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Maternal and neonatal blood vitamin D status and neurodevelopment at 24 months of age:a prospective birth cohort study

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World Journal of Pediatrics 2023年第9期19卷 883-893页

作者： Yue Zhang Chun-Yan Zhou Xi-Rui Wang Xian-Ting Jiao Jun Zhang Ying Tian luan-luan li Chen Chen Xiao-Dan Yu Department of Developmental and Behavioral Pediatrics Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China MOE-Shanghai Key Lab of Children’s Environmental Health Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Background This study aimed to explore the relationship of 25-hydroxyvitamin D[25(OH)D]in three trimesters and at birth with neurodevelopment at 24 months of *** From 2013 to 2016,pregnant women from the Shanghai Birth Cohort in China were recruited for the ***,649 mother-infant pairs were *** 25(OH)D was measured with mass spectrometry in three trimesters,and cord blood was divided into deficiency(<20 and<12 ng/mL,respectively),insufficiency(20–30 and 12–20 ng/mL,respectively),and sufficiency(≥30 and≥20 ng/mL,respectively).Bayley-III scale was used to assess cognitive,language,motor,social-emotional,and adaptive behavior development at 24 months of *** Bayley-III scores were grouped into quartiles,and scores within the lowest quartile were defined as suboptimal *** After adjusting for confounding factors,cord blood 25(OH)D in the sufficient group was positively correlated with cognitive[β=11.43,95%confidence interval(CI)=5.65–17.22],language(β=6.01,95%CI=1.67–10.3),and motor scores(β=6.43,95%CI=1.73–11.1);cord blood 25(OH)D in the insufficient group was also positively correlated with cognitive scores(β=9.42,95%CI=3.74–15.11).Additionally,sufficient vitamin D status in the four periods and persistent 25(OH)D≥30 ng/mL throughout pregnancy were associated with a lower risk of suboptimal cognitive development in adjusted models,although the effects were attenuated after applying the false discovery rate *** Cord blood 25(OH)D≥12 ng/mL has a significant positive association with cognitive,language,and motor development at 24 months of *** vitamin D status in pregnancy might be a protective factor for suboptimal neurocognition development at 24 months of age.

关键词： 25-hydroxyvitamin D Children’s neurodevelopment Cord blood Maternal vitamin D status

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The Cyclophilin AtCYP71 Interacts with CAF-1 and LHP1 and Functions in Multiple Chromatin Remodeling Processes

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Molecular Plant 2011年第4期4卷 748-758页

作者： Hong li Sheng luan Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA

Chromatin is the primary carrier of epigenetic information in higher eukaryotes. AtCYP71 contains both cyclophilin domain and WD40 repeats. Loss of AtCYP71 function causes drastic pleiotropic phenotypic defects. Here, we show that AtCYP71 physically interacts with FAS1 and LHP1, respectively, to modulate their distribution on chromatin. The Ihpl cyp71 double mutant showed more severe phenotypes than the single mutants, suggesting that AtCYP71 and LHP1 synergistically control plant development. Such synergism was in part illustrated by the observation that LHP1 association with its specific target loci requires AtCYP71 function. We also demonstrate that AtCYP71 physically interacts with FAS1 and is indispensable for FAS1 targeting to the KNAT1 locus. Together, our data suggest that AtCYP71 is involved in fundamental processes of chromatin assembly and histone modification in plants.

关键词： Arabidopsis cyclophilin like heterochromatin protein 1 histone mark chromatin assembly factor Chromatin Immunoprecipitation.

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Chitosan Obtained from Cell Wall of Aspergillus Niger Mycelium

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Chemical Research in Chinese Universities 2004年第2期20卷 156-158页

作者： HUANGHui-li liNWen-luan liNJian-ming CollegeofMaterialsScienceandEngineering HuaqiaoUniversityQuanzhouP.R.China

Chitin from cell walls of Aspergillus Niger mycelium was prepared. A new method for the preparation of high deacetylation degree chitosan was studied in a dilute sodium hydroxide solution at a high pressure. The experimental results indicate that the deacetylation degree of the chitosan can reach 80% under the condition of a 5.00 mol/L sodium hydroxide solution at 0.1 MPa of pressure for 1 h. This method shows the advantages of the applications in the industry production and environment protection.

关键词： Aspergillus Niger Chitosan Deacetylation degree

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Effects of rare earth elements on inclusions and impact toughness of high-carbon chromium bearing steel

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Journal of Materials Science & Technology 2019年第7期35卷 1298-1308页

作者： Chaoyun Yang Yikun luan Dianzhong li Yiyi li Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

High-carbon chromium bearing steels with different rare earth (RE) contents were prepared to investigate the effects of RE on inclusions and impact toughness by different techniques. The results showed that RE addition could modify irregular Al2O3 and MnS into regular RE inclusions. With the increase of RE content, the reaction sequence of RE and potential inclusion forming elements should be O, S, As, P and C successively. RE inclusions containing C might precipitate in molten steel and solid state, but the precipitation tem perature was significantly higher than that of carbides in high-carbon chromium bearing steel. For experim ental bearing steels, the volume fraction of inclusions increased steadily with the increase of RE content, but smaller and more dispersed inclusions could be obtained by 0.018% RE content compared with bearing steel without RE, whereas the continuous increase of RE content led to an increasing trend for inclusion size and a gradual deterioration for inclusion distribution. RE addition could improve the transverse impact toughness and isotropy of bearing steel, and for modified highcarbon chrom ium bearing steel by RE alloying, the increase of RE content continuously increased both transverse and longitudinal im pact toughness until excessive RE addition.

关键词： High-carbon chromium bearing steel Rare earth Inclusions Impact toughness

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Bimetallic anchoring catalysis for C–H and C–C activation

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Science China Chemistry 2021年第11期64卷 1923-1937页

作者： Jiang-Fei li Yu-Xin luan Mengchun Ye State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryFrontiers Science Center for New Organic MatterNankai UniversityTianjin300071China

Following the age of directing group,anchoring catalysis starts coming to the center of the *** from the directinggroup strategy that needs a preinstalled directing group in substrates,anchoring catalysis relies on a reversible interaction between a substrate and a catalyst,which then directs metal to activate inert chemical *** reversible directing effect not only generates good site-and stereo-selectivity as traditional directing groups do but also eliminates the requirement of stoichiometric amounts of directing *** variously reported anchoring catalysis,coordinative bimetallic anchoring catalysis in general displays superior reactivity than others because coordinative bonding not only affords strong interaction of catalysts with substrates but also displays good compatibility with substrates and reaction *** recent years,big progress has been achieved for coordinative bimetallic anchoring *** review gave a detailed summary of this field,including catalyst development,catalyst types,reaction types and reaction mechanisms.

关键词： C–H activation C–C activation bimetallic catalysis enantioselective anchoring catalysis

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Progress on the Fault Diagnosis Approach for lithium-ion Battery Systems:Advances,Challenges,and Prospects

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Protection and Control of Modern Power Systems 2024年第5期9卷 16-41页

作者： Hanxiao liu luan Zhang liwei li School of Control Science and Engineering Shandong UniversityJinan 250061China School of Computer Science and Technology Shandong UniversityQingdao 266237China

Because of their advantages of high energy and power density,low self-discharge rate,and long lifespan,lithium-ion batteries(liBs)have been widely used in many applications such as electric vehicles,energy storage systems,smart grids,***,lithium-ion battery systems(liBSs)frequently malfunction because of complex working conditions,harsh operating environment,battery inconsistency,and inherent defects in battery ***,safety of liBSs has become a prominent problem and has attracted wide ***,efficient and accurate fault diagnosis for liBs is very *** paper provides a comprehensive review of the latest research progress in fault diagnosis for ***,the types of battery faults are comprehensively introduced and the characteristics of each fault are ***,the fault diagnosis methods are systematically elaborated,including model-based,data processing-based,machine learning-based and knowledge-based *** latest research is discussed and existing issues and challenges are presented,while future developments are also *** aim is to promote further researches into efficient and advanced fault diagnosis methods for more reliable and safer liBs.

关键词： Battery management system battery safety fault diagnosis lithiumion battery system

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凡纳对虾parkin共调基因和parkin在抗白斑综合征病毒中的表达分析和SNP开发

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渔业科学进展 2025年第1期46卷 194-209页

作者：薛倩李旭鹏李洋栾生罗坤孔杰邢群孟宪红浙江海洋大学水产学院浙江舟山316021 海水养殖生物育种与可持续产出全国重点实验室中国水产科学研究院黄海水产研究所山东青岛266071 青岛海洋科技中心海洋渔业科学与食物产出过程功能实验室山东青岛266237 邦普种业科技有限公司山东潍坊261311

本实验室前期研究中基于全基因组关联分析(GWAS)方法筛选到抗白斑综合征病毒(WSSV)候选基因:parkin共调基因(PACRG)。PACRG与帕金森病相关基因parkin共用一个双向启动子,二者共同参与细胞自噬过程,从而在细胞保护方面发挥作用。本研究... 详细信息

本实验室前期研究中基于全基因组关联分析(GWAS)方法筛选到抗白斑综合征病毒(WSSV)候选基因:parkin共调基因(PACRG)。PACRG与帕金森病相关基因parkin共用一个双向启动子,二者共同参与细胞自噬过程,从而在细胞保护方面发挥作用。本研究对凡纳对虾(Penaeus vannamei)PACRG和parkin在抗WSSV中的功能进行探讨,对其mRNA和氨基酸序列进行特征分析,利用real-timePCR技术检测对虾感染WSSV后不同时间、不同组织中PACRG和parkin的表达水平。通过荧光原位杂交技术(FISH)进行空间定位。利用PCR和Sanger测序技术获得单核苷酸多态性位点(SNP)并进行抗WSSV的关联分析。结果显示,PACRG开放阅读框(ORF)全长600bp,编码199个氨基酸,预测包含一个ParcG结构域。parkinORF序列全长1653bp,编码550个氨基酸,预测包含UBQ、IBR结构域和一个信号肽结构。与多物种进行同源序列比对发现,凡纳对虾PACRG氨基酸序列与日本对虾(Penaeus japonicus)的同源性高达89.70%;凡纳对虾parkin氨基酸序列与中国对虾(Penaeus chinensis)和斑节对虾(Penaeus monodon)的同源性高达93.45%。PACRG和parkin蛋白的保守性较高。感染WSSV后,PACRG和parkin在对虾肝胰腺、鳃、肌肉和眼柄中的表达水平发生显著变化,其中,眼柄中PACRG和parkin表现出极相似的组织表达模式。在肌肉中,PACRGmRNA和WSSV在空间位置上呈现高度重叠状态。结合上述结果,推测PACRG和parkin在凡纳对虾与WSSV的互作中发挥功能。在PACRG中筛选到2个SNP位点,在parkin中筛选到15个SNP位点,其中位于parkin非翻译区(UTR)的5个SNP位点与抗WSSV性状显著相关。本文为研究凡纳对虾抗WSSV的分子机制和抗病分子育种提供了理论依据和参考数据。

关键词：凡纳对虾白斑综合征病毒(WSSV) parkin共调基因(PACRG) parkin基因 SNP

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A Critical Review of Real Gas Effects on the Regenerative Refrigerators

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Journal of Thermal Science 2021年第3期30卷 782-806页

作者： CAO Qiang luan Mingkai li Peng WEI li WU Yan Institute of Refrigeration and Cryogenics School of Mechanical EngineeringTongji UniversityShanghai 201804China Shanghai Key Laboratory of Vehicle Aerodynamics and Vehicle Thermal Management Systems Tongji UniversityShanghai 201804China Department of Electrical Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201804China

The regenerative refrigeration is an important reverse work-heat conversion cycle with a theoretical coefficient of performance(COP)identical to the Carnot *** regenerative refrigerators are capable of working down to 4 K and largely fulfill the refrigeration requirement of modern technologies in many fields,especially for space ***,the enthalpy flow associated with the pressure dependence,abbreviated as pressure-induced enthalpy flow,brought about by real gas effects degrades the theoretical COP of the refrigerator to below about 30% of the Carnot efficiency at the temperatures of below the critical *** paper reviews the long history of exploring the real gas effects which dates back to the 1970 s and continues to *** explorations of uncovering the loss mechanism and reducing such losses are *** theories that are in accordance with experimental results and simulation results are *** further carry out analyses on the expansion components,including the pulse tube and the clearance *** inferences are made in order to explore the long-lasting puzzles about real gas *** is emphasized that the underlying cause of the loss in the regenerator is an indirect effect of the real gas *** study about carrying out a direct verification of the theory is proposed.

关键词： real gas effects regenerative refrigerators loss mechanism reduction methods

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Thermal Annealing and Graphene Modification of Exfoliated Hydrogen Titanate Nanosheets for Enhanced lithium-ion Intercalation Properties

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Journal of Materials Science & Technology 2014年第9期30卷 839-846页

作者： Xinning luan Ying Wang Department of Mechanical and Industrial Engineering Louisiana State UniversityBaton Rouge LA 70803 USA

Hydrogen titanate has been considered as a promising lithium intercalation material due to its unique layered structure. In the present work, we fabricate 2D graphene/hydrogen titanate hybrid nanosheets for application as anode materials in lithium-ion batteries. H2Ti307 nanosheets are synthesized by exfoliation of a layered precursor via interacting bulky tetrabutylammonium （TBA＋） cations, followed by ion exchange with Na＋ ions and washing with water. The as-prepared hydrogen titanate nanosheets are well-dispersed exhibiting ultra-thin thickness with a lateral size up to a few micrometers. The sample is then annealed at 450, 650 Rnd 850 ℃, to optimize its li＋-intercalation property. Heating at 450 ℃ leads to well-crystallized hydrogen titanate with a trace amount of TiO2. Heating at 650 and 850 ℃ results in mixed sodium titanates, since some sodium ions in the interlayer structure cannot be washed away and become chemically bonded to [TiO6] octahedra at high temperatures. Electrochemical properties of all the four samples are then evaluated by charged/discharged for 100 electrochemical cycles at 0.01-2.5 V vs. li＋/li at a specific current of 170 mA g-1. The unannealed hydrogen titanate delivers the highest initial discharge capacity of 130.5 mA h g-l, higher than 124.6 mA h g-1 from hydrogen titanate annealed at 450 ℃, as well as 101.3 and 63.8 mA h g-1 from hydrogen titanate annealed at 650 and 850℃, respectively, due to the high surface area from well-dispersed unannealed nanosheets. However, after 100 electrochemical cycles, well-crystallized hydrogen titanate annealed at 450 ℃ retain the highest charge capacity of 115.2 mA h g-1, corresponding to a capacity retention of 92.5%, while unannealed hydrogen titanate exhibits a final capacity of 72.1 mA h g-1 and a capacity retention of only 55.2%. To further improve energy density of lithium-ion battery, graphene/hydrogen titanate hybrid nanosheets are fabricated by adding graphene nanosheets into hydrogen titanates

关键词： Hydrogen titanate Sodium titanate Graphene nanosheets Exfoliation process lithium-ion battery

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Cutting of Graphite at Atomic and Close-to-Atomic Scale Using Flexible Enhanced Molecular Dynamics

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Nanomanufacturing and Metrology 2022年第3期5卷 240-249页

作者： Jinshi Wang Fengzhou Fang luan li State Key Laboratory of Precision Measuring Technology and Instruments Laboratory of Micro/Nano Manufacturing Technology(MNMT)Tianjin UniversityTianjin 300072China Centreof Micro/Nano Manufacturing Technology(MNMT-Dublin) University College DublinDublin 4Ireland

Atomic and close-to-atomic scale manufacturing is the key technology for the production of next-generation devices with atomic *** an important approach of mechanical processing,cutting has evolved as a potential candidate to generate an atomically smooth surface;thus,exploring its ultimate capability is *** this paper,single-crystal graphite,whose lattice structure and chemical bond property are of representation for demonstration,is selected to study the mechanism of atomic layer removal using molecular dynamics.A localized workpiece,which is dynamically updated on the basis of the tool position,is used to improve the computation *** principle and bullet points of this modeling method are first introduced,followed by a series of simulations under various undeformed chip thicknesses and tool edge *** addition,different potentials for the tool-workpiece interaction are tested,and the effect on the material response is *** on the analysis of deformation,the number of carbon layers removed,and cutting forces,the chip formation mechanism and further understanding of the controllability of cutting at atomic and close-to-atomic scale can be achieved.

关键词： Atomic and close-to-atomic scale Cutting Enhanced molecular dynamics Graphite ACSM

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