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ANA-HEp2 pattern evaluation in pancreatic cancer:What can the autoantibodies tell us?

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 104-106页

作者： Amanda PB Albuquerque Amanda R Fernandes Angela LBP Duarte henrique de Ataide Mariz José GCA Júnior luiz A Mattos Maira Galdino da Rocha Pitta Moacyr JBM Rego Laboratory of Immunomodulation and New Therapeutical Approaches Research Centre for Therapeutic Innovation Suely Galdino(NUPIT-SG)Federal University of PernambucoRecifePEBrazil Rheumatology service Hospital das ClínicasRecifePEBrazil General surgery service Hospital das ClínicasRecifePEBrazil Oncology service Hospital das ClínicasRecifePEBrazil

To the Editor:Pancreatic neoplasms are mainly diagnosed by imaging methods and confirmed by biopsies[1].Imaging techniques and the tumor markers carbohydrate antigen 19-9(CA19-9)or carcinoembryonic antigen(CEA)used fo... 详细信息

关键词： neoplasms pattern specificity

Urban Mobility： Method of Analysis of the Adequacy of Public Policies in Cities Based on the Principles Proposed by the UN

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Journal of Civil Engineering and Architecture 2018年第5期12卷 335-343页

作者： Maurício Kunz henrique Aniceto Kujawa Alcindo Neckel Tania Fuga school of Architecture and Urbanism of Meridional College (IMED) Group of Studies and Research on Urban Mobility (NEPMOUR) Passo Fundo RS 99070-220 Brazil

Addressing urban mobility is a priority for government agencies due to increasing problems of travel and lack of accessibility, generated by increasing rates of population growth and motorization. The general objective of this study is to propose a method of analysis of the adequacy of policies, aimed at sustainable mobility and its impacts on urbanism. Methodologically, the analysis is based on the parameters proposed by the UN （United Nations）, namely, sectorial planning, mobility funding, management efficiency of urban mobility systems; and mobility system and support for green technology. The object of study is the public policies expressed in urban mobility plans, master plans and regional development plans. Through the applicability of this method, the results show the possibility of verifying the adequacy of public policies as a mechanism that induces improvements in urban mobility with greater levels of sustainability and the possibility of universalized access to users.

关键词： Urban sustainability universality of access urbanism.

Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate

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World Journal of Experimental Medicine 2020年第1期10卷 1-9页

作者： Juliana souza Vieira Emanuelle Juliana Cunha Juliana Feltrin de souza luis henrique Koeler Chaves Jessica Lakes de souza Allan Fernando Giovanini Clinical Dentistry University PositivoCuritibaPR 81280330Brazil stomatology Department University Federal of ParanáCuritibaPR 80210-170Brazil

BACKGROUND The epiphyseal growth plate is an important anatomical segment localized on the ends of a long *** the abovementioned atractive reasons for alendronate’s use,few data on the effect of alendronate during epiphyseal growth *** Verify the effect of alendronate on the growth epiphyseal plate,and compare its effect with the size of the femur during the double-staining of the immunolocalization of transforming growth factor-β1(TGF-β1)and bone morphogenetic protein-2(BMP2)in endochondral ossifing in specimens that have received *** Forty newborn rats were randomly divided into two groups:a control group(were given applications of 1 mg/kg physiologic saline)and a group that received Alendronate(a dose of 2.5 mg/kg).These groups were then divided into two subgroups for euthanasia in two and 12 d of *** euthanasia,the femurs were removed,and the femoral bones were measured linearly between the apex of the greater trochanter until the lower intercondylar midlle face to verify the probable bone growth between 3 and 12 d in control and alednroanto treated ***,the surgical pieces were also sent to the histopathology laboratory to produce histological *** obtained slides were stained with hematoxylin and eosin to measure each of the cartilage zones in endochondral *** other slides were immunohistochemically tested for anti-TGF-β1 and BMP-2 antibodies to investigate the immunolocalization of these proteins in the epiphyseal plaque *** On the third day,some diferences between the control group and specimens treated with alendronate were ***,we found similarities in size between the femoral bones when we compared the control group with the specimens that received *** the 12^th day,the bone size of the mice receiving the drug was significantly smaller than those of the control *** results coincide with changes in the TGF-β1 and BMP-2 *** the speci

关键词： Alendronate Bone development Epiphyseal plate Bone morphogentic protein-2 Transforming growth factor-β1

Effects of environmental conditions and space on species turnover for three plant functional groups in Brazilian savannas

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Journal of Plant Ecology 2019年第6期12卷 1047-1058页

作者： Hélio Menegat Divino Vicente silvério henrique A.Mews Guarino R.Colli Ana Clara Abadia Leonardo Maracahipes-santos Lorrayne A.Gonçalves Jhany Martins Eddie Lenza Universidade do Estado de Mato Grosso Campus Universitário de Nova XavantinaRua Prof.Dr.Renato Figueiro VarellaCaixa Postal0878690-000Nova XavantinaMTBrazil Instituto de Pesquisa Ambiental da Amazônia Rua Horizontina 10478640-000CanaranaMTBrazil Centro de Ciências Biológicas e da Natureza Universidade Federal do AcreCaixa Postal 50069920-900Rio BrancoACBrazil Departamento de Zoologia Universidade de Brasília70910-900BrasíliaDFBrazil

Aims Different plant functional groups display diverging responses to the same environmental ***,we assess the effects of environmental and spatial predictors on species turnover of three functional groups of Brazilian savannas(Cerrado)plants—trees,palms and lianas—across the transition zone between the Cerrado and Amazon biomes in central *** We used edaphic,climatic and plant composition data from nine one-hectare plots to assess the effects of the environment and space on species turnover using a Redundancy Analysis and Generalized Dissimilarity Modeling(GDM),associated with variance *** Findings We recorded 167 tree species,5 palms and 4 liana *** variation was most important in explaining species turnover,relative to geographic distance,but the best predictors differed between functional groups:geographic distance and silt for lianas;silt for palms;geographic distance,temperature and elevation for *** distances alone exerted little influence over species turnover for the three functional *** pure environmental variation explained most of the liana and palm turnover,while tree turnover was largely explained by the shared spatial and environmental *** effects of geographic distance upon species turnover leveled off at about 300 km for trees,and 200 km for lianas,whereas they were unimportant for palm species *** results indicate that environmental factors that determine floristic composition and species turnover differ substantially between plant functional groups in ***,we recommend that studies that aim to investigate the role of environmental conditions in determining plant species turnover should examine plant functional groups separately.

关键词： environmental gradient spatial gradient Neotropical savannas ecological tension zone life forms ecological groups

Optimization of the Chitinase Production by Different Metarhizium anisopliae strains under solid-state Fermentation with silkworm Chrysalis as substrate Using CCRD

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Advances in Microbiology 2012年第3期2卷 268-276页

作者： Cynthia Barbosa Rustiguel Joao Atílio Jorge luis henrique souza Guimaraes Department of Biology Faculdade de FilosofiaCiencias e Letras de Ribeirao PretoUniversidade de Sao PauloSao PauloBrazil

Entomopathogenic fungi, such as Metarhizium anisopliae, are able to control various insect pests. These fungi attack the integument of the host using an enzymatic complex. Among the enzymes found in this complex, chitinase is an important component. However, the relation between the chitinase production and the virulence from different M. anisopliae strains has not been analyzed. In this manuscript it is presented the chitinase production by four M. anisopliae strains with different potential of virulence in solid-state Fermentation using silkworm chrysalis as substrate. The higher chitinase level was obtained with the strain IBCB 360 (7.14 U/g of substrate) with potential virulence of 68% on Diatrea saccharalis. The enzyme production was optimized for all strains using a factorial planning (CCRD) considering the cultivation time and medium humidity as independent variables. The maximal production of chitinase was obtained at a range from 8 to 12-days old cultures and from 45% to 62% of moisture according to the surface response plot, with high R2 value. The enzyme production by the strain IBCB 167 was increased two-folds under optimized conditions, while for the strains IBCB 360 and 425 the chitinase production was increased four-folds and nine-folds for the strain IBCB 384.

关键词： Entomopathogenic Fungus Metarhizium anisopliae Chitinase solid-state Fermentation

Complex Domain Wavelet-Based Denoising of Measured UHF Wireless Channel Power Delay Profiles

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International Journal of Communications, Network and system sciences 2010年第3期3卷 253-255页

作者： Maurício henrique Costa Dias Gláucio Lima siqueira 不详

This work extends the use of wavelet-based denoising as an alternative processing scheme to improve measured mobile-radio channel power delay profiles. It has already been reported that, when applied on real domain data (amplitude only), denoising provides mainly a qualitative improvement. Here, phase content was also considered, leading to significant qualitative and quantitative improvement of the processed profiles. signal-to-noise ratios and dynamic ranges improvements as high as 50 dB have been observed.

关键词： Wireless Propagation Channel Wideband Channel sounding UHF Measurements Wavelets Denoising

soil Mapping of a small Watershed in a Brazilian savanna Biome: A semi-Automatic Approach

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Journal of Geographic Information system 2014年第2期6卷 79-87页

作者： Larissa Ane de sousa Lima Adriana Reatto henrique Llacer Roig Centro de Pesquisa Agropecuária do Cerrado Empresa Brasileira de Pesquisa Agropecuária Brasilia Brazil Geosciences Institute University of Brasilia Brasilia Brazil

The objective of this work is to propose a semi-automatic methodology for the creation of a semidetailed to detailed watershed’s soil map. This methodological proposal is based on the traditional method (field work and photo interpretation) and on morphometric variables analysis, using data originated from the Digital Elevation Model (DEM) of the shuttle Radar Topography Mission (sRTM) program. The steps taken through this methodological proposal were the identification of the hydromorphic areas boundaries through interpretation of aerial orthophotographs;the compartmentalization of the relief through color composition techniques using the morphometric variables—slope, altimetry and horizontal curvature;the development of a pedological database based on data gathered in the field;the elaboration of a preliminary soil map based on the compartmentalized relief and on the dataset of the soils sampled in the field;the elaboration and adjustment of the final soil map according to the interpretation of aerial photographs and also the physical and chemical analyses of the soils. This semi-automatic methodology demonstrated improved efficiency in defining the soil units, reducing operation time and subjectivity of the process, thereby contributing to the systematization of soil mapping at watershed level in scale 1:50,000, as well as, promoting better knowledge between the relation of the geomorphic and soil variables in the Brazilian savanna Cerrado.

关键词： semi-Automatic Mapping sRTM Morphometric Pedological Maps

Tetramethrin Identified in Fat Adjacent to Mammary Carcinoma in a Male Dog—Case Report

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Open Journal of Pathology 2012年第3期2卷 102-105页

作者： Fernanda C.Figueiroa Paulo Ricardo O.Bersano Fabio henrique E.Andrade Noeme s.Rocha school of Veterinary Medicine and Animal science Sao Paulo State University(UNESP)BotucatuBrazil Maranhao state University(UEMA) Sao LuisBrazil

Canine mammary tumors (CMT) are very common in female dogs, representing approximately 50% of all tumors in this species, but are highly uncommon in male dogs and are primarily related to hyperestrogenism. There is considerable scientific interest in the possible role of environmental contaminants in the etiology of mammary tumors, specifically in relation to synthetic chemical substances released into the environment to which living beings are either directly or indirectly exposed. In this study, the presence of pyrethroid insecticide was observed in adipose tissue adjacent to canine mammary tumors. High Precision Liquid Chromatography—HPLC was adapted to detect and identify environmental contaminants in adipose tissue adjacent to malignant mammary tumor in one male dog, Akita, 12 years old. After surgery, the mass was carefully examined for malignant neoplastic lesions. Five grams of adipose tissue adjacent to the tumor was collected to detect environmental contaminants. The pyrethroid was identified as tetramethrin, at 0.20 μg/g. This is the first report in which the environmental contaminant level was detectable in adipose tissue of this male dog with a malignant mammary tumor, by HPLC. Results suggest the possible involvement of pyrethroid in the canine mammary tumor carcinogenesis since this animal did not present any other tumor that could cause hyperestrogenism.

关键词： Tetramethrin Mammary Tumor Male Dog Environmental Contaminants

Neoarchean and Rhyacian TTG-sanukitoid suites in the southern s?o Francisco Paleocontinent,Brazil:Evidence for diachronous change towards modern tectonics

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Geoscience Frontiers 2020年第5期11卷 1763-1787页

作者： henrique Bruno Vitalino Elizeu Monica Heilbron Claudio de Morisson Valeriano Rob strachan Mike Fowler samuel Bersan Hugo Moreira Ivo Dussin luiz Guilherme do Eirado silva Miguel Tupinamba Julio Almeida Carla Neto Craig storey Universidade Do Estado Do Rio de Janeiro Faculdade de GeologiaTektosGrupo de Pesquisa Em GeotectonicaRua Sao Francisco Xavier 524MaracanaRio de JaneiroBrazil University of Portsmouth School of Earth and Environmental SciencesBurnaby BuildingBurnaby RoadPortsmouthUK Universit€at salzburg Department of Geography and GeologyKapitelgasse4-65020SalzburgAustria Universidade Federal de Ouro Preto Departamento de GeologiaCampus Morro Do CruzeiroOuro PretoMGBrazil Laboratorio de Geocronologia e Isotopos Radiog^enicos Universidade Do Estado Do Rio de JaneiroRua Sao Francisco Xavier 524MaracanaRio de JaneiroBrazil

The southern portion of the sao Francisco Palaeocontinent in Brazil is denoted by Archean nuclei and Paleoproterozoic magmatic arcs that were amalgamated during siderian to Orosirian orogenic processes(ca.2.4-2.1 Ga).New isotopic U-Pb in zircon and sm-Nd whole rock combined with major and trace element composition analyses constrain the crystallization history of the Neoarchean Piedade block(at ca.2.6 Ga)and the Paleoproterozoic Mantiqueira Complex(ca.2.1-1.9 Ga).These therefore display quite different magmatic histories prior to their amalgamation at ca.2.05 ***-Nd and Rb-sr isotopes imply a mixed mantle-crustal origin for the samples in both units.A complete Palaeoproterozoic orogenic cycle,from subduction to collision and collapse,is recorded in the Piedade Block and the Mantiqueira *** to Orosirian subduction processes(ca.2.2-2.1 Ga)led to the generation of coeval(ca.2.16 Ga)TTG suites and sanukitoids,followed by late(2.10-2.02 Ga)high-K granitoids that mark the collisional *** collisional accretion of the Mantiqueira Complex against the Piedade Block at 2.08-2.04 Ga is also recorded by granulite facies metamorphism in the latter terrane,along the Ponte Nova suture *** collisional stage was closely followed by the emplacement of within-plate tholeiites at ca.2.04 Ga and by alkaline rocks(syenites and enriched basic rocks)at ca.1.98 Ga,marking the transition to an extensional tectonic *** discovery of two episodes of TTG and sanukitoid magmatism,one during the Neoarchean in the Piedade Complex and another during the Rhyacian in the Mantiqueira Complex,indicates that the onset of subduction-related melting of metasomatized mantle was not restricted to Neoarchean times,as generally believed,but persisted much later into the Paleoproterozoic.

关键词： Geodynamics High Ba–sr granitoids Diachronous TTG-sanukitoid transition Paleoproterozoic Mantiqueira complex