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Diabetes, Allopathic and Alternative Methods (Kombucha) for Its Treatment

Journal of Diabetes Mellitus 2022年第4期12卷 187-203页

作者： Guillermo Nolasco-Rodríguez Laura Esmeralda Ordaz-Castro Esther Albarrán-Rodríguez lucia garcía-delgado Jacinto Bañuelos-Pineda Manuel Rosales-Cortés Department of Veterinary Medicine University Science Center Biological and Agricultural Zapopan Mexico

Introduction: Diabetes is a disease characterized by an increase in blood glucose due to disorders in insulin production, this disease is widely distributed throughout the world. Objective: to review and systematize the general information on diabetes, as well as the traditional treatments and the findings on kombucha as an alternative method. Method: the information retrieval technique or literature review was used on the topics of diabetes, allopathic methods, kombucha, preparation procedures, chemical and microbiological components and pharmacological effects of the drink. Results: Various sources of information were found that explain the definition of diabetes and its classification. it commonly presents in four ways depending on the signs, the common ones being type 1, associated with destruction of the β cells of the pancreas and mainly affects minors, and type 2, which is related to genetic and environmental problems and It affects people over 18 years of age, and less frequently gestational diabetes and MODY type. Traditional drugs such as sulfonylureas, glinides and biguanides, thiazolidinediones and α-glucosidase inhibitors are used to control this disease, or alternative therapies are used such as kombucha, a fermented beverage that has its origins in China and is spread worldwide by its beneficial effects in chronic degenerative diseases such as diabetes, due to its chemical and microbiological content. Conclusion: The information establishes important data on kombucha as one of the complementary alternatives for the treatment of diabetes.

关键词： Diabetes Mellitus Alternative Medicine Kombucha Traditional Medicine Pathophysiology of Diabetes

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Effect of Kombucha and Its Non-Polar Components on Morphological Aspects of the Pancreas of Diabetic Rats with Streptozotocin

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Open Journal of Veterinary Medicine 2022年第12期12卷 201-217页

作者： Guillermo Nolasco-Rodríguez Rubén González-Valadez lucia garcía-delgado Esther Albarrán-Rodríguez José Ricardo Cuellar-Pérez Jacinto Bañuelos-Pineda Manuel Rosales-Cortés University Center Biological and Agricultural Sciences University of Guadalajara Zapopan México Department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan México

Objective: to evaluate the protective effect of kombucha and its components not polar, in pancreas of diabetic rats treated with streptozotocin. Material and methods: ninety-six male Wistar rats of 120 to 170 g of PC were used;four groups of 24 animals were formed: control (GC), control treatment (GCTx), kombucha treatment (GTxK) and treatment with non-polar components of kombucha (GTxCNP). Diabetes was induced in the last three groups with an intraperitoneal injection of streptozotocin at a dose of 65 mg/kg BW. At the same time, treatment was started in the different groups;GC and GCTx groups were administered, orally, 1 ml of sterile saline solution;to the GTxK group 324 mg/kg of kombucha;and to GTxCNP 0.006 mg/kg of the non-polar components. For the histopathological study, pancreas samples were obtained on days 1, 7, 14 and 21 and fixed in formalin. They were processed with the histological technique, 5-micron-thick sections were made and stained with the hematoxylin-eosin technique. Finally, the number of islets of Langerhans per field observed with the 10x objective was quantified. The results were subjected to a one-way analysis of variance and Tukey’s test (p Results: Significant changes in the number of islets were observed in histological sections of the pancreas. The groups treated with streptozotocin showed a significant decrease in the number of islets 7 days after starting treatment;Likewise, their number was lower in the GCTx group compared to the GTxK and GTxCNP groups (p ≤ 0.05). At 14 and 21 days, the lowest number of islets was maintained, although only in the GCTx and GTxK groups (p ≤ 0.05). Streptozotocin is a drug that can be used in rats to induce an experimental model of diabetes with an effect that can last up to 21 days. Conclusions: This fermented beverage and its non-polar components can be a complementary treatment alternative for diabetes mellitus, since it prevents further damage to the β cells of the pancreas and the Islets of Langerh

关键词： Diabetes Kombucha Rats Streptozotocin Non-Polar Components of Kombucha

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Effect of a 5% Neem Solution on the Presence of Ticks in Cattle in Two Locations in Jalisco, Mexico

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Open Journal of Veterinary Medicine 2019年第12期9卷 185-193页

作者： Esther Albarrán-Rodríguez Paloma Del Rosario Del Real Quezada Manuel Rosales Cortés Guillermo Nolasco Rodríguez lucia garcía delgado Guillermo Ruíz Cano Héctor Marcelo Cruz Alba División de Ciencias Veterinarias Centro Universitario de Ciencias Biológicas y Agropecuarias Universidad de Guadalajara Jalisco Mexico Laboratorios DESPPO. S.A. de C.V. Tepatitlán de Morelos Jalisco México

The objective of this work was to evaluate the effect of a 5% neem extract on the presence of ticks. Forty creole cattle were used, divided into four groups: 2 experimental and 2 controls, in the towns of Cocula and El Chante, Jalisco. The tick count was by direct palpation, and with an acarometer (25 cm2). Eight body regions were evaluated: neck, thorax, flank and thigh, left and right. At zero time, after the initial tick count, it was applied by spraying and once, the 5% neem extract, at a dose of 10 ml/L. Ticks were quantified at 7, 14, 21, 28, 35 and 42 days post-treatment. The data were subjected to descriptive statistical analysis and Sum of Kruskal-Wallis Ranges (α = 0.05) (SigmaStat 3.1). In Cocula, at zero time, the average of ticks was in neck 32, in thorax 64, in flanks 96 and in thighs 129 (average per animal 323 ticks). In subsequent sampling, the average decreased in the experimental group to 1 or 4 parasites. In “El Chante”, an average of 60 ticks was found at the time of the neck, in the thorax 121, in flanks 181 and in thighs 242 (average per animal 600 ticks). In subsequent sampling, the average decreased in the experimental group, with averages of 1 to 4. Statistical differences (p ≤ 0.001) were found between the groups. It can be concluded that 5% neem extract has a repellent and tick effect in cattle for at least 42 days.

关键词： Tick Boophilus Neem Azadirachta indica Cattle

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Protective and Regenerative Effect of the Extract of Kombucha and the Fungus Ganoderma sichuanense on the Islets of Langerhans of Diabetic Rats

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Open Journal of Veterinary Medicine 2023年第10期13卷 173-185页

作者： Pedro Hinojosa-Gómez Sergio Fausto-Guerra Guillermo Nolasco-Rodríguez lucia garcía-delgado Víctor Barragán-Cano Manuel Rosales-Cortés Esther Albarrán-Rodríguez José Ricardo Cuéllar-Pérez Department of Veterinary Medicine University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico Doctorate of Sciences in Ecophysiology and Genetic Resources University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico Department of Botany and Zoology University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico

Objective: The present study consisted of challenging the extract of kombucha and the fungus Ganoderma reported as hypoglycemic and used as alternative treatments against diabetes on the number and morphology of islets of Langerhans. Material and Methods: 64 Wistar rats were used in 4 groups: one control, three experimental, streptozotocin, Kombucha y Ganoderma induced diabetes with streptozotocin. Divided into four post-induction stages at 2, 15, 30 and 45 days of treatment, sacrificing 4 rats at each stage, to perform the morphological analysis of the pancreas. Results: A decrease in the islets of Langerhans in size, volume and the number of cells within them was identified for the streptozotocin group from the second stage until almost disappearing due to diabetes, in the groups of Kombucha y Ganoderma the same was observed but they were recovered with the extract treatments and the average number of islets was similar in these groups, the group of Ganoderma. Conclusion: Under the conditions of this work, a protective and regenerative effect of both extracts is identified.

关键词： Rats Diabetes Streptozotocin Ganoderma Kombucha Pancreas

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GRP7 phase separation as an interpreter of temperature cues

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Molecular Plant 2024年第6期17卷 842-844页

作者： Sunita Pathak lucia C.Strader Department of Biology Duke UniversityDurhamNCUSA

Plants are exposed to a range of daily and seasonal temperatures and thus are required to regulate their cellular processes under fluctuating temperature *** various temperature-responsive genes,GLYCINE-RICH RNA BINDING PROTEIN7(GRP7)encodes a glycine-rich RNA-binding protein that provides freezing tolerance to plants(Carpenter et al.,1994;Kim et al.,2008)by acting as an RNA chaperone(Kwak et al.,2011).

关键词： conditions. separation

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Improving colorectal cancer screening programs

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World Journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar J Cordero lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World Journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

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A triangular architectural relation model among sustainability,beauty,and power

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Frontiers of Architectural Research 2024年第4期13卷 699-711页

作者： Ján Legény RobertŠpaček TomášHubinský lucia Benkovičová Faculty of Architecture and Design Slovak University of Technology in BratislavaBratislavaSlovakia

Sustainability,beauty,and power are notions that hit our contemporary perception every ***,they have been an integral part of architecture and urban planning in various forms since the *** paper presents their fundamental descriptions,followed by an assessment of their mutual relations and impact on architecture through a triangular architectural relation model developed by the authors of the *** the theoretical thought experiment,it highlights eight boundary models along with their main characteristics,in particular,the implosion,explosion,shared-control,utilitarian,no-control,supremacy,inside-forced,and outside-forced architectural related *** models can help predict future events,explain past events,make decisions,and plan strategies,or reveal problems and propose new *** applications include determination of the causes of certain results or finding out the responsibility and mechanisms that led to *** authors are of the opinion that the mutual denominator of sustainability,beauty,and power represents ethics that should be forced in architectural education and practice.

关键词： Triangular architectural relation model Sustainability Beauty Power Thought experiment Interpretation

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Familiar Ghosts:Imagining Lives,Re-imagining the Nation,Inventing the Future

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Journal of Foreign Languages and Cultures 2024年第1期8卷 31-47页

作者： lucia BOLDRINI University of London

This article focuses on novels that,located on the boundary between biography,autobiography and fiction,between detailed archival historical research and imagination,between the documentary and the speculative,seek to reconstruct the life of an ancestor of the writer-narrator to reflect on the traumas,exploitation,hopes,and desires of generations who,in their diasporas,also helped create their modern nations,or whose story challenges the exclusions on which the concept of the nation has been *** texts discussed are Melania Mazzucco's Vita,Vona Groarke's Hereafter:The Telling Life of Ellen O'Hara,Wu Ming 2 and Antar Mohamed's Timira:Romanzo Meticcio,and Maryse Conde's Victoire,les saveurs et les *** their center is the negotiation between the individual truth and the relational story across generations on the one hand,and,on the other hand,the tracing of collective histories such as those of nation,of colonization,of diaspora,of internal and external displacement,of rights and emancipation(the downtrodden,the poor,women,the migrant,the refugees),of the origins of dispossession and the permanence of its *** the core of the narratives is also the ghostliness of the erased(from history,from memory,from citizenship),the departed(in the sense of being dead and of having traveled away),and the in-between(generic:between the historical and documentary on the one hand,and the novelistic,the fable,fantasy on the other;geographical:between countries,between places,nationalities,national affiliations;historical:across generations;racial:the mestizo,the mulatto).It is,specifically,the biofictional imagination that enables these diasporic,transnational,transracial accounts to open up the possibility of a different,liberating future,by offering the space to imagine such a future,but also by recognizing,through its explicit acknowledgement of its recourse to fictionality,that it does not aim to construct a new myth to replace historical fact,but that it invites all

关键词： biofiction diaspora genealogical accounting ghosts life narratives national history transnationalism

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Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos Santos Gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health Sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGROUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05).CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

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Demystifying polyphosphate-accumulating organisms relevant to wastewater treatment: A review of their phylogeny, metabolism, and detection

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Environmental Science and Ecotechnology 2024年第5期21卷 1-16页

作者： lucia Ruiz-Haddad Muhammad Ali Mario Pronk Mark C.Mvan Loosdrecht Pascal E.Saikaly Environmental Science and Engineering Program Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Water Desalination and Reuse Center Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Department of Civil Structural&Environmental EngineeringTrinity College DublinThe University of DublinDublin2Ireland Department of Biotechnology Delft University of TechnologyDelft2629 HZthe Netherlands

Currently,the most cost-effective and efficient method for phosphorus(P)removal from wastewater is enhanced biological P removal(EPBR)via polyphosphate-accumulating organisms(PAOs).This study integrates a literature review with genomic analysis to uncover the phylogenetic and metabolic diversity of the relevant PAOs for wastewater *** findings highlight significant differences in the metabolic capabilities of PAOs relevant to wastewater ***,Candidatus Dechloromonas and Candidatus Accumulibacter can synthesize polyhydroxyalkanoates,possess specific enzymes for ATP production from polyphosphate,and have electrochemical transporters for acetate and *** contrast,Tetrasphaera,Candidatus Phosphoribacter,Knoellia,and Phycicoccus possess PolyP-glucokinase and electrochemical transporters for sugars/amino ***,this review explores various detection methods for polyphosphate and PAOs in activated sludge wastewater treatment ***,FISH-Raman spectroscopy emerges as one of the most advanced detection ***,this review provides critical insights into PAO research,underscoring the need for enhanced strategies in biological phosphorus removal.

关键词： Polyphosphate-accumulating organisms(PAOs) Enhanced biological phosphorus removal (EBPR)Tetrasphaera Ca.accumulibacter Ca.phosphoribacter Knoellia Phycicoccus

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