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Status of aquatic organisms resources and their environments in yangtze River system(201.-2021.⋆

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile yang Li Shen Yongfeng He Huiwu Tian Lei Gao Jinming Wu Zhigang Mei Nian Wei Lin Wang Tingbing Zhu Feifei Hu Jinling Gong Hongchun Du Xinbin Duan Huatang Deng Daoqun Wang Fengyue Zhu {1.feng Li Fan Wu Huijun Ru yan zhang Junyi Li Junlin yang {1.tao Zhou Dongdong Fang Yinping Wang Danqing Lin yanping yang Peijie Li Silei Liu Jian yang Ping Zhuang Sikai Wang Tao zhang Gang yang Wenbo yang Lilai Yuan Kun Cao Shuo xu Huiyuan Liu Zhiqiang Liang Chongrui Wang Hong Li Xiping Yuan Xin yang Yilong Fu yanping zhang Haixin zhang Zhiying Tao Sheng Wang Xiaoping Gao Binsong Jin Kemao Li Guojie Wang Shenglong Jian Yingqin Li Chenjiang xue Chun{1. Lei Shaowei xue Yi Sun Bin Zhu Ke Shao Xingkun Hu Meihua Xiong Jun Du Bin He Tao yan Yingying Huang Yuanchao Zou Biwen Xie Yongming Wang Bin Li Fei Liu Yaoyao zhang Fei Fan Zhijian Wang Jing Huang Haoran Gu Hailong Ge yan Dan yan Li Shuqiao Wang Chuang zhang lu Zhou xue Wang Sheng Zeng yan Xiang xugang He Jianhui Qin Chengxing Xia Jie Hou Yifu Shi Lifang Gao Zhiqiang Zhu Hongbao Shen {1. Du xuejun Duan Jiawu Xiong Deguo yang Shaoping Liu Zhaohui Ni Hui zhang Kai Liu Feng Zhao Yingren Li Jianwei Wang Qiwei Wei yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhan430223China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai200090China Institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China Hunan Fisheries Science Institute Changsha410153China Jiangxi Fisheries Research Institute Nanchang330039China Jiujiang Academy of Fishery Sciences Jiujiang332000China School of Life Sciences Nanchang UniversityNanchang330031China Qinghai Provincial Fishery Technology Extension Center Xining810012China yunnan Academy of Fishery Sciences Kunming650111China Institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries Institute Sichuan Academy of Agricultural SciencesChengdu611731China School of Life Sciences Neijiang Normal UniversityNeijiang641100China School of Life Sciences Southwest UniversityChongqing400715China Chongqing Fishery Sciences Research Institute Chongqing401120China Guizhou Fisheries Research Institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China Hubei Fisheries Science Research Institute Wuhan430070China Shaanxi Fisheries Research Institute Xi’an710086China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning Institute of State Forestry and Grassland Administration Changsha410014China

The yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of yangtze Fisheries Resources and Environment Investigation(201.-2021.supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 24 institutes and universities that located in the yangtze River basin surveys the status of(1.fish species composition and spatial distribution,(2)current fish abundance,(3)endangered fishes,(4)yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the yangtze River mainstream and 1. of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 1.3 genus,37 families,and 1. orders)before 201.,but only 323 fish species(including 1. new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole yangtze River *** is estimated that there were 886 million individuals weighing 1.4.8 million kg,merely equivalent to 27.3%of the resources in 1.50s,30.9%of the resources in 1.60s,or 58.7%of the resources in *** the new list of protected fishes that recorded in the yangtze River system,only 1. of 29 were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes yangtze finless porpoise Resources Aquatic ecosystem Fisheries Background investigation yangtze river system

甘草酚调节肠道菌群及其代谢产物激活自噬拮抗5-氟尿嘧啶致小鼠结肠损伤的机制研究

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营养学报 2024年第4期46卷 372-382页

作者：路上云徐佳丽许杨张会霞刘子玲邱服斌山西医科大学公共卫生学院营养与食品卫生学教研室

目的探究甘草酚（glycyrol, GC）是否通过调节肠道菌群及其代谢产物激活自噬减轻结肠损伤。方法雄性Balb/C小鼠（6 w龄）适应性喂养1.w后，随机分为对照组(N)：灌胃生理盐水1. d+腹腔注射生理盐水3 d；结肠损伤模型组(5-FU)：灌胃生... 详细信息

目的探究甘草酚（glycyrol, GC）是否通过调节肠道菌群及其代谢产物激活自噬减轻结肠损伤。方法雄性Balb/C小鼠（6 w龄）适应性喂养1.w后，随机分为对照组(N)：灌胃生理盐水1. d+腹腔注射生理盐水3 d；结肠损伤模型组(5-FU)：灌胃生理盐水1. d+腹腔注射5-氟尿嘧啶（5-fluorouracil,5-FU,1.0 mg/kg) 3 d；甘草酚干预组(GC)：灌胃GC (20 mg/kg) 1.d+腹腔注射生理盐水3 d;GC+5-FU组：灌胃GC(20 mg/kg)1. d+腹腔注射5-FU (1.0 mg/kg) 3d；抗生素组(AB)：灌胃抗生素（200μl）1.d+腹腔注射生理盐水3d;GC+5-FU+AB组：灌胃抗生素（200μl）1.d+灌胃GC (20 mg/kg) 1.d+腹腔注射5-FU(1.0 mg/kg)3d，每组8只。采用HE染色、Western blot分析等，确定GC对小鼠结肠损伤的保护作用；通过1.S rDNA高通量测序、代谢组学等分析GC对小鼠肠道菌群结构、肠道菌群代谢产物、结肠自噬水平的影响；利用相关性分析，阐明GC是否通过调节肠道菌群及其代谢产物激活自噬保护结肠损伤的作用机制。结果与5-FU组相比，GC可显著增加小鼠的体重、摄食量，提高结肠超氧化物歧化酶(superoxide Dismutase,SOD)、过氧化氢酶（catalase,CAT）活力，显著降低结肠白细胞介素-1.(interleukin1.eta,IL-1.)、白细胞介素-6(interleukin 6, IL-6)和肿瘤坏死因子-α(tumor necrosis factor alpha, TNF-α)的表达水平，并明显减轻小鼠结肠组织病理学损伤；GC还可以改善小鼠肠道菌群结构，上调厚壁菌门和弯曲菌门的丰度、下调变形菌门和拟杆菌门的丰度，恢复拟杆菌科、毛螺旋菌科和普雷沃氏菌科等的异常变化，并显著下调胆钙化醇等6种肠道菌群代谢产物的水平，明显上调TNK等8种肠道菌群代谢产物的水平；相关性分析结果显示，多种肠道菌群代谢产物与小鼠结肠自噬水平有相关性。结论 GC激活自噬减轻结肠损伤与其调节肠道菌群及其代谢产物有关。[营养学报，2024,46(4):372-382]

关键词：甘草酚结肠自噬肠道菌群代谢产物

高脂饮食对孕期小鼠脂肪组织构成和炎症特征的影响

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上海交通大学学报（医学版） 2024年第8期44卷 981-990页

作者：卢星宇徐一丹刘亦沁张骞仁董艳上海交通大学医学院附属新华医院内分泌科上海200092 上海交通大学医学院附属新华医院消化科上海200092 上海市儿科医学研究所上海200092

目的·探究高脂饮食后雌鼠孕前、孕期脂肪组织的改变及其对子代脂肪组织可能产生的影响。方法·C57BL/6J雌性小鼠随机接受普通饮食(CON组,n=1.)和高脂饮食(HFD组,n=1.) 5周;根据是否妊娠再分为普通饮食非妊娠组(CON-UN组)、普通饮食妊娠... 详细信息

目的·探究高脂饮食后雌鼠孕前、孕期脂肪组织的改变及其对子代脂肪组织可能产生的影响。方法·C57BL/6J雌性小鼠随机接受普通饮食(CON组,n=1.)和高脂饮食(HFD组,n=1.) 5周;根据是否妊娠再分为普通饮食非妊娠组(CON-UN组)、普通饮食妊娠组(CON-P组)和高脂饮食非妊娠组(HFD-UN组)、高脂饮食妊娠组(HFD-P组)。雌鼠在孕期和哺乳期均维持原有饮食。雌鼠分别于喂饲5周或孕1..5 d取其白色脂肪组织(内脏)和棕色脂肪组织(肩胛)。两组孕鼠的子代断乳后,分别接受普通饮食至第1.周,取子代脂肪组织。采用苏木精-伊红(H-E)染色观察脂肪细胞的变化;流式细胞术检测白色脂肪组织中CD4^(+)T细胞、CD8^(+)T细胞、总T细胞、CD4^(+)T细胞/CD8^(+)T细胞比值及NK细胞的比例;实时荧光定量聚合酶链反应(RT-PCR)检测白色脂肪组织IL-6和IL-1. mRNA的表达。结果·高脂饮食喂养5周后,HFD组雌鼠体质量高于CON组雌鼠(P1.mRNA表达水平升高;分别与CON-UN组和CON-P组比较,差异均具有统计学意义(均P<0.05)。育龄期雌鼠(HFD-UN组)脂肪组织中NK细胞比例降低,但在妊娠期(HFD-P组) NK细胞比例则明显升高,两者呈现相反趋势。HFD组子代断乳后恢复普通饮食,其体质量、白色脂肪和棕色脂肪质量仍显著高于CON组子代(均P<0.05),且白色脂肪细胞体积显著增大。结论·高脂饮食可引起育龄期和妊娠期雌鼠脂肪细胞结构、免疫细胞比例改变及炎症水平升高,并影响子代脂肪组织结构;脂肪组织可能是介导肥胖代际传递的新载体。

关键词：高脂饮食脂肪组织妊娠母子代际传递

妊娠合并糖尿病并发产褥期感染临床特征和病原菌及其耐药性

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中华医院感染学杂志 2024年第13期34卷 2037-2040页

作者：张云燕卢冠名周艳春王宗杰南宁市妇幼保健院产科广西南宁530011 南宁市妇幼保健院检验科广西南宁530011

目的探讨妊娠合并糖尿病(GMD)并发产褥期感染临床特征、病原菌特点及耐药性。方法回顾性选取2020年1.-2022年1.月南宁市妇幼保健院收治的1.4例GMD并发产褥期感染患者为研究组,同期1.0例非糖尿病产褥期感染患者为对照组。比较不同感染... 详细信息

目的探讨妊娠合并糖尿病(GMD)并发产褥期感染临床特征、病原菌特点及耐药性。方法回顾性选取2020年1.-2022年1.月南宁市妇幼保健院收治的1.4例GMD并发产褥期感染患者为研究组,同期1.0例非糖尿病产褥期感染患者为对照组。比较不同感染部位病原菌分布情况;比较两组产褥期感染病原菌分布及耐药性情况。结果两组临床特征及病原菌感染部位比较,均无统计学差异。31.例产褥期感染患者共分离出病原菌322株,两组革兰阳性菌、真菌比较,无统计学差异,而研究组革兰阴性菌较对照组多,且研究组大肠埃希菌较对照组多(P50%,两组产褥期感染的大肠埃希菌对青霉素、头孢他啶、诺氟沙星、左氧氟沙星、阿米卡星、哌拉西林的耐药性均50%。结论GMD患者并发产褥期感染与患者一般资料以及病原菌感染部位等因素无关,GMD可影响产褥期感染患者病原菌特点及耐药性,可增加革兰阴性菌感染率,也可提高金黄色葡萄球菌耐药性。

关键词：妊娠合并糖尿病产褥期感染流行病学病原菌耐药性金黄色葡萄球菌表皮葡萄球菌大肠埃希菌

精氨酸甲基转移酶(PRMT)7通过IGF-1.号通路调控人骨髓间充质干细胞成脂分化的研究

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生物化学与生物物理进展 2024年第6期51卷 1406-1417页

作者：郭倩卿佳陆大壮王叙李扬张慧张应飞刘云松周永胜张萍国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心口腔数字医学北京市重点实验室北京大学口腔医学院口腔医院修复科北京100081

目的本研究旨在明确精氨酸甲基转移酶(PRMT)7在人骨髓间充质干细胞(hBMSCs)成脂分化过程中的变化以及是否调控hBMSCs成脂分化,进而探索相应的调控机制。方法通过定量反转录PCR(qRT-PCR)和蛋白质印迹(Western blot)检测hBMSCs成脂分化过... 详细信息

目的本研究旨在明确精氨酸甲基转移酶(PRMT)7在人骨髓间充质干细胞(hBMSCs)成脂分化过程中的变化以及是否调控hBMSCs成脂分化,进而探索相应的调控机制。方法通过定量反转录PCR(qRT-PCR)和蛋白质印迹(Western blot)检测hBMSCs成脂分化过程中PRMT7的变化;通过qRT-PCR和Western blot实验证明PRMT7稳定敲低细胞系构建成功。进行油红O染色和定量分析,以及qRT-PCR和Western blot实验检测PRMT7稳定敲低细胞系成脂分化水平的变化;通过裸鼠体内异位成脂实验,油红O染色检测PRMT7稳定敲低细胞系体内异位成脂的效果;通过qRT-PCR和Western blot证明PRMT7稳定过表达细胞系构建成功。进行油红O染色和定量分析以及qRT-PCR和Western blot实验检测PRMT7稳定过表达细胞系成脂分化水平的变化;通过q RT-PCR和Western blot实验检测敲低PRMT7和过表达PRMT7的细胞中IGF-1.达水平的变化。在PRMT7稳定敲低细胞系中转染siIGF-1.通过qRT-PCR和Western blot检测IGF-1.表达水平验证敲低效率。通过油红O染色和定量分析,qRT-PCR实验检测转染siIGF-1.敲低组hBMSCs成脂分化水平的变化。结果本文发现:在hBMSCs成脂过程中,PRMT7表达水平明显降低(P1.;敲低PRMT7后hBMSCs的成脂分化能力增强(P1.;敲低PRMT7后hBMSCs的体内异位成脂分化能力增强;过表达PRMT7后hBMSCs的成脂分化能力减弱(P1.;PRMT7敲低后IGF-1.达水平增加(P1.;PRMT7过表达后IGF-1.达水平降低(P1.;转染siIGF-1.,各细胞系IGF-1.达水平明显降低(P1.;敲低组转染siIGF-1.成脂分化能力明显降低(P1.。结论本研究通过细胞水平和裸鼠皮下移植实验发现PRMT7显著抑制hBMSCs成脂分化,机制研究发现PRMT7对hBMSCs成脂分化的调控作用依赖IGF-1.号通路。上述研究表明,PRMT7可能是治疗相关疾病的潜在分子靶点,为PRMT7和hBMSCs应用于相关疾病治疗提供了新思路。

关键词：精氨酸甲基转移酶7 成脂分化骨髓间充质干细胞 IGF-1.号通路

基于萘并呋喃的比色型Zn^(2+)荧光探针的构建及性能

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发光学报 2024年第9期45卷 1568-1577页

作者：肖嘉扬宗洪凤怀玉芦海成高云高妍辽宁科技大学化学工程学院辽宁鞍山114051

锌离子(Zn^(2+))作为一种对人体至关重要的微量金属元素,在维持人体正常生理功能、能量转换、新陈代谢和信号传递等方面扮演着关键角色,人体内Zn^(2+)的检测和监控对于预防和治疗相关疾病具有非常重要的意义。利用萘并[2,1.b]呋喃-2-碳... 详细信息

锌离子(Zn^(2+))作为一种对人体至关重要的微量金属元素,在维持人体正常生理功能、能量转换、新陈代谢和信号传递等方面扮演着关键角色,人体内Zn^(2+)的检测和监控对于预防和治疗相关疾病具有非常重要的意义。利用萘并[2,1.b]呋喃-2-碳酰肼与4-(二乙氨基)水杨醛进行缩合,设计合成了比色响应Zn^(2+)的荧光分子探针(SPA)。探针SPA识别Zn^(2+)后荧光大幅增强且波长发生红移。利用HR-MS考察了探针SPA对Zn^(2+)的响应机制。探针SPA识别Zn^(2+)的检测限可低至1.1. nmol/L。探针SPA已成功应用于HeLa细胞中Zn^(2+)的共聚焦成像以及活鼠体内Zn^(2+)的荧光成像。

关键词：萘并呋喃锌离子荧光探针细胞成像小鼠成像

Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第6期30卷 565-578页

作者： Wen-Peng Wang Dan Shi Duo yun Jun Hu Jie-Fu Wang Jia Liu {1.-Peng {1.g Ming-Rui Li Jun-FengWang Da-lu Kong Department of Colorectal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Gastrointestinal Surgery Tianjin Nan Kai HospitalTianjin Medical UniversityTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM RepairInstitute of Integrative Medicine for Acute Abdominal DiseasesTianjin 300100China Department of Oncology The First Hospital of HohhotHohhot 010000Inner Mongolia Autonomous RegionChina Department of Endocrinology Dazhou Central HospitalDazhou 635000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a deadly malignancy with limited treatment ***(DUBs)have been confirmed to play a crucial role in the development of malignant ***2 is a DUB involved in con-trolling protein deubiquitination and influencing critical cellular processes in *** To investigate the impact of JOSD2 on the progression of *** Bioinformatic analyses were employed to explore the expression,prognosis,and enriched pathways associated with JOSD2 in *** transduction was utilized to manipulate JOSD2 expression in ESCC cell lines(KYSE30 and RESULTS )Preliminary research indicated that JOSD2 was highly expressed in ESCC tissues,which was associated with poor *** analysis demonstrated that JOSD2 was upregulated in ESCC cell lines compared to normal esophageal ***2 knockdown inhibited ESCC cell activity,including proliferation and colony-forming ***,JOSD2 knockdown decreased the drug resistance and migration of ESCC cells,while JOSD2 overexpression enhanced these *** vivo xenograft assays further confirmed that JOSD2 promoted tumor proliferation and drug resistance in ***,JOSD2 appears to activate the MAPK/ERK and PI3K/AKT signaling *** spectrometry was used to identify crucial substrate proteins that interact with JOSD2,which identified the four primary proteins that bind to JOSD2,namely USP47,IGKV2D-29,HSP90AB1.and *** JOSD2 plays a crucial role in enhancing the proliferation,migration,and drug resistance of ESCC,suggesting that JOSD2 is a potential therapeutic target in ESCC.

关键词： Esophageal squamous cell carcinoma JOSD2 Ubiquitination Biomarker Targeted therapy Drug resistance

生酮饮食治疗患儿基线营养状况和主要照顾者对其知晓现况调查研究

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中国实用儿科杂志 2024年第7期39卷 524-529页

作者：龚晓妍卢忠英张赟健郁莉斐周水珍钱甜国家儿童医学中心(上海) 复旦大学附属儿科医院临床营养科上海201102 国家儿童医学中心(上海) 复旦大学附属儿科医院神经内科上海201102

目的调查生酮饮食治疗启动前期患儿基线营养状况和主要照顾者对生酮饮食疗法(ketogenicdiet therapies,KDTs)的知晓现况,为后续有效治疗和长程管理模式的探索提供依据。方法采用前瞻性队列研究设计,纳入2021.7月至2024年1.于复旦大学... 详细信息

目的调查生酮饮食治疗启动前期患儿基线营养状况和主要照顾者对生酮饮食疗法(ketogenicdiet therapies,KDTs)的知晓现况,为后续有效治疗和长程管理模式的探索提供依据。方法采用前瞻性队列研究设计,纳入2021.7月至2024年1.于复旦大学附属儿科医院神经内科接受KDTs患儿及其主要照顾者作为研究对象,患儿完善营养筛查与评估。采用现场调查方式对主要照顾者进行问卷调查,了解患儿日常饮食行为习惯和主要照顾者在启动前期对KDTs知晓情况。结果研究共纳入1.4例患儿,有效问卷回收率1.0%。所有患儿均存在营养风险。在针对患儿日常饮食行为习惯的调查中发现,55.3%的患儿存在挑食偏食问题。在启动生酮饮食治疗前期,89.4%的主要照顾者通过神经内科专科就诊知晓患儿可行生酮饮食治疗,25.0%通过微信、网络、书籍知晓,1..6%通过病友群知晓。对于KDTs执行问题,72.1.的主要照顾者担心患儿难以接受此类特殊饮食,28.8%担心无法胜任临床实施流程,22.1.担心自身无法准确掌握生酮饮食治疗团队的教学。对于疗效期待,主要照顾者均期望患儿癫痫发作得到有效控制,79.8%期望治疗的同时能够改善患儿认知行为能力,77.9%期望同时能够减停所有抗癫痫药物。结论启动KDTs的患儿存在中度或高度营养风险,部分患儿存在营养不足或过剩问题。患儿日常存在膳食摄入不均衡的比例较高。主要照顾者对于疗效期待值较高。KDTs团队在常规诊疗过程中需关注患儿营养状况,加大KDTs宣教力度,以保障其能够安全有效实施。

关键词：生酮饮食营养状况主要照顾者现况调查

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1. experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao zhang Jun-Zheng Wang Li-Tao {1.g Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo xu-Yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-yun Li Ren-Ming-Jie Li xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-xuan Liu Shu-Kui Liu {1.-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang {1.g Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-{1.g Xing Rui xu Yin xu Tao xue Yu-lu {1. Nan Yi Chun-xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou zhang Lei zhang Zhen-Hua zhang Zhen-Yu zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1.,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1.89–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1.2)^(0ν)>1.0×1.^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge