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ZIF-8 coated gold nanospheres: A multi-responsive drug delivery system promoting the killing effect of photothermal therapy against osteosarcoma cells

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Nano Research 2024年第3期17卷 1772-1784页

作者： Miao Lei Weiye Cai luetao zou Bin Yu Lin Chen Yang Cao Shanlin Xiang Chao Song Jiandu Lei Wei Jiang Zhenming Hu Department of Orthopedics Orthopedic Laboratory of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou 646699China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China Department of Orthopedics Chongqing University Three Gorges HospitalChongqing 404000China Department of Geriatrics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025China Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing 100083China

Photothermal therapy(PTT)has been widely used in the treatment of tumors,but its efficacy is greatly limited by the inability of precise drug delivery and the increase of heat shock proteins(HSPs)caused by high *** article describes a therapeutic strategy to enhance PTT with starvation therapy in conjunction with ferroptosis mechanism.A nanoparticle platform ZIF-8@GA was constructed by wrapping together glucose oxidase(GOX)and gold nanospheres(AuNPs)loaded with dihydroartemisinin(DHA)with zeolitic imidazolate framework-8(ZIF-8).This platform can take advantage of the micro-environment of osteosarcoma(OS)cells,featuring low pH and high reactive oxygen species(ROS),for precision drug *** can effectively catalyze glucose to produce gluconic acid and H_(2)O_(2),and DHA can also induce ROS production in OS *** produced by GOX and DHA can further generate lipid peroxidation(LPO)and lead to ferroptosis of OS *** the same time,ROS and LPO produced can inhibit the expression of HSPs,thereby increasing the therapeutic effect of *** vitro experiments show that the nanoparticles are pH and ROS responsive.1μg/mL GOX combined with 0.2μg/mL DHA promotes ferroptosis of OS cells,and increases the killing effect of near-infrared(NIR)on OS *** in vivo experiments showed that the nano drug-delivery platform combined with PTT can effectively inhibit the growth of OS ***,this study provides a new idea for the treatment of OS with biomaterials combined with various treatment methods.

关键词： zeolitic imidazolate framework-8(ZIF-8) gold nanospheres(AuNPs) photothermal therapy(PTT) starvation therapy ferroptosis

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Analyzing the Dissemination of News by Model Averaging and Subsampling

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Journal of Systems Science & Complexity 2024年第5期37卷 2104-2131页

作者： zou Jiahui School of Statistics Capital University of Economics and Business

The dissemination of news is a vital topic in management science, social science and data science. With the development of technology, the sample sizes and dimensions of digital news data increase remarkably. To alleviate the computational burden in big data, this paper proposes a method to deal with massive and moderate-dimensional data for linear regression models via combing model averaging and subsampling methodologies. The author first samples a subsample from the full data according to some special probabilities and split covariates into several groups to construct candidate models. Then, the author solves each candidate model and calculates the model-averaging weights to combine these estimators based on this subsample. Additionally, the asymptotic optimality in subsampling form is proved and the way to calculate optimal subsampling probabilities is *** author also illustrates the proposed method via simulations, which shows it takes less running time than that of the full data and generates more accurate estimations than uniform subsampling. Finally,the author applies the proposed method to analyze and predict the sharing number of news, and finds the topic, vocabulary and dissemination time are the determinants.

关键词： Asymptotic optimality dissemination of news linear regression models model averaging optimal subsampling

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Image Fusion Based on Bioinspired Rattlesnake Visual Mechanism Under Lighting Environments of Day and Night Two Levels

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Journal of Bionic Engineering 2024年第3期21卷 1496-1510页

作者： Yong Wang Hongmin zou College of Communication Engineering Jilin UniversityChangchun130012China

This study,grounded in Waxman fusion method,introduces an algorithm for the fusion of visible and infrared images,tailored to a two-level lighting environment,inspired by the mathematical model of the visual receptive field of rattlesnakes and the two-mode cells'*** research presented here is segmented into three *** the first segment,we design a preprocessing module to judge the ambient light intensity and divide the lighting environment into two levels:day and *** second segment proposes two distinct network structures designed specifically for these daytime and nighttime *** the daytime images,where visible light information is predominant,we feed the ON-VIS signal and the IR-enhanced visual signal into the central excitation and surrounding suppression regions of the ON-center receptive field in the B channel,***,for nighttime images where infrared information takes precedence,the ON-IR signal and the Visual-enhanced IR signal are separately input into the central excitation and surrounding suppression regions of the ON-center receptive field in the B *** outcome is a pseudo-color fused *** third segment employs five different no-reference image quality assessment methods to evaluate the quality of thirteen sets of pseudo-color images produced by fusing infrared and visible *** images are then compared with those obtained by six other methods cited in the relevant *** empirical results indicate that this study's outcomes surpass the comparative results in terms of average gradient and spatial *** one or two sets of fused images underperformed in terms of standard deviation and entropy when compared to the control *** sets of fused images did not perform as well as the comparison in the QAB/F *** conclusion,the fused images generated through the proposed method show superior performance in terms of scene detail,visual perception,and image sharpness

关键词： Rattlesnake Visible image Infrared image Daylight Bionic

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Conceptual transition from molecular to atomic: unleashing a new era in hydrogen therapy for chronic disease

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National Science Review 2024年第4期11卷 17-18页

作者： Zhigang zou Eco-materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures and Department of PhysicsNanjing University

The dysregulated overexpression of reactive oxygen and nitrogen species (RONS)intricately links to the occurrence and development of diverse chronic diseases[1–3]. Hydrogen therapy stands out as a promising treatment methodology recognized for effectively mitigating RONS and maintaining intracellular redox equilibrium, thereby yielding therapeutic benefits [4,5].

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Security-Reliability Tradeoff Analysis for Jamming Aided Decode-and-Forward Relay Networks

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China Communications 2024年第5期21卷 218-228页

作者： zou Ronggui zou Yulong Zhu Jia Li Bin School of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China

In this paper,we explore a cooperative decode-and-forward(DF)relay network comprised of a source,a relay,and a destination in the presence of an *** improve physical-layer security of the relay system,we propose a jamming aided decodeand-forward relay(JDFR)scheme combining the use of artificial noise and DF relaying which requires two stages to transmit a ***,in stage one,the source sends confidential message to the relay while the destination acts as a friendly jammer and transmits artificial noise to confound the *** stage two,the relay forwards its re-encoded message to the destination while the source emits artificial noise to confuse the *** addition,we analyze the security-reliability tradeoff(SRT)performance of the proposed JDFR scheme,where security and reliability are evaluated by deriving intercept probability(IP)and outage probability(OP),*** the purpose of comparison,SRT of the traditional decode-and-forward relay(TDFR)scheme is also *** results show that the SRT performance of the proposed JDFR scheme is better than that of the TDFR ***,it is shown that for the JDFR scheme,a better SRT performance can be obtained by the optimal power allocation(OPA)between the friendly jammer and user.

关键词： decode-and-forward relay friendly jammer physical layer security power allocation security-reliability tradeoff

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Design of Robust Var Reserve Contract for Enhancing Reactive Power Ancillary Service Market Efficiency

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 767-771页

作者： Yunyang zou Yan Xu School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In a deregulated Var market, market power issue is more serious than in an energy market since reactive power cannot be transmitted over long distances. This letter designs a multi-timescale Var market framework, where market power that may arise in the hourly-ahead Var support service market due to system configuration deficiency and market structure flaws can be eliminated by day-ahead contract-based Var reserve service market. Settlement of day-ahead Var reserve contract is formulated as a two-stage robust optimization (TSRO) model considering worst case of uncertainty realization and potential market power that may arise in hourly-ahead market. TSRO with integer recourses is then solved by a new column and constraint generation algorithm. Results show a robust Var reserve contract can fully eliminate market power, and prevent suppliers from manipulating market prices.

关键词： Market efficiency market power reactive power ancillary service two-stage robust optimization Var reserve

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A pseudoclassical theory for the wavepacket dynamics of the kicked rotor model

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 34-43页

作者： Zhixing zou Jiao Wang Department of Physics and Key Laboratory of Low Dimensional Condensed Matter Physics(Department of Education of Fujian Province) Xiamen UniversityXiamen 361005China Lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou 730000China

In this study, we propose a generalized pseudoclassical theory for the kicked rotor model in an attempt to discern the footprints of the classical dynamics in the deep quantum regime. Compared with the previous pseudoclassical theory that applies only in the neighborhoods of the lowest two quantum resonances, the proposed theory is applicable in the neighborhoods of all quantum resonances in principle by considering the quantum effect of the free rotation at a quantum resonance. In particular, it is confirmed by simulations that the quantum wavepacket dynamics can be successfully forecasted based on the generalized pseudoclassical dynamics, offering an intriguing example where it is feasible to bridge the dynamics in the deep quantum regime to the classical dynamics. The application of the generalized pseudoclassical theory to the PT-symmetric kicked rotor is also discussed.

关键词： quantum-classical correspondence kicked rotor model pseudoclassical theory wavepacket dynamics

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Dynamic Development Characteristics and Driving Factors of High Quality Development Level in China’s Five Major Urban Agglomerations

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Chinese Geographical Science 2024年第5期34卷 777-790页

作者： zou Weiyong XU Lingli School of Economics Guangdong Ocean UniversityZhanjiang 524088China School of Economics Shanghai UniversityShanghai 200444China

High-quality development is the primary task of comprehensively building a socialist,modern country,as well as the primary task of building urban agglomerations in *** on the five development concepts,this paper used the entropy method to measure the High Quality Development Index(HQDI)of the five major urban *** results showed that the HQDI of the five major urban agglomerations shows a fluctuating upward ***,using the Dagum Gini coefficient to explore the sources of HQDI development differences in urban agglomerations,we found that the main source of HQDI differences in urban agglomerations was inter-regional differences,while intra-regional differences were not ***,kernel density estimation was used to test the dynamic evolution trend of HQDI within urban *** was a polarisation phenomenon in the HQDI of urban agglomerations,such as the Pearl River Delta urban agglomeration and the Chengdu-Chongqing urban *** overall,the degree of imbalance had ***,using geographic detectors to examine the driving factors of HQDI in urban agglomerations,we found that the main driving forces for improving HQDI in urban agglomerations were economic growth,artificial intelligence technology and fiscal *** the interaction factors had greater explanatory power for the spatial differentiation of HQDI,which can be divided into two types:two-factor improvement and non-linear *** study is conducive to improving and enriching the theoretical system for evaluating the high quality development of urban agglomerations,and provides policy references for promoting the high quality development of urban agglomerations.

关键词： urban agglomeration High Quality Development Index(HQDI) spatio-temporal evolution driving factors

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Forming process chain for manufacturing complex conical-section profiled rings:On a co-design method

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Chinese Journal of Aeronautics 2024年第6期37卷 485-503页

作者： Lei LIANG Chaojiang zou Lianggang GUO State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Guizhou Aviation Technology Development Co.Ltd Guiyang 550081China

The final quality of complex conical-section rings depends on co-design of multiple processes in forming process *** this study,for a complex aeroengine casing ring with a large slope and a flange on its end,a co-design method of the forming process chain is put forward towards the objective of precision forming,which not only proposes a standard process route composed of multiple processes of upsetting,punching,rectangular ring rolling,loose tooling forging and profiled ring rolling,but also presents co-design methods of dies and blanks for all the *** profiled ring rolling,a design method of preformed blank that makes the blank and the target conical-section ring have the same axial volume distribution is *** the method,the axial metal redistribution during the process can be alleviated greatly thus improving the forming stability and precision of the *** on the geometric features of designed preformed blank,design methods of blanks and dies for loose tolling forging,rectangular ring rolling,punching and upsetting are proposed *** view of the key roles of loose tooling forging(manufacturing the preformed blank)and profiled ring rolling on the final quality of the conical ring parts,inherited FE simulations for these two processes are performed to verify the proposed design methods and determine appropriate design *** is demonstrated that the proposed design method has significant advantages in improving forming ***,a suggestive value 1.5 of the rolling ratio for profiled ring rolling(a key design parameter)is given based on comprehensive consideration of multiple indicators such as ring roundness,deformation uniformity and forming *** corresponding industrial experiments performed illustrate that a high forming precision of the conical-section aeroengine casing ring is achieved.

关键词： Complex conical-section ring Co-design of forming process chain Profiled ringrolling Preformed blank Loose tooling forging

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Bending results of graphene origami reinforced doubly curved shell

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Defence Technology（防务技术） 2024年第5期35卷 198-210页

作者： Nan Yang Yunhe zou Mohammad Arefi School of Architecture and Civil Engineering Qiqihar UniversityQiqihar 161006HeilongjiangChina School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina Inner Mongolia Key Laboratory of Special Service Intelligent Robotics Hohhot 010051Inner MongoliaChina Faculty of Mechanical Engineering Department of Solid MechanicsUniversity of KashanKashan87317-51167Iran

The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjected to mechanical and thermal *** effective material properties of the graphene origami auxetic reinforced Cu matrix are developed using micromechanical models cooperate both material properties of graphene and Cu in terms of temperature,volume fraction and folding *** principle of virtual work is used to derive governing equations with accounting thermal *** numerical results are analytically obtained using Navier's technique to investigate impact of significant parameters such as thermal loading,graphene amount,folding degree and directional coordinate on the stress,strain and deformation responses of the *** graphene origami materials may be used in aerospace vehicles and structures and defence technology because of their low weight and high stiffness.A verification study is presented for approving the formulation,solution methodology and numerical results.

关键词： Graphene origami Copper matrix Doubly curved Shear deformable Auxetic metamaterial

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