Dear Editor,Allogeneic or autologous hematopoietic stem cell transplantation(HSCT)concerns an increasing number of ***,89070 allogeneic and autologous HSCT procedures were reported in 2016,representing a 7%increase pe...
详细信息
Dear Editor,Allogeneic or autologous hematopoietic stem cell transplantation(HSCT)concerns an increasing number of ***,89070 allogeneic and autologous HSCT procedures were reported in 2016,representing a 7%increase per year since 1991.1 Improved transplant strategies and therapeutic efficacy have made HSCT a curative option for various indications,mostly comprising malignant blood cell pathologies but also including solid tumors or benign conditions.2 The conditioning regimen for transplantation often includes alkylating agents and/or total body irradiation(TBI).2 These treatments usually lead to permanent infertility.3 In men,the consequences include the impairment and reduction of Sertoli and Leydig cells,leading to the suppression of the spermatogonia pool and increased release of gonadotrophin.3 Although sperm banking can mitigate the risk of infertility.
Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii(Harms) J. Leonard(G. tessmannii) and evaluate its ***: NMRI mice were used to determine the acute toxicity of G. *** concentrations of...
详细信息
Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii(Harms) J. Leonard(G. tessmannii) and evaluate its ***: NMRI mice were used to determine the acute toxicity of G. *** concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 *** order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ ***: LD50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical ***: The results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake.
暂无评论