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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella Martini Corrado Magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè luigi fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodule<3,and 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

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Primary hepatic carcinoid:A case report and literature review

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World Journal of Gastroenterology 2009年第19期15卷 2418-2422页

作者： luigi Maria fenoglio Sara Severini Domenico Ferrigno Giovanni Gollè Cristina Serraino Christian Bracco Elisabetta Castagna Chiara Brignone Fulvio Pomero Elena Migliore Ezio David Mauro Salizzoni Department of Internal Medicine Santa Croce and Carle Hospital12100 CuneoItaly Department of Pathology San Giovanni Battista Hospital10126 TurinItaly Liver Transplantation Center San Giovanni Battista Hospital10126 TurinItaly

Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide *** 54.5% arise in the gastrointestinal tract and frequently metastasize to the *** hepatic carcinoid tumors(PHCT) are extremely rare;only 95 cases have been reported.A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical *** previous medical history,since 2003,included an echotomography of the dishomogeneous parenchymal area but no focal lesions.A computed tomography scan performed in 2005 showed an enhanced pseudonodular-like lesion of about 2 ***-magnetic resonance imaging identified the lesion as a possible *** positive findings were obtained with positron emission *** suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine *** was positive for anti chromogranin antibodies,Ki67 antibodies and *** scintigraphy indicated intense activity in the *** investigations were performed to exclude the presence of extrahepatic *** of PHCT was *** patient underwent left hepatectomy,followed by hormone therapy with sandostatine *** months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe,which was histologically *** postoperative clinical course was uneventful,with a negative follow-up for hematochemical,clinical and radiological investigations at 18 mo *** of PHCT is based principally on the histopathological confi rmation of a carcinoid tumor and the exclusion of a non-hepatic primary *** resection is the recommended primary treatment for *** rate and survival rate in patients treated with resection were 18% and 74%,respectively.

关键词：原发性肝类癌文献复习病例报告神经内分泌肿瘤细胞 PHCT 电脑断层扫描免疫组织化学临床表现

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Epidemiology, clinical-treatment patterns and outcome in 256 hepatocellular carcinoma cases

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World Journal of Gastroenterology 2013年第21期19卷 3207-3216页

作者： luigi fenoglio Cristina Serraino Elisabetta Castagna Adele Cardellicchio Fulvio Pomero Maurizio Grosso Carlo Senore Department of Internal Medicine Santa Croce Hospital12100 CuneoPiedmontItaly Department of Diagnostic Radiology Santa Croce Hospital12100 CuneoPiedmontItaly AO Città della Salute e della Scienza CPO Piemonte10123 TurinPiedmontItaly

AIM: To analyze the epidemiology, clinical characteristics, treatment patterns and outcome in hepatocellular carcinoma (HCC) patients. METHODS: We analyzed clinical, pathological and therapeutic data from 256 consecutive patients, examined at S. Croce Hospital in Cuneo-Piedmont, with a diagnosis of HCC between 30th June 2000 and 1st July 2010. We analyzed the hospital imaging database and examined all medical records, including the diagnosis code for HCC (155.0 according to the ICD-9M classification system), both for inpatients and outpatients, and discovered 576 relevant clinical records. After the exclusion of reports relating to multiple admissions for the same patient, we identified 282 HCC patients. Moreover, from this HCC series, we excluded 26 patients: 1 patient because of an alternative final diagnosis, 8 patients because of a lack of complete clinical data in the medical record and 17 patients because they were admitted to different health care facilities, leaving 256 HCC patients. To highlight possible changes in HCC patterns over the ten-year period, we split the population into two five-year groups, according to the diagnosis period: 30 th June 2000-30th June 2005 and 1st July 2005-1st July 2010. Patients underwent a 6-mo follow up. RESULTS: Two hundred and fifty-six HCC patients were included (male/female 182/74; mean age 70 years), 133 in the first period and 123 in the second. Hepatitis C virus (HCV) infection was the most common HCC risk factor (54.1% in the first period, 50.4% in the second;P = 0.63); in the first period, 21.8% of patients were alcoholics and 15.5% were alcoholics in the second period (P > 0.05); the non-viral/non-alcoholic etiology rate was 3.7% in the first period and 20.3% in the second period (P < 0.001). Child class A patients increased significantly in the second period (P < 0.001). Adjusting for age, gender and etiology, there was a significant increase in HCC surveillance during the second period (P = 0.01). Differences bet

关键词： Hepatocellular carcinoma Epidemiology Clinical characteristics Surveillance Survival

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Common bile duct schwannoma:A case report and review of literature

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World Journal of Gastroenterology 2007年第8期13卷 1275-1278页

作者： luigi fenoglio Sara Severini Paola Cena Elena Migliore Christian Bracco Fulvio Pomero Sergio Panzone Giovan Battista Cavallero Alberto Silvestri Rodolfo Brizio Felice Borghi Department of Internal Medicine Santa Croce and Carle Hospital Cuneo Italy Department of Pathology Santa Croce and Carle Hospital Cuneo Italy Department of General Surgery Santa Croce and Carle Hospital Cuneo Italy

Schwannoma is a myelin sheath tumor complicated with neurofibroma, neurofibromatosis and neurogenic sarcoma. Peripheral nerve sheath tumors represent 2%-6% of gastrointestinal tract stromal tumors (GIST), but there are deficient data about location of neurogenic tumors in the biliary system and only nine cases of schwannoma of the extrahepatic biliary tract have been reported. These tumors are clinically non-specific. They are usually symptomatic by compressing the close or adjacent structures when being retroperitoneal, and their preoperative diagnosis is extremely difficult. This paper reviews the literature data and describes a case of schwannoma of the common bile duct associated with cholestasis in a healthy young woman, diagnosed and treated in our department. This case is of interest on account of the complexity of its diagnosis and the atypical macroscopic growth pattern of the tumor.

关键词：胆总管胆管神经鞘瘤病例报告文献综述

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