检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

中药配位化学研究进展

中国中药杂志 2006年第16期31卷 1309-1313页

作者：李英华吕秀阳刘霄柳叶浙江大学制药工程研究所浙江杭州310027

从中药毒理学和药理学、中药功效成分的改进以及中药功效成分的分离制备和鉴定3个方面论述了中药配位学说在中药研究领域中的重要意义,并列举了中药配位研究领域常用的技术。指出中药配位热力学和动力学的研究、中药中微量元素的存在状... 详细信息

从中药毒理学和药理学、中药功效成分的改进以及中药功效成分的分离制备和鉴定3个方面论述了中药配位学说在中药研究领域中的重要意义,并列举了中药配位研究领域常用的技术。指出中药配位热力学和动力学的研究、中药中微量元素的存在状态与药效和毒性关系的研究、利用配位作用开发高效分离吸附剂或者高效分离色谱柱、利用有机成分与某些金属或微量元素生成有色配合物的特性开发高灵敏度的分析方法可能成为中药现代化研究过程中的热点和关键。

关键词：配位化学中药

Xiangshao Granules Ameliorate Post-stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2025年第1期31卷 28-38页

作者： LI Cheng-gang XU lu-shan SUN Liang XU Yu-hao CAO Xiang ZHAO Chen-chen XIA Sheng-nan ZHANG Qing-xiu XU Yun Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Objective To investigate the therapeutic effect of Xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),and PSD+XSG(n=14)groups according to a random number *** PSD models were constructed using chronic unpredictable mild stress(CUMS)after middle cerebral artery occlusion(MCAO).The sham group only experienced the same surgical operation,but without MACO and CUMS *** XSG group received XSG(60 mg/kg per day)by gavage for 4 *** mice in the sham and vehicle groups were given the same volume of 0.9%saline at the same *** body weight and behavior tests including open field test,sucrose preference test,tail suspension test,and elevated plus-maze test,were used to validate the PSD mouse ***-time fluorescence quantitative polymerase chain reaction(RT-qPCR),enzyme-linked immunosorbent assay(ELISA),and immunofluorescence staining were used to evaluate the anti-inflammatory effects of *** potential molecular mechanisms were explored and verified through network pharmacology analysis,Nissl staining,Western blot,ELISA,and RT-qPCR,*** The body weight and behavior tests showed that MCAO combined with CUMS successfully established the PSD *** alleviated neuronal damage,reduced the expressions of pro-apoptotic proteins Caspase-3 and B-cell lymphoma-2(BCL-2)-associated X(BAX),and increased the expression of anti-apoptotic protein BCL-2 in PSD mice(Pluding tumor necrosis factor-α,interleukin(IL)-1β,and IL-6 via the toll-like receptor 4/nuclear factor kappa-B signaling pathway in PSD mice(Plusion XSG could reverse

关键词： post-stroke depression Xiangshao Granules indoleamine 2,3-dioxygenase 1 Chinese medicine

Unveiling expression patterns,mechanisms,and therapeutic opportunities of transmembrane protein 106C:From pan-cancers to hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第2期17卷 144-162页

作者： Jian-Di Li Rong-Quan He Yi-Wu Dang Zhi-Guang Huang Dan-Dan Xiong lu Zhang xiu-Fang Du Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Although transmembrane protein 106C(TMEM106C)has been elucidated to be overexpressed in cancers,its underlying mechanisms have not yet been fully *** To investigate the expression levels and molecular mechanisms of TMEM106C across 34 different cancer types,including liver hepatocellular carcinoma(LIHC).METHODS We analyzed TMEM106C expression patterns in pan-cancers using microenvironment cell populations counter to evaluate its association with the tumor *** set enrichment analysis was conducted to identify molecular pathways related to *** immunoprecipitation followed by sequencing(ChIP-seq)analysis was conducted to identify upstream transcriptional regulators of *** LIHC,we examined mRNA profiles,performed in-house quantitative polymerase chain reaction,immunohistochemistry,and constructed a co-expression gene *** assays,including cell counting kit-8,cell cycle,apoptosis,migration,and invasion,were *** effect of nitidine chloride(NC)on LIHC xenograft was evaluated through RNA sequencing and molecular ***,potential therapeutic agents targeting TMEM106C were *** TMEM106C was significantly overexpressed in 27 different cancer types and presaged poor prognosis in four of these types,including *** pan-cancers,TMEM106C was inversely correlated to the abundances of immune and stromal ***,TMEM106C was significantly linked to cell cycle and DNA replication pathways in ***-seq analysis predicted CCCTC-binding factor as a pivotal transcriptional factor targeting the TMEM106C gene in *** analysis showed that TMEM106C was upregulated in 4657 LIHC compared with 3652 normal liver tissue[combined standardized mean difference=1.31(1.09,1.52)].Inhouse LIHC samples verified the expression status of *** TMEM106C expression signified worse survival conditions in LIHC patients treated with sorafenib,a tyrosin

关键词： Transmembrane protein 106C Pan-cancers Liver hepatocellular carcinoma Molecular biology Nitidine chloride

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

藜芦混碱与芍药苷配伍引起的化学反应研究

中国现代应用药学 2005年第z1期22卷 613-615页

作者：潘浪胜吕秀阳吴平东浙江大学材料与化工学院制药工程研究所浙江杭州310027 湘潭大学化工学院湖南湘潭411105

目的研究藜芦混碱与芍药苷配伍引起的化学反应。方法藜芦混碱与芍药苷单独和按不同比例配伍,在70℃下加热4.5 h。在优化的RP-HPLC条件下进行分析,比较色谱指纹图谱,考察组分相对峰面积变化和配伍比例之间的关系。结果配伍后veratridine... 详细信息

目的研究藜芦混碱与芍药苷配伍引起的化学反应。方法藜芦混碱与芍药苷单独和按不同比例配伍,在70℃下加热4.5 h。在优化的RP-HPLC条件下进行分析,比较色谱指纹图谱,考察组分相对峰面积变化和配伍比例之间的关系。结果配伍后veratridine和芍药苷的相对峰面积下降;检出4个新色谱峰。结论藜芦混碱与芍药苷配伍引起了化学反应。

关键词：藜芦混碱芍药苷药对配伍化学反应

基于内嵌钴/氮掺杂多孔碳三维石墨烯笼的抗团聚高效氧还原电催化剂

在线全文

学校读者我要写书评

暂无评论

电化学 2018年第6期24卷 715-725页

作者：修陆洋于梦舟杨鹏举王治宇邱介山精细化工国家重点实验室辽宁省能源材料化工重点实验室大连理工大学化工学院辽宁大连116024

氧还原反应是决定燃料电池、金属-空气电池等多种新型清洁能源存储与转化技术之性能与应用的关键反应.铂及其合金是目前催化活性最好的氧还原反应催化剂,但其高昂的成本限制了规模化应用.在小尺寸效应作用下,微纳米结构催化剂颗粒在电... 详细信息

氧还原反应是决定燃料电池、金属-空气电池等多种新型清洁能源存储与转化技术之性能与应用的关键反应.铂及其合金是目前催化活性最好的氧还原反应催化剂,但其高昂的成本限制了规模化应用.在小尺寸效应作用下,微纳米结构催化剂颗粒在电极制备与电化学反应过程中的团聚限制了催化剂本征催化活性的充分发挥.本文基于喷雾热解技术,发展了一种基于内嵌钴/氮掺杂多孔碳三维石墨烯笼的高活性、抗团聚非贵金属氧还原反应催化剂.此结构中,金属有机骨架化合物ZIF-67衍生的钴/氮掺杂多孔碳纳米结构是催化氧还原反应的活性中心,包覆其外的三维石墨烯笼不仅可在钴/氮掺杂碳纳米结构之间构建连续的三维载流子传导网络,且可高效抑制其在催化剂制备与电化学反应过程中的团聚与活性损失.在碱性电解液中,此类非贵金属催化剂表现出可与铂基催化剂媲美的氧还原反应活性和优异的稳定性.

关键词：氧还原反应电催化剂钴/氮掺杂碳三维石墨烯喷雾干燥

基于Laguerre的多组分稀土萃取分布式模型预测控制

在线全文

学校读者我要写书评

暂无评论

控制与决策 2025年第03期40卷 1005-1014页

作者：朱建勇张琳陆荣秀杨辉华东交通大学电气与自动化工程学院江西省先进控制与优化重点实验室

针对多级子工艺稀土萃取生产采用人工根据经验逐级调药的方式,容易导致人工循环调药、生产指标波动大的问题,提出一种基于Laguerre函数的分布式模型预测控制方法调节药剂量.首先,基于多稀土组分萃取机理建立具有串联结构的分布式状态空... 详细信息

针对多级子工艺稀土萃取生产采用人工根据经验逐级调药的方式,容易导致人工循环调药、生产指标波动大的问题,提出一种基于Laguerre函数的分布式模型预测控制方法调节药剂量.首先,基于多稀土组分萃取机理建立具有串联结构的分布式状态空间方程,拓展成嵌有积分器的增广状态空间模型;其次,利用多组分稀土萃取中各级子工艺仅与其上游子工艺存在耦合的特点,构造一种具有输入约束的非迭代递阶求解分布式药剂量目标优化函数;由于采用较大的预测时域能够实现更高的控制精度,但会急剧增大其计算量,为此,利用Laguerre函数表示控制增量,将原目标函数转化为含有Laguerre系数的目标函数,并利用二次规划进行求解.这种方法使得计算量与预测时域无关,而仅与Laguerre函数的系数数量有关,不会随着预测时域的范围改变.仿真实验表明了所提出方法的有效性.

关键词：溶剂萃取预测函数串联过程状态空间约束处理分布式预测控制

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na yang lu Lv Shu-Meng Han Li-Yun He Zi-Yi Li Yu-Cheng yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Mingzhen xiu Jianghong Zhang Yu lu Xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu Liang Chunwang Zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

关键词：

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing Li xiufang Li Zi-xiu lu Linzhe Lü Jin Liu luyao Liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

关键词：