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β-Globin Gene Cluster Haplotypes and Clinical Severity in Sickle Cell Anemia Patients in Southern Brazil

Open Journal of Blood Diseases 2014年第2期4卷 16-23页

作者： Maria ALda Silva Joao RFriedrisch Christina MBittar Meide Urnau Joice Merzoni Vanessa SValim Bruna Amorin Annelise Pezzi Jose Artur BChies lucia mda rocha silla Laboratory of Hematopoietic Cell Culture and Molecular Analysis Center for Experimental ResearchPorto AlegreBrazil Hematology and Bone Marrow Transplantation of Hospital de Clinicas de Porto Alegre Porto AlegreBrazil Post-Graduation in Medicine:Medical Sciences Federal University of Rio Grande do SulPorto AlegreBrazil Laboratory of Immunogenetics Department of GeneticsUFRGSPorto AlegreBrazil

Hematopoietic stem cell transplantation(HSCT)has emerged as a curative strategy for sickle cell anemia(SCA);it is necessary to find markers of SCA clinical severity to spare those SCA patients whose clinical course is mild from the morbidity and mortality associated with HSCT. Haplotypes have been correlated with the severity of clinical manifestations in SCA patients, and fetal hemoglobin(HbF)and socioeconomic status(SeS)have also been described as negative factors. We studied these factors and their impact on clinical manifestations in a population of Southern Brazilian patients attending the Center for Sickle Cell Anemia at Hospital de Clínicas de Porto Alegre/RS, Brazil. Clinical severity was defined as two or more veno-occlusive episodes per year. The βS haplotypes were determined by PCR in 75 SCA patients. Among the 150 βS chromosomes analyzed, 99(66%)were identified as Bantu(Ban), 41(27%)asBenin(Ben), and 10(7%)as other haplotypes. Most patients in our sample(62.7%)belonged to lower SeS groups, precluding meaningful statistical analysis of SeS impact on clinical severity. There was no correlation between haplotypes or HbF level and SCA clinical severity. Gene polymorphisms and environmental issues have to be taken into consideration.

关键词： Sickle Cell Anemia β-Globin Fetal Hemoglobin and Clinical Severity

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Nickel sulfate solution fluoride separation with hydrous zirconium oxide

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert M.Nigri Ummul K.Sultana André L.A.Santos James W.Vaughan Sonia D.F.rocha Department of Mining Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of Chemical Engineering University of QueenslandSt Lucia 4072Australia

Fluoride is an impurity in nickel sulfate production,which is required for electric vehicle *** zirconium oxide(HZO)was evaluated for removing fl uoride from nickel sulfate *** fluoride removal occurred at pH value 4 and optimal pH value is 4–5,considering Zr *** availability decreases with pH due to hydrogen fluoride and zirconium fluoride aqueous *** removal is initially rapid,with 50 wt.%removal in 7 min,followed by slow removal up to 68 wt.%after 72 h and follows second order rate *** removal was dominated by an ion exchange mechanism and resulting Zr–F bonds were observed using Fourier-transform infrared *** presence of nickel sulfate decreased loading capacity compared to a salt-free *** maintained adsorption capacity through five cycles of loading and regeneration.

关键词： Hydrous zirconium oxide Nickel sulfate Fluoride Adsorption Anion exchange

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Agressive inflammatory myofibroblastic tumor of the liver with underlying schistosomiasis:A case report

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World Journal of Gastroenterology 2010年第33期16卷 4233-4236页

作者： Vera lucia Pannain Juliana Vial Passos Ariovaldo da rocha Filho Cristiane Villela-Nogueira Adriana Caroli-Bottino Department of Pathology Clementino Fraga Filho University HospitalFederal University of Rio de Janeiro Department of Internal Medicine Clementino Fraga Filho University HospitalFederal University of Rio de Janeiro

Inflammatory myofibroblastic tumor(IMT)occurs infrequently in the *** is controversial whether it represents a low grade mesenchymal neoplasm or a reactive inflammatory *** recurrence and metastasis are rare and some tumors are associated with infectious *** report on a case of a large and partially resected IMT with local recurrence and diaphragm and kidney infiltration detected on routine surveillance two years ***,the tumor showed spindle cells without atypia,mitosis or necrotic areas in a myxoid and collagenized background with inflammatory *** the liver portal tracts,granulomatous lesions with viable eggs of Schistosoma mansoni were *** demonstrated spindle cells which were smooth-muscle actin and vimentin *** conclusion,this case points out that these histological patterns do not predict the aggressive biological behavior of the lesion.A reason for the recurrence and the infiltration may be incomplete tumor *** investigation is necessary in order to better clarify an infectious cause in some IMTs.

关键词： Inflammatory myofibroblastic tumor Liver Recurrence Schistosoma mansoni

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盐胁迫下耐盐砧木通过保持光合能力和库强提高嫁接辣椒的产量

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辣椒杂志 2016年第2期14卷 38-50页

作者： Consuelo Penella Marco Landi lucia Guidi Sergio G.Nebauer Elisa Pellegrini Alberto San Bautista Damiano Remorini Cristina Nali Salvador López-Galarza Angeles Calatayud 刘越(译) 孔秋生(译) 西班牙农业研究院园艺系西班牙瓦伦西亚比萨大学农业、食品与环境系意大利比萨巴伦西亚理工大学蔬菜生产系西班牙瓦伦西亚华中农业大学园艺林学学院

本研究通过两个试验评价了耐盐辣椒A25(Capsicum annuum L.)作为砧木的表现。第一个试验是在普通土壤条件下进行的田间试验,与商业辣椒品种Adige自根植株(A)相比,以A25为砧木的嫁接组合(A/A25)果实产量大大提高(75%),而脐腐病的发病率... 详细信息

本研究通过两个试验评价了耐盐辣椒A25(Capsicum annuum L.)作为砧木的表现。第一个试验是在普通土壤条件下进行的田间试验,与商业辣椒品种Adige自根植株(A)相比,以A25为砧木的嫁接组合(A/A25)果实产量大大提高(75%),而脐腐病的发病率明显降低(31%)。为深入研究该现象的作用机制,第二个试验于温室中80 mM NaCl处理14 d后,分别检测A和A/A25的长势、矿质成分分布、气体交换、叶绿素荧光参数、抗氧化系统和脯氨酸含量。与对照相比,盐胁迫显著抑制A的植株生长(叶片干质量下降40.6%),而对A/A25没有影响。A/A25与A的叶片及根的离子(Na^+和Cl^-)积累量相似。虽然超氧化物岐化酶、过氧化氢酶和抗坏血酸过氧化物酶的活性增强,非光化学淬灭增加,保护机制被激活,但A植株光合碳同化明显减少(45.6%),且丙二醛(mda)大量积累表明植株受到了盐胁迫的伤害。相反,A/A25具有发达的根系,能通过保持光合性能来保证接穗和根系在盐胁迫条件下的生长。在盐胁迫下,A/A25的过氧化氢酶和抗坏血酸过氧化物酶活性未发生改变,mda水平未显著升高,表明A/A25的氧化应激反应没有被激活。在该研究中,脯氨酸水平升高有利于保护由盐胁迫引起的酶稳定性伤害,保证植物的光合性能。以上结果表明,嫁接缓解了盐胁迫对光合作用的负面影响,维持了嫁接植株的长势,提高了商品产量。

关键词：抗氧化系统辣椒叶绿素荧光嫁接盐胁迫脯氨酸

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