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Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy

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World Journal of Gastroenterology 2008年第26期14卷 4222-4226页

作者： Hua Li ping lu yang lu Cai-Gang Liu Hui-Mian Xu Shu-Bao Wang Jun-Qing Chen Department of Surgical Oncology First Affiliated Hospital of China Medial UniversityShenyang 110001 Liaoning Province China

AIM:To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC. METHODS: Data were collected from 85 poorly- differentiated EGC patients who were surgically treated. Association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. RESULTS: Univariate analysis showed that tumor size (OR = 5.814, 95% CI = 1.050 - 32.172, P = 0.044), depth of invasion (OR = 10.763, 95% CI = 1.259 - 92.026, P = 0.030) and lymphatic vessel involvement (OR = 61.697, 95% CI = 2.144 - 175.485, P = 0.007) were the significant and independent risk factors for LNM. The LNM rate was 5.4%, 42.9% and 50%, respectively, in poorly differentiated EGC patients with one, two and three of the risk factors, respectively. No LNM was found in 25 patients without the three risk factors. Forty-four lymph nodes were found tohave metastasis, 29 (65.9%) and 15 (34.1%) of the lymph nodes involved were within N1 and beyond N1, respectively, in 12 patients with LNM. CONCluSION: Endoscopic mucosal resection alone may be sufficient to treat poorly differentiated intramucosal EGC (≤ 2.0 cm in diameter) with no histologically-confirmed lymphatic vessel involvement. When lymphatic vessels are involved, lymph node dissection beyond limited (D1) dissection or D1+ lymph node dissection should be performed depending on the tumor location.

关键词： Poorly differentiated early gastriccancer Lymph node metastasis Clinicopathological characteristics Endoscopic mucosal resection

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Scattering Law Analysis Based on Hapke and Lommel-Seeliger Models for Asteroidal Taxonomy

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Research in Astronomy and Astrophysics 2017年第10期17卷 83-90页

作者： Xiang-Jie Huang Xiao-ping lu Jian-yang Li Bao Mei Chih-Hao Hsia Hai-Bin Zhao Macao University of Science and Technology lunar and Planetary Science Laboratory Macao University of Science and Technology - Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration Chinese Academy of Sciences Key Laboratory of Planetary Sciences Chinese Academy of Sciences Planetary Science Institute Purple Mountain Observatory Chinese Academy of Sciences

In deriving the physical properties of asteroids from their photometric data, the scattering law plays an important role, although the shape variations of asteroids result in the main variations in lightcurves. By following the physical behaviors of light reflections, Hapke et al. deduced complex functions to represent the scattering process, however, it is very hard to accurately simulate the surface scattering law in reality. For simplicity, other numerical scattering models are presented for efficiently calculating the physical properties of asteroids, such as the Lommel-Seeliger （LS） model. In this article, these two models are compared numerically. It is found that in some numerical applications the LS model in simple form with four parameters can be exploited to replace the Hapke model in complex form with five parameters. Furthermore, the generated synthetic lightcurves by the Cellinoid shape model also show that the LS model can perform as well as the Hapke model in the inversion process. Finally, by applying the Principal Component Analysis （PCA） technique to the parameters of the LS model, we present an efficient method to classify C and S type asteroids, instead of the conventional method using the parameters of the Hapke model.

关键词： scattering -- techniques: photometric -- minor planets -- asteroids: general

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Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B:A meta-analysis

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World Journal of Hepatology 2024年第3期16卷 465-476页

作者： Shi-Yi Liu Dian Wang Jing Liu lu-ping yang Gong-Ying Chen Department of Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Medicine Hangzhou Normal UniversityHangzhou 310011Zhejiang ProvinceChina Department of Infectious and Hepatology Diseases Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

BACKGROUND Although hepatitis B virus infection is the leading cause of chronic liver injury globally,nonalcoholic fatty liver disease(NAFLD)is gradually gaining attention as another major chronic liver *** number of patients having chronic hepatitis B(CHB)with concomitant hepatic steatosis has *** To analyze the effect of NAFLD on the response to antiviral treatment in patients with *** Relevant English studies were systematically searched across PubMed,EMBASE,Web of Science,and Cochrane Library until October *** in which the treatment outcomes were compared between patients with CHB only and those with CHB and hepatic steatosis were *** Of the 2502 retrieved studies,11 articles were finally *** response until 48 wk(OR=0.87,95%CI:0.50–1.53,P=0.000)and 96 wk(OR=0.35,95%CI:0.24–0.53,P=0.24)and virological response until 96 wk(OR=0.80,95%CI:0.43–1.49,P=0.097)were lower in patients with hepatic steatosis than in patients with CHB *** Hepatic steatosis lowers the biochemical response to antiviral treatment in patients with CHB.

关键词： Nonalcoholic fatty liver disease Hepatitis B virus Antiviral treatment effect Meta-analysis

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Clinicopathological Characteristics as Predictive Factrs for Lymph Node Metastasis in Submucosal Gastric Cancer

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Chinese Journal of Clinical Oncology 2007年第4期4卷 237-240页

作者： Caigang Liu ping lu yang lu lua Li Ruishan Zhang Huimian Xu Shubao Wang Junqing Chen Department of Oncology First Affiliated Hospital of China Medial University Shenyang 110001. China.

OBJECTIVE To identify clinicopathological characteristics as predictive factors for lymph node metastasis in submucosal gastric cancer, and in addi- tion to establish objective criteria as indications for endoscopic submucosal dissection (ESD). METHODS Data from 130 patients with submucosal gastric cancer were collected, and the relationship between their clinicopathological characteris- tics and the presence of lymph node metastasis was retrospectively analyzed by multivariate analysis. RESULTS In the multivariate logistic regression model, a tumor size of 2 cm or more and an undifferentiated histologic type were found to be inde- pendent risk clinicopathological characteristics for lymph node metastasis. Among 130 patients with submucosal carcinoma, no lymph node metastases were observed in 17 patients who showed neither of the two risk clinicopath- ological characteristics. Lymph node metastasis occurred in 61.1% (22/36) of the patients who had both risk clinicopathological characteristics. CONCluSION A tumor size of 2 cm or more and an undifferentiated histologic type were significantly and independently related to lymph node metastasis in submucosal gastric cancer. It is rational for the paitients with neither of these two independent risk clinicopathological characteristics to undergo an ESD.

关键词： early gastric cancer lymph node metastasis clinicopathological characteristics endoscopic mucosal resection.

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Distribution of solitary Iymph nodes in primary gastric cancer:A retrospective study and clinical implications

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World Journal of Gastroenterology 2007年第35期13卷 4776-4780页

作者： Cai-Gang Liu ping lu yang lu Feng Jin Hui-Mian Xu Shu-Bao Wang Jun-Qing Chen Department of Surgical Oncology First Affiliated Hospital of China Medial University Heping Shenyang110001 Liaoning Province China

AIM： To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS： We investigated 173 cases with solitary or single station metastatic lymph nodes （LN） from among 2476 gastric carcinoma patients. The location of metastatic LN, histological type and growth patterns were analyzed retrospectively. RESULTS： Of 88 solitary node metastases cases, 65 were limited to perigastric nodes （N1）, while 23 showed skipping metastasis. Among 8 tumors in the upper third stomach, 3 involved right paracardial LN （station number： No.1）, and one in the greater curvature was found in No.1. In the 28 middle third stomach tumors, 10 were found in LN of the lesser curvature （No.3） and 6 in LN of the left gastric artery （No.7）; 5 of the 20 cases on the lesser curvature spread to No.7, while 2 of the 8 on the greater curvature metastasized to LN of the spleen hilum （No.10）. Of 52 lower third stomach tumors, 13 involved in No.3 and 19 were detected in inferior pyloric LN （No.6）; 9 of the 29 cases along the lesser curvature were involved in No.6. CONCluSION： Transversal and skipping metastases of sentinel lymph nodes （SLN） are notable, and rational lymphadenectomy should, therefore, be performed.

关键词： Gastric cancer Metastatic lymph node,Lymph node dissection Rational lymphadenectomy Sentinel lymph node

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VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 852-864页

作者： Pei-Shan Hu Ting Li Jin-Fei Lin Miao-Zhen Qiu De-Shen Wang Ze-Xian Liu Zhan-Hong Chen lu-ping yang Xiao-Long Zhang Qi Zhao Yan-Xing Chen Yun-Xin lu Qi-Nian Wu Heng-Ying Pu Zhao-Lei Zeng Dan Xie Huai-Qiang Ju Hui-Yan luo Rui-Hua Xu Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouPeople’s Republic of China Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouPeople’s Republic of China Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease the Third Affiliated Hospital of Sun Yat-sen University510060 GuangzhouPeople’s Republic of China

The acidic tumor microenvironment provides an energy source driving malignant tumor *** of cells to an acidic environment leads to the emergence of cancer stem *** expression of the vitamin D receptor(VDR)is closely related to the initiation and development of colorectal carcinoma(CRC),but its regulatory mechanism in CRC stem cells is still *** study revealed that acidosis reduced VDR expression by downregulating peroxisome proliferator-activated receptor delta(PPARD)*** of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in *** nuclear export signal in VDR was sensitive to acidosis,and VDR was exported from the *** immunoprecipitation(ChIP)and assay for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq)analyses showed that VDR transcriptionally repressed SRY-box 2(SOX2)by binding to the vitamin D response elements in the promoter of SOX2,impairing tumor growth and drug *** demonstrated that a change in the acidic microenvironment combined with overexpression of VDR substantially restricted the occurrence and development of CRC in *** findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling,resulting in a lack of efficacy of vitamin D in antineoplastic process.

关键词： SOX2 vitamin colorectal

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西部县域特色经济与技术路线选择——以陕西省西乡县为例

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陕西理工学院学报（社会科学版） 2005年第2期23卷 33-35,41页

作者：吕阳平中共西乡县委陕西西乡723500

　西部贫困地区经济落后的原因在于受到城乡二元分割的社会结构、小农经济为主的传统农业结构、自然资源贫乏、资本进入障碍、要素结构等多重因素制约。在经济转型期间,由于存在路径依赖障碍,贫困地区政府如何从资源禀赋出发来选择发展... 详细信息

　西部贫困地区经济落后的原因在于受到城乡二元分割的社会结构、小农经济为主的传统农业结构、自然资源贫乏、资本进入障碍、要素结构等多重因素制约。在经济转型期间,由于存在路径依赖障碍,贫困地区政府如何从资源禀赋出发来选择发展道路、确定发展战略;如何制定产业政策、建立主导产业;如何引导生产方式和生产组织形式变革、培育优势资源,吸引资本进入、构建产业体系,从而建立起自己的特色经济,走出一条城乡协调发展、产业协调发展的路子;这些都是西部县域经济发展必须解决的重大问题。本文以西乡县发展县域经济的实践为案例,重点讨论贫困地区发展特色经济与技术路线选择的关系,以求从诱致性技术变迁理论的角度,解读技术路线演进与发展特色经济的关系。

关键词：路线选择县域特色经济西乡县陕西省西部贫困地区城乡协调发展产业协调发展县域经济发展发展县域经济贫困地区发展社会结构经济落后农业结构小农经济资源贫乏进入障碍多重因素要素结构转型期间路径依赖

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一种时空域优化的高精度交错网格差分算子与正演模拟

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地球物理学报 2016年第11期59卷 4223-4233页

作者：雍鹏黄建平李振春曲璐萍李庆洋袁茂林关哲中国石油大学(华东)地球科学与技术学院青岛266580 中国石油大学(北京)地球物理与信息工程学院北京102249 莱斯大学地球科学学院美国德克萨斯州休斯顿77005

如何有效压制数值频散是有限差分正演模拟研究中的关键问题之一.近年来,许多学者对二阶声波方程的差分算子开展了大量的优化工作,在压制频散方面取得不错的效果.一阶压强-速度方程广泛用于研究地震波在地下变密度模型中传播规律,目前针... 详细信息

如何有效压制数值频散是有限差分正演模拟研究中的关键问题之一.近年来,许多学者对二阶声波方程的差分算子开展了大量的优化工作,在压制频散方面取得不错的效果.一阶压强-速度方程广泛用于研究地震波在地下变密度模型中传播规律,目前针对一阶方程的优化工作大多只是在空间差分算子上展开.本文在前人研究的基础上,推导出一阶声波方程中压强场与偏振速度场之间的解析关系,据此在传统交错网格基础上给出一种高精度的显式时间递推格式,该递推格式将时间差分与空间差分算子结合在一起,并采用共轭梯度法得到精确时间递推匹配系数,实现时空差分算子的同时优化.在编程实现算法的基础上,通过频散分析与三个典型模型测试表明:本文方法能够较为有效地压制时间频散与空间频散,提高数值计算精度;同时对复杂模型也有很好适用性.

关键词：数值频散一阶压强-速度方程优化差分算子交错差分递推格式共轭梯度法

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多种材料联合栓塞治疗食管胃底静脉曲张临床疗效分析

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介入放射学杂志 2011年第7期20卷 566-568页

作者：路延平秦好朴张孟增河北医科大学附属邢台市人民医院放射科河北邢台054031

目的评价经皮经肝食管胃底静脉曲张栓塞术(PTO)的临床疗效及应用价值。方法以明胶海绵,无水乙醇和弹簧圈为栓塞剂联合栓塞治疗48例食管胃底静脉曲张破裂出血患者。结果 48例患者食管胃底曲张静脉均超选择插管,成功栓塞。17例急性上消化... 详细信息

目的评价经皮经肝食管胃底静脉曲张栓塞术(PTO)的临床疗效及应用价值。方法以明胶海绵,无水乙醇和弹簧圈为栓塞剂联合栓塞治疗48例食管胃底静脉曲张破裂出血患者。结果 48例患者食管胃底曲张静脉均超选择插管,成功栓塞。17例急性上消化道出血患者中1例因全身状况差,术后第7天再次出血死亡。33例患者术后胃镜复查显示,胃底曲张静脉完全消失者27例,明显改善者6例,35例患者术后得到随访,随访4～36个月,再出血5例,死亡2例。结论多种材料联合栓塞治疗食管胃底静脉曲张栓塞术创伤小、操作安全、疗效确切,值得推广应用。

关键词：门静脉高压食管胃底静脉曲张栓塞治疗性

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人参皂苷Rg1通过自噬抑制Raw 264.7巨噬细胞凋亡

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解剖学报 2016年第5期47卷 599-606页

作者：凌露杨萍盖盛坤刘燃陈媛丽陆地孙林昆明医科大学第二附属医院心血管内科昆明650101 昆明医科大学基础医学院人体解剖学与组织学胚胎学系昆明650500 临汾市人民医院心内科山西临汾041000 昆明医科大学生物医学工程研究中心昆明650500

目的探讨人参皂苷Rg1在血清剥夺诱导的Raw 264.7巨噬细胞自噬和凋亡中的作用及其机制。方法体外培养小鼠Raw 264.7巨噬细胞随机分为空白对照组、不同时间(12、24、36、48和60h)血清剥夺处理组、人参皂苷Rg1(50μmol/L)+不同时间(24、36... 详细信息

目的探讨人参皂苷Rg1在血清剥夺诱导的Raw 264.7巨噬细胞自噬和凋亡中的作用及其机制。方法体外培养小鼠Raw 264.7巨噬细胞随机分为空白对照组、不同时间(12、24、36、48和60h)血清剥夺处理组、人参皂苷Rg1(50μmol/L)+不同时间(24、36和48h)血清剥夺处理组;依据最佳血清剥夺时间进一步分为空白对照组、血清剥夺(36h)处理组、人参皂苷Rg1(50μmol/L)+血清剥夺(36h)处理组、人参皂苷Rg1(50μmol/L)+血清剥夺(36h)+3-甲基腺嘌呤(3-MA)(5mmol/L,1h)处理组。采用Western blotting检测LC3、Atg 5、Beclin 1、cleaved Caspase-3、Bcl-2及Bax蛋白水平的表达变化;采用免疫荧光双标记检测细胞内LC3蛋白水平表达的变化;采用Hoechst 33342/PI荧光双染检测细胞凋亡的变化。结果不同时间(12、24、36、48和60h)血清剥夺诱导Raw264.7巨噬细胞凋亡;与血清剥夺处理组相比,人参皂苷Rg1处理组LC3、Atg 5及Beclin 1蛋白表达水平显著上调;加入3-MA抑制剂后,凋亡细胞较人参皂苷Rg1处理组明显增多,且Bcl-2蛋白表达水平明显下调的同时,cleaved Caspase-3和Bax蛋白表达水平则显著上调。结论人参皂苷Rg1通过促进血清剥夺诱导的Raw 264.7巨噬细胞自噬,发挥抗凋亡的保护作用。

关键词：人参皂苷Rg1 自噬 Raw 264.7巨噬细胞免疫印迹法免疫荧光双标记法 Hochest 33342/PI荧光双染小鼠

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