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企业金融化对企业创新的影响

江苏商论 2025年第1期 91-96页

作者：罗敏昆明理工大学云南昆明650504

随着经济发展进入高质量发展阶段,引导企业“脱虚向实”,创新升级已然是一个重要的关注点。本文基于2007—2022年中国A股制造业企业数据,实证探究了企业金融化对企业创新的影响效应及高管金融背景、外部环境不确定性在两者间的调节效应... 详细信息

随着经济发展进入高质量发展阶段,引导企业“脱虚向实”,创新升级已然是一个重要的关注点。本文基于2007—2022年中国A股制造业企业数据,实证探究了企业金融化对企业创新的影响效应及高管金融背景、外部环境不确定性在两者间的调节效应。研究认为,适当投资能够促进企业创新,过度的金融化会抑制企业创新。该结论在经过更换模型、倾向得分匹配两个稳健性检验后依旧成立。调节效应显示,高管金融背景能够弱化两者间的倒U关系,而环境不确定性发挥正向调节作用。本文为探究企业金融化与企业创新的关系提供了丰富的经验证据,对为企业创新配置金融资产,提供稳定现金流环境,合理进行金融投资具有重要的实践启示。

关键词：企业金融化企业创新倒U型关系

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换热管与管板连接有限元分析

当代化工 2018年第12期47卷 2630-2633页

作者：罗惠敏谢阳紫王蕾张舒中国石油集团东北炼化工程有限公司沈阳分公司辽宁沈阳110167

使用ANSYS有限元模拟软件,通过计算确定高温工况下换热管液压胀接压力对换热管和管板连接处密封性能的影响,并给出其相互间的关系曲线。为预防换热器在换热管同管板连接处发生泄漏提供一种计算方法,为换热器的设计提供一定的参考。

关键词：有限元胀接压力开槽尺寸密封

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian luo Chuanhui Xu Linxi Li Yunxiang Ji Yezhong Wang Yingjia Li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Distributed fiber optic sensing system for vibration monitoring of 3D printed bridges

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Optoelectronics Letters 2025年第1期21卷 28-34页

作者： ZHAO Shuai ZHOU Ran luo mingming LIU Jianfei LIU Xiongfei ZHOU Tao School of Electronic Information Engineering Hebei University of Technology Tianjin Key Laboratory of Electronic Materials and Devices School of Civil Engineering and Transportation Hebei University of Technology Tianjin Jinhang Institute of Technical Physics

The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities, including design, construction, and maintenance of bridges, tunnels, ports and other infrastructures. In this paper, a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment, covering a vibration frequency from 5 Hz to 25 kHz. The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state, windblown disturbance, and walking vibration. Moreover, the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences, respectively. The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge, which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.

关键词： Spinning (fibers)

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椭圆封头—筒体结构可靠性设计公式推导

当代化工 2019年第8期48卷 1894-1897页

作者：罗惠敏杨溪荣韦权权中国石油集团东北炼化工程有限公司沈阳分公司

依据国际安全联合委员会(JCSS)推荐使用的由拉克维茨等出的JC法(可靠度计算方法)和第四强度理论,推导了压力容器椭圆封头和薄壁圆形筒体的可靠度计算公式。采用ANSYS中蒙特卡洛可靠度计算方法对上述公式的正确性进行了验证,同时分析了... 详细信息

依据国际安全联合委员会(JCSS)推荐使用的由拉克维茨等出的JC法(可靠度计算方法)和第四强度理论,推导了压力容器椭圆封头和薄壁圆形筒体的可靠度计算公式。采用ANSYS中蒙特卡洛可靠度计算方法对上述公式的正确性进行了验证,同时分析了对结构可靠度影响较大的因素。以上研究为压力容器的可靠性分析提供了一定的参考。

关键词： JC法可靠度分析蒙特卡洛压力容器