninsula are studied under the optical microscope. Specifically, the study concerns the leaves of Quercus robur subsp. robur, Q. orocantabrica, Q. petraea and Q. pyrenaica, and of possible hybrids between Q. orocantabrica and Q. petraea and between Q. orocantabrica and Q. pyrenaica. The results highlight histological differences between Q. robur and Q. orocantabrica, and also differentiate the morphological characteristics of Q. petraea and Q. pyrenaica. Similarities can also be observed between Q. petraea and its possible hybrid with Q. orocantabrica, and between Q. pyrenaica and its hybrid with Q. orocantabrica. The aspects observed under the optical microscope complement the observations obtained by means of the scanning electron microscope, and as a consequence of this, two new nothospecies are described: Q. xpuentei (Q. orocantabrica × Q. petraea) and Q. xpenasii (Q. orocantabrica × Q. pyrenaica).

关键词： Histology Iberian Peninsula Optical Microscopy Quercus SEM

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如何及为什么评价文化机构的效率?西班牙的方法及应用

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中国文化产业评论 2019年第1期27卷 186-209页

作者：路易斯·塞萨尔·赫拉罗·普列托玛利亚·何塞·德尔·巴利奥·忒拉多黄莺(译) 西班牙巴亚多利德大学华中师范大学

本文写作目的是提出一种方法论的途径来评价文化机构的效率,特别是博物馆,因为这是文化遗产领域最具特色的机构。文章对案例研究的不同应用方法进行了回顾以说明这些途径和方法是如何随着时间的推移而发展的。我们还对区域博物馆系统的... 详细信息

本文写作目的是提出一种方法论的途径来评价文化机构的效率,特别是博物馆,因为这是文化遗产领域最具特色的机构。文章对案例研究的不同应用方法进行了回顾以说明这些途径和方法是如何随着时间的推移而发展的。我们还对区域博物馆系统的绩效评估进行了具体的实证应用,以探索某些外在因素,如制度管理模式和博物馆位置,对效率水平的影响。我们采用数据环绕分析这种非参数化的方法用于衡量这些机构的效率,还采用了一个复杂的生产函数,它包含了许多与博物馆所实现的各种功能相适应的输入和输出形式:保存、研究、交流和展览。研究最重要的发现表明,至少有一半选到的博物馆是高效运作的。最高效的博物馆是那些位于城区的博物馆,由地区政府管理,而市级管理下的乡村博物馆则效率较低。这项工作旨在证明这种方法以及这些技术在制定指导方针和提供关于使用文化机构资源的建议方面的有效性。

关键词：效率评价博物馆管理数据发展分析文化经济西班牙

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Duodenal biopsy may be avoided when high transglutaminase antibody titers are present

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World Journal of Gastroenterology 2009年第38期15卷 4775-4780页

作者： Santiago Vivas Jose G Ruiz de Morales Sabino Riestra Laura Arias Dolores Fuentes Noemi Alvarez Sara Calleja Mercedes Hernando Blanca herrero Javier Casqueiro luis Rodrigo Department of Gastroenterology Hospital de León Institute of Biomedicine University of León Immunology Section Hospital de León Department of Gastroenterology Hospital Universitario Central de Asturias Department of Pathology Hospital de León Department of Pediatrics Hospital de León Faculty of Biology and Environmental Sciences University of León

AIM:To evaluate the predictive value of tissue transglutaminase (tTG) antibodies for villous atrophy in adult and pediatric populations to determine if duodenal biopsy can be ***: A total of 324 patients with celiac disease (CD; 97 children and 227 adults) were recruited prospectively at two tertiary centers. Human IgA class anti-tTG antibody measurement and upper gastrointestinal endoscopy were performed at diagnosis. A second biopsy was performed in 40 asymptomatic adults on a gluten-free diet (GFD) and with normal tTG ***: Adults showed less severe histopathology (26% vs 63%, P<0.0001) and lower tTG antibody titers than children. Levels of tTG antibody correlated with Marsh type in both populations (r=0.661, P<0.0001). Multiple logistic regression revealed that only tTG antibody was an independent predictor for Marsh type 3 lesions, but clinical presentation type and age were not. A cut-off point of 30 U tTG antibody yielded the highest area under the receiver operating characteristic curve (0.854). Based on the predictive value of this cut-off point, up to 95% of children and 53% of adults would be correctly diagnosed without biopsy. Despite GFDs and decreased tTG antibody levels, 25% of the adults did not recover from villous atrophy during the second year after ***: Strongly positive tTG antibody titers might be sufficient for CD diagnosis in children. However, duodenal biopsy cannot be avoided in adults because disease presentation and monitoring are different.

关键词： Biopsy Celiac disease Diagnosis Duodenum Transglutaminases

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C3G contributes to platelet activation and aggregation by regulating major signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2103-2117页

作者： Sara Gutiérrez-herrero Cristina Fernández-Infante luis Hernández-Cano Sara Ortiz-Rivero Carlos Guijas Víctor Martín-Granado JoséRamón González-Porras Jesús Balsinde Almudena Porras Carmen Guerrero Instituto de Biología Molecular y Celular del Cáncer(IMBCC) University of Salamanca-CSICSalamancaSpain Instituto de Investigación Biomédica de Salamanca(IBSAL) SalamancaSpain Instituto de Biología y Genética Molecular(IBGM) Consejo Superior de Investigaciones Científicas(CSIC)University of ValladolidValladolidSpain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) MadridSpain Departamento de Hematologiá Hospital Universitario de Salamanca(HUS)SalamancaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaComplutense University of Madrid.Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC)MadridSpain Departamento de Medicina University of SalamancaSalamancaSpain

C3G is a GEF(guanine nucleotide exchange factor)for Rap GTPases,among which the isoform Rap1b is an essential protein in platelet *** transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemostatic function of platelets through its participation in the thrombin-PKCRap1b pathway.C3G also plays important roles in angiogenesis,tumor growth,and metastasis through its regulation of the platelet *** addition,C3G contributes to megakaryopoiesis and ***,we used a platelet-specific C3G-KO mouse model to further support the role of C3G in hemostasis.C3G-KO platelets showed a significant delay in platelet activation and aggregation as a consequence of the defective activation of Rap1,which resulted in decreased thrombus formation in ***,we explored the contribution of C3G-Rap1b to platelet signaling pathways triggered by thrombin,PMA or ADP,in the referenced transgenic mouse model,through the use of a battery of specific *** found that platelet C3G is phosphorylated at Tyr504 by a mechanism involving *** phosphorylation was shown to be positively regulated by ERKs through their inhibition of the tyrosine phosphatase ***,C3G participates in the ADP-P2Y12-PI3K-Rap1b pathway and is a mediator of thrombin-TXA2 ***,it inhibits the synthesis of TXA2 through cPLA2 *** together,our data reveal the critical role of C3G in the main pathways leading to platelet activation and aggregation through the regulation of Rap1b.

关键词： C3G platelet activation

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Visual perception alterations in COVID-19:a preliminary study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： María Begoña Coco-Martín luis Leal-Vega Irene Alcoceba-herrero Ainhoa Molina-Martín Dolores de-Fez María JoséLuque Carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara David PPiñero Group of Applied Clinical Neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision

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Pharmacogenetics implementation in the clinics:information and guidelines for germline variants

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Cancer Drug Resistance 2019年第1期2卷 53-68页

作者： Gladys Olivera luis Sendra María Joséherrero Pablo Berlanga Pablo Gargallo Yania Yáñez Andrea Urtasun Jaime Font de Mora Victoria Castel Adela Cañete Salvador FAliño Pharmacogenetics Platform Instituto de Investigación Sanitaria la FeValencia 46026Spain Department of Pharmacology University of ValenciaValencia 46010Spain Department of Pediatric and Adolescent oncology Institute Gustave Roussy CenterVillejuif 94800France Pediatric Oncology Unit Hospital Universitario y Politécnico la FeValencia 46026Spain Pediatric Clinical and Translational Research in Cancer Instituto de Investigación Sanitaria la FeValencia 46026Spain

The aim of this work was to supply an overview of the germline Pharmacogenetics that can be already implemented in the oncology clinical *** explanation of the three pillars considered necessary for determining which genetic polymorphisms should be used has been *** are PharmGKB single nucleotide polymorphism(SNP)-Drug Clinical Annotations with levels of evidence 1 or 2;the genetic information provided in the drug labels by the drug regulatory main agencies(Food and Drug Administration and European Medicines Agency,mainly);and the guidelines elaborated by international expert consortia(mainly Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group).A summary of the relevant SNPs and the recommendations on how to apply their results has also been compiled.

关键词： Polymorphisms Pharmacogenetic PharmGKB guidelines oncology clinical implementation

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Proposed Protocol for Neuropathic Pain Assessment

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Occupational Diseases and Environmental Medicine 2020年第4期8卷 149-162页

作者： Mª Teófila Vicente herrero Mª Victoria Ramírez Iñiguez de la Torre luis Reinoso Barbero Asociacion Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of Correos Valencia Spain Asociacion Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of Correos Albacete Spain Asociacion Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad Internacional de la Rioja La Rioja Spain

Introduction: Pain with neuropathic characteristics is one of the most limiting as a consequence of injury or disease that affects the somatosensory system. Objective: An assessment protocol is proposed to quantify the impact of neuropathic pain integrating personal, clinical, work and social aspects and to establish guidelines in its management and evolutionary control. Method: The medical literature on neuropathic pain and its impact is reviewed as a basis for including the variables that must be part of the protocol. Results: The variables are quantified individually and by groups of factors. The final result is stratified into four grades (mild, moderate, severe, extreme), which will serve for the subsequent control, monitoring and prevention of risks. Conclusion: The proposed protocol evaluates the impact of neuropathic pain in all aspects of the person who suffers it and quantifies the results establishing degrees for its control, follow-up and clinical, social and occupational intervention.

关键词： Neuropathic Pain Limitations Assessment Occupational Health Occupational Medicine

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Proposed Protocol for Risk Assessment and Stratification

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Occupational Diseases and Environmental Medicine 2020年第3期8卷 99-110页

作者： Teófila Vicente-herrero Victoria Ramírez Iñiguez de la Torre Teresa del Campo Balsa luis Reinoso Barbero Alejandro Fernández Montero Juan Carlos Rueda Garrido Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of Correos Valencia Spain Occupational Health and Safety Services of Correos Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad International de la Rioja La Rioja Spain Department of Occupational Medicine Universidad de Navarra Navarra Spain SABIC Medical Services Cartagena Spain

Introduction: COVID-19 disease is a highly contagious viral infection caused by the SARS-CoV-2 coronavirus. There is growing interest in Public Health and Occupational Health in identifying the COVID-19 prognostic factors, needed to stratified patients by risk being necessary to consider occupational variables as well as individual and clinical factors of the workers. Objective: The aim of this study was to perform a tool to identify the more vulnerable workers for COVID-19 that will be useful to value their work limitations. Methods: A review of medical literature about the vulnerability for COVID-19 is taken into account occupational risks and occupational preventive measures. Results: It is proposed an index of vulnerability criteria for COVID-19 in workers based on quantifying individual characteristics, pre-existing medical conditions and its control, high risk of occupational exposure, and prevention and protection strategies in the workplace. The final result is stratified into three degrees of vulnerability that will serve to propose the most appropriate preventive measures. Conclusion: This proposal protocol assesses about the vulnerability for COVID-19 infection in workers to help decide the preventive management at workplace in this pandemic situation.

关键词： COVID-19 Vulnerability Occupational Health Occupational Medicine

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Proposed Occupational Vulnerability Index COVID-19

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Occupational Diseases and Environmental Medicine 2020年第4期8卷 175-187页

作者： Mª Teófila Vicente-herrero Mª Victoria Ramírez Iñiguez de la Torre Mª Teresa del Campo Balsa luis Reinoso Barbero Juan Carlos Rueda Garrido Cristina Santamaría Navarro Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of SPP Correos Valencia Spain Occupational Health and Safety Services of SPP Correos Albacete Spain Occupational Health and Safety Services of SPA ITEM-Prevención Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad Internacional de la Rioja La Rioja Spain Occupational Medicine SABIC Medical Services Cartagena Spain University-PDI. Instituto de Matemática Multidisciplinar. Universitat Politècnica de València Valencia Spain

Introduction: Vulnerable is someone who can be hurt or receive injury, physically or morally. The work environment appears as one of the dimensions in which social vulnerability develops and social and occupational vulnerability is defined. The literature does not include an assessment of quantified occupational vulnerability as it already exists in the case of social vulnerability. The aim of this paper is to identify and quantify the variables included in the Protocol for the Assessment of Vulnerability to COVID-19 in such a way that the result can be quantified and allows for a predictive effect on the degree of vulnerability. Methodology: The starting point is the design of a protocol proposal that includes 29 variables. Data is collected from a sample of 420 workers, quantifying the results according to each variable, the overall scores for each group of aspects assessed and, finally, the total score that estimates the degree of vulnerability according to established ranges. Results: Variables that have the highest coefficient and, therefore, the greatest weight in the probability of reaching a group of high or medium vulnerability are cardiovascular disease, cancer, and coagulation alteration. The weight of the labour aspects due to inadequate working conditions stands out. Conclusions: The results obtained with this protocol allow us to make a quantified assessment of labour vulnerability to COVID-19 by integrating individual variables of the worker, his working conditions and the preventive actions of his company against COVID-19, and can be useful as an Occupational Vulnerability Index (OVI).

关键词： COVID-19 Index Occupational Vulnerability Occupational Health Occupational Medicine

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta herrero-Romero luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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