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Climate change and infectious disease: a review of evidence and research trends

Infectious Diseases of Poverty 2023年第3期12卷 89-89页

作者： Paige Van de Vuurst luis e.escobar Virginia Tech Graduate School Translational BiologyMedicineand Health ProgramBlacksburgVAUSA Department of Fish and Wildlife Conservation Virginia TechBlacksburgVAUSA Center for emerging Zoonotic and Arthropod-Borne Pathogens Virginia TechBlacksburgVAUSA Global Change Center Virginia TechBlacksburgVAUSA Facultad de Ciencias Agropecuarias Universidad de La SalleBogotáColombia

Background Climate change presents an imminent threat to almost all biological systems across the *** recent years there have been a series of studies showing how changes in climate can impact infectious disease *** of these publications focus on simulations based on in silico data,shadowing empirical research based on feld and laboratory data.A synthesis work of empirical climate change and infectious disease research is still *** We conducted a systemic review of research from 2015 to 2020 period on climate change and infectious diseases to identify major trends and current gaps of *** was sourced from Web of Science and PubMed literary repositories using a key word search,and was reviewed using a delineated inclusion criteria by a team of *** Our review revealed that both taxonomic and geographic biases are present in climate and infectious disease research,specifcally with regard to types of disease transmission and localities *** investigations on vector-borne diseases associated with mosquitoes comprised the majority of research on the climate change and infectious disease ***,demographic trends in the institutions and individuals published revealed research bias towards research conducted across temperate,high-income *** also identifed key trends in funding sources for most resent literature and a discrepancy in the gender identities of publishing authors which may refect current systemic inequities in the scientifc *** Future research lines on climate change and infectious diseases should considered diseases of direct transmission(non-vector-borne)and more research efort in the *** of local research in low-and middle-income countries was generally *** on climate change and infectious disease has failed to be socially inclusive,geographically balanced,and broad in terms of the disease systems studied,limiting our cap

关键词： Climate change Infectious disease Research trend Systematic review

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Reconstructing landscapes of ungulate parturition and predation using vegetation phenology

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Current Zoology 2022年第3期68卷 275-283页

作者： Paige VAN De VUURST Seth A.MOORe edmund J.ISAAC Yvette CHeNAUX-IBRAHIM Tiffany M.WOLF luis e.escobar Department of Fish and Wildlife Conservation Virginia TechBlacksburgVA 24061USA Department of Biology and environment Grand Portage Band of Lake Superior ChippewaGrand PortageMN 55605USA Veterinary Population Medicine University of MinnesotaSt PaulMN 55108USA

enhanced vegetation index(eVI)data can be used to identify and define the space in which ungulates practice parturition and encounter *** study explores the use of eVI data to identify landscapes linked to ungulate parturition and predation events across space,time,and environmental *** a case study,we used the moose population(Alces alces)of northern Minnesota in the *** remotely sensed eVI data rasters and global positioning system collar data,we quantified how vegetation phenology and moose movement shaped the births and predation of 52 moose calves from 2013 to 2020 on or adjacent to the Grand Portage Indian *** known sources of predation were American black bears(Ursus americanus,n=22)and gray wolves(Canis lupus,n=28).Satellite-derived data summarizing seasonal landscape features at the local level revealed that landscape heterogeneity use by moose can help to quantitatively identify landscapes of parturition and predation in space and time across large *** phenology proved to be differentiable between adult moose ranges,sites of cow parturition,and sites of calf *** characteristics of each moose group were consistent and tractable based on environment,suggesting that sites of parturition and predation of moose are predictable in space and *** is possible that moose selected specific landscapes for parturition despite risk of increased predation of their calves,which could be an example of an"ecological trap."This analytical framework can be employed to identify areas for future ungulate research on the impacts of landscape on parturition and predation dynamics.

关键词： bear eVI moose parturition predation prey vegetation phenology

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Revealing the complexity of vampire bat rabies "spillover transmission"

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Infectious Diseases of Poverty 2023年第1期12卷 102-110页

作者： luis e.escobar Andres Velasco-Villa Panayampalli S.Satheshkumar Yoshinori Nakazawa Paige Van de Vuurst Department of Fish and Wildlife Conservation Virginia TechBlacksburgVAUSA Virginia Tech Graduate School Translational BiologyMedicineand Health ProgramBlacksburgVAUSA Global Change Center Virginia TechBlacksburgVAUSA Center for emerging Zoonotic and Arthropod‑Borne Pathogens Virginia TechBlacksburgVAUSA Facultad de Ciencias Agropecuarias Universidad de La SalleBogotáColombia Poxvirus and Rabies Branch Centers for Disease Control and Prevention1600 Clifton Rd.NEAtlantaGA 30333USA

Background The term virus'spillover’embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new,naïve yet susceptible and permissive host *** transmission can result in a virus becoming pathogenic,causing disease and death to the new host if successful infection and transmission takes *** text The scientific literature across diverse disciplines has used the terms virus spillover,spillover transmission,cross-species transmission,and host shift almost indistinctly to imply the complex process of establishment of a virus from an original host(source/donor)to a naïve host(recipient),which have close or distant taxonomic or evolutionary *** transmission may result in unsuccessful onward transmission,if the virus dies off before ***,successful viral establishment in the new host can occur if subsequent secondary transmission among individuals of the same novel species and among other sympatric susceptible species *** such,virus spillover transmission is a common yet highly complex phenomenon that encompasses multiple subtle stages that can be deconstructed to be studied separately to better understand the drivers of disease *** virus(RABV)is a well-documented viral pathogen which still inflicts heavy impact on humans,companion animals,wildlife,and livestock throughout Latin America due substantial spatial temporal and ecological—natural and expansional—overlap with several virus reservoir ***,the rabies disease system represents a robust avenue through which the drivers and uncertainties surrounding spillover transmission can be unravel at its different subtle stages to better understand how they may be affected by coarse,medium,and fine scale *** The continued study of viral spillover transmission necessitates the elucidation of its complexities to better assess the cross-scale impacts of ecological force

关键词： Bat-borne diseases Rabies Spillover Transmission

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Transmission risk of Oropouche fever across the Americas

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Infectious Diseases of Poverty 2023年第3期12卷 90-90页

作者： Daniel Romero-Alvarez luis e.escobar Albert J.Auguste Sara Y.Del Valle Carrie A.Manore Biodiversity Institute and Department of ecology&evolutionary Biology Uni-versity of KansasLawrenceKS 66044USA Information Systems and Mod-eling(A-1) Los Alamos National LaboratoryLos AlamosNMUSA OneHealth Research Group Facultad de MedicinaUniversidad de las AméricasQuitoEcuador Department of Fish and Wildlife Conservation Virginia TechBlacks-burgVA 24061USA Center for emerging Zoonoticand Arthropod-Borne PathogensVirginia TechBlacksburgVA 24061USA Department of ento-mology Fralin Life Science InstituteCollege of Agriculture and Life SciencesVirginia TechBlacksburgVA 24061USA Theoretical Biology and Biophysics(T-6) Los Alamos National LaboratoryLos AlamosNMUSA

Background Vector-borne diseases(VBDs)are important contributors to the global burden of infectious diseases due to their epidemic potential,which can result in signifcant population and economic *** fever,caused by Oropouche virus(OROV),is an understudied zoonotic VBD febrile illness reported in Central and South *** epidemic potential and areas of likely OROV spread remain unexplored,limiting capacities to improve epidemiological *** To better understand the capacity for spread of OROV,we developed spatial epidemiology models using human outbreaks as OROV transmission-locality data,coupled with high-resolution satellite-derived vegetation phe‑*** were integrated using hypervolume modeling to infer likely areas of OROV transmission and emergence across the *** Models based on one-support vector machine hypervolumes consistently predicted risk areas for OROV transmission across the tropics of Latin America despite the inclusion of diferent parameters such as diferent study areas and environmental *** estimate that up to 5 million people are at risk of exposure to ***,the limited epidemiological data available generates uncertainty in *** example,some out‑breaks have occurred under climatic conditions outside those where most transmission events *** distribu‑tion models also revealed that landscape variation,expressed as vegetation loss,is linked to OROV *** Hotspots of OROV transmission risk were detected along the tropics of South *** loss might be a driver of Oropouche fever *** based on hypervolumes in spatial epidemiology might be considered an exploratory tool for analyzing data-limited emerging infectious diseases for which little understand‑ing exists on their sylvatic *** transmission risk maps can be used to improve surveillance,investigate OROV ecology and epidemiology,and inform early detection.

关键词： Oropouche virus Oropouche fever Spatial modeling Hypervolumes Distribution modeling Risk mapping One-class support vector machines Convex-hulls

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Neglected tropical diseases risk correlates with poverty and early ecosystem destruction

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Infectious Diseases of Poverty 2023年第2期12卷 129-129页

作者： Arthur Ramalho Magalhães Cláudia Torres Codeço Jens-Christian Svenning luis e.escobar Paige Van de Vuurst Thiago Gonçalves-Souza Laboratory of ecological Synthesis and Biodiversity Conservation (eCOFUN) Federal Rural University of Pernambuco Recife Brazil Scientific Computation Program (PROCC) Oswaldo Cruz Foundation (Fiocruz) Rio de Janeiro Brazil Center for ecological Dynamics in a Novel Biosphere (eCONOVO) & Center for Biodiversity Dynamics in a Changing World (BIOCHANGe) Department of Biology. Aarhus University Aarhus Denmark Department of Fish and Wildlife Conservation Virginia Tech Blacksburg USA Center for emerging Zoonotic and Arthropod-Borne Pathogens Virginia Tech Blacksburg USA Translational Biology Medicine and Health Program Virginia Tech Graduate School Blacksburg USA

Background Neglected tropical diseases affect the most vulnerable populations and cause chronic and debilitating *** vulnerability is a well-known and important determinant of neglected tropical *** example,poverty and sanitation could influence parasite ***,the quantitative impact of socioeconomic conditions on disease transmission risk remains poorly *** This study investigated the role of socioeconomic variables in the predictive capacity of risk models of neglected tropical zoonoses using a decade of epidemiological data(2007–2018)from ***-borne diseases investigated in this study included dengue,malaria,Chagas disease,leishmaniasis,and Brazilian spotted fever,while directly-transmitted zoonotic diseases included schistosomiasis,leptospirosis,and *** and socioeconomic predictors were combined with infectious disease data to build environmental and socioenvironmental sets of ecological niche models and their performances were *** Socioeconomic variables were found to be as important as environmental variables in influencing the estimated likelihood of disease transmission across large spatial *** combination of socioeconomic and environmental variables improved overall model accuracy(or predictive power)by 10%on average(Peaching a maximum of 18%in the case of dengue *** domestic product was the most important socioeconomic variable(37%relative variable importance,all individual models exhibited Pecreasing relationship with disease indicating poverty as a major factor for disease *** of natural vegetation cover between 2008 and 2018 was the most important environmental variable(42%relative variable importance,Penvironmental models,exhibiting a decreasing relationship with disease probability,showing that these diseases are especially prevalent in areas where natural ecosystem destruction is

关键词： Disease ecology ecological niche model Socioecological system Vector-borne diseases Zoonosis Brazil

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Ca-based materials derived from calcined cigarette butts for CO_(2)capture and thermochemical energy storage

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Journal of environmental Sciences 2024年第6期140卷 230-241页

作者： Nabil Amghar Virginia Moreno Pedro e.Sánchez-Jiménez Antonio Perejón luis A.Pérez-Maqueda Instituto de Ciencia de Materiales de Sevilla C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain Instituto de Tecnología de Materiales(ITM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain Departamento de Química Inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

Cigarette butts(CBs)are one of the most common types of litter in the *** to the toxic substances they contain,the waste generated poses a harmful risk to the environment,and therefore there is an urgent need for alternative solutions to landfill ***,this work presents a possible revalorization of this waste material,which implies interesting environmental *** were used as sacrificial templates for the preparation of CaO-based materials by impregnation with calcium and magnesium nitrates followed by flaming *** materials presented enhanced porosity for their use in the Calcium Looping process applied either to thermochemical energy storage or CO_(2)capture *** influence of the concentration of Ca and Mg in the impregnating solutions on the multicycle reactivity of the samples was *** improved multicycle performance was obtained in terms of conversion for both applications.

关键词： Cigarette butts Calcium-Looping CO_(2)Capture Thermochemical energy storage

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Sex-specific life-history trait expression in hybrids of a cave- and surface-dwelling fish (Poecilia mexicana, Poecilidae)

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Current Zoology 2024年第4期70卷 421-429页

作者： Rüdiger Riesch luis R.Arriaga Ingo Schlupp Department of Biological Sciences Royal Holloway University of LondonEghamTW20 OEXUK CeFe CNRSUnivMontpellierEPHEIRDMontpellierFrance Department of Biology University of OklahomaNormanOK 73019USA

evaluating the fitness of hybrids can provide important insights into genetic differences between species or diverging *** focused on surface-and cave-ecotypes of the widespread Atlantic molly Poecilia mexicana and raised F1 hybrids of reciprocal crosses to sexual maturity in a common-garden *** were reared in a fully factorial 2 x 2 design consisting of lighting(light ***)and resource availability(high *** food).We quantified survival,ability to realize their full reproductive potential(i.e.,completed maturation for males and 3 consecutive births for females)and essential life-history *** to the performance of pure cave and surface fish from a previous experiment,F1s had the highest death rate and the lowest proportion of fish that reached their full reproductive *** also uncovered an intriguing pattern of sex-specific phenotype expression,because male hybrids expressed cave molly life histories,while female hybrids expressed surface molly life *** results provide evidence for strong selection against hybrids in the cave molly system,but also sug-gest a complex pattern of sex-specific(opposing)dominance,with certain surface molly genes being dominant in female hybrids and certain cavemollygenes beingdominant in malehybrids.

关键词： dominance life-history evolution local adaptation postzygotic isolation selection against hybrids.

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A cleaner production strategy for acid mine drainage prevention of waste rock:A porphyry copper case

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International Journal of Mining Science and Technology 2024年第8期34卷 1163-1177页

作者： Yesica L.Botero Isabelle Demers luis A.Cisternas ArnoldoÁvila Mostafa Benzaazoua Departamento de Ingeniería Química y Procesos de Minerales Universidad de AntofagastaAntofagasta1240000Chile Research Institute on Mines and environment Universitédu Québec en Abitibi-TémiscamingueRouyn-NorandaQC J9X5E4Canada eriez Flotation Group Chile S.A. Santiago1240000Chile Geology and Sustainable Mining Institute University Mohammed Ⅵ PolytechnicLot 660 Hay Moulay RachidBen Guerir 43150Morocco

An in-process technology approach is proposed to identify the source of acid mine drainage(AMD)generation and prevent its formation in a porphyry copper waste rock(WR).Adopting actions before stockpiling the WR enables the establishment of potential contaminants and predicts the more convenient method for AMD prevention.A WR sample was separated into size fractions,and the WR’s net acidgenerating potential was quantified using chemical and mineralogical *** diameter of physical locking of sulfides(DPLS)was determined,and the fractions below the DPLS were desulfurized using ***,the WR fractions and tailing from the flotation test were submitted to acid-base accounting and weathering tests to evaluate their acid-generating *** show that the WR’s main sulfide mineral is pyrite,and the DPLS was defined as 850μm.A sulfide recovery of 91%was achieved using a combination of HydroFloat^(®)and Denver cells for a size fraction lower than *** grinding was *** results show that size fractions greater than DPLS and the desulfurized WR are unlikely to produce *** outcomes show that in-processing technology can be a more proactive approach and an effective tool for avoiding AMD in a porphyry copper WR.

关键词： Waste rock Porphyry copper ore Desulfurization Acid mine drainage HydroFloat^(®) In-process technology Cleaner production

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Neurogenic potential of NG2 in neurotrauma:a systematic review

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Neural Regeneration Research 2024年第12期19卷 2673-2683页

作者： Yuri R.Rigo Radharani Benvenutti luis V.Portela Nathan R.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MeDLINe,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

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Towards an integrated risk analysis security framework according to a systematic analysis of existing proposals

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Frontiers of Computer Science 2024年第3期18卷 199-216页

作者： Antonio SANTOS-OLMO luis enrique SÁNCHeZ David G.ROSADO Manuel A.SeRRANO Carlos BLANCO Haralambos MOURATIDIS eduardo FeRNÁNDeZ-MeDINA GSyA Research Group University of Castilla-La ManchaCiudad Real 13071Spain Institute for Analytics and Data Science University of EssexColchester CO43SQUK Alarcos Research Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Research group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The information society depends increasingly on risk assessment and management systems as means to adequately protect its key information *** availability of these systems is now vital for the protection and evolution of ***,several factors have led to an increasing need for more accurate risk analysis *** are:the speed at which technologies evolve,their global impact and the growing requirement for companies to *** analysis processes must consequently adapt to these new circumstances and new technological *** objective of this paper is,therefore,to present the results of an exhaustive analysis of the techniques and methods offered by the scientific community with the aim of identifying their main weaknesses and providing a new risk assessment and management *** analysis was carried out using the systematic review protocol and found that these proposals do not fully meet these new *** paper also presents a summary of MARISMA,the risk analysis and management framework designed by our research *** basis of our framework is the main existing risk standards and proposals,and it seeks to address the weaknesses found in these *** is in a process of continuous improvement,as is being applied by customers in several european and American *** consists of a risk data management module,a methodology for its systematic application and a tool that automates the process.

关键词： information security management security system security risk assessment and management

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