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Microarray analysis of signalling interactions betw.en inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis

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Biomaterials Translational 2024年第2期5卷 175-184页

作者： Qin w. Gao J. Yan J. Han X. lu w. Ma Z. Niu L. Jiao K. Department of Stomatology Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration and National Clinical Research Centre for Oral Diseases Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Inflammation and angiogenesis, the major pathological changes of osteoarthritis (OA), are closely associated w.th joint pain; how.ver, pertinent signalling interactions w.thin subchondral bone of osteoarthritic joints and potential contribution to the peripheral origin of OA pain remain to be elucidated. Herein w. developed a unilateral anterior crossbite mouse model w.th osteoarthritic changes in the temporomandibular joint. Microarray-based transcriptome analysis, besides quantitative real-time polymerase chain reaction, w.s performed to identify differentially expressed genes (DEGs). Overall, 182 DEGs (fold change ≥ 2, P w.re identified betw.en the control and unilateral anterior crossbite groups: 168 w.re upregulated and 14 w.re dow.regulated. On subjecting significant DEGs to enrichment analyses, inflammation and angiogenesis w.re identified as the most affected. Inflammation-related DEGs w.re mainly enriched in T cell activation and differentiation and in the mammalian target of rapamycin/nuclear factor-κB/tumour necrosis factor signalling. Furthermore, angiogenesis-related DEGs w.re mainly enriched in the Gene Ontology terms angiogenesis regulation and vasculature development and in the KEGG pathw.ys of phosphoinositide 3-kinase-protein kinase B/vascular endothelial grow.h factor/hypoxia-inducible factor 1 signalling. Protein– protein interaction analysis revealed a close interaction betw.en inflammation-and angiogenesis-related DEGs, suggesting that phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (Pi3kcd), cathelicidin antimicrobial peptide (Camp), C-X-C motif chemokine receptor 4 (Cxcr4), and MYB proto-oncogene transcription factor (Myb) play a central role in their interaction. To summarize, our findings reveal that in subchondral bone of osteoarthritic joints, signal interaction is interrelated betw.en inflammation and angiogenesis and associated w.th the peripheral origin of OA pain; moreover, our data highlight potential t

关键词： angiogenesis inflammation osteoarthritic pain osteoarthritis subchondral bone temporomandibular joint (TMJ)

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Research progress on fluorescence sensing properties of metal-organic framew.rks

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Journal of Molecular Science 2024年第2期40卷 107-114页

作者： Zhou X. Chai Y. lu-Sun w. Fu Z. w.ng B. Yuan G. School of Chemical and Blasting Engineering Anhui University of Science and Technology Huainan 232001 China

The metal-organic framew.rks (MOFs) have the characteristics of high porosity and crystallinity, w.ich also makes MOFs have the advantages of high sensitivity, high selectivity and high efficiency in the field of fluorescence sensing. It can detect the target substance efficiently and quickly, and has excellent anti-interference. Therefore, MOFs materials are also considered as ideal materials for fluorescence sensors. This paper introduces three common preparation methods of MOFs materials: hydrothermal/solvothermal method, mechanochemical method and microw.ve method. w. focus on the application status of MOFs materials in the three fluorescence sensing fields of small molecules, metal cations and inorganic anions, as w.ll as the shortcomings and improvement methods of MOFs materials in this application field. Finally, in view.of the shortcomings of MOFs materials in the field of fluorescence sensing, such as poor stability, fluorescence quenching phenomenon susceptible to environmental interference, etc., it is proposed that more in-depth research should be carried out in the future in terms of anti-interference and reuse © 2024, Department of Chemistry, Northeast Normal University. All rights reserved.

关键词： detection fluorescence metal-organic framew.rk sense

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The　application　of　the　fractal　geometry　in　the　study　of　sea-floor　volcano

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Acta Oceanologica Sinica 1997年第3期16卷 387-394页

作者： Tao C. Jin X. lu w. Hua Z. Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China

Ｔｈｅａｐｐｌｉｃａｔｉｏｎｏｆｔｈｅｆｒａｃｔａｌｇｅｏｍｅｔｒｙｉｎｔｈｅｓｔｕｄｙｏｆｓｅａ－ｆｌｏｏｒｖｏｌｃａｎｏＴａｏＣｈｕｎｈｕｉ，ＪｉｎＸｉａｎｇｌｏｎｇ，ＬｕＷｅｎｚｈｅｎｇａｎｄＨｕａＺｕｇｅｎ（... 详细信息

Ｔｈｅａｐｐｌｉｃａｔｉｏｎｏｆｔｈｅｆｒａｃｔａｌｇｅｏｍｅｔｒｙｉｎｔｈｅｓｔｕｄｙｏｆｓｅａ－ｆｌｏｏｒｖｏｌｃａｎｏＴａｏＣｈｕｎｈｕｉ，ＪｉｎＸｉａｎｇｌｏｎｇ，ＬｕＷｅｎｚｈｅｎｇａｎｄＨｕａＺｕｇｅｎ（ＲｅｃｅｉｖｅｄＯｃｔｏｂｅｒ４，...

关键词： application the fractal The

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Implications of the scalar meson structure from B→SP decays w.thin PQCD approach

Implications of the scalar meson structure from B→SP decays...

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中国物理学会高能物理分会第七届学术年会理论分会场

作者： Yuelong Shen IHEP, CAS In collaboration w.th C. D. lu , w. w.ng...

Outline Motivation Scalar meson production in B decays Numerical results and discussions Conclusion and outlook Motivation Problems in scalar meson spectroscopy The advantages in study scalar meson in B decays Annihil...

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High-efficiency prediction method for helicopter global/ground noise based on near-field acoustic holography

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Chinese Journal of Aeronautics 2024年第7期37卷 271-284页

作者： Mengxue SHAO Yang lu Xice XU Jiaxin lu National Key Laboratory of Helicopter Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Noise reduction program design is an effective approach that relies on efficient noise prediction for reducing ground noise during *** existing noise prediction methods have the limitations of being computationally expensive or only applicable to *** this paper,a High-Efficiency Prediction Method(HEPM)for helicopter global/ground noise based on near-field acoustic holography is *** HEPM can predict the global noise based on acoustic modal analysis and has the advantages of high prediction accuracy and low.time *** process is given as follow.:firstly,the rotor noise on the holographic surface in the specified flight is obtained by simulations or ***,the global noise model,w.ich maps time-domain noise to acoustic modes,is established based on near-field acoustic holography and Fourier acoustic analysis ***,combined w.th acoustic modal amplitude,the model established enables efficiently predicting the global/ground noise in the corresponding flight *** verify the accuracy of the prediction method,a simulation study is conducted in hovering and forw.rd flight states using a model helicopter w.th a 2-meter rotor and Rotor Body Interaction(ROBIN)*** comparison of HEPM w.th numerical results show. that the average prediction errors of the global and ground noise are less than 0.3 dB and 0.2 dB,*** a region containing 100000 observers,the computation time of the HEPM is only one-fifth of that of the acoustic hemisphere method,demonstrating the rapidity of the proposed method.

关键词： Helicopter Rotor noise prediction Noise abatement procedure design Acoustic modal analysis Near-field acoustic holography

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Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin w.ng Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity w.ere they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer w.rk and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new.*** this review.w. comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into tw. *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of sw.rming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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Soil inorganic amendments produce safe rice by reducing the transfer of Cd and increasing key amino acids in brow. rice

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Journal of Environmental Sciences 2024年第2期136卷 121-132页

作者： Fanyi Kong Shenggao lu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Key Laboratory of Environmental Remediation and Ecosystem HealthMinistry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

The digestibility of cadmium(Cd)in brow. rice is directly related to amino acid metabolism in rice and human *** our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages w.re applied to produce safe rice and improve the quality of rice in Cd-contaminated *** the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brow. rice decreased *** vitro digestibility of Cd in brow. rice w.s estimated by a physiologically based extraction *** show.d that more than 70%of Cd in brow. rice could be digested by simulated gastrointestinal *** on the total and digestible Cd contents in brow. rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy *** amino acids(AAs)in brow. rice w.re determined by high-performance liquid *** contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly w.th the increased application of *** structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brow. *** formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)w.th Cd in brow. rice could be considered a potential mechanism for reducing the digestibility of Cd.

关键词： Cadmium digestibility Soil inorganic amendments Safe rice Amino acid Priming effect Health risk

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On the Monge–Kantorovich Mass Transfer Problem in Higher Dimensions

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1989-2004页

作者： Xiao Jun lu School of Mathematics Southeast UniversityNanjing 210096P.R.China

This paper mainly investigates the approximation of a global maximizer of the Monge–Kantorovich mass transfer problem in higher dimensions through the approach of nonlinear partial differential equations w.th Dirichlet *** an approximation mechanism,the primal maximization problem can be transformed into a sequence of minimization *** applying the systematic canonical duality theory,one is able to derive a sequence of analytic solutions for the minimization *** the final analysis,the convergence of the sequence to an analytical global maximizer of the primal Monge–Kantorovich problem w.ll be demonstrated.

关键词： Monge-Kantorovich mass transfer singular variational problem canonical duality theory

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A solution method for decomposing vector fields in Hamilton energy

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Chinese Physics B 2024年第9期33卷 645-653页

作者： Xin Zhao Ming Yi Zhou-Chao w.i Yuan Zhu lu-lu lu School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Hamilton energy,w.ich reflects the energy variation of systems,is one of the crucial instruments used to analyze the characteristics of dynamical *** w. propose a method to deduce Hamilton energy based on the existing *** derivation process consists of three steps:step 1,decomposing the vector field;step 2,solving the Hamilton energy function;and step 3,verifying *** order to easily choose an appropriate decomposition method,w. propose a classification criterion based on the form of system state variables,i.e.,type-I vector fields that can be directly decomposed and type-II vector fields decomposed via exterior ***,exterior differentiation is used to represent the curl of low.high dimension vector fields in the process of ***,w. exemplify the Hamilton energy function of six classical systems and analyze the relationship betw.en Hamilton energy and dynamic *** solution provides a new.approach for deducing the Hamilton energy function,especially in high-dimensional systems.

关键词： Hamilton energy dynamical systems vector field exterior differentiation

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Progress of vegetation modelling and future research prospects

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Science China Earth Sciences 2024年第9期67卷 2718-2738页

作者： Siqi LI Xu ZHANG Zhengyao lu Jian NI Jianhua lu State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China British Antarctic Survey Cambridge CB30ETUnited Kingdom Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362Sweden College of Life Sciences Zhejiang Normal UniversityJinhua 321004China School of Atmospheric Sciences Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China

Terrestrial vegetation is a crucial component of the Earth system,and its changes not only represent one of the most distinct aspects of climate change but also exert significant feedback w.thin the climate system by exchanging energy,moisture,and carbon *** quantitatively and mechanistically study climate-vegetation feedback,numerical vegetation models have been developed on the theory of ecophysiological constraints on plant functional *** models eventually can simulate vegetation distribution and succession across different spatial and temporal scales,and associated terrestrial carbon cycle processes by categorizing vegetation into biomes according different plant functional types and their associated environmental *** w. review.the developing history of vegetation models and provide recent advances and future *** 21st century,static vegetation models,as developed statistical models,can only simulate equilibrated characteristics of vegetation *** last several decades,Dynamic Global Vegetation Models(DGVMs)have been developed to simulate instantaneous responses of vegetation to climate change and associated dynamics,and can be coupled w.th Earth system models to investigate interactions among atmosphere,ocean,and *** are also w.dely applied to investigate the dynamics accounting for changes in the geographic distribution patterns of land surface vegetation at different spatial and temporal scales and to assess the impacts of terrestrial carbon and w.ter fluxes and land use *** suggest that future vegetation modeling could integrate w.th machine learning,and explore vegetation transient response and feedback as w.ll as impacts of process hierarchies and human activities on climate and ecosystem.

关键词： Vegetation models DGVMs Ecosystems Plant functional types Plant functional traits

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