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Mitochondrial ROS and Aging:Understanding Exercise as a Preventive Tool

journal of Science in Sport and Exercise 2020年第1期2卷 15-24页

作者： Henver S.Brunetta Andrew M.Holwerda luc j.c.van loon Graham P.Holloway Department of Human Health and Nutritional Sciences University of GuelphGuelphON NIG 2W1Canada Department of Physiological Sciences Federal University of Santa CatarinaFlorianopolisBrazil Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical CentreMaastrichtThe Netherlands

Sarcopenia,which is characterized by reduction in muscle mass and strength,contributes to several age-related conditions,including insulin resistance and *** the importance of maintaining muscle mass for healthy aging,the mechanisms contributing to sarcopenia are not fully ***,mitochondria appear to play a key role in the underlying condition,and importantly,respond robustly to exercise *** are intracellular organelles largely attributed to maintaining ATP concentrations,however,the importance of this organelle in overall cellular homeostasis has been expanded in the last decades to include redox signaling,calcium homeostasis,inflammation,and *** lines of evidence suggest that mitochondrial bioenergetics are altered in aged skeletal muscle,resulting in an increase in reactive oxygen species(ROS)production,while conversely genetic/pharmacological approaches that attenuate mitochondrial ROS promote healthy aging and maintenance of muscle *** observations suggest that increased free radicals are one of the bases of the aging process and related ***,we reviewed the current knowledge regarding mitochondrial function and redox balance in aged human skeletal muscle,highlighting the implications of redox unbalance on skeletal muscle mass maintenance and muscle ***,we describe the benefits of exercise and nutrition interventions in the context of improving mitochondrial bioenergetics and functional outcomes regarding skeletal muscle mass and function.

关键词： Mitochondria Redox state Aging Sarcopenia.Exercise Nutrition

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Effects of pyrethroid and organophosphate insecticides on reared black soldier fly larvae(Hermetia illucens)

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Insect Science 2024年第3期31卷 817-834页

作者： Nathan Meijer Lisa Zoet Theo de Rijk Paul Zomer Deborah Rjkers H.j.van der Fels-Klerx joop j.A.van loon Wageningen Food Safety Research(WFSR) Part of Wageningen University and ResearchWageningenThe Netherlands Bestico B.V. Industrieweg 6Berkel en RodenrjsThe Netherlands Plant Sciences Group Laboratory of EntomologyWageningen UniversityWageningenTheNetherlands

Black soldier fly larvae(Hermetia illucens)receive growing interest as a potential alternative animal feed *** insects may be exposed to insecticide residues in the rearing *** study aimed to investigate the effects of six different pyrethroid and organophosphate insecticides on this insect species'*** toxicity of two"model"substances for each of these classes(cypermethrin;pirimiphosmethyl)was quantified,with and without the synergist piperonyl butoxide(PBO).critical effect doses corresponding to 10%yield(cED10)for cypermethrin(0.4 mg/kg)and pirimiphos-methyl(4.8 mg/kg)were *** addition of PBO to cypermethrin enhanced its relative potency with a factor *** data were compared against the relative toxicity of two analogue substances in each class(permethrin,deltamethrin;chlorpyrifosmethyl,malathion).Results suggest that exposure to concentrations complying with legal limits can cause significant reductions in *** to multiple substances at lower concentrations resulted in negative additive and synergistic *** the tested substances,deltamethrin was most toxic,causing 94%yield at 0.5 mg/*** results suggested that transfer of tested substances to the larval biomass was substance-and concentration-specific,but appeared to be correlated to reduced yields and the presence of *** of organophosphates was overall low(ct biomass(~0.01 mg/kg),high transfer may result in *** is recommended that rearing companies implement lower contractual thresholds,and that policymakers consider adjusting legally allowed maximum residue levels in insect feed.

关键词： feed insects pesticides rearing substrate

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Plant cell wall-mediated disease resistance:current understanding and future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina lucıa jorda Miguel Angel Torres Marina Martın-Dacal Diego jose Berlanga Patricia Fernandez-calvo Elena Gomez-Rubio Sonsoles Martın-Santamarıa centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(EcDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific EcD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,Nod/MYc factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their EcDs(LRR-MAL RKs),catharanthus roseus REcEPTOR-LIKE KINASE 1-LIKE group(crRLK1L)with Malectin-like domains in their EcDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

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Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions

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Virologica Sinica 2024年第1期39卷 123-133页

作者： Hongbo Guo Dan Liu Kuan Liu Yao Hou chunyang Li Qiudi Li Xiaohui Ding Monique M.A.Verstegen jikai Zhang Lingli Wang Yibo Ding Renxian Tang Xiucheng Pan Kuiyang Zheng luc j.Wvan der Laan Qiuwei Pan Wenshi Wang Department of Pathogen Biology and Immunology Jiangsu Key Laboratory of Immunity and MetabolismJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhou221004China Department of Gastroenterology and Hepatology Erasmus MC-University Medical CenterRotterdamNL-3015 CNthe Netherlands Department of Surgery Erasmus MC Transplant InstituteUniversity Medical CenterRotterdam3015CENL-3015 CNthe Netherlands Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical UniversityXuzhou221002China

Hepatitis E virus(HEV)infection can cause severe complications and high mortality,particularly in pregnant women,organ transplant recipients,individuals with pre-existing liver disease and immunosuppressed ***,there are still unmet needs for treating chronic HEV ***,we screened a best-in-class drug repurposing library consisting of 262 drugs/*** screening,we identified vidofludimus calcium and pyrazofurin as novel anti-HEV *** calcium is the next-generation dihydroorotate dehydrogenase(DHODH)inhibitor in the phase 3 pipeline to treat autoimmune diseases or SARS-coV-2 *** selectively targets uridine monophosphate synthetase(UMPS).Their anti-HEV effects were further investigated in a range of cell culture models and human liver organoids models with wild type HEV strains and ribavirin treatment failure-associated HEV ***,both drugs exhibited a sizeable therapeutic window against *** instance,the Ic50 value of vidofludimus calcium is 4.6–7.6-fold lower than the current therapeutic doses in ***,their anti-HEV mode of action depends on the blockage of pyrimidine ***,two drugs robustly inhibited ribavirin treatment failure-associated HEV mutants(Y1320H,G1634R).Their combination with IFN-αresulted in synergistic antiviral *** conclusion,we identified vidofludimus calcium and pyrazofurin as potent candidates for the treatment of HEV *** on their antiviral potency,and also the favorable safety profile identified in clinical studies,our study supports the initiation of clinical studies to repurpose these drugs for treating chronic hepatitis E.

关键词： Hepatitis Evirus(HEV) Drug repurposing Vidofludimus calcium Pyrazofurin Pyrimidine biosynthesis

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Geochemical,mineralogical,and petrological analyses for the interpretation of the sedimentary environment of the Middle-Late Ordovician Majiagou Formation(northern china)as a tool for more effective gas exploration

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Petroleum Science 2022年第6期19卷 2519-2532页

作者： jie Gao Da-Wei Lv A.j.(Tom) van loon Dun Wu Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and TechnologyQingdaoShandong266590China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyShandong266071China college of Earth Science and Engineering Shandong University of Science and TechnologyShandong266590China Exploration Research Institute Anhui Provincial Bureau of Coal GeologyHefeiAnhui230088China

core samples from the deeply buried Ordovician Majiagou Formation below the Huainan coalfield(E china) have been investigated for their carbonate types,major and trace elements(including rare earth elements) and c and O isotopes,The objective was to get a better insight into the possible occurrences of gas(and possibly oil) derived from carboniferous *** was found that the carbonates are dolomites with strongly varying amounts of caO and *** low concentrations of SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3)indicate deposition in a normal marine environment with little terrigenous input,The Na_(2)O/K_(2)O,Fe/Mn and Sr/Ba ratios,as well as the Ga values indicate mainly a marine salinity and a hot and humid *** slight depletion of ce and Eu,the depletion of heavy rare earth elements(HREE) and the enrichment of light rare earth elements(LREE) indicate deposition in a reducing *** thus appears that the Majiagou Formation below the Huainan coalfield closely resembles that in the eastern part of the Ordos Basin,where several gas reservoirs are present,so that the Majiagou Formation under the Huainan coalfield represents a promising target for hydrocarbon exploration.

关键词： Majiagou Formation Middle Ordovician Major-element analysis REE analysis Trace-element analysis Hydrocarbon exploration

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The control of Pleistocene palaeogeography on the distribution of sandy patches in a silty Holocene lagoon(central Netherlands)

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journal of Palaeogeography 2022年第4期11卷 565-583页

作者： Ai-Ping Fan A.j.(Tom)van loon Ren-chao Yang college of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoChina Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

The brackish lagoon in the central part of The Netherlands was closed by a dike in 1932 and gradually changed into a *** of this lake were reclaimed and the surficial sediments of one of the polders(Noordoostpolder),reclaimed in 1942,has been investigated in detail by mapping of the walls of some1500 km of drainage ditches approx.1.4 m *** appeared that the sediments consist of an uncommonly large amount of silt,to different degrees mixed with reworked peat that had developed during the Holocene *** sandy deposits occur locally,at places that are at first sight distributed in a haphazard *** various sandy patches have different characteristics(grain-size distribution,rounding of the grains,mineral composition).These sands cannot have been introduced from the sea,nor can they have been supplied by the rivers that discharged into the lagoon,so they must have a local *** is found that several types of Pleistocene sandy or diamictic deposits below the Holocene peat and lagoonal sediments had an irregular topography and became eroded during the Holocene by wave *** resulted in sandy deposits around these Pleistocene highs,which consisted of glacial tills(boulder clays),river dunes(formed by aeolian activity along rivers under dry permafrost conditions)and coversand ridges,formed by aeolian activity in a belt between the ice margin and the more distal loess *** finding implies that palaegeographical interpretations of local grain-size anomalies in a specific deposit should not only consider facies changes due to changes in the sediment supply,but should also consider local erosion leading to the exposure of previously deposited material with a divergent composition.

关键词： Lagoonal palaeogeography Netherlands Noordoostpolder Wave erosion Abrasion Holocene

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Lagoonal carbonate deposition preceding rifting-related uplift:evidence from the Bartonian-Priabonian(Eocene)of the northwestern Gulf of Suez(Egypt)

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journal of Palaeogeography 2022年第1期11卷 8-30页

作者： Emad S.Sallam Dmitry A.Ruban A.j.(Tom)van loon Department of Geology Faculty of ScienceBen ha UniversityFarid Nad a Street 15Ben ha 13518Egypt K.G.Razumovsky Moscow State University of Technologies and Management(the First cossack University) Zemlyanoy Val Street 73Moscow 109004Russia c college of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

Sedimentary successions in the northwestern Gulf of Suez provide important clues to the understanding of the geological evolution of NE Africa during the middle and late *** study focuses on detailed facies analyses in order to characterize the depositional environments and system tracts of the Bartonian-Priabonian succession cropping out in this ***-Priabonian carbonate deposits in five stratigraphic sections constitute,from base to top,the Gebel Hof,Observatory,Sannur,Qurn,and Wadi Hof *** formations contain four local assemblage zones of larger benthic *** of litho-,bio-,and microfacies in the succession resulted in the recognition of 12 lithofacies *** lithofacies are represented by packages of lime-mudstones,wackestones,packstones,pack-to grainstones,grainstones,rudstones,boundstones and *** lithofacies have been grouped into four geneticallyrelated facies associations that represent,respectively,tidal flats/shallow subtidal,restricted-shelf/lagoonal,shoal bar,and outer-shelf lagoon/reefal depositional environments in a downslope shallow-marine inner-ramp *** vertical transitions of these facies associations,representing facies changes through time,imply fluctuations of the regional sea *** two peaks in the Bartonian correspond to well-known global eustatic sea-level rises;the pronounced Priabonian regression must be ascribed to the known global eustatic sea-level fall in combination with regional tectonic *** facies distribution suggests that the study area was located in the direct vicinity of some islands during the Bartonian-Priabonian.

关键词： Lagoonal facies Sea-level fluctuations Middle Eocene Late Eocene Eastern Desert

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The impact of prehospital blood sampling on the emergency department process of patients with chest pain:a pragmatic non-randomized controlled trial

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World journal of Emergency Medicine 2023年第4期14卷 257-264页

作者： johan L.van Nieuwkerk M.christien van der Linden Rolf j.Verheul Merel van loon-van Gaalen Marije janmaat Naomi van der Linden Emergency Department Haaglanden Medical Centre&Emergency Medical Services Haaglandenthe Hague 2501 CBthe Netherlands Research and Development Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Laboratory Services Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Emergency Department Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Faculty of Health University of Applied Sciences LeidenLeiden 2300 AJthe Netherlands Faculty of Technology Policy and ManagementDelft University of TechnologyDelft 2628 BXthe Netherlands

BAcKGROUND:In patients with chest pain who arrive at the emergency department(ED)by ambulance,venous access is frequently established prehospital,and could be utilized to sample *** blood sampling may save time in the diagnostic *** this study,the association of prehospital blood draw with blood sample arrival times,troponin turnaround times,and ED length of stay(LOS),number of blood sample mix-ups and blood sample quality were ***:The study was conducted from October 1,2019 to February 29,*** patients who were transported to the ED with acute chest pain with low suspicion for acute coronary syndrome(AcS),outcomes were compared between cases,in whom prehospital blood draw was performed,and controls,in whom blood was drawn at the *** analyses were used to assess the association of prehospital blood draw with the time ***:Prehospital blood draw was performed in 100 *** 406 patients,blood draw was performed at the *** blood draw was independently associated with shorter blood sample arrival times,shorter troponin turnaround times and decreased LOS(Pces in the number of blood sample mix-ups and quality were observed(P>0.05).cONcLUSION:For patients with acute chest pain with low suspicion for AcS,prehospital blood sampling is associated with shorter time intervals,while there were no significant differences between the two groups in the validity of the blood samples.

关键词： Blood specimen collection crowding Emergency medical services Troponin

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Artificial intelligence for characterization of diminutive colorectal polyps:A feasibility study comparing two computer-aided diagnosis systems

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第1期5卷 11-22页

作者： Quirine Eunice Wennie van der Zander Ramon M Schreuder Ayla Thijssen carolus H j Kusters Nikoo Dehghani Thom Scheeve Bjorn Winkens Mirjam c M van der Ende-van loon Peter H N de With Fons van der Sommen Ad A M Masclee Erik j Schoon Department of Gastroenterology and Hepatology Maastricht University Medical CenterMaastricht 6202 AZNetherlands GROW School for Oncology and ReproductionMaastricht UniversityMaastricht 6200 MDNetherlands Division of Gastroenterology and Hepatology Catharina Hospital EindhovenEindhoven 5602 ZANetherlands Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBNetherlands Department of Methodology and Statistics Maastricht UniversityPostbus 6166200 MD MaastrichtNetherlands School for Public Health and Primary care Maastricht UniversityMaastricht 6200 MDNetherlands

BAcKGROUND Artificial intelligence(AI)has potential in the optical diagnosis of colorectal *** To evaluate the feasibility of the real-time use of the computer-aided diagnosis system(cADx)AI for coloRectal Polyps(AI4cRP)for the optical diagnosis of diminutive colorectal polyps and to compare the performance with cAD EYE^(TM)(Fujifilm,Tokyo,japan).cADx influence on the optical diagnosis of an expert endoscopist was also *** AI4cRP was developed in-house and cAD EYE was proprietary software provided by *** cADxsystems exploit convolutional neural *** polyps were characterized as benign or premalignant and histopathology was used as gold ***4cRP provided an objective assessment of its characterization by presenting a calibrated confidence characterization value(range 0.0-1.0).A predefined cut-off value of 0.6 was set with valuescating benign and values≥0.6 indicating premalignant colorectal *** confidence characterizations were defined as values 40%around the cut-off value of 0.6(0.76).Self-critical AI4cRP’s diagnostic performances excluded low confidence *** AI4cRP use was feasible and performed on 30 patients with 51 colorectal ***-critical AI4cRP,excluding 14 low confidence characterizations[27.5%(14/51)],had a diagnostic accuracy of 89.2%,sensitivity of 89.7%,and specificity of 87.5%,which was higher compared to *** EYE had a 83.7%diagnostic accuracy,74.2%sensitivity,and 100.0%*** performances of the endoscopist alone(before AI)increased nonsignificantly after reviewing the cADx characterizations of both AI4cRP and cAD EYE(AI-assisted endoscopist).Diagnostic performances of the AI-assisted endoscopist were higher compared to both cADx-systems,except for specificity for which cAD EYE performed *** Real-time use of AI4cRP was *** confidence values provided by a cADx is novel and self-critical AI4cRP sho

关键词： Artificial intelligence colorectal polyp characterization computer aided diagnosis Diminutive colorectal polyps Optical diagnosis Self-critical artificial intelligence

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Palaeogeographical development of two merging delta systems(Eocene Shahejie Formation)in the Bohai Bay Basin,E china and implications for hydrocarbon exploration

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journal of Palaeogeography 2023年第4期12卷 564-586页

作者： Ren-chao Yang Yang Li Ai-Ping Fan A.j.van loon(Tom) jin Li Zuo-Zhen Han jie chen Shandong Provincial Key Laboratory of Depositional Mineralization&Sedimentary Minerals Shandong University of Science and TechnologyQingdao 266590China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China Department of Resource Science and Engineering Shandong Institute of Petroleum and Chemical TechnologyDongying 257061China

Two deltas developed simultaneously during the Eocene on the eastern side of a large lake that existed in the Dongying Sub-basin,which forms part of the Bohai Bay Basin in eastern *** rivers that built the deltas had different catchment areas,which resulted in sediments with different permeability and porosity,due to differences in sorting and mud *** deltas prograded,and mass flows that originated frequently on their fronts formed lobes that expanded *** eventually led to merging of both deltas,a feature that has rarely been described from ancient deposits thus *** analysis and seismic reflection data show that the merging of the two deltas took place in nine phases,determined by phases of slower progradation or even temporary retrogradation in *** alternation of sediments from both deltas and their eventual mixing makes the architecture of the merged deltas much more complex than that of'classical'single *** affects the predictability of the spatial distribution of possible reservoir characteristics significantly,but detailed core analysis shows that the best hydrocarbon reservoirs consist of sand bodies formed in distributary channels on the delta plains,and of sandy turbidites formed in the deep-lacustrine environment in front of the merged deltas.

关键词： Delta development Merging deltas Palaeogeography Bohai Bay Basin Lacustrine environment Eocene Hydrocarbon exploration

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