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Neural Regeneration Research 2006年第3期1卷 264-266页

作者： yudan lue Weihong Lin Dihui Ma Department of Neurology First Clinical Hospital of Jilin University. Changchun 130021 Jilin Province China

OBJECTIVE： To review the relationship between calcium ion channel and epilepsy for well investigating the pathogenesis of epilepsy and probing into the new therapeutic pathway of epilepsy. DATA SOURCES： A computer-based online research Calcium ion channel and epilepsy related articles published between January 1994 and December 2006 in the CKNI and Wanfang database with the key words of ＂calcium influxion, epilepsy, calcium-channel blocker＂. The language was limited to Chinese. At the same time, related articles published between January 1993 and December 2006 in Pubmed were searched for on online with the key words of ＂calcium influxion, epilepsy＂ in English. STUDY SELECTION ： The materials were selected firstly. Inclusive criteria： ① Studies related to calcium ion channel and the pathogenesis of epilepsy. ② Studies on the application of calcium ion channel blocker in the treatment of epilepsy. Exclusive criteria： repetitive or irrelated studies. DATA EXTRACTION ： According to the criteria, 123 articles were retrieved and 93 were excluded due to repetirive or irrelated studies. Altogether 30 articles met the inclusive criteria, 11 of them were about the structure and characters of calcium ion channel, 10 about calcium ion channel and the pathogenesis of epilepsy and 9 about calcium blocker and the treatment of epilepsy. DATA SYNTHESIS ： Calcium ion channels mainly consist of voltage dependent calcium channel and receptor operated calcium channel. Depolarization caused by voltage gating channel-induced influxion is the pathological basis of epileptic attack, and it is found in many studies that many anti-epileptic drugs have potential and direct effect to rivalizing voltage-dependent calcium ion channel. CONCLUSION ： Calcium influxion plays an important role in the seizure of epilepsy. Some calcium antagonists seen commonly are being tried in the clinical therapy of epilepsy that is being explored, not applied in clinical practice. If there are enough evidences to j

关键词： ion channels calcium channel clinical significance key words clinical practice

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Narcolepsy in patient with multiple sclerosis

Narcolepsy in patient with multiple sclerosis

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第五届中国睡眠医学论坛

作者： Wangzan lue yudan Lin Weihong Department of Neurology Jilin University

＜正＞Narcolepsy and multiple sclerosis are both related to autoimmune systerm,the clinical and diagnosis characteristics with narcolepsy and multiple sclerosis will be reported in this case.【Report of case】A 20-years old girl was reffered for evaluation for narcolepsy.2years ago,she was diagnosed with relapsing-remitting MS,she replased 3times,2 months ago she showed excessive daytime sleep with Epworth sleep scale of 11 and sleep paralysis,she had no catalepsy and hallucinations,she could remit after using methylprednisolone,and she didn’ t use interferon beta,she has no narcolepsy family history, neurology examination was normal except for Eye vertical motion,both brisk patellar reflex,and both side Babinski sign positive,MRI of her showed lesions in pons and hypothalamus,polysomnography PSG did not show any evidence of sleep breath disorder and sleep periodic limb movement,subsequent multiple sleep latency testing showed reduced mean sleep latency and 2 of 5 sleep onset REM periods. Human leukocyte antigen subtypesDR2,DQB1 of his cerebrospinal fluid was negative.【Conclusion】Narcolepsy may occur before and after multiple sclerosis,patients with MS and excessive daytime sleep should be evaluated for narcolepsy,and narcolepsy patients should be assessed for multiple sclerosis.

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