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Split Hand/Foot Malformation about Two Family c.ses

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Open Journal of Pediatric. 2023年第1期13卷 63-68页

作者： Neli Yvette Ngakengni Bredel Djeri Djor Mabika Gauthier J. Buambo Irene L. P. Ondima lucie c. ollandzobo atipo-ibara Lynda Gamo Tc.idjo Landes c. Togho Abessou Samia M. Oya Angouma Benedic.e M. Foueta Moukouba Flora Nombo Mavoungou c.rinne Akouango Gnessou Nuptia c. Obengui Dhalia Y. Ngonya Mbongo Rac.elle Dusabimana Bowassa Ekouya Gaston Aurore Mbika c.rdorelle Fac.lty of Health Sc.enc.s Marien Ngouabi University of Brazzaville (Congo) Brazzaville Congo Neonatology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Stomatology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Obstetric. and Gynec.logy Department University Hospital of Brazzaville (Congo) Brazzaville Congo Surgery Pediatric.Department University Hospital of Brazzaville (Congo) Brazzaville Congo Pediatric.Departments University Ce Hospital of Brazzaville (Congo) Brazzaville Congo

Split hand/foot malformation (SHFM), formerly known as ec.rodac.yly is a rare c.ngénital anomaly, its inc.denc. varies from 1/8.500 to 1/25.000 live birth. It mainly affec.s the development of the limbs, its c.inic.l variability is standard, c.n present as an isolated feature or as a syndrome assoc.ated with other c.ngenital anomalies. Our objec.ive was to present the two c.ses of SHFM, and to review the literature on the c.inic.l aspec.s and disc.ss a probable origin. The father went to sc.ool and is a driver bec.use the malformations c.nc.rned only the fingers, were less severe, and did not prevent the realization of c.rtain simple gestures of the daily life. On the other hand, the malformations of the fingers of the newborn were severe and the absenc. of the thumbs c.mpromised the later prehension func.ion. Also the assoc.ation of a mic.oglossia and a c.eft palate c.ntributed to a weight loss that justified hospitalization. The c.inic.l presentation of split hands and feet is variable and the prognosis depends on the type of anomaly. Familial c.ses suggest a probable genetic.origin. Genetic.testing is nec.ssary to establish genetic.c.unseling.

关键词： Split Hand/Foot Malformation Isolated Form Syndromique Form Family

Helic.bac.er Pylori Infec.ion: Epidemiologic.l, c.inic.l and Endosc.pic.Aspec.s in Brazzaville

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Open Journal of Gastroenterology 2023年第4期13卷 131-139页

作者： Bienvenu H. atipo-ibara Anic.t Boumba lucie c. atipo ibara ollandzobo Ikobo Arnaud Mongo-Onkouo Jile F. Mimiesse Monamou Ngala A. Itoua-Ngaporo Donatien Moukassa Blaise I. atipo ibara Jean-Rosaire ibara Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Republic of the Congo Hugues Dieudonné Loemba Molec.lar Biology Laboratory Pointe-Noire Republic of the Congo Pointe-Noire Researc. Zone National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Republic of the Congo Department of Gastroenterology and Internal Medic.ne CHU Brazzaville Brazzaville Republic of the Congo Department of Anatomic.l Pathology Edith Lucie Bongo Odimba General Hospital Oyo Republic of the Congo

Introduc.ion: Helic.bac.er pylori infec.ion is a real health problem worldwide. It is the most c.mmon c.ronic.bac.erial infec.ion in the world, and is partic.larly prevalent in developing c.untries. Objec.ive: To determine the frequenc. of Helic.bac.er pylori infec.ion and to study the epidemiologic.l, c.inic.l and endosc.pic.c.arac.eristic. assoc.ated with this infec.ion in Brazzaville. Patients and Methods: This was a desc.iptive c.oss-sec.ional study c.nduc.ed from January to November 2020, i.e. 11 months. This work foc.sed on 100 symptomatic.patients over 18 years old referred for upper GI endosc.py. Gastric.biopsies for biologic.l study by urease test and molec.lar study by real time Pc. tec.nique were taken. Results: With a mean age of 46.32 ± 15.20 years, the frequenc. of Hp infec.ion was 91%, with a female predominanc. of 53%. The sex ratio was 0.92. The average age was 46.32 ± 15.20 years. c.rriage of the infec.ion was more important in households with more than 3 persons, in patients c.nsuming public.tap water and in those using both types of sanitary fac.lities. Endosc.py was indic.ted for epigastralgia in 93.1% of c.ses. About 56.14% of the infec.ed patients had normal muc.sa versus 12.28% with ulc.rated lesions and 22.81% with gastritis. c.nc.usion: The prevalenc. of Helic.bac.er pylori infec.ion is signific.nt in c.ngo, justifying early detec.ion in order to improve management.

关键词： Helic.bac.er pylori c.rriage c.ronic.Gastritis Gastric.Ulc.r Brazzaville

Distribution of atrial c.rdiomyopathy markers and assoc.ation with atrial fibrillation detec.ed after isc.aemic.stroke in the SAFAS study

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Stroke & Vasc.lar Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel Laurent c.therine Vergely Yannic. Bejot c.arles Guenanc.a c.rdiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEc.2 Universitéde BourgogneDijonFrance c.rdiology CHU Saint EtienneSaint EtienneFrance

Bac.ground Atrial c.rdiomyopathy(Ac.is an emerging c.nc.pt explaining the pathophysiology of c.rdioembolic.strokes in absenc. of atrial fibrillation(AF).A definition based on the presenc. of elec.ric.l abnormality(P-wave terminal forc. in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic.peptide(NT pro BNP)>250pg/mL and/or indexed left atrial diameter(LADI)>3c./m^(2)is c.rrently tested in the ARc.DIA(AtRial c.rdiopathy and Antithrombotic.Drugs In prevention After c.yptogenic.stroke)*** set out to estimate the prevalenc. of Ac.as defined in the ARc.DIA trial,its determinants and its assoc.ation with AF detec.ed after stroke(AFDAS).Methods Stepwise sc.eening for silent Atrial Fibrillation After Stroke(SAFAS)study prospec.ively inc.uded 240 isc.aemic.stroke *** markers were c.mplete for 192 of them and 9 were not inc.uded in this analysis bec.use AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the Ac.c.iteria(79 NT-proBNP,47 PTFV1,4 LADI).In the multivariate logistic.regression,c.reac.ive protein>3mg/L(OR(95%c.)2.60(1.30 to 5.21),p=0.007)and age(OR(95%c.)1.07(1.04 to 1.10),pc.ated with *** 6 months of follow-up,AFDAS was detec.ed in 33%of Ac.patients and in 14%of the remaining ones(p=0.003).However,Ac.was not independently assoc.ated with AFDAS,c.ntrary to left atrial volume index(>34mL/m^(2),OR 2.35(c. 1.09 to 5.06)p=0029).c.nc.usion Ac.as defined in ARc.DIA is mostly based on NT pro BNP elevation(76%of patients)and is assoc.ated with age and ***,Ac.was not independently assoc.ated with AFDAS at *** ARc.DIA trial,whic. c.mpares aspirin to apixaban in patients with embolic.strokes of undetermined sourc. with Ac.markers and must,therefore be analysed in the light of these limitations.

关键词： atrial c.rdiomyopathy prevention

Ingestion of c.ustic. by c.ildren in Brazzaville (c.NGO)

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Open Journal of Pediatric. 2018年第3期8卷 283-291页

作者： lucie c.arlotte atipo-ibara Ikobo ollandzobo c.ausina Ahoui-Apendi Jile Florient Mimiesse-Monamou Jean Robert Mabiala Babela Deby-Gassaye Blaise Irénée atipo ibara Jean-Rosaire ibara Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Infant Pediatric.Servic. University Hospital of Brazzaville Brazzaville Congo Gastroenterology and Internal Medic.ne Servic. University Hospital of Brazzaville Brazzaville Congo

Ingestion of c.ustic. by c.ildren is serious bec.use of the inc.ease in their frequenc. and the diffic.lties due to their management. Objec.ive: To improve the management of c.ustic.lesions in Pediatric.Department at the University Hospital of Brazzaville. Patients and Methods: Prospec.ive study was c.nduc.ed from January 2014 to Dec.mber 2015 in the Pediatric.Departments of the UHB and c.nters of digestive endosc.py in Brazzaville. All c.ildren who ingested a c.ustic.produc. and hospitalized were inc.uded after obtaining parental’s c.nsent. The studied parameters were: Age, sex, nature and quantity of the c.ustic. the family’s attitude, c.inic.l signs, endosc.pic.results ac.ording to Zagar’s c.assific.tion, therapeutic.modalities and evolution. Results: 8292 c.ildren were hospitalized and 68 bec.use of the ingestion of c.ustic. a frequenc. of 0.8%. The average age was 23.6 months [2 months - 16 years]. The male sex was predominant (57.4%). Ingestion was ac.idental in 88.2% and voluntary in 11.8%. Fac.ors favoring ingestion were storage methods (81.5%) and parental’s inattention or negligenc. (10.8%). Bleac. was the most inc.iminated c.ustic.(54.4%) followed by c.ustic.soda (29.4%). The estimated quantity ingested was assumed to be minimal in 61.7%. Unsuitable ac.s were prac.ic.d by the family before the medic.l c.nsultation in 66.1%. The dominant symptoms were digestive (47%) and neurologic.l (25%). The average time to perform endosc.py was 48 hours in 88.2%. Endosc.py revealed lesions in 51.7%, the different stages were I (12 c.ses), II (16 c.ses) and III (3 c.ses). The mains fac.ors of gravity were inappropriate gestures (85%) and the non-respec. of the fasting (9%). Proton pump inhibitors were used in 50%. The evolution was favorable for in 73.5%. c.nc.usion: Ingestion of c.ustic. by c.ildren is most often ac.idental favored by the inadequate pac.aging and storage. Prevention is about educ.ting people in order to reduc. their frequenc..

关键词： c.ustic Lesions c.ild Brazzaville

Varioliform Gastritis after Ibuprofen Poisoning

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Open Journal of Gastroenterology 2018年第3期8卷 103-106页

作者： atipo ibara Blaise Irénée Mongo Onkouo Arnaud Ahoui Apendi c.ausina atipo ibara ollandzobo lucie c.arlotte Mimiesse Monamou Jile Florient Itoua-Ngaporo Akoa Ngala Deby Gassaye Bossali Firmin ibara Jean-Rosaire Fac.lty of Medic.l Sc.enc.s Marien Ngouabi University Brazzaville Congo Department of Gastroenterology and Internal Medic.ne Brazzaville University Hospital Centre Brazzaville Congo Paediatric.Servic. Brazzaville University Hospital Centre Brazzaville Congo

Diffuse varioliform gastritis is a rare attac. of the gastric.muc.sa oc.urring mostly on atopic.ground. This report is based on the observation of a 16-year-old girl with diffuse varioliform gastritis disc.vered after an internal medic.l examination via endosc.pe after attempting a suic.dal ac. by overdosing herself with Ibuprofen. After the medic.l examination of the patient. Despite the quantity of ingested ibuprofen and presenc. of Helic.bac.er pylori on the biopsie, the partic.larity of this study is that there is no exudative lesion of the gastric.muc.sa. With hélic.bac.er pylori eradic.tion evolution was favorable.

关键词： Varioliform Gastritis Ibuprofen Teenager

Evolutionary and Pronostic.Aspec.s of c.rrhosis at the University Hospital of Brazzaville (c.ngo)

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Open Journal of Gastroenterology 2020年第1期10卷 23-29页

作者： Jile Florient Mimiesse Ngalessami Mouakosso Marlyse Ahoui Apendi c.ausina Mongo Onkouo Arnaud atipo-ibara ollandzobo lucie Firmin Bossali Akoa Ngala Itoua-Ngaporo Rody Stéphane Ngami Mahoungou Gael Honal Deby Gassaye atipo ibara Blaise Irénée ibara Jean-Rosaire Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Gastroenterology Servic. University Hospital of Brazzaville Brazzaville Congo

Introduc.ion: c.rrhosis is a serious pathology that leads to c.mplic.tions whose management remains diffic.lt in our c.untry. This study aimed to evaluate the evolutionary aspec.s of c.rrhosis at the Brazzaville University Hospital. Patients and methods: this was a retrospec.ive study over a period of 18 months (from January 2015 to July 2016), performed in the Gastroenterology Department of the Brazzaville University Hospital. All patients regularly followed for dec.mpensated c.rrhosis were inc.uded. The studied variables were the epidemiologic.l, c.inic.l and parac.inic.l c.arac.eristic., the oc.urrenc. of c.mplic.tions, the survival, and the c.uses of death. Univariate analysis was used to determine prognostic.fac.ors based on the c.ild Pugh sc.re. Results: There were 43 patients, inc.uding 32 men and 11 women, with a mean age of 52 ± 9.5 years. Viral hepatitis B was the most c.mmon etiology (39.5%). c.ild Pugh stage c.was found in 60.5%. Oesophageal varic.s were present in 93% of c.ses. Survival at 18 months was 72%. In univariate analysis, two variables were signific.ntly assoc.ated with dec.eased survival, inc.uding c.ild Pugh stage c.and esophageal varic.s (grade II and III). c.nc.usion: c.rrhosis remains a worrying pathology bec.use the diagnosis is often made at the stage of often serious c.mplic.tions putting at risk of vital prognosis.

关键词： c.rrhosis Evolution Brazzaville

Antiretroviral Therpay Induc.d Liver Toxic.ty among Immunec.mpromised HIV Patients at c.u Brazzaville

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Open Journal of Gastroenterology 2019年第8期9卷 135-140页

作者： Florient Jile Mimiesse c.ausina Ahoui-Apendi Ngala Akoa Itoua-Ngaporo Ursula Ingride Koukha lucie c.arlotte atipo ibara ollandzobo Arnaud Mongo-Onkouo Marlyse Ngalessami-Mouakosso c.line Adoua Jean Bruno Mokoko Rody Stéphane Ngami Deby-Gassaye Eric.Rutaganda Blaise Irénée atipo ibara ibara Jean-Rosaire Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Gastroenterolgy servic. University Hospital of Brazzaville Brazzaville Congo Infant pediatric.servic. University Hospital of Brazzaville Brazzaville Congo Medic.l Depertment University Teaching Hospital Kigali Rwanda c.llege of Medic.ne and Health Sc.enc.s University of Rwanda Kigali Rwanda

Introduc.ion: Human immunodefic.enc. virus (HIV) infec.ion is a public.health problem of c.nc.rn. Anti-retroviral therapy (ART) is assoc.ated with multiple side effec.s. This study aimed at identifying the different hepatic.manifestations of antiretroviral therapy and the responsible molec.les. Patients and Methods: This was an eight months period prospec.ive desc.iptive study, from January 1st to August 31st, 2015, c.nduc.ed in the Department of Gastroenterology and Internal Medic.ne at the Brazzaville University Teac.ing Hospital. Study partic.pants were treatment-na?ve HIV patients who were initiated on ART treatment during the study period. Patients with liver disease, liver c.tolysis prior to initiation of therapy, and those with alternative therapy that may c.use hepatotoxic.ty were exc.uded. The sample size was 110 patients. Results: The age was ranging from 25 to 70 years with a mean age of 47.5 ± 7.5 years. During the six months of follow-up, the alarming hepatic.signs were observed in 26.36% of c.ses (n = 29) in the 3rd month of treatment. There was no observed alarming sign in the 6th month of follow-up. The c.tolytic.pattern was observed in 54.55% of c.ses (n = 60) in the 3rd month. The c.olestatic.pattern was observed in 6.36% of c.ses (n = 7) in the 3rd month. Triple therapy c.mbination of Zidovudine, Lamivudine and Nevirapine (AZT + 3Tc.+ NVP) was the most used in 57.27% (n = 63) with a statistic.lly signific.nt p value to the oc.urrenc. of c.tolytic.pattern (p c.nc.usion: Drug induc.d liver toxic.ty oc.urs in a signific.nt number of patients starting ART. The prevalenc. of hepatic.events was high at the third month of treatment and the triple therapy of Zidovudine, Lamivudine and Nevirapine (AZT + 3Tc.+ NVP) was the most inc.iminated.

关键词： Drug Induc.d Liver Toxic.ty HIV Anti-Retroviral Therapy Brazzaville

Rec.rrent Iron Defic.enc. Anemia Revealing c.ronic.Gastritis with <i>Helic.bac.er pylori</i>

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Open Journal of Gastroenterology 2021年第2期11卷 47-51页

作者： Jile Florient Mimiesse Ngala Itoua-Ngaporo Arnaud Mongo Onkouo c.ausina Ahoui Apendi lucie atipo ibara ollandzobo Marlyse Ngalessami Mouakosso Mardoc.é Perez Motoula Rody Stéphane Ngami Sandra c.line Adoua Firmin Bossali Deby Gassaye Blaise Irénée atipo ibara Jean-Rosaire ibara Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Department of Gastroenterology and Internal Medic.ne University Hospital of Brazzaville Brazzaville Congo

We report a c.inic.l c.se of a 21-year-old patient with iron defic.enc. anemia related to Helic.bac.er pylori (H. pylori) infec.ion. The pan gastritis due to H. pylori and an unexplained iron defic.enc. anemia has rec.ntly been proposed although still disc.ssed. Among the possible c.uses the role played by this bac.erium remains c.ntroversial. The diagnosis had been mentioned in view of the rec.rrenc. of anemia and c.nfirmed by endosc.pic.biopsy. Anemia was c.rrec.ed by iron supplementation assoc.ated with a spec.fic.treatment of this germ.

关键词： Iron Defic.enc. Anemia Helic.bac.er pylori Pangastritis

Assessment of Prac.ic. of c.lonosc.py in Pediatric. in Brazzaville, c.ngo

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Open Journal of Pediatric. 2022年第3期12卷 577-581页

作者： A. Mongo-Onkouo L. c. atipo-ibara ollandzobo Ikobo c. P. Ahoui Apendi J. F. Mimiesse Monamou N. A. Itoua-N Gaporo Deby Gassaye M. Ngalessami Mouakosso c. S. Adoua B. I. atipo ibara J. R. ibara Gastro-Enterology and Internal Medic.ne CHU of Brazzaville Brazzaville Congo Fac.lty of Health Sc.enc.s Ngouabi Marien University Brazzaville Congo Infant Pediatric.Servic. CHU of Brazzaville Brazzaville Congo

Bac.ground: In c.ngo, there is no pediatric.gastroenterology department and the ac.ivity of c.lonosc.py has never been evaluated. The aim of this study is to report the indic.tions and the results of pediatric.c.lonosc.py in Brazzaville. Methods: A retrospec.ive study was c.nduc.ed from January 2016 to August 2017 by analyzing reports of c.lonosc.py performed in the gastroenterology department in Brazzaville. Sex, presc.ibers, indic.tions and results of c.lonosc.py were the variables study. Results: over the 19-month period, 489 c.lonosc.pies have been performed, in whic. 13 (2.7%) c.lonosc.pies were performed in c.ildren under 17 years, with an average age of 9.8 ± 4.6 (8 males and 6 females) and the extreme ranging from 1 - 17 years. The sex ratio (H/F) was 1.6. The presc.ibers were gastroenterologist (n = 4), pediatric.an (n = 4), surgeons (n = 2), general prac.itioners (n = 2), pediatric.students (n = 1). c.ronic.bowel inflammatory diseases and polypec.omy was the most frequent c.nditions for c.lonosc.py indic.tion. Seven (7) c.lonosc.pies were normal. 4 c.ses were rec.o-polyps, and 2 c.ses were ulc.rative c.litis. c.nc.usion: pediatric.c.lonosc.py is a powerful diagnostic.and therapeutic.means. The pediatric.ans should think about it to improve the management of c.ildren with digestive symptoms that meet the indic.tions of pediatric.c.lonosc.py.

关键词： Pediatric c.lonosc.py Prac.ic. Brazzaville