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ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells

Biomedical and Environmental Sciences 2024年第8期37卷 834-849页

作者： Jing Xie Jiaxin Tang Yuan Li Xue Kong Wei Wang haibo Wu Department of Pathology the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina

Objective Vasculogenic mimicry(VM)is a novel vasculogenic process integral to glioma stem cells(GSCs)in glioblastoma(GBM).However,the relationship between VM and ataxia-telangiectasia mutated(ATM)serine/threonine kinase activation,which confers chemoradiotherapy resistance,remains *** We investigated VM formation and phosphorylated ATM(pATM)levels by CD31/GFAPperiodic acid-Schiff dual staining and immunohistochemical staining in 145 GBM *** stem-like cells(GSLCs)derived from the formatted spheres of U87 and U251 cell lines and their pATM level and VM formation ability were examined using western blot and three-dimensional *** the examination of the function of pATM in VM formation by GSLCs,ATM knockdown by shRNAs and deactivated via ATM phosphorylation inhibitor KU55933 were *** VM and high pATM expression occurred in 38.5% and 41.8% of tumors,respectively,and were significantly associated with reduced progression-free and overall *** with VM-positive GBMs exhibited higher pATM levels(r_(s)=0.425,P=0.01).The multivariate analysis established VM as an independent negative prognostic factor(P=0.002).Furthermore,GSLCs expressed high levels of pATM and formed vascular-like networks in *** inactivation or knockdown hindered VM-like network formation concomitant with the downregulation of pVEGFR-2,VE-cadherin,and laminin *** VM may predict a poor GBM prognosis and is associated with pATM *** propose that pATM promotes VM through extracellular matrix modulation and VE-Cadherin/pVEGFR-2 activation,thereby highlighting ATM activation as a potential target for enhancing anti-angiogenesis therapies for GBM.

关键词： Glioblastoma Vasculogenic mimicry Ataxia-telangiectasia mutated(ATM) Glioma stem-like cell

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All-optical nanoscale thermometry with silicon carbide color centers

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Photonics Research 2024年第8期12卷 1696-1702页

作者： CHENGYING LIU haibo HU ZHENGTONG LIU SHUMIN XIAO JUNFENG WANG YU ZHOU QINGHAI SONG Ministry of Industry and Information Technology Key Laboratory of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China Pengcheng Laboratory Shenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen-Hong Kong International Science and Technology ParkShenzhen 518045China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China College of Physics Sichuan UniversityChengdu 610065China

All-optical thermometry plays a crucial role in precision temperature measurement across diverse *** defects in solids are one of the most promising sensors due to their excellent sensitivity,stability,and ***,it faces limitations,such as the microwave heating effect and the complexity of spectral *** these challenges,we introduce a novel approach to nanoscale optical thermometry using quantum defects in silicon carbide(SiC),a material compatible with complementary metal-oxide-semiconductor(CMOS)*** method leverages the intensity ratio between anti-Stokes and Stokes emissions from SiC color centers,overcoming the drawbacks of traditional techniques such as optically detected magnetic resonance(ODMR)and zero-phonon line(ZPL)*** technique provides a real-time,highly sensitive(1.06%K^(-1)),and diffraction-limited temperature sensing protocol,which potentially helps enhance thermal management in the future miniaturization of electronic components.

关键词： carbide optical centers

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Catalytic Reaction Kinetics of Propylene Dimerization to 4-Methyl-1-Pentene Using Cu-K/K_(2)CO_(3) Solid Base Catalyst

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 78-87页

作者： Jin haibo Chai Jing Yang Suohe He Guangxiang Ma Lei Guo Xiaoyan College of New Materials and Chemical Engineering Beijing Institute of Petrochemical Technology/Beijing Key Laboratory of Fuel Cleaning and Efficient Catalytic Emission Reduction TechnologyBeijing102617China

The catalysis technology of propylene dimerization to form 4-methyl-1-pentene(4MP1)using a Cu-K/K_(2)CO_(3) solid base catalyst is a well-known heterogeneous catalytic *** this study,the intrinsic kinetics of propylene dimerization were studied in a fixed-bed continuous *** and external diffusion during the dimerization reaction experiments were eliminated by adjusting the flow rate of the carrier gas and the particle size of the catalyst ***,the concentration changes of each substance at the outlet of the catalyst bed under different residence times were ***,the suitable reaction kinetics equations was derived using the Langmuir Hinshelwood-Hougen-Watson kinetic ***,the activation energy for each reaction involved in the dimerization reaction was *** activation energies of 4MP1,branched by-products,and 1-hexene were 115.0,150.8,and 177.4 kJ/mol,*** effect of process conditions on propylene dimerization with solid base catalysts was studied through kinetic model *** comparing the theoretical values obtained from the simulation with the experimental results,the applicability and accuracy of the kinetic model were verified.

关键词： propylene dimerization 4-methyl-1-pentene intrinsic kinetics surface reaction

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P-aminobenzoic acid promotes retinal regeneration through activation of Ascl1a in zebrafish

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Neural Regeneration Research 2024年第8期19卷 1849-1856页

作者： Meihui He Mingfang Xia Qian Yang Xingyi Chen haibo Li Xiaobo Xia Eye Center of Xiangya Hospital Central South UniversityChangshaHunan ProvinceChina Hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

The retina of zebrafish can regenerate completely after injury.M ultiple studies have demonstrated that metabolic alte rations occur during retinal damage;however to date no study has identified a link between metabolites and retinal regeneration of ***,we performed an unbiased metabolome sequencing in the N-methyl-D-aspartic acid-damaged retinas of zebrafish to demonstrate the metabolomic mechanism of retinal *** the differentially-ex pressed metabolites,we found a significant decrease in p-aminobenzoic acid in the N-methyl-D-aspartic acid-damaged retinas of ***,we investigated the role of p-aminobenzoic acid in retinal regeneration in adult *** rtantly,p-aminobenzoic acid activated Achaetescute complex-like 1a expression,thereby promoting Müller glia reprogramming and division,as well as Müller glia-derived progenitor cell ***,we eliminated folic acid and inflammation as downstream effectors of PABA and demonstrated that PABA had little effect on Müller glia *** together,these findings show that PABA contributes to retinal regeneration through activation of Achaetescute complex-like 1a expression in the N-methyl-Daspartic acid-damaged retinas of zebrafish.

关键词： Achaetescute complex-like 1a(Ascl1a) metabolomics Müller glia p-aminobenzoic acid(PABA) retina regeneration zebrafish

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Linear paired electrolysis of furfural to furoic acid at both anode and cathode in a multiple redox mediated system

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Green Energy & Environment 2024年第1期9卷 104-113页

作者： Xinxin Li Linchuan Cong haibo Lin Fangbing Liu Xiangxue Fu Hai-Chao Xu Nan Lin State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130012JilinChina State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina

Implementing a new energy-saving electrochemical synthesis system with high commercial value is a strategy of the sustainable development for upgrading the bulk chemicals preparation technology in the ***,we report a multiple redox-mediated linear paired electrolysis system,combining the hydrogen peroxide mediated cathode process with the I2 mediated anode process,and realize the conversion of furfural to furoic acid in both side of the dividedﬂow cell *** reasonably controlling the cathode potential,the undesired water splitting reaction and furfural reduction side reactions are *** the galvanostatic electrolysis,the two-mediated electrode processes have good compatibility,which reduce the energy consumption by about 22%while improving the electronic efﬁciency by about 125%.This system provides a green electrochemical synthesis route with commercial prospects.

关键词： Multiple redox mediated system Linear paired electrolysis Furfural Furoic acid

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Research on Fatigue Damage Behavior of Main Beam Sub-Structure of Composite Wind Turbine Blade

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Structural Durability & Health Monitoring 2024年第3期18卷 277-297页

作者： Haixia Kou Bowen Yang Xuyao Zhang Xiaobo Yang haibo Zhao School of Mechanical Engineering Lanzhou Jiaotong UniversityLanzhou730070China School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhou730070China

Given the difficulty in accurately evaluating the fatigue performance of large composite wind turbine blades(referred to as blades),this paper takes the main beam structure of the blade with a rectangular cross-sectionas the simulation object and establishes a composite laminate rectangular beam structure that simultaneouslyincludes the flange,web,and adhesive layer,referred to as the blade main beam sub-structure specimen,throughthe definition of blade *** paper examines the progressive damage evolution law of the compositelaminate rectangular beam utilizing an improved 3D Hashin failure criterion,cohesive zone model,B-K failurecriterion,and computer simulation *** static loading,the layup angle of the anti-shear web hasa close relationship with the static load-carrying capacity of the composite laminate rectangular beam;under fatigueloading,the fatigue damage will first occur in the lower flange adhesive area of the whole composite laminaterectangular beam and ultimately result in the fracture failure of the entire *** results provide a theoreticalreference and foundation for evaluating and predicting the fatigue performance of the blade main beamstructure and even the full-size blade.

关键词： Composite laminate wind turbine blade sub-structure progressive damage analysis user material subroutine cohesive zone model

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Cable-driven legged landing gear for unmanned helicopter:Prototype design,optimization and performance assessment

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Science China(Technological Sciences) 2024年第4期67卷 1196-1214页

作者： TIAN BaoLin GAO haibo YU HaiTao SHAN HaoMin HOU JunChen YU HongYing DENG ZongQuan State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China China Academy of Aerospace Science and Innovation Beijing 100048China

Unmanned helicopters equipped with adaptive landing gear will dramatically extend their application especially in dealing with challenging *** study presents a novel cable-driven legged landing gear(CLG)with differential transmission for unmanned helicopters in complex landing *** obtain the preferred configuration of the legged mechanism,a multi-objective optimization framework for the CLG is constructed by concurrently considering terrain adaptability,landing stability and reasonable linkage of internal *** non-dominated sorting genetic algorithmⅡis employed to numerically acquire the optimal scale parameters that guide the mechanical design of the *** unmanned helicopter prototype equipped with the devised CLG is developed with key performance *** results show that the devised CLG can provide energy-efficient support over uneven terrains(totally driven torque demand less than 0.1 N m)in quasi-static landing tests,and favorable terrain adaptability(posture fluctuation of the fuselage less than±1°)in unknown slope landing *** exhibited merits give the proposed CLG the potential to enhance the landing performance of future aircraft in extreme environments.

关键词： unmanned helicopter adaptive landing gear experimental verification

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Temperature-adaptive metasurface radiative cooling device with excellent emittance and low solar absorptance for dynamic thermal regulation

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Advanced Photonics 2024年第4期6卷 70-82页

作者： Junlin Yang Qianyi Li Shiqiao Liu Debao Fang Jingyao Zhang haibo Jin Jingbo Li Beijing Institute of Technology School of Materials Science and EngineeringBeijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green ApplicationsBeijingChina

Passive radiative cooling is a promising passive cooling technology that emits heat to deep space without energy ***,the persistent challenge of overcooling in static radiative techniques has raised *** a desirable solution is suggested based on vanadium dioxide(VO_(2))in the form of a Fabry-Perot(F-P)resonant cavity,the inherent contradiction between desired high emissivity(ε)and low solar absorptance(α_(sol))remains a notable ***,we employed a simple mask-filling technique to develop a temperature-adaptive metasurface radiative cooling device(ATMRD)for dynamic thermal *** and experimental results substantially evidenced that multiple localized polariton resonances were induced by the VO_(2)metasurface,significantly enhancing the thermal emittance of the *** engineered ATMRD achieved an amazing switch of the atmospheric window emittance from 0.13 to 0.85 when the surface temperature exceeds a pre-set transition temperature,accompanied by a commendableα_(sol)of 27.71%.The mechanism of multiple localized polariton resonances is discussed in detail to understand the enhanced performance based on the investigation of the relationship between the metasurface structure and multiple localized polariton *** demonstrate an efficient smart radiative technique achieved by a simple micro/nanoprocess and,most importantly,contribute a valuable reference for the design of radiative devices,which is crucial in various areas such as passive cooling,smart windows,multifunctional electromagnetic response,and space application technologies.

关键词： dynamic radiative cooling metasurface vanadium dioxide emittance plasmon resonance

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Channel-Feedback-Free Transmission for Downlink FD-RAN:A Radio Map Based Complex-Valued Precoding Network Approach

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China Communications 2024年第4期21卷 10-22页

作者： Zhao Jiwei Chen Jiacheng Sun Zeyu Shi Yuhang Zhou haibo Xuemin(Sherman)Shen School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310058China Department of Mathematics and Theories Peng Cheng LaboratoryShenzhen 518000China Department of Electrical and Computer Engineering University of WaterlooWaterlooOntarioN2L 3G1Canada

As the demand for high-quality services proliferates,an innovative network architecture,the fully-decoupled RAN(FD-RAN),has emerged for more flexible spectrum resource utilization and lower network ***,with the decoupling of uplink base stations and downlink base stations in FDRAN,the traditional transmission mechanism,which relies on real-time channel feedback,is not suitable as the receiver is not able to feedback accurate and timely channel state information to the *** paper proposes a novel transmission scheme without relying on physical layer channel ***,we design a radio map based complex-valued precoding network(RMCPNet)model,which outputs the base station precoding based on user *** comprises multiple subnets,with each subnet responsible for extracting unique modal features from diverse input ***,the multimodal embeddings derived from these distinct subnets are integrated within the information fusion layer,culminating in a unified *** also develop a specific RMCPNet training algorithm that employs the negative spectral efficiency as the loss *** evaluate the performance of the proposed scheme on the public DeepMIMO dataset and show that RMCPNet can achieve 16%and 76%performance improvements over the conventional real-valued neural network and statistical codebook approach,respectively.

关键词： beamforming complex neural networks deep learning FD-RAN

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A Multi-Constraint Path Optimization Scheme Based on Information Fusion in Software Defined Network

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Computers, Materials & Continua 2024年第4期79卷 1399-1418页

作者： Jinlin Xu Wansu Pan Longle Cheng haibo Tan Munan Yuan Xiaofeng Li Hefei Institutes of Physical Science Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

The existingmultipath routing in Software Defined Network (SDN) is relatively blind and inefficient, and there is alack of cooperation between the terminal and network sides, making it difficult to achieve dynamic adaptationof service requirements and network resources. To address these issues, we propose a multi-constraint pathoptimization scheme based on information fusion in SDN. The proposed scheme collects network topology andnetwork state information on the network side and computes disjoint paths between end hosts. It uses the FuzzyAnalytic Hierarchy Process (FAHP) to calculate the weight coefficients of multiple constrained parameters andconstructs a composite quality evaluation function for the paths to determine the priority of the disjoint paths. TheSDN controller extracts the service attributes by analyzing the packet header and selects the optimal path for flowrule forwarding. Furthermore, the service attributes are fed back to the path composite quality evaluation function,and the path priority is dynamically adjusted to achieve dynamic adaptation between service requirements andnetwork status. By continuously monitoring and analyzing the service attributes, the scheme can ensure optimalrouting decisions in response to varying network conditions and evolving service demands. The experimentalresults demonstrated that the proposed scheme can effectively improve average throughput and link utilizationwhile meeting the Quality of Service (QoS) requirements of various applications.

关键词： SDN multi-constraint path information fusion FAHP

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