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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-lu liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Optimization of production well patterns for natural gas hydrate reservoir: Referring to the results from production tests and numerical simulations

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China Geology 2025年第1期8卷 39-57页

作者： Lang-feng Mu Hao-tian liu Chi Zhang Yi Zhang Hai-long lu School of Earth and Space Sciences Peking UniversityBeijing 100871China Beijing International Center for Gas Hydrate School of Earth and Space SciencesPeking UniversityBeijing 100871China Chinese Academy of Geological Sciences China Geological SurveyMinistry of Natural Resources Beijing 100037China College of Engineering Peking UniversityBeijing 100871China National Engineering Research Center of Natural Gas Hydrate Exploration and Development Guangzhou 511458China China National Oil and Gas Exploration and Development LTD Corporation Petro-ChinaBeijing 100034China

Natural gas hydrate is a clean energy source with substantial resource *** contrast to conventional oil and gas,natural gas hydrate exists as a multi-phase system consisting of solids,liquids,and gases,which presents unique challenges and complicates the mechanisms of seepage and *** domestic and international natural gas hydrate production tests typically employ a single-well production *** this approach has seen some success,it continues to be hindered by low production rates and short production ***,there is an urgent need to explore a new well network to significantly increase the production of a single *** paper provides a comprehensive review of the latest advancements in natural gas hydrate research,including both laboratory studies and field *** further examines the gas production processes and development outcomes for single wells,dual wells,multi-branch wells,and multi-well systems under conditions of depressurization,thermal injection,and CO_(2) *** this basis,well types and well networks suitable for commercial exploitation of natural gas hydrate were explored,and the technical direction of natural gas hydrate development was *** study shows that fully exploiting the flexibility of complex structural wells and designing a well network compatible with the reservoir is the key to improving production from a single ***,multi-well joint exploitation is identified as an effective strategy for achieving large-scale,efficient development of natural gas hydrate.

关键词： Gas Hydrate Production Depressurization Heat Injection Replacement Multi-Branch Well Well patterns Hydrate exploration engineering

Integrating well logs, 3D seismic, and earthquake data for comprehensive prediction of 3D in-situ stress orientations: A case study from the Weiyuan area in the Sichuan Basin, China

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Petroleum Science 2025年第1期22卷 210-221页

作者： Huan Cao Yang Zhao Hai-Chao Chen Le-Le Zhang Cheng-Gang Xian Ji-Dong Yang lu liu State Key Laboratory of Petroleum Resources and Engineering and Unconventional Petroleum Research Institute China University of Petroleum (Beijing) Department of Geophysics China University of Petroleum (East China) Aramco Beijing Research Center Aramco Asia

Determining the orientation of in-situ stresses is crucial for various geoscience and engineering applications. Conventional methods for estimating these stress orientations often depend on focal mechanism solutions(FMSs) derived from earthquake data and formation micro-imager(FMI) data from well ***, these techniques can be costly, depth-inaccurate, and may lack spatial coverage. To address this issue, we introduce the use of three-dimensional(3D) seismic data(active sources) as a lateral constraint to approximate the 3D stress orientation field. Recognizing that both stress and fracture patterns are closely related to seismic velocity anisotropy, we derive the orientation of azimuthal anisotropy from multi-azimuth 3D seismic data to compensate for the lack of spatial stress orientation information. We apply our proposed workflow to a case study in the Weiyuan area of the Sichuan Basin, China, a region targeted for shale gas production. By integrating diverse datasets, including 3D seismic, earthquakes, and well logs, we develop a comprehensive 3D model of in-situ stress(orientations and magnitudes). Our results demonstrate that the estimated anisotropy orientations from 3D seismic data are consistent with the direction of maximum horizontal principal stress(SHmax) obtained from FMIs. We analyzed 12earthquakes(magnitude > 3) recorded between 2016 and 2020 for their FMSs and compressional axis(Paxis) orientations. The derived SHmax direction from our 3D stress model is 110°ES(East-South), which shows excellent agreement with the FMSs(within 3.96°). This close alignment validates the reliability and precision of our integrated method for predicting 3D SHmax orientations.

关键词： In-situ stress orientation SHmax Azimuthal velocity anisotropy Focal source mechanism Formation micro-imager

A multi-affinity supramolecular nanolayer reinforced PVDF-LLZTO composite polymer electrolyte for stable solid-state lithium batteries

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Nano Research 2025年第2期18卷 317-327页

作者： Changfei liu Sailong Wang Zhengyi lu Jiaqing Zhao Yuchen Wu Chaojie Ren Ruizhi Yang Chao Jin College of Energy Soochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhou 215006China

Technical breakthrough of composite polymer electrolyte(CPE)is one of the key factors that determines the commercial process of the current solid-state lithium ***,high interface impedance limits its electrochemical *** is crucial to optimize the design of multiphase interfaces among different components in CPE for regulating Li+***,a multi-affinity self-assembled 12-crown-4-TFSI(12C4-TFSI)supramolecular nanolayer is introduced into poly(vinylidene difluoride)-Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(PVDF-LLZTO)CPE as interface *** a result,enhanced Li+conductivity of 4.29×10^(-4)S·cm^(-1),Li+transfer number of 0.44,and stable electrochemical window voltage of 4.8 V ***/Li+at 30℃ are *** symmetric Li||Li cell exhibits an improved critical current density(CCD)of 1.2 mA·cm^(-2) and steady cycling at 0.2 mA·cm^(-2) for over 850 h without visible voltage *** assembled LiǁLiFePO4 coin solid-state cell delivers a high initial discharge capacity of 172.9 mAh·g^(-1) at 0.1 C,rate capability(up to 5.0 C)and outstanding cycling stability with a capacity retention of 87.2% after over 750 cycles at 1.0 *** associated LiǁLiFePO4 pouch cell presents an initial specific discharge capacity of 112.3 mAh·g−1 and successfully runs 30 cycles with a final capacity of 101.8 mAh·g^(-1).This work offers a facile strategy to optimize multiphase interfaces of PVDF-LLZTO CPE for stable solid-state lithium battery.

关键词： solid-state lithium battery composite polymer electrolyte interface impedance modifier supramolecular

A review of motion planning for redundant space manipulators

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Science China Technological Sciences 2025年第3期68卷 34-57页

作者： Ziqiang ZHANG Xiaoshuo liu Meng NING Xiaohui LI Weihui liu Ye lu College of Mechanical and Energy Engineering Beijing University of Technology School of Mechanical Engineering Jiangnan University Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control Engineering Department of Civil Engineering Monash University

Redundant space manipulators(RSM) exhibit high flexibility and can assist astronauts in completing various onorbit service(OOS) tasks, which have been applied to the International Space Station(ISS) and China Space Station(CSS).Motion planning stands as a fundamental technology within RSM, guiding the manipulator to reach designated positions smoothly and execute operational tasks with optimal performance. Nevertheless, the intricate nature of the space environment presents challenges to the motion planning of RSM. In this paper, in response to issues such as maintenance difficulties after RSM failures, base floating caused by weightlessness, flexible deformation of structures due to large-scale operations, and multiple obstacles with uncertainty, fault-tolerant motion planning, motion planning considering base floating, motion planning under structural flexibility deformation, and obstacle avoidance motion planning are examined. At present, the increasingly complex OOS tasks have brought new challenges to the motion planning of RSM. These challenges encompass motion planning for new mechanism configurations, dynamic motion planning, multi-RSM and multi-task planning, the improvement of motion planning efficiency, and the efficient implementation and precise process monitoring of motion. With the advancement of motion planning technology, RSM is poised to play an increasingly significant role in ISS and CSS.

关键词： redundant space manipulator on-orbit service motion planning main challenges

Gradient nanostructure enabled exceptional fretting fatigue properties of Inconel 718 superalloy through submerged abrasive waterjet peening

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Chinese Journal of Aeronautics 2025年第1期38卷 586-606页

作者： Shulei YAO Yuxin CHI Xianhao ZHU Kaiming ZHANG Tiwen lu Kaishang LI Ning WANG Chengcheng ZHANG Shuang liu Xiancheng ZHANG Shantung TU Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China AECC Commercial Aircraft Engine Co.LTD Shanghai Engineering Research Center for Commercial Aircraft EngineShanghai 201108China

Submerged Abrasive Waterjet Peening(SAWJP)shows great application potential in augmenting the fatigue properties of metallic ***,the present work aims to investigate the influence of SAWJP on the Surface Integrity(SI)and Fretting Fatigue(FF)properties of Inconel 718(IN718)superalloy and illustrate the microstructural evolution,FF life improvement,and fretting wear ***,the SI of the IN718 specimen was examined following treatment via *** showed that the specimen subjected to SAWJP formed a total plastic deformation layer of 56μ*** maximum microhardness and Compressive Residual Stress(CRS)measured across the depth of the SAWJP-treated specimens exhibited an increase in values ranging between 522 HV and 541 HV and 1171–1380 MPa,*** FF test results of the specimen before and after SAWJP treatment at ambient temperatures indicated that the FF life of the SAWJP-treated specimen surpassed that of the as-received specimen by a factor of *** examination of the FF fracture,contact surface,and crack propagation behavior revealed the crucial factors contributing to the enhanced FF resistance of the IN718 specimen,including the gradient nanostructure characterized by ultra-refined grains,substantial CRS,and elevated microhardness,which were all induced by the SAWJP treatment.

关键词： Submerged abrasive waterjet peening Inconel 718 superalloy Microstructural evolution Surface integrity Fretting fatigue

Scalable preparation of asymmetrical bilayer sulfide/halide electrolyte membranes for all-solid-state batteries with high voltage

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Science China Technological Sciences 2025年第3期68卷 101-113页

作者： Shenghao JING Yanchen liu Yang lu Hanzhou liu Yang liu Siliang liu Zongliang ZHANG Fangyang liu School of Metallurgy and Environment Central South University Engineering Research Centre of Advanced Battery Materials Ministry of Education Hunan Provincial Key Laboratory of Nonferrous Value-added Metallurgy Hunan Energy Frontiers New Materials Technology Co. Ltd. National Energy Metal Resources and New Materials Key Laboratory

All-solid-state batteries （ASSBs） are considered to be the most promising candidates for improving battery safety and energy *** electrolytes have a narrow electrochemical window,which hinders their applications coupled with high-voltage *** electrolytes with high-voltage endurance can help solve this ***,the combination of spraying and slurry-coating methods was adopted as a practical route to process a free-standing Li6PS5Cl （LPSCl） asymmetrical electrolyte membrane （19.23Ωcm2,75μm） decorated with a 10μm Li3In Cl6（LICl） *** LICl-LPSCl asymmetrical electrolyte membranes enhanced the high-voltage stabilities to match those of LiNi0.83Co0.11Mn0.06O2（NCM811） and Li1.2Ni0.13Co0.13Mn0.54O2（LRMO） *** NCM811|LICl-LPSCl|n Si ASSB achieved an initial coulombic efficiency（ICE） of 85.13%and a capacity retention of 77.16%after 200 *** with the LPSCl membrane,the LICl-LPSCl membrane displayed high stability with the LRMO cathode as the charging cut-off voltage increased to 4.7 V,which improved the initial charge capacity from 143 to 270 mAh g-1and achieved stable cycling of 160 m Ah g-1at 0.5 ***,we attempted continuous LICl-LPSCl membrane production and utilized the product to fabricate a pouch-type ASSB based on *** fabrication of the LICl-LPSCl electrolyte membrane demonstrated its potential for controllable and industryadaptable applications in ASSBs.

关键词： all-solid-state batteries halide electrolyte sulfide electrolyte high-voltage asymmetrical

Consensus Control Strategy for the Treatment of Tumour With Neuroadaptive Cellular Immunotherapy

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IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 575-584页

作者： Jiayue Sun Dongni Li Huaguang Zhang lu liu Wenyue Zhao IEEE the State Key Laboratory of Synthetical Automation for Process Industries the College of Information Science and Engineering Northeastern University the Department of Breast Surgery The First Hospital of China Medical University the Department of Thoracic Surgery The First Hospital of China Medical University

This paper presents a novel neuro-adaptive cellular immunotherapy control strategy that leverages the high efficiency and applicability of chimeric antigen receptor-engineered T(CAR-T) cells in treating cancer. The proposed real-time control strategy aims to maximize tumor regression while ensuring the safety of the treatment. A dynamic growth model of cancer cells under the influence of cellular immunotherapy is established for the first time, which aligns with clinical experimental *** the backstepping method, a novel consensus reference model is designed to consider the characteristics of cancer cell changes during the treatment process and conform to clinical rules. The model is segmented and continuous, with cancer cells expected to decrease in a step-like manner. Furthermore, a prescribed performance mechanism is constructed to maintain the therapeutic effect of the proposed scheme while ensuring the transient performance of the system. Through the analysis of Lyapunov stability, all signals within the closed-loop system are proven to be semiglobally uniformly ultimately bounded(SGUUB). Simulation results demonstrate the effectiveness of the proposed control strategy, highlighting its potential for clinical application in cancer treatment.

关键词： Cellular immunotherapy therapy chimeric antigen receptor-engineered T (CAR-T) cells neuro-adaptive control novel consensus reference model prescribed performance mechanism

Bifunctional bridging capping layer enables 24.5%efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期68卷 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu Jing Li Shucheng Qin Ke Hu Xin Jiang Wenbin Lai Minchao liu Zhe liu Chenxing lu Jinyuan Zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information EngineeringZhejiang Normal UniversityJinhua 321004China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Developing a bridge capping layer between perovskite and hole transport layer materials(HTMs)in the n-i-p perovskite solar cells(pero-SCs)is an effective approach to modify the morphology of HTMs and passivate the perovskite ***,we select the quinoxaline-based bifunctional passivation agent,quinoxalin-6-yl-methylamine hydrochloride(Qx MACl),as the bridging layer,and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p *** to theπ-πstacking among the common quinoxaline units in the bridge layer and HTM,Qx MACl induces theπ-πstacking of the PBQ12 film and improves the film morphology of HTMs with better ***,Qx MACl can effectively passivate the perovskite surface,and PBQ12 possesses appropriate energy levels and high hole *** pero-SCs based on FAPbI_(3)with PBQ12/Qx MACl treatment showed a higher power conversion efficiency(PCE)of 24.05%and outstanding stability,maintaining 95.4%and 92.1%of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85℃,*** further enhance the PCE of the PBQ12/Qx MACl-based devices,we developed a non-metal ion dopant for the PBQ12 *** trace doping of PBQ12 HTM by the non-metal ion dopant,the PCE of the PBQ12/Qx MACl-based devices reached 25.24%(the calibrated PCE of 24.55%by the National Institute of Metrology,China).

关键词： D-A copolymer hole transport materials bifunctional bridge capping layer passivation perovskite solar cells