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Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H_(3)K79 modifications

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Chinese Chemical Letters 2024年第10期35卷 321-324页

作者： Kun zou Yihang Xiao jinyu Yang Mingxuan Wu Department of Chemistry Zhejiang UniversityHangzhou 310027China Department of Chemistry School of ScienceWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Histone H3K79 modifications are essential to regulate chromatin structure and gene transcription,but understanding of the molecular mechanisms is *** H3K79 is at globular domain,short histone peptide cannot mimic H3K79 in ***,reconstituted nucleosome-based chemical tools are ideally used to investigate H3K79 *** consequence,H3K79-modified histone H3 with additional chemical handles are required,but such synthesis is challenging and *** we report a facile semisynthesis method that enables multifunctional histone H3 readily available.H3K79-containing fragment is short for straight peptide synthesis that was later ligated to recombinant expressed H3 fragments for full-length product in large *** a result,nucleosomes with H3K79 modifications as well as photo-reactive group and affinity tag were obtained to investigate potential binding *** believe this method that enhances synthetic accessibility of nucleosome probes will accelerate understanding of the underexplored H3K79 modifications.

关键词： Histone H3K79 modifications Methylation Succinylation Semisynthesis Nucleosome probes

Recent advances in the biosynthesis of coumarin and its derivatives

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Green Chemical Engineering 2024年第2期5卷 150-154页

作者： Yusong zou Yuxi Teng Joy Li Yajun Yan School of Chemical Materials and Biomedical EngineeringCollege of EngineeringThe University of GeorgiaAthensGA30602USA North Oconee High School BogartGA30622USA

Coumarin and its derivatives,presenting in many organisms(plants,fungi,and bacteria),are critical metabolites composed of fused benzene andα-pyrone *** unique biological and chemical properties,coumarin derivatives possess great technological potential in the agrochemicals,pharmaceuticals,food,and cosmetic *** increasing demand for coumarin derivatives accelerates the research in biological and chemical synthesis to provide stable and scalable sources of ***,the complex structures and unknown pathways have limited the progress in the biosynthesis of coumarin ***,we summarize recent developments and provide a detailed analysis of coumarin derivative biosynthetic pathways in different organisms.

关键词： Coumarin derivatives Biosynthetic pathways Biotransformation Metabolic engineering

Lattice water fuels acidic water oxidation

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Science China Chemistry 2024年第7期67卷 2132-2133页

作者： Minyue Zhao Jianyong Feng Zhaosheng Li Zhigang zou Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093China Jiangsu Key Laboratory for Nano Technology Nanjing UniversityNanjing 210093China

In comparison to commercial alkaline water electrolysis technologies,proton-exchange membrane water electrolyzers(PEMWEs)offer intriguing advantages for hydrogen production,such as high current density,compact system ... 详细信息

关键词： Lattice alkaline system

Fabrication of surface passivated two-dimensional MFI zeolite for alkylation between toluene with methanol

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 115-124页

作者： Zhenyuan zou Shengzhi Gan Ting Pu Xingxing Zeng Yi Huang Baoyu Liu School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China School of Engineering Institute for Materials&Processesthe University of EdinburghEdinburgh EH93FBUnited Kingdom

The fabrication of suitable MFI zeolites to effectively produce para-xylene through the alkylation between toluene and methanol is highly ***,the two-dimensional pillared MFI zeolite was modified by silicalite-1,and its morphology and structure were systematically investigated by tuning the concentration of Si species during the secondary crystallization *** MFI zeolites were characterized by X-ray diffraction,transmission electron microscopy,pyridine-infrared and N_(2) adsorption-desorption *** characterization results showed that the external Brønsted acid sites of surface passivated P-MFI-x samples have been successfully ***,the P-MFI-23 showed long lifetime and high selectivity of para-xylene(about 35%)based on the cooperation between opened interlamellar structure and passivated silicalite-1 *** was found that the accumulated hard coke in the interior of MFI zeolites not only blocked the channels of zeolites but also covered the acidic sites,resulting in the deactivation of ***,the highest selectivity of para-xylene(about 48%)can be achieved for P-MFI-30 under harsh reaction condition,which also exhibited excellent regeneration property in the alkylation reaction between toluene and *** strategy described in present research may open a window for the design of other advanced materials.

关键词： alkylation MFI nanosheets catalysis

Extensive Resetting of Feldspar Pb Isotopic Composition in Archean–Paleoproterozoic Granitic Rocks from the Kongling Terrane,South China:Implications for Tracing Thermal Evolutionary History

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 386-398页

作者： MENG Fanxue LU Jie zou Zongqi GUO Jingliang MENG Yuanku College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China

Feldspar Pb isotopes have been widely used to trace magmatic formation and evolution ***,it remains unclear whether post-magmatic thermal events can affect feldspar Pb isotopic ***,the in situ Pb isotopic composition of feldspar hosted in granitic rocks(thirteen Archean and one Paleoproterozoic)from the northern Kongling terrane,Yangtze Craton,South China,is *** samples reveal a substantial variation in their Pb isotopic composition,spanning the gap between the 1.9 Ga and present-day geochrons,which indicates extensive resetting by later tectonothermal *** resetting was interpreted to have likely resulted from Paleoproterozoic and Neoproterozoic tectonothermal events related to the assembly and breakup of the Columbia and Rodinia *** results suggest that Pb isotopes should be used cautiously when tracing magma sources and petrogenesis in magmatic rocks that have experienced post-magmatic ***,the in situ Pb isotopic composition of feldspar in ancient granitoids may also potentially be used to reveal later tectonothermal *** extensive resetting of the Pb isotopic composition in feldspar by regional thermal events may also provide new insights into our understanding of the Pb isotope paradox.

关键词： in situ Pb isotope Pb isotope resetting thermal event Archean-Paleoproterozoic Kongling terrane

Origin of the Yueguang gold deposit in Xinhua, Hunan Province, South China: insights from fl uid inclusion and hydrogen–oxygen stable isotope analysis

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Acta Geochimica 2024年第2期43卷 235-254页

作者： Hongxin Fan Qiang Wang Yulong Yang Yao Tang Hao zou College of Earth Sciences Chengdu University of TechnologyChengdu 610059China College of Earth Sciences Jilin UniversityJilin 130061China

The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South *** represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,west of the Baimashan granitic *** order to discern the characteristics of the ore-formingﬂuids,the underlying mineralization processes,and establish a foundation for the origin of the Yueguang gold depositﬂuid inclusion micro-thermometry,as well as quartz hydrogen and oxygen isotope analysis,have been carried out on samples obtained from various stages of *** hydrothermal miner-alization stages within the Yueguang gold deposit can be categorized into three stages:(i)the barren,pre-ore quartz-pyrite stage(Stage Ⅰ),the quartz-pyrite-gold stage(Stage Ⅱ),and the post-ore quartz-carbonate stage(Stage Ⅲ),with the second stage being the main mineralization ***ﬂuid inclusions identiﬁed in samples from the main min-eralization stage can predominantly be described with the NaCl–H_(2)O and CO_(2)–NaCl–H_(2)O *** inclusions display homogenization temperatures ranging from 158.8 to 334.9℃,and theﬂuid salinity ranges from 0.3%to 4.0%(wt.%NaCl equiv.).Laser Raman spectroscopy analysis of individual inclusions further reveals the presence of gas-phases such as CO_(2),CH_(4),and N_(2).Isotopic analysis indicatesδ^(18)Oﬂuid values ranging from 3.95 to 6.7‰ and δDH_(2)O values ranging from-71.9 to-55.7‰.These results indi-cate that the ore-formingﬂuid of the Yueguang gold deposit belongs to metamorphic hydrothermalﬂuids of middle-low temperature and low *** the process of ore formation,gold is transported in the form of Au(HS)2-complexes,with gold deposition being driven byﬂuid ***,the Yueguang gold deposit is categorized as an orogenic gold deposit dominated by metamorphic hydrother-malﬂ*** may become a new target for gold exploration in the Baimashan region,central Hunan Province.

关键词： Hunan province Yueguang gold deposit Fluid inclusions Hydrogen–oxygen isotopes Laser Raman Fluid immiscibility Orogenic gold deposit

Advances in functional coatings on biliary stents

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Regenerative Biomaterials 2024年第2期3卷 55-75页

作者： Kaining Yang Wenxin Sun Lanyue Cui Yuhong zou Cuie Wen Rongchang Zeng Department of Bioengineering College of Chemical and Biological EngineeringShandong University of Science and TechnologyQingdao 266590China Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China school of Engineering RMIT UniversityMelbourneVIC3001Australia

Biliary stenting is an important interventional method for the prevention and treatment of biliary tract ***,complications,such as postoperative biliary infection and re-stenosis,frequently occur due to the extensive scope of the biliary system and the complex composition of *** com-bination of coating technology and biliary stents is expected to bring new approaches to the solution of these *** cutting-edge advance on functional coatings on biliary stents is reviewed from seven perspectives:anticorrosion,-bacterial,-tumor,stone-dissolving,X-ray visibility,anti-stent migration and functional composite *** de-velopment trend is also *** performance of the numerous functional coatings for various purposes is generally up to expectations,but the balance between the medica tions'effectiveness and their safety needs to be further *** contemporary investigations have advanced to the leve of animal experiments,offering crucial fundamental assurance for broader human *** combination of biliary stent and functional coatings is an innovative idea with great potential for future development.

关键词： biliary stent coating anticorrosion antibacterial antitumor stone-dissolving X-ray visibility antistent migration

Vesicular drug delivery systems for oral absorption enhancement

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Chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui zou Meng Cheng Kaili Hu Jianfang Feng Liangxing Tu Jiangxi University of Chinese Medicine Nanchang 330006China Guangxi University of Chinese Medicine Nanning 530200China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： Vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

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Genes & Diseases 2024年第3期11卷 248-263页

作者： Shuo Li Tiande zou Jun Chen Jiaming Li Jinming You Jiangxi Province Key Laboratory of Animal Nutrition Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Fibroblast growth factor 21(FGF21)was originally identified as an important meta-bolic regulator which plays a crucial physiological role in regulating a variety of metabolic pa-rameters through the metabolic *** a novel multifunctional endocrine growth factor,the role of FGF21 in the metabolic network warrants extensive *** insight was obtained from the observation that the FGF21-dependent mechanism that regulates lipid metabolism,glycogen transformation,and biological effectiveness occurs through the coordi-nated participation of the liver,adipose tissue,central nervous system,and sympathetic *** review focuses on the role of FGF21-uncoupling protein 1(UCP1)signaling in lipid metabolism and how FGF21 alleviates non-alcoholic fatty liver disease(NAFLD).Additionally,this review reveals the mechanism by which FGF21 governs glucolipid *** research on the role of FGF21 in the metabolic network has mostly focused on the crucial pathway of glucolipid ***21 has been shown to have multiple regulatory roles in the metabolic *** an adequate understanding of the concrete regulatory path-ways of FGF21 in the metabolic network has not been attained,this review sheds new light on the metabolic mechanisms of FGF21,explores how FGF21 engages different tissues and organs,and lays a theoretical foundation for future in-depth research on FGF21-targeted treatment of metabolic diseases.

关键词： Adipose FGF21 Insulin homeostasis Lipid metabolism Liver Metabolicnetwork