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Chinese Medical Journal 2020年第10期133卷 1248-1250页

作者： lu-lu liu Yu Wang Yu Gu Shan-Shan Li Bi-Lin Chen Kun-lu Shen Xin Su departm ent of Respiratory and Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002China Department of Respiratory and Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjingJiangsu 210002China Department of Respiratory and Critical Care Medicine Jinling HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China.

To the Editor:A multicenter retrospective survey in China shows that the most common pulmonary fungal disease is pulmonary aspergillosis.[1]The diagnosis of invasive pulmonary aspergillosis(IPA)remains challenging because of the high false-negative and false-positive rate of galactomannan(GM)*** research reports that the IPA misdiagnosis rate can be as high as 73%.Besides,GM is time consuming,making the diagnosis delayed.

关键词： diagnosis aspergillosis pulmonary

MicroRNA-210 Plays a Critical Role in the Angiogenic Effect of Isoprenaline on Human Umbilical Vein Endothelial Cells via Regulation of Noncoding RNAs

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Chinese Medical Journal 2016年第22期129卷 2676-2682页

作者： You-You Yan Zhi-Hui Wang Lei Zhao Dan-Dan Song Chao Qi lu-lu liu Jun-Nan Wang Department of Cardiology The Second Affiliated Hospital of Jilin University Changchun Jilin 130041 China Department of Clinical Laboratory The Second Affiliated Hospital of Jilin University Changchun Jilin 130041 China

Background：β-adrenoceptors play a crucial regulatory role in blood vessel endothelial *** （ISO,a β-adrenergic agonist） has been reported to promote angiogenesis through upregulation of vascular endothelial growth factor （VEGF） expression;however,the underlying mechanism remains to be *** is widely accepted that certain noncoding RNAs,including microRNAs （miRNAs） and long noncoding RNAs （lncRNAs）,can regulate endothelial cell behavior,including their involvement in ***,we aimed to investigate whether noncoding RNAs participate in ISO-mediated angiogenesis using human umbilical vein endothelial cells （HUVECs）.Methods：We evaluated VEGF-A messenger RNA （mRNA） and protein levels in ISO-treated HUVECs by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay,*** establish whether noncoding RNAs are associated with ISO-mediated angiogenesis,we measured expression of the miRNAs miR-210,miR-21,and miR-l,as well as that of the lncRNAs growth arrest-specific transcript 5 （GAS5）,maternally expressed 3 （MEG3）,and metastasis-associated lung adenocarcinoma transcript 1 （MALAT1） in HUVECs exposed to ***,to ascertain its importance in ISO-mediated angiogenesis,we constructed the HUVECs with overexpressing miR-210 and detected the subsequent expression of VEGF-A and noncoding *** statistical analyses were performed using SPSS 16.0 *** comparisons were carried out by one-way analysis of ***：VEGF-A mRNA levels were elevated in the ISO group （1.57 ± 0.09） compared to those in the control group （P 〈 0.01）.Moreover,concentrations of VEGF-A in culture supernatants significantly differed between the control （113.00 ± 19.21 pg/ml） and ISO groups （287.00 ± 20.27 pg/ml;P 〈 0.01）.Expression of miR-1,miR-21,and miR-210 was higher （3.89 ± 0.44,2.87 ± 087,and 3.33 ± 1.31,respectively） in ISO-treated cells than that in controls （P 〈 0.01）,whereas that of GAS5 and M

关键词： Angiogenesis Isoprenaline Long Noncoding RNAs MicroRNAs

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu liu Xingyu Wu lufan Zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

圆形纤维增强塑料缠绕混凝土柱在持续轴向压缩下的面向设计的模型分析（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第1期16卷 47-58页

作者： Hui liu Ming-hua HE Jia GUO Yong-jiu SHI Zhao-xin HOU lu-lu liu Department of Civil Engineering Tsinghua University Central Research Institute of Building and Construction Co. Ltd. China Metallurgical Group Corporation Research Institute of Highway of China Ministry of Transport Institute of Chemical Machinery Zhejiang University College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics

目的:在实际工程服役过程中,纤维增强塑料(FRP)约束混凝土柱在遭遇极限荷载前往往已经经历了长时间的轴压荷载作用。因此,相比其短期力学性能,本文旨在研究FPR约束混凝土柱在长期荷载作用后的力学性能。创新点:1.考虑长期轴压荷载作用,... 详细信息

目的:在实际工程服役过程中,纤维增强塑料(FRP)约束混凝土柱在遭遇极限荷载前往往已经经历了长时间的轴压荷载作用。因此,相比其短期力学性能,本文旨在研究FPR约束混凝土柱在长期荷载作用后的力学性能。创新点:1.考虑长期轴压荷载作用,提出一种轴压作用下圆形截面FRP约束混凝土柱的长期变形分析模型;2.提出了长期轴压作用后的FRP约束混凝土本构模型,从本构关系的角度描述两个方面的影响机理。方法:运用混凝土和FRP徐变的长期变形分析迭代计算方法(图3)。结论:1.提出的长期变形分析模型实现了对FRP约束混凝土柱任意目标时刻的应力和应变状态的高效、准确预测;2.将提出的本构模型嵌入有限元软件中,有效地实现对长期轴压作用的考虑;3.基于Open Sees有限元软件,验证了长期变形分析模型和本构模型的有效性和准确性。

关键词： FRP约束混凝土柱长期荷载长期变形徐变本构模型

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng Lijuan Shi Qun Yi Yao liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

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含盐量对路肩石灰土基层结冰温度的影响

公路交通科技 2017年第2期34卷 50-55页

作者：刘路路刘晓燕李哲长安大学公路学院陕西西安710064

为了研究含盐量对高等级公路路肩石灰土基层结冰温度的影响,将合肥—淮南高速公路田家庵段两侧土样配成掺灰比为3%的石灰土,分别在含水率为8%,11%,14%,17%与含盐量为0.5%,1.5%,2.5%,3.5%条件下进行结冰温度与无侧限抗压强度试验,分析得... 详细信息

为了研究含盐量对高等级公路路肩石灰土基层结冰温度的影响,将合肥—淮南高速公路田家庵段两侧土样配成掺灰比为3%的石灰土,分别在含水率为8%,11%,14%,17%与含盐量为0.5%,1.5%,2.5%,3.5%条件下进行结冰温度与无侧限抗压强度试验,分析得出了基于含盐量、含水率为变量的无侧限抗压强度与结冰温度预报方程。结果表明:不同含水率石灰土的无侧限抗压强度随含盐量增加近似成二次多项式函数模型减小;不同含水率石灰土的结冰温度随含盐量增加近似成线性函数模型增长;含盐量为1.5%~1.9%,含水率为13.5%~14.5%,结冰温度较素石灰土明显降低,满足无侧限抗压强度规范要求。

关键词：道路工程路肩石灰土基层无侧限抗压强度结冰温度含盐量

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan liu Yujia lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui liu Xingxing Fang Liangming Zhang Bin liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Model and Practice for Dissemination and Extension of the Sino-Dutch Cooperation Project

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Model and Practice for Dissemination and Extension of the Si...