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Heterometallic Mg-Ni-Mg Complex Promoted Hydrosilylation of Alkenes: Catalytic Performance and Intermediates Characterization

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Chinese Journal of Chemistry 2024年第18期42卷 2133-2139页

作者： Yanping Cai Shengjie Jiang Xin xu Key laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochowUniversitySuzhouJiangsu215123China

Background and Originality Content The catalytic hydrosilylation of unsaturated hydrocarbons,facilitated by transition metal(TM),is widely recognized as a proficient technique for the synthesis of high-value organosilicon compounds'ti-4l over the past few decades,the most dominant *** in hydrosilylation processes have been constituted by pre-Ccious metar complexesroceinerecent vears omore sustainabile earth-abundant metal catalysts have received increased attentionj2-14l The classcal mechanism of transition metal-catalyzed hydrosilylation is generally accomplished through a series of fundamental processes(Scheme 1a),including(i)coordination and oxidative addition of Si-H bond to a low-valent metal center to form e.g.,o-complex or silyl metal hydride;(ii)insertion of.C-C multipe bonds intometal-hdridelsior metal-silicon bond;jiol and(ii)reductive elimination that forwards the hydrosilylated product with Markovnikov or anti-Markovnikov selectivity.

关键词： Heterometallic complex Cooperative effect Hydrosilylation Magnesium Nickel hydride

lÉVY AREA ANAlYSIS AND PARAMETER ESTIMATION FOR FOU PROCESSES VIA NON-GEOMETRIC ROUGH PATH THEORY

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Acta Mathematica Scientia 2024年第5期44卷 1609-1638页

作者： Zhongmin QIAN Xingcheng xu Mathematical Institute University of OxfordOxfordOX26GGUK Shanghai Artificial Intelligence laboratory Shanghai200232China School of Mathematical Sciences Peking UniversityBeijing100871China

This paper addresses the estimation problem of an unknown drift parameter matrix for a fractional Ornstein-Uhlenbeck process in a multi-dimensional *** tackle this problem,we propose a novel approach based on rough path theory that allows us to construct pathwise rough path estimators from both continuous and discrete observations of a single *** approach is particularly suitable for high-frequency *** formulate the parameter estimators,we introduce a theory of pathwise Itôintegrals with respect to fractional Brownian *** establishing the regularity of fractional Ornstein-Uhlenbeck processes and analyzing the long-term behavior of the associated lévy area processes,we demonstrate that our estimators are strongly consistent and pathwise *** findings offer a new perspective on estimating the drift parameter matrix for fractional Ornstein-Uhlenbeck processes in multi-dimensional settings,and may have practical implications for fields including finance,economics,and engineering.

关键词： Itôintegration lévy area non-geometric rough path fOU processes pathwise stability long time asymptotic high-frequency data

Multifunctional RGD coated a single-atom iron nanozyme:A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer

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Nano Research 2024年第6期17卷 5469-5478页

作者： Haoqi Pan xu Chen Mingming Xiao He xu Jiansheng Guo Zhiyi lu Dong Cen Xianjun Yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Key laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Qianwan Institute of CNITECHNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Key laboratory of laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer ***,short half-life period of hydroxyl radical(·OH)results in unsatisfied ***,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2)O_(2)via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer *** Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates *** magnetic resonance imaging(MRI)showed decreased T2 signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-l1 *** research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.

关键词： single-atom iron nanozyme pancreatic cancer immunotherapy ferroptosis

Mechanism analysis of foam penetration in EPB shield tunnelling with a focus on FER and soil particle size

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Underground Space 2024年第4期17卷 170-187页

作者： He Huang Quan Sun Tao xu Wanhuan Zhou State Key laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoMacao 999078China Department of Civil and Environmental Engineering University of MacaoMacao 999078China School of Transportation Southeast UniversityNanjing 210000China

Parameters of foam penetration in earth pressure balance(EPB)shield tunnelling,such as permeability coefficients and penetration distances,significantly impact tunnel face ***,existing studies have faced inaccuracies in analysing these parameters due to imitations in experimental *** study addresses this issue by employing enhanced methods for a more precise analysis of foam *** involving three distinct sand types(coarse,medium,and fine)and three foam expansion ratios(FER)(10,15,and 20)are conducted using a modified model test *** from a novel computer vision-based method,the model test outcomes unveil two distinct foam penetration paths:liquid migration(l_(w))and bubble migration(l_(f)).Three penetration phases-namely,injection,blockage&drainage,and breakage—are identified based on l_(w)and l_(f)*** initial"injection"phase conforms to Darcy’s law and is amenable to mathematical *** foam with FER of 15 has the maximum viscosity and,hence the l_(f)and permeability in the penetration tests with FER of 15 are the lowest in the same *** bubble size distribution of foam with different FER shows minor ***,the characteristics of foam penetration vary due to the distinct particle size distribution(PSD)of different *** penetration creates low-permeability layers in both medium and fine sands due to the larger bubble size of the foam compared to the estimated pore sizes of medium and fine *** the coarse sand results in a different situation due to its large pore *** distinctive characteristics of foam penetration in different sand strata are notably shaped by FER,PSD,and pore size *** insights shed light on the complex interactions during foam penetration at the tunnel face,contributing valuable knowledge to EPB shield tunnelling practices.

关键词： EPB Soil conditioning Foam penetration Permeability Tunnel face

Finely regulated luminescent Ag-In-Ga-S quantum dots with green-red dual emission toward white light-emitting diodes

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Opto-Electronic Advances 2024年第9期7卷 54-63页

作者： Zhi Wu leimeng xu Jindi Wang Jizhong Song Key laboratory of Materials Physics of Ministry of Education Laboratory of Zhongyuan LightSchool of PhysicsZhengzhou UniversityDaxue Road 75Zhengzhou 450052China

Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-based ***,enormous attention has been paid to how to narrow their broadband spectra,ignoring the application advantages of the broadband *** this work,the AIGS QDs with controllable broad green-red dual-emission are first reported,which is achieved through adjusting the size distribution of QDs by controlling the nucleation and growth of AIGS ***,the AIGS QDs exhibit broad dual-emission at green-and red-band evidenced by photoluminescence(Pl)spectra,and the Pl relative intensity and peak position can be finely ***,the dual-emission is the intrinsic characteristics from the difference in confinement effect of large particles and tiny particles confirmed by temperature-dependent Pl ***,the AIGS QDs(the size consists of 17 nm and 3.7 nm)with 530 nm and 630 nm emission could successfully be synthesized at 220°*** combining the blue light-emitting diode(lED)chips and dual-emission AIGS QDs,the constructed white light-emitting devices(WlEDs)exhibit a continuous and broad spectrum like natural sunlight with the Commission Internationale de l’Eclairage(CIE)chromaticity coordinates of(0.33,0.31),a correlated color temperature(CCT)of 5425 K,color rendering index(CRI)of 90,and luminous efficacy of radiation(lER)of 129 lm/W,which indicates that the AIGS QDs have huge potential for lighting applications.

关键词： quantum dots Ag-In-Ga-S dual emission white light-emitting diodes

Acetic acid-and furfural-based adaptive evolution of Saccharomyces cerevisiae strains for improving stress tolerance and lignocellulosic ethanol production

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Chinese Journal of Chemical Engineering 2024年第8期72卷 26-33页

作者： Omama Rehman Youduo Wu Quan Zhang Jin Guo Cuihuan Sun Huipeng Gao Yaqing xu Rui xu Ayesha Shahid Chuang xue State Key laboratory of Fine Chemicals Frontiers Science Centre for Smart Materials Oriented Chemical EngineeringEngineering Research Center of Application and Transformation for Synthetic BiologySchool of BioengineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China SINOPEC Dalian Research Institute of Petroleum and Petrochemicals Co. Ltd.Dalian 116041China Microbial Research Institute of liaoning Province Chaoyang 122000China Yunnan Provincial Rural Energy Engineering Key laboratory Kunming 650600China US-Pak Center for Advanced Studies in Agriculture and Food Security University of AgricultureFaisalabadPakistan

Acetic acid and furfural are known as prevalent inhibitors deriving from pretreatment during lignocellulosic ethanol *** negatively impact cell growth,glucose uptake and ethanol biosynthesis of Saccharomyces cerevisiae *** of industrial *** strains with high tolerance towards these inhibitors is thus critical for efficient lignocellulosic ethanol *** this study,the acetic acid or furfural tolerance of different *** strains could be significantly enhanced after adaptive evolution via serial cultivation for 40 generations under stress *** acetic acid-based adaptive strain SPSC01-TA9 produced 30.5 g·l^(-1)ethanol with a yield of 0.46 g·g^(-1)in the presence of 9 g·l^(-1)acetic acid,while the acetic acid/furfural-based adaptive strain SPSC01-TAF94 produced more ethanol of 36.2 g·l^(-1)with increased yield up to 0.49 g·g^(-1)in the presence of both 9 g·l^(-1)acetic acid and 4 g·l^(-1)*** improvements were also observed during non-detoxified corn stover hydrolysate culture by SPSC01-TAF94,which achieved ethanol production and yield of 29.1 g·l^(-1)and 0.49 g·g^(-1),respectively,the growth and fermentation efficiency of acetic acid/furfural-based adaptive strain in hydrolysate was 95%higher than those of wildtype strains,indicating the acetic acid-and furfural-based adaptive evolution strategy could be an effective approach for improving lignocellulosic ethanol *** adapted strains developed in this study with enhanced tolerance against acetic acid and furfural could be potentially contribute to economically feasible and sustainable lignocellulosic biorefinery.

关键词： Saccharomyces cerevisiae lignocellulosic ethanol production Adaptive evolution Acetic acid Furfural

Analytic Smoothing Effect of the Time Variable for the Spatially Homogeneous landau Equation

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Journal of Partial Differential Equations 2024年第1期37卷 88-103页

作者： xu Chaojiang xu Yan School of Mathematics and Key laboratory of Mathematical MIIT Nanjing University of Aeronautics and AstronauticsNanjing 210016China.

In this work,we study the Cauchy problem of the spatially homogeneous landau equation with hard potentials in a close-to-equilibrium *** prove that the solution to the Cauchy problem enjoys the analytic regularizing effect of the time variable with an l^(2)initial datum for positive *** that the smoothing effect of the Cauchy problem for the spatially homogeneous landau equation with hard potentials is exactly same as heat equation.

关键词： Spatially homogeneous landau equation analytic smoothing effect hard potentials.

A multilayer network diffusion-based model for reviewer recommendation

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Chinese Physics B 2024年第3期33卷 700-717页

作者：黄羿炜徐舒琪蔡世民吕琳媛 Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Institute of Dataspace Hefei Comprehensive National Science CenterHefei 230088China Big Data Research Center University of Electronic Science and Technology of ChinaChengdu 611731China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Cyber Science and Technology University of Science and Technology of ChinaHefei 230026China

With the rapid growth of manuscript submissions,finding eligible reviewers for every submission has become a heavy *** systems are powerful tools developed in computer science and information science to deal with this ***,most existing approaches resort to text mining techniques to match manuscripts with potential reviewers,which require high-quality textual information to perform *** this paper,we propose a reviewer recommendation algorithm based on a network diffusion process on a scholar-paper multilayer network,with no requirement for textual *** network incorporates the relationship of scholar-paper pairs,the collaboration among scholars,and the bibliographic coupling among *** results show that our proposed algorithm outperforms other state-of-the-art recommendation methods that use graph random walk and matrix factorization and methods that use machine learning and natural language processing,with improvements of over 7.62%in recall,5.66%in hit rate,and 47.53%in ranking *** work sheds light on the effectiveness of multilayer network diffusion-based methods in the reviewer recommendation problem,which will help to facilitate the peer-review process and promote information retrieval research in other practical scenes.

关键词： reviewer recommendation multilayer network network diffusion model recommender systems complex networks

long way up:rethink diseases in light of phase separation and phase transition

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Protein & Cell 2024年第7期15卷 475-492页

作者： Mingrui Ding Weifan xu Gaofeng Pei Pilong li State Key laboratory of Membrane Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for life Sciences Beijing 100084China NuPhase Therapeutics Beijing 100083China

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

关键词： multivalency compartments aberant phase separation therapeutics gain or loss of phase separation diseases