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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar Bushra Khan luis Gand Arnab Nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut Bertalanffy Saverio francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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How secure can we expect the surveillance policies to be after the implementation in T1 polyps with carcinoma?

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 502-508页

作者： Cristina Mateos Sanchez Elvira Quintanilla Lazaro luis Ramon Rabago Department of Gastroenterological Severo Ochoa HospitalMadridLeganes 28911Spain Department of Gastroenterology San Rafael HospitalMadrid 28016Spain

Approximately 7%of the polyps resected endoscopically have an adenocarcinoma focus,with no previous endoscopic evidence of *** raises the question of whether endoscopic resection has been ***,there is no consensus on what the endoscopic and histological criteria for good prognosis are,the appropriate follow-up strategy and what are the long-term *** aim of the retrospective study by fábián et al was to evaluate the occurrence of local relapse or distant metastasis in those tumors that were resected endoscopically compared to those that underwent oncologic *** concluded that,regardless of the treatment strategy chosen,there was a higher recurrence rate than described in the literature and that adherence to follow-up was *** management approach for an endoscopically benign polyp histologically confirmed as adenocarcinoma depends on the presence of any of the previously described poor prognostic histological *** none of these factors are present and the polyp has been completely resected en bloc(R0),active surveillance is considered appropriate as endoscopic resection is deemed *** results highlight,once again,the need for further multicentric clinical practice studies to obtain more evidence for the purpose of establishing appropriate treatment and follow-up strategies.

关键词： pT1 adenocarcinoma polyps pT1 follow up management Histological recurrence rate of pT1 adenocarcinoma Endoscopic and histologic poor prognostic criteria

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Predicting major adverse cardiovascular events after orthotopic liver transplantation using a supervised machine learning model:A cohort study

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World Journal of Hepatology 2024年第2期16卷 193-210页

作者： Jonathan Soldera Leandro luis Corso Matheus Machado Rech Vinícius Remus Ballotin Lucas Goldmann Bigarella fernanda Tomé Nathalia Moraes Rafael Sartori Balbinot Santiago Rodriguez Ajacio Bandeira de Mello Brandão Bruno Hochhegger Post Graduate Program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom Postgraduate Program in Pathology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Engineering Universidade de Caxias do SulCaxias do Sul 95070-560Brazil School of Medicine Universidade de Caxias do SulCaxias do Sul 95070-560Brazil Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

BACKGROUND Liver transplant(LT)patients have become older and *** rate of post-LT major adverse cardiovascular events(MACE)has increased,and this in turn raises 30-d post-LT *** cardiac stress testing loses accuracy when applied to pre-LT cirrhotic *** To assess the feasibility and accuracy of a machine learning model used to predict post-LT MACE in a regional *** This retrospective cohort study involved 575 LT patients from a Southern Brazilian academic *** developed a predictive model for post-LT MACE(defined as a composite outcome of stroke,new-onset heart failure,severe arrhythmia,and myocardial infarction)using the extreme gradient boosting(XGBoost)machine learning *** addressed missing data(below 20%)for relevant variables using the k-nearest neighbor imputation method,calculating the mean from the ten nearest neighbors for each *** modeling dataset included 83 features,encompassing patient and laboratory data,cirrhosis complications,and pre-LT cardiac *** performance was assessed using the area under the receiver operating characteristic curve(AUROC).We also employed Shapley additive explanations(SHAP)to interpret feature *** dataset was split into training(75%)and testing(25%)*** was evaluated using the Brier *** followed Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis guidelines for ***-learn and SHAP in Python 3 were used for all *** supplementary material includes code for model development and a user-friendly online MACE prediction *** Of the 537 included patients,23(4.46%)developed in-hospital MACE,with a mean age at transplantation of 52.9 *** majority,66.1%,were *** XGBoost model achieved an impressive AUROC of 0.89 during the training *** model exhibited accuracy,precision,recall,and f1-score values of 0.84,0.85,0.80,and 0.79,***

关键词： Liver transplantation Major adverse cardiac events Machine learning Myocardial perfusion imaging Stress test

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flowback and early-time production modeling of unconventional gas wells using an improved semi-analytical method

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Petroleum Science 2023年第6期20卷 3441-3449页

作者： Miao Zhang Kien Nguyen Zhi-Qiang Wang luis f.Ayala College of Petroleum Engineering China University of PetroleumBeijing102249China University of Tulsa USA The Pennsylvania State University USA

Multiple fractured horizontal wells (MfHWs) currently are the only possible means of commercial production from the low and ultra-low permeability unconventional gas reservoirs. In early production time, flowback fluid, which constitutes of hydraulic water and gas flow within fractures, is collected and analyzed. flowback analysis has been shown to be a useful tool to estimate key properties of the hydraulic fracture such as conductivity and pore volume. Until date, most tools of flowback analysis rely on empirical and approximate methods. This study presents an improved Green-function-based semi-analytical solution for performance analysis of horizontal gas wells during flowback and early production periods. The proposed solution is derived based on coupling the solutions of two domains: a rigorously derived Green’s function-based integral solution for single-phase gas flow in matrix, and a finite-difference, multiphase solution for gas–water two-phase flow in the fracture. The validity of proposed semi-analytical solution is verified by finely gridded numerical models built in a commercial simulator for a series of synthetic cases considering a variety of fluid and reservoir property combinations, as well as various different production constraints. Comparisons against available empirical and approximate methods are also provided for these cases.

关键词： Hydraulic fractures flowback Unconventional gas wells

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Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: mathematical and modelling aspects of porous media

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frontiers of Chemical Science and Engineering 2021年第2期15卷 399-409,F0004页

作者： fernando f.Rivera Berenice Miranda-Alcantara German Orozco Carlos Ponce de Leon luis f.Arenas National Council of Science and Technology(CONACYT) Mexico City 03940Mexico Center of Research and Technological Development in Electrochemistry(CIDETEQ) Queretaro 76703Mexico Electrochemical Engineering Laboratory Energy Technology Research GroupFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries(RfBs)and other electrochemical *** order to determine their predictive capability,turbulent Reynolds-averaged Navier-Stokes(RANS)and free flow plus porous media(Brinkman)models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RfB for laboratory *** different platinized titanium electrodes were considered,a plate plus a turbulence promoter and an expanded metal *** pressure drop was validated against experimental data obtained with typical cerium *** was found that the pressure drop values were better described by the RANS approach,whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

关键词： CfD simulation porous media porous electrode pressure drop redox flow battery

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Introduction to the special issue on “COVID-19”

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Geoscience frontiers 2022年第6期13卷 208-209页

作者： luis f.O.Silva Weijun Li Teresa Moreno Department of Civil and Environmental Universidad de la CostaCUC Department of Atmospheric Sciences School of Earth SciencesZhejiang University Institute for Environmental Assessment and Water Research Consejo Superior de Investigaciones Científicas

COVID-19 pandemic is wreaking havoc and bringing the whole world into a standstill in an unprecedented fashion. Joint efforts from multiple sectors to address the various aspects of environment and public health through usage of green technologies have become essential. The application of cleaner and effective technologies can be expanded to management and control, pollution mitigation and valorization of waste. In this Special Issue of Geoscience frontiers, we present contributions addressing the interactions of COVID-19 in relation to environment and human health.

关键词： bringing expanded COV

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Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia

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World Journal of Gastroenterology 2016年第18期22卷 4567-4575页

作者： Roberto Herrera-Goepfert luis f Onate-Ocana José luis Mosqueda-Vargas luis A Herrera Clementina Castro Julia Mendoza Rodrigo González-Barrios Department of Pathology Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Clinical Research Division Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Unidad de Investigacion Biomedica en Cancer Instituto Nacional de Cancerologia (INCan)-Instituto de Investigaciones Biomedicas (IIB) Universidad Nacional Autonoma de Mexico (UNAM) 14080 Mexico DF Mexico

AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar ***: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by ***: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection.

关键词： DNA methylation Esophageal columnar metaplasia Thrombospondin-1 Death-associated protein kinase Helicobacter pylori cagA

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Comparative carbon emission assessments of recycled and natural aggregate concrete: Environmental influence of cement content

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Geoscience frontiers 2021年第6期12卷 66-75页

作者： Marian Sabǎu Dan V.Bompa luis f.O.Silva Department of Civil and Environmental Engineering Universidad de la Costa080020 BarranquillaColombia Department of Civil and Environmental Engineering University of SurreyGuildford GU27XHUK Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru

This work examines the environmental and geochemical impact of recycled aggregate concrete production with properties representative for structural *** environmental influence of cement content,aggregate production,transportation,and waste landfilling is analysed by undertaking a life cycle assessment and considering a life cycle inventory largely specific for the *** obtain a detailed insight into the optimum life cycle parameters,a sensitivity study is carried out in which supplementary cementitious materials,different values of natural-to-recycled aggregate content ratio and case-specific transportation distances were *** results show that carbon emissions were between 323 and 332 kgCO_(2)e per cubic metre of cement only natural aggregate *** values can be reduced by up to 17%by replacing 25%of the cement with fly *** contrast,carbon emissions can increase when natural coarse aggregates are replaced by recycled aggregates in proportions of 50%and 100%,and transportation is not included in ***,the concrete with 50%recycled aggregate presented lower increase,only 0.3%and 3.4%for normal and high strength concrete,*** some cases,the relative contribution of transportation to the total carbon emissions increased when cement was replaced by fly ash in proportions of 25%,and case-specific transportation distances were *** absolute values,the concrete mixes with 100%recycled aggregates and 25%fly ash had lower carbon emissions than concrete with cement and natural aggregates *** environmental benefits can be obtained when the transportation distances of fly ash are relatively short(15–25 km)and the cement replacement by fly ash is equal or higher than 25%,considering that the mechanical properties are adequate for practical *** observations from this paper show that recycled aggregate concrete with strength characteristics representative for structural members can have lowe

关键词： Life cycle assessment Recycled aggregate Natural aggregate Transportation distance OpenLCA

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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-fong Departamento de fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Environmental geochemistry:Introduction

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Geoscience frontiers 2022年第1期13卷 374-375页

作者： luis f.O.Silva Marcos L.S.Oliveira Department of Civil and Environmental.Universidad de la Costa CUCCalle 58#55-66BarranquillaAtlánticoColombia Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru

Assessing the physical,geographic,chemical,and geological aspects are important to understand environmental impacts as well as health concerns in view of building a more sustainable planet with circular economies that would last for the foreseeable *** the recent years,the significance of incorporating ecosystem,anthropogenic activities,and climate has fortified from being an academic concern(e.g.,WEf,2011)into a broadly societal concern as the forecasted realities of environmental deterioration and global climate change come to pass.

关键词： geochemistry climate planet

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