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国家政权建设视域下农村“生活治理”的实践研究——基于华北F村的田野调查

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湖南农业大学学报（社会科学版） 2024年第3期25卷 59-67页

作者：卢丛丛邓大才华中师范大学中国农村研究院湖北武汉430079

国家政权建设的核心在于政治权力集中和对社会经济生活调控能力的提高。国家发展取向从生产本位向生活本位的转型,推动农村“生活治理”的出现。农民日常生活的开放性与权威缺位,形成了国家介入的正当性与耦合性。农村日常生活领域,规... 详细信息

国家政权建设的核心在于政治权力集中和对社会经济生活调控能力的提高。国家发展取向从生产本位向生活本位的转型,推动农村“生活治理”的出现。农民日常生活的开放性与权威缺位,形成了国家介入的正当性与耦合性。农村日常生活领域,规则力量与非规则事务、刚性管治与软事务间的冲突,要求“生活治理”不仅要有中间载体,也应当是软治理。通过规则嵌入的实践,“生活治理”实现对农村社会的知识再造与制度构建。基于此,“生活治理”在重构日常生活权力的基础上,实现日常生活权力的国家化。

关键词：国家政权建设生活治理规则嵌入日常生活

选择性雄激素受体调节剂治疗骨质疏松症的研究

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中国骨质疏松杂志 2024年第8期30卷 1197-1203页

作者：陆聪聪钱进张桢边振宇浙江中医药大学第四临床医学院浙江杭州310053 西湖大学医学院附属杭州市第一人民医院骨科浙江杭州310006

骨质疏松症(osteoporosis,OP)是常见的临床疾病,对于该疾病的治疗仍以药物治疗为主。选择性雄激素受体调节剂(selective androgen receptor modulators,SARMs)是一种具有组织选择性的激动剂,可以对骨组织的雄激素受体(androgen receptor... 详细信息

骨质疏松症(osteoporosis,OP)是常见的临床疾病,对于该疾病的治疗仍以药物治疗为主。选择性雄激素受体调节剂(selective androgen receptor modulators,SARMs)是一种具有组织选择性的激动剂,可以对骨组织的雄激素受体(androgen receptor,AR)产生强大合成代谢作用,同时又降低了传统雄激素治疗带来的副作用,因此被认为是有前途的OP雄激素药物治疗的替代品。目前,多项OP相关的临床前研究表明SARMs具有治疗效果,其中有些进入了临床试验阶段。本综述通过阐述雄激素与骨组织AR之间的关系,解释SARMs治疗OP的可能机制,并就SARMs的研究进展进行总结。

关键词：选择性雄激素受体调节剂骨质疏松症雄激素受体雄激素

A review on the synthesis of transition metal nitride nanostructures and their energy related applications

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Green Energy & Environment 2023年第2期8卷 406-437页

作者： Qiao luo congcong lu Lingran Liu Maiyong Zhu Research School of Polymeric Materials School of Materials Science&EngineeringJiangsu UniversityZhenjiangJiangsu 212013China

Transition metal nitrides(TMN)have recently grabbed immensely appealing as ideal active materials in energy storage and catalysis fields on account of their remarkable electrical conductivity,excellent chemical stability,wide band gap and tunable *** pure TMN and TMN-based materials have been extensively studied concerned with their preparation approaches,nanostructures,and favored performance in various ***,the processes towards synthesis of TMN are numerous and *** appropriate method to obtain target TMN with desired structure is crucial,which further affects its practical application ***,this review offers a timely and comprehensive summary of the synthetic ways to TMN and their application in energy related *** synthesis section is categorized into in-situ and ex-situ based on where the N element in TMN origins ***,overviews on the energy related applications including energy storage,electrocatalysis and photocatalysis are *** the end,the problems to be solved and the development trend of the synthesis and application of transition metal nitrides are prospected.

关键词： Transition metal nitride In-situ Ex-situ Energy storage Electrocatalysis Photocatalysis

Rational permeability coefficient of a permeable lining for composite tunnel lining structures

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岩石力学与工程学报 2017年第8期36卷 1930-1938页

作者： lu congcong LI Zongli College of Water Resources and Architectural Engineering Northwest A&F University

Various factors influence the tunneling are simplified considering the axial symmetry of the composite lining *** analytical expressions for the seepage field,stress,and displacement in the surrounding rock and those for the grouting circle,permeable lining,and ordinary lining are obtained according to the principle of effective *** seepage discharge,plastic zone,stress,and displacement around a tunnel affected by the different permeability coefficient ratios between the permeable lining and surrounding rock are *** reasonable value of permeability coefficient for the permeable lining are *** results show that the grouting circle controls the tunnel seepage discharge well and has a reasonable permeability coefficient and an optimal *** grouting circle controls the plastic zone development in the surrounding rock,i.e.,the thicker the grouting circle,the smaller the plastic zone in the surrounding *** tunnel seepage discharge and the effective stress in the grouting circle and lining increase gradually with the increasing of permeability coefficient ratio and tend to be stable after the ratio reaches *** analysis on the factors such as the stability of tunnel seepage discharge,the plastic zone of the surrounding rock and the stress around the tunnel indicates that it is relatively reasonable for the permeability coefficient ratio to be greater than or equal to 0.1.

关键词：《岩石力学与工程学报》期刊编辑工作工程

基于Sentinel-2影像的果树提取方法及其空间分析研究——以甘肃省平凉市为例

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江苏林业科技 2024年第3期51卷 22-29页

作者：柳涛盖艾鸿赵鹏伟刘桦鲁聪聪李莺莺甘肃农业大学资源与环境学院甘肃兰州730070

利用遥感技术对果园进行快速监测,准确掌握苹果园地面积与空间种植分布状况,有助于促进当地经济的发展。目前针对丘陵区果园提取的研究较少,相关方法的有效性和可靠性仍然存在问题。以甘肃省平凉市为研究区域,采用NDVI,RVI,EVI,SIPI,LSW... 详细信息

利用遥感技术对果园进行快速监测,准确掌握苹果园地面积与空间种植分布状况,有助于促进当地经济的发展。目前针对丘陵区果园提取的研究较少,相关方法的有效性和可靠性仍然存在问题。以甘肃省平凉市为研究区域,采用NDVI,RVI,EVI,SIPI,LSWI,NDWI等指标对输入数据进行增强,通过基于数据增强的梯度提升树算法提取研究区苹果种植面积。为验证该方法的有效性,引入最小距离法、CART决策树法、支持向量机法和随机森林4种机器学习算法进行对比分析,结果表明,梯度提升树算法分类精度最高,总体分类精度(Overall Accuracy,OA)达到89.3%,Kappa系数为0.77,分类效果及一致性均最佳。此外,采用基于数据增强的梯度提升树法分别对2019—2023年的苹果园进行提取,获得平凉市苹果园种植变化情况,各区县苹果园种植面积除泾川县外整体呈现上升趋势,泾川县和静宁县种植面积最大,其次为庄浪县、灵台县和崆峒区,最小的为崇信县和华亭市。

关键词：遥感梯度提升树数据增强 Sentinel-2影像 Kappa系数平凉市

Practical consideration for design and optimization of the step feed process

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Frontiers of Environmental Science & Engineering 2013年第1期7卷 135-142页

作者： Shijian GE Yongzhen PENG congcong lu Shuying WANG College of Environmental and Energy Engineering Key Laboratory of Beijing Water Quality Science and Water Environment Recovery Engineering Beijing University of Technology Beijing 100124 China

Based on the anoxic/oxic (A/O) step feed process, a modified University of Cape Town (UCT) step feed process was developed by adding an anaerobic zone and adjusting sludge return pipeline. Performance evaluation of these two types of processes was investigated by optimizing operational parameters, such as the anaerobic/anoxic/oxic volumes, internal recycle ratios, and sludge retention times, for removal of chemical oxygen demanding (COD), nitrogen, and phosphorus. Results showed high removal efficiencies of COD of (85.0±1.7)%, ammonium of (99.7±0.2)%, total nitrogen (TN) of (85.5±1.7)%, phosphorus of (95.1±3.3)%, as well as excellent sludge settleability with average sludge volume index of (83.7±9.5) L·mg in the modified UCT process. Moreover, (61.5±6.0)% of influent COD was efficiently involved in denitrification or phosphorus release process. As much as 35.3% of TN was eliminated through simultaneous nitrification and denitrification process in aerobic zones. In addition, the presence of denitrifying phosphorus accumulating organisms (DNPAOs), accounting for approximately 39.2% of PAOs, was also greatly beneficial to the nitrogen and phosphorus removal. Consequently, the modified UCT step feed process was more attractive for the wastewater treatment plant, because it had extremely competitive advantages such as higher nutrient removal efficiencies, lower energy and dosages consumption, excellent settling sludge and operational assurance.

关键词： step feed anoxic/oxic (A/O) University of Cape Town (UCT) simultaneous nitrification and denitrification (SND) denitrifying phosphorus removal biological nutrient removal (BNR)

嵌入型政权:治理精细化背景下农村基层政权的实践及逻辑

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天津行政学院学报 2022年第5期24卷 20-28页

作者：卢丛丛华中师范大学中国农村研究院湖北武汉430079

治理精细化背景下,中西部农村基层呈现出“嵌入型政权”的样态。不同于税改后的悬浮化以及项目下乡的内卷化样态,“嵌入型政权”表现为基层政权的重心下沉、组织嵌入与权威嵌入。基层政权的这一新实践,是基于“行政激活自治”的运作机制... 详细信息

治理精细化背景下,中西部农村基层呈现出“嵌入型政权”的样态。不同于税改后的悬浮化以及项目下乡的内卷化样态,“嵌入型政权”表现为基层政权的重心下沉、组织嵌入与权威嵌入。基层政权的这一新实践,是基于“行政激活自治”的运作机制,即行政力量通过事件输入的利益关联、干部下沉的过程监督、组织再造的动员结构,在激活自治动力、促成自治行动和塑造自治能力的基础上,实现了政权下沉。基层政权这一自主调适的关键路径在于找回自治,其实现可能性在于践行自治的群众路线。因此,基层政权悬浮化困境并非内生于“乡政村治”体制,困境化解也不在于去行政化的纯粹自治,而是行政与自治的有效结合。

关键词：治理精细化基层政权嵌入型政权行政激活自治群众路线

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乡村治理共同体的实践逻辑与基层政权转型

求实 2023年第2期 69-80,M0005页

作者：邓大才卢丛丛华中师范大学中国农村研究院湖北武汉430079

建设社会治理共同体是提升社会治理效能的重要路径。囿于国家治理视角相对抽象化与社会治理视角相对表层化的局限,基层治理视角理应回归社会治理共同体的实然逻辑。作为基层社会治理共同体的自主实践,乡村治理共同体实践样态体现为目标... 详细信息

建设社会治理共同体是提升社会治理效能的重要路径。囿于国家治理视角相对抽象化与社会治理视角相对表层化的局限,基层治理视角理应回归社会治理共同体的实然逻辑。作为基层社会治理共同体的自主实践,乡村治理共同体实践样态体现为目标一致的公共事务、“一核多元”的协商共治和责权利一体的分类治理。该实践基于“行政激活自治”机制,通过利益关联、责任网络与动员结构构建,实现自治动力激活、自治能力提升与自治行动促成,保证乡村治理共同体有效运转。乡村治理共同体实现基层政权的重心下沉、组织嵌入与权威嵌入,形成“嵌入型政权”,而从“悬浮型政权”向“嵌入型政权”转型,蕴含了国家治理、政府治理与基层治理的基本逻辑,增强了基层治理韧性。

关键词：基层治理乡村治理治理共同体行政激活自治嵌入型政权悬浮型政权治理韧性

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang congcong Xu Benyan lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging