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Achieving a superior Na storage performance of Fe-based Prussian blue cathode by coating perylene tetracarboxylic dianhydride amine

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Carbon Energy 2024年第5期6卷 53-64页

作者： Xin-Yuan Fu lu-lu zhang Zhao-Yao Chen Yunkai Xu Junxiu Wu Cheng-Cheng Wang Xiao-Kai Ding Xue-Lin Yang Jun lu Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering&New EnergyChina Three Gorges UniversityYichangHubeiChina College of Materials and Chemical Engineering China Three Gorges UniversityYichangHubeiChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina

Fe-based Prussian blue(Fe-PB)cathode material shows great application potential in sodium(Na)-ion batteries due to its high theoretical capacity,long cycle life,low cost,and simple preparation process.However,the crystalline water and vacancies of Fe-PB lattice,the low electrical conductivity,and the dissolution of metal ions lead to limited capacity and poor cycling stability.In this work,a perylene tetracarboxylic dianhydride amine(PTCDA)coating layer is successfully fabricated on the surface of Fe-PB by a liquid-phase method.The aminated PTCDA(PTCA)coating not only increases the specific surface area and electronic conductivity but also effectively reduces the crystalline water and vacancies,which avoids the erosion of Fe-PB by electrolyte.Consequently,the PTCA layer reduces the charge transfer resistance,enhances the Na-ion diffusion coefficient,and improves the structure stability.The PTCA-coated Fe-PB exhibits superior Na storage performance with a first discharge capacity of 145.2 mAh g^(−1) at 100 mA g^(−1).Long cycling tests exhibit minimal capacity decay of 0.027%per cycle over 1000 cycles at 1 A g^(−1).Therefore,this PTCA coating strategy has shown promising competence in enhancing the electrochemical performance of Fe-PB,which can potentially serve as a universal electrode coating strategy for Na-ion batteries.

关键词： cathode material coating Fe-based Prussian blue Na-ion batteries perylene tetracarboxylic dianhydride amine

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N,S-codoped porous carbon nanosheets decorated with Fe_(3)C nanoparticles as high-performance anode materials for lithium ion hybrid supercapacitors

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Rare Metals 2022年第7期41卷 2517-2526页

作者： Lin Gao lu-lu zhang Xue-Lin Yang College of Electrical Engineering&New Energy Hubei Collaborative Innovation Center for Microgrid of New EnergyThree Gorges UniversityYichang 443002China

The practical applications of carbon anode for lithium-ion batteries(LIBs)are largely obstructed by their moderate rate capability and cyclic stability.Herein,we report a N,S-codoped porous carbon nanosheet(NSC)decorated with Fe_(3)C nanoparticles(Fe_(3)C/NSC)by a one-pot pyrolysis process.The high surface area and abundant defects of NSC can not only promote electrons and ions transfer,but also induce high pseudocapacitive contribution.More importantly,the synergistic catalysis effect of Fe-Nx and Fe_(3)C can catalyze the reversible conversion of some solid electrolyte interface(SEI)components to offer excess capacity during cycling.As expected,the Fe_(3)C-NSC anode delivers a discharge capacity of750 mAh·g^(-1)under a current density of 0.5 A·g^(-1)through 500 cycles and retains a dis-charge capacity of 366 mAh·g^(-1)at 4 A·g^(-1)after 1600 cycles,respectively.Most importantly,the lithium-ion capacitors based on Fe_(3)C/NSC anode demonstrate a high energy density of 249.5 Wh·kg^(-1)at 560 W·kg^(-1).

关键词： Fe_(3)C/NSC Lithium-ion batteries Pseudocapacitive behavior Lithium-ion capacitors

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Identification of novel PKD1 mutations in two Chinese families with autosomal dominant polycystic kidney disease by targeted next generation sequencing

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Chinese Medical Journal 2020年第6期133卷 738-740页

作者： Qun Liu Jun-Xia Ruan Jing-Shu zhang lu-lu zhang Guang-Rong Qiu Department of Medical Genetics School of Life SciencesChina Medical UniversityShenyangLiaoning 110122China Dalian Municipal Women and Children's Medical Center DalianLiaoning 116037China

To the Editor:Autosomal dominant polycystic kidney disease(ADPKD)is a common inherited kidney disease with an estimated incidence of 1 in 400 to 1 in 1000.[1] It is a late-onset systemic disorder characterized by the development and progressive enlargement of cysts in the kidney,eventually leading to end-stage renal disease.[2] Previous studies have shown that ADPKD is a heterogeneous monogenic disorder resulting from mutations in two genes:PKD1 and PKD2.Clinical data showed that PKD1 and PKD2 mutations account for 85% and 15% of ADPKD cases,respectively.[3]

关键词： PKD1 kidney Clinical

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Inhibitory Effects of Sulfur Dioxide on Rat Myocardial Fibroblast Proliferation and Migration

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Chinese Medical Journal 2018年第14期131卷 1715-1723页

作者： lu-lu zhang Jun-Bao Du Chao-Shu Tang Hong-Fang Jin Ya-Qian Huang Department of Pediatrics Peking University First Hospital Beijing 100034 China Division of Small Molecules and Cardiovascular Disease Key Laboratory of Molecular Cardiology Ministry of Education Beijing 100083 China Department of Physiology and Pathophysiology Peking University Health Science Centre Beijing 100091 China

Background： Myocardial fibrosis is an important pathological change has not yet been fully elucidated. The study was designed to examine fibroblast proliferation and migration inhibitor. in many heart diseases, but its pathogenesis is very complex and whether endogenous sulfur dioxide （SO2） is a novel myocardial Methods： Primary rat myocardial fibroblasts were isolated and transfected with aspartate aminotransferase （AAT1 and AAT2） knockdown lentivirus or empty lentivirus. SO2 content in the supematant was determined with high-performance liquid chromatography, and the expressions of AATI, AAT2, proliferating cell nuclear antigen （PCNA）, phosphorylated extracellular signal-regulated protein kinase （p-ERK）, and total ERK （T-ERK） in the cells were detected. Cell migration was detected by wound healing test. Independent sample t-test （for two groups） and one-way analysis of variance （three or more groups） were used to analyze the results. Results： Both AATI and AAT2 knockdown significantly reduced SO2 levels （F = 31.46, P 〈 0.01） and AATI/2 protein expression （AAT1, t = 12.67, P 〈 0.01 ; AAT2, t = 9.61, P 〈 0.01 ）, but increased PCNA expression and Cell Counting Kit-8 （CCK-8） activity as well as the migration in rat primary myocardial fibroblasts （P 〈 0.01）. Supplementation of SO： rather than pyruvate significantly inhibited the increase in proliferation and migration caused by AAT knockdown （P 〈 0.01）. Mechanistically, the ratio of p-ERK to T-ERK was significantly increased in the AAT1/2 knockdown groups compared with that in the empty lentivirus group （AATI, t = -7.36, P 〈 0.01; AAT2, t = 10.97, P 〈 0.01 ）. Whereas PD98059, an inhibitor of ERK activation, successfully blocked AAT knockdown-induced PCNA upregulation （F = 74.01, P 〉 0.05）, CCK-8 activation （F = 50.14, P 〉 0.05）, and migration augmentation in myocardial fibroblasts （24 h,F= 37.08, P〉 0.05; 48 h, F= 58.60, P〉 0.05）. Conclusion： Endogenous SO2 might be a novel myocardial fibrob/ast proliferation and migration inhibitor via inhibiting the ERK signaling

关键词： Endogenous Fibroblast Migration Proliferation Sulfur Dioxide

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A differential control method for the proportional directional valve

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 892-902页

作者： Bo JIN Ya-guang ZHU Wei LI De-sheng zhang lu-lu zhang Fei-fei CHEN The State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Ningbo HOYEA Machinery Manufacture Co. Ltd.

For the proportional directional valve controlled by two proportional solenoids, the normal control method(NCM) energizes only one solenoid at a time. The performance of the valve is greatly influenced by the nonlinearity of the proportional solenoid, such as dead zone and low force gain with a small current, and this effect cannot be eliminated by a simple dead-zone current compensation. To avoid this disadvantage, we propose the differential control method(DCM). By employing DCM, the controller outputs differential signals to simultaneously energize both solenoids of the proportional valve, and the operating point is found by analyzing the force output of the two solenoids to make a minimum variation of the current force gain. The comparisons of the valve response characteristics are made between NCM and DCM by nonlinear dynamic simulation and experiments. Simulation and experimental results show that by using DCM, the frequency response of the valve is greatly enhanced, especially when the input is small, which means that the dynamic characteristics of the proportional valve are improved.

关键词： Differential control method Frequency response Proportional directional valve Spool displacement feedback

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Primary site and regional lymph nodeinvolvement are independent prognosticfactors for early？stage extranodal nasal？typenatural killer/T cell lymphoma

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Chinese Journal of Cancer 2016年第5期35卷 255-263页

作者： Shao‑Qing Niu Yong Yang Yi‑Yang Li Ge Wen Liang Wang Zhi‑Ming Li Han‑Yu Wang lu‑lu zhang Yun‑Fei Xia Yu‑Jing zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China Department of Radiation Oncology Cancer Hospital and InstitutePeking Union Medical College(PUMC)and Chinese Academy of Medical Sciences(CAMS)Beijing 100021P.R.China Department of Nuclear Medicine The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150GuangdongP.R.China Department of Hematological Oncology Sun Yatsen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:Nasal-type extranodal natural killer/T-cell lymphoma(ENKTCL) originates primarily in the nasal cavity or extra-nasal sites within the upper aerodigestive tract.However,it is unclear whether the primary site can serve as an independent prognostic factor or whether the varying clinical outcomes observed with different primary sites can be attributed merely to their propensities of regional lymph node involvement.The aim of this study was to investigate the prognostic implications of the primary site and regional lymph node involvement in patients with early-stage nasal-type ENKTCL.Methods:To develop a nomogram,we reviewed the clinical data of 215 consecutively diagnosed patients with early-stage nasal-type ENKTCL who were treated in Sun Yat-sen University Cancer Center with chemotherapy and radiotherapy between 2000 and 2011.The predictive accuracy and discriminative ability of the nomogram were determined using a concordance index(C-index) and calibration curve.Results:The 5-year overall survival(OS) and progression-free survival(PFS) rates of patients with nasal ENKTCL were higher than those of patients with extra-nasal ENKTCL(OS:68.2%vs.46.0%,P = 0.030;PFS:53.4%vs.26.6%,P = 0.010).The 5-year OS and PFS rates of patients with Ann Arbor stage IE ENKTCL were higher than those of patients with Ann Arbor stage HE ENKTCL(OS:66.3%vs.59.2%,P = 0.003;PFS:51.4%vs.40.3%,P = 0.009).Multivariate analysis showed that age >60 years,ECOG performance status score >2,elevated lactate dehydrogenase(LDH) level,extranasal primary site,and regional lymph node involvement were significantly associated with lower 5-year OS rate;age >60 years,elevated LDH level,extra-nasal primary site,and regional lymph node involvement were significantly associated with lower 5-year PFS rate.The nomogram included the primary site and regional lymph node involvement based on multivariate analysis.The calibration curve showed good agreement between the predicted and actual 5-year OS and PFS rates,and the C-indexes of the nomogram for the OS a

关键词： Extranodal natural killer/T-cell lymphoma (ENKTCL), Nasal cavity, Lymph node, Prognosis, Nomogram

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Relationship between Prognosis and Time Interval from Cholecystectomy to Reoperation in Postoperative Incidental Gallbladder Carcinoma

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Chinese Medical Journal 2018年第20期131卷 2503-2505页

作者： Jing Du Xin-Wei Yang Zhi-Jian Wen Chen Xue Yao-Min Wu Meng-Chao Wu lu-lu zhang Department of Military Health Service Management College of Health Service Second Military Medical University Shanghai 200433 China Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital Shanghai 200438 China Department of Hepatobiliary Pancreatic Vascular Surgery No. 174 Hospital of People's Liberation Army Xiamen University Xiamen Fujian 361000 China

To the Editor： Gallbladder cancer （GBC）, a rare entity with poor prognosis, is often discovered incidentally during or after cholecystectomy.It tends to disseminate early through lymphatic, peritoneal, endobiliary, and hematogenous pathways. Patients usually present with metastatic diseases. If GBC is suspected during cholecystectomy, conversion to open surgery to perform radical resection after confirmation of cancer by intraoperative frozen biopsy is considered. When GBC is diagnosed after cholecystectomy, reoperation for radical resection according to depth of invasion of cancer （T stage） is inevitable. However, reoperation with radical surgery is not performed in all patients for several reasons including refusal to undergo radical surgery, poor medical condition, or cancer progression suggesting unresectability.

关键词： RADICAL RESECTION CANCER

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Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

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Genes & Diseases 2024年第2期11卷 1050-1065页

作者： Xiaoxuan Wang Lijuan luo Jingtao Xu Qiuping lu Haichao Xia Yanran Huang lulu zhang Liping Xie Habu Jiwa Shiqiong Liang Xiaoji luo Jinyong luo Key Laboratory of Diagnostic Medicine Designated By the Chinese Ministry of Education School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Bladder cancer (BC) is one of the most common malignant tumors in the urinary system.Due to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat BC.Echinatin (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor potential.Herein,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular mechanism.We found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC cells.Besides,Ecn had no notable cytotoxicity towards human normal cells.We subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC cells.Remarkably,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC cells.In summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling pathways.More meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.

关键词： Bladder cancer Combination chemotherapy Echinatin p38 Wnt/β-catenin

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Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1677-1692页

作者： Dongsheng Bai Jiawei Zhao Runde Wang Jiaying Du Chen Zhou Chunyang Gu Yuxiang Wang lulu zhang Yue Zhao Na lu State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal conse-quences.Despite identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is evident.In our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus barrier.This enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory response.Importantly,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy drugs.Mechanistically,E.copr up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRNA and an increase in mucin synthesis in goblet cells.An espe-cially significant finding is that E.copr activates the AhR pathway,thereby promoting the expression of AUF1.In summary,our results strongly indicate that E.copr enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRNA stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

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Ternary Ni-based Prussian blue analogue with superior sodium storage performance induced by synergistic effect of Co and Fe

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Carbon Energy 2021年第5期3卷 827-839页

作者： lu-lu zhang Cheng Wei Xin-Yuan Fu Zhao-Yao Chen Bo Yan Pan-Pan Sun Kai-Jun Chang Xue-Lin Yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering&New EnergyChina Three Gorges UniversityYichangHubeiChina College of Materials and Chemical Engineering China Three Gorges UniversityYichangHubeiChina Hubei Gaobo Technology Inc. JingzhouHubeiChina

Prussian blue analogue Na2Ni[Fe(CN)6](Ni-PB)has been widely studied as a cathode material for sodium-ion battery due to its excellent cycling performance.However,Ni-PB has a low theoretical capacity of 85 mAh g^(−1) because of the electrochemical inertness of Ni.Herein,ternary Ni-PB is successfully synthesized by double doping with Co and Fe at Ni-site,and the effect of doping with Co and Fe on the electrochemical performance of Ni-PB is systematically investigated through theoretical calculations and electrochemical tests.The first principles calculations confirm that double doping with Co and Fe can significantly reduce the energy barrier and bandgap of Ni-PB.X-ray diffraction and composition analysis results indicate that ternary NiCoFe-PB composite not only has good crystallinity and high Na content but also has low defects and crystal water.Electrochemical tests reveal that,besides the capacity contribution of high-spin Co/Fe and low-spin Fe,Co-doping enhances the electrochemical activity of low-spin Fe and Fe-doping improves the activity of high-spin Co;moreover,double doping can decrease the diffusion resistance of Na+ions through solid electrolyte interface film,accelerate the kinetics for both ion diffusion process and Faradic reaction,and increase active sites.Under the synergistic effect of Co and Fe,this ternary NiCoFe-PB exhibits outstanding electrochemical performance with a high initial discharge capacity of 120.4 mAh g^(−1) at 20mA g^(−1) and an extremely low capacity fading rate of 0.0044%per cycle at a high current density of 2 A g^(−1) even after 10,000 cycles,showing great application potential of ternary NiCoFe-PB in the field of large-scale energy storage.

关键词： cathode materials doping Prussian blue analogue sodium-ion batteries synergistic effect

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