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Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling

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Journal of Genetics and Genomics 2023年第7期50卷 473-485页

作者： Hongwei Jing Xiaolu Yang Ryan J.Emenecker Jian Feng Jian Zhang Marcelo Rodrigues Alves de Figueiredo Patarasuda chaisupa R.clay Wright Alex S.Holehouse lucia c.strader Jianru Zuo State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of chinese Academy of Sciences Beijing 100049China Department of Biology Duke UniversityDurhamNC 27008USA Department of Neurobiology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry and Molecular Biophysics Washington University School of MedicineSt.LouisMO 63110USA center for Biomolecular condensates(cBc) Washington University in St.LouisSt.LouisMO 63130USA Department of Biological Systems Engineering Virginia TechBlacksburgVA 24061USA The Translational Plant Sciences center(TPSc) Virginia TechBlacksburgVA 24061USA cAS center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesBeijing 100101China

The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and *** signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-AcETIc AcID(Aux/IAA)family of transcriptional ***,many auxin-modulated physiological processes are also regulated by nitric oxide(NO)that executes its biological effects predominantly through protein S-nitrosylation at specific cysteine ***,little is known about the molecular mechanisms in regulating the interactive NO and auxin ***,we show that NO represses auxin signaling by inhibiting IAA17 protein *** induces the S-nitrosylation of cys-70 located in the intrinsically disordered region of IAA17,which inhibits the TIR1-IAA17 interaction and consequently the proteasomal degradation of *** accumulation of a higher level of IAA17 attenuates auxin ***,an IAA17^(c70W)nitrosomimetic mutation renders the accumulation of a higher level of the mutated protein,thereby causing partial resistance to auxin and defective lateral root *** together,these results suggest that S-nitrosylation of IAA17 at cys-70 inhibits its interaction with TIR1,thereby negatively regulating auxin *** study provides unique molecular insights into the redox-based auxin signaling in regulating plant growth and development.

关键词： Arabidopsis thaliana Auxin Aux/IAA Nitric oxide S-nitrosylation Intrinsically disordered region

Demystifying polyphosphate-accumulating organisms relevant to wastewater treatment: A review of their phylogeny, metabolism, and detection

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Environmental Science and Ecotechnology 2024年第5期21卷 1-16页

作者： lucia Ruiz-Haddad Muhammad Ali Mario Pronk Mark c.Mvan Loosdrecht Pascal E.Saikaly Environmental Science and Engineering Program Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Water Desalination and Reuse center Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Department of civil Structural&Environmental EngineeringTrinity College DublinThe University of DublinDublin2Ireland Department of Biotechnology Delft University of TechnologyDelft2629 HZthe Netherlands

currently,the most cost-effective and efficient method for phosphorus(P)removal from wastewater is enhanced biological P removal(EPBR)via polyphosphate-accumulating organisms(PAOs).This study integrates a literature review with genomic analysis to uncover the phylogenetic and metabolic diversity of the relevant PAOs for wastewater *** findings highlight significant differences in the metabolic capabilities of PAOs relevant to wastewater ***,candidatus Dechloromonas and candidatus Accumulibacter can synthesize polyhydroxyalkanoates,possess specific enzymes for ATP production from polyphosphate,and have electrochemical transporters for acetate and *** contrast,Tetrasphaera,candidatus Phosphoribacter,Knoellia,and Phycicoccus possess PolyP-glucokinase and electrochemical transporters for sugars/amino ***,this review explores various detection methods for polyphosphate and PAOs in activated sludge wastewater treatment ***,FISH-Raman spectroscopy emerges as one of the most advanced detection ***,this review provides critical insights into PAO research,underscoring the need for enhanced strategies in biological phosphorus removal.

关键词： Polyphosphate-accumulating organisms(PAOs) Enhanced biological phosphorus removal (EBPR)Tetrasphaera ca.accumulibacter ca.phosphoribacter Knoellia Phycicoccus

Improving colorectal cancer screening programs

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World Journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar J cordero lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain centre for Research in Molecular Medicine and chronic Diseases(ciMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World Journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble scD26 colonoscopy Immunoscores

Transport and Metabolism of the Endogenous Auxin Precursor Indole-3-Butyric Acid

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Molecular Plant 2011年第3期4卷 477-486页

作者： lucia c. strader Bonnie Bartel Department of Biochemistry and cell Biology Rice University Houston TX 77005 USA

Plant growth and morphogenesis depend on the levels and distribution of the plant hormone auxin. Plants tightly regulate cellular levels of the active auxin indole-3-acetic acid （IAA） through synthesis, inactivation, and transport. Although the transporters that move IAA into and out of cells are well characterized and play important roles in devel- opment, little is known about the transport of IAA precursors. In this review, we discuss the accumulating evidence sug- gesting that the IAA precursor indole-3-butyric acid （IBA） is transported independently of the characterized IAA transport machinery along with the recent identification of specific IBA efflux carriers and enzymes suggested to metabolize IBA. These studies have revealed important roles for IBA in maintaining IAA levels and distribution within the plant to support normal development.

关键词： Auxin auxin transport indole-3-butyric acid IBA.

connected phytohormone biosynthesis pathways at the core of growth-stress tradeoffs

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Molecular Plant 2022年第7期15卷 1087-1089页

作者： Katelyn Sageman-Furnas lucia strader Duke University DurhamNC 27708USA

How plants experiencing environmental stress regulate their growth to survive is a fundamental question crucial for future food *** and high salinity both represent osmotic stresses that severely decrease crop yields *** how plants cope with these stresses becomes increasingly critical as the world faces a rapid deterioration of arable *** respond to stress by activating stress-avoidance or stress-tolerance pathways,reprogramming gene regulatory networks,and increasing protective solutes(reviewed in claeys and lnze,2013;Zhang et al.,2020).

关键词： programming stress critical

Effect of operational parameters on the performance of an anaerobic sequencing batch reactor(AnSBR)treating protein-rich wastewater

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Environmental Science and Ecotechnology 2024年第1期17卷 89-99页

作者： Zhe Deng Julian Muñoz Sierra Ana lucia Morgado Ferreira Daniel cerqueda-Garcia Henri Spanjers Jules B.van Lier Delft University of Technology Faculty of Civil Engineering and GeosciencesStevinweg 12628 CNDelftthe Netherlands Veolia Water Technologies Techno center Netherlands B.V.-Biothane Tanthofdreef 212623 EWDelftthe Netherlands KWR Water Research Institute Groningenhaven 7P.O.Box 10723430 BBNieuwegeinthe Netherlands Institute of Ecology.A.c Cluster Cientifico y Tecnologico BioMimic®Carretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico

Treating protein-rich wastewater using cost-effective and simple-structured single-stage reactors presents several *** this study,we applied an anaerobic sequencing batch reactor(AnSBR)to treat protein-rich wastewater from a *** focused on identifying the key factors influencing the removal of chemical oxygen demand(cOD)and the settling performance of the *** AnSBR achieved a maximum total cOD removal of 90%,a protein degradation efficiency exceeding 80%,and a cOD to methane conversion efficiency of over 70%at organic loading rates of up to 6.2 g cOD L^(-1)d^(-1).We found that the variations in both the organic loading rate within the reactor and the hydraulic retention time in the buffer tank had a significant effect on cOD *** hydraulic retention time in the buffer tank and the reactor,which determined the ammonification efficiencies and the residual carbohydrate concentrations in the reactor liquid,affected the sludge ***,the genus clostridium sensu stricto 1,known as protein-and lipids-degraders,was predominant in the *** analysis showed a significant correlation between the core microbiome and ammonification efficiency,highlighting the importance of protein degradation as the governing process in the *** results will provide valuable insights to optimise the design and operation of AnSBR for efficient treatment of protein-rich wastewater.

关键词： Anaerobic digestion Anaerobic sequencing batch reactor (AnSBR) Protein Microbial community Slaughterhouse wastewater

Effect of biochar on the metabolome of soybean seedlings

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Oil crop Science 2024年第1期9卷 60-68页

作者： Nathalia E.Silva Mariana G.Aguilar Osania E.Ferreira Gleicia M.Paulino Jaqueline c.L.carvalho Lúcia P.S.Pimenta Alan R.T.Machado Programa de Pos-graduaçao em ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de Engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de ciencias Exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(ScB300),400℃(ScB400)and 600℃(ScB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear Magnetic *** Relative Germination,Relative Average Radicle Growth and Germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for ScB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： Germination Metabolomics 1H NMR Pyrolysis Sugarcane bagasse

Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine

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clinical Traditional Medicine and Pharmacology 2024年第4期5卷 19-26页

作者： Gorika Tomar Mitushi Singh Isha Sharma Anuj Nautiyal Saurabh Aggarwal Subhash chandra Havagiray R.chitme cassio Rocha Medeiros Micheline de Azevedo Lima lucia Raquel de Lima Henrique Douglas Melo coutinho Bhavna Kumar Department of Pharmacy Practice School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Medicine Shri MahantIndiresh HospitalSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmaceutical chemistry School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmacology and Toxicology Amity Institute of PharmacyAmity UniversitySector-125Noida 201313 UPGwaliorIndia cEcAPE college Av.Padre Cícero3917-São JoséJuazeiro do Norte 63024-015CEBrazil Department of Molecular Biology Federal University of Paraiba-UFPBJoao Pessoa 58051-900ParaibaBrazil Department of Biological chemistry Regional University of Cariri-URCACrato 63105-000CEBrazil Department of Pharmaceutics DIT UniversityDehradun 248009UttarakhandIndia

Background:Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disorder characterized by insulin resistance and ***,a commonly prescribed treatment for T2DM,is known for its effectiveness in improving glycemic *** studies suggest that metformin may also influence testosterone levels in male patients,a hormone crucial for male reproductive health,muscle mass maintenance,and overall quality of *** plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side–effects of metformin ***:To assess the impact of metformin treatment on testosterone levels in male patients with T2DM compared to non-diabetic males,and to evaluate the potential implications of traditional medical treatments in managing the consequences of reduced testosterone ***:This study is a prospective observational investigation conducted among a total of 60 patients,divided into two groups:30 males taking metformin as a hyperglycaemic agent with T2DM and 30 males without any diabetic *** study was be carried out in different outpatient department of Shri Mahant Indiresh Hospital,Patel Nagar,Dehradun to assess the level of testosterone in male patients with T2DM taking metformin and in non-Diabetic *** on these findings,potential traditional medicines methods for reducing testosterone levels were ***:It was demonstrated that male patients with T2DM undergoing metformin treatment exhibited significant reduction in testosterone serum levels compared to non-diabetic *** plants were examinedand,and clinical studies were conducted on *** was discovered that these plants have been effective in increasingtestosterone level,suggesting their potential use as therapy for ***:This study shows reduction in the testosterone levels,which may lead to low sex drives and induction of low testosterone induced erectile dy

关键词： Type 2 diabetes mellitus Testosterone Metformin Erectile dysfunction Hyperglycaemia

Telomere and telomerase in chronic liver disease and hepatocarcinoma

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World Journal of Gastroenterology 2014年第20期20卷 6287-6292页

作者： lucia carulli claudia Anzivino Department of Biomedical Metabolic and Neural Sciences. University of Modena and Reggio Emilia 41126 Modena Italy

The pathogenesis of liver cirrhosis is not completely *** in the majority of patients,the risk factors may be identified in B and c viral hepatitis,alcohol intake,drugs or fatty liver disease,there is a small percentage of patients with no apparent risk *** addition,the evolution of chronic liver disease is highly heterogeneous from one patient to *** patient with identical risk factors,some rapidly progress to cirrhosis and hepatocellular carcinoma(Hcc)whereas others have a benign ***,a genetic predisposition may contribute to the development of cirrhosis and *** supporting the role of genetic factors as a risk for cirrhosis has been accumulating during the past *** addition to the results from epidemiological studies,polymorphisms studies and data on twins,the concept of telomere shortening as a genetic risk factor for chronic liver disease and Hcc has been *** we review the literature on telomerase mutations,telomere shortening and liver disease including hepatocellular carcinoma.

关键词： chromosomes Telomere Telomerase Liver-cirrhosis Hepatocarcinoma