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Skin 3D Bioprinting. Applications in Cosmetology

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第1期3卷 85-89页

作者： Cristina Velasquillo Eduardo A. Galue lourdes rodriquez Clemente Ibarra L. Guillermo Ibarra-Ibarra Biotecnología Instituto Nacional de Rehabilitación Mexico City Mexico Wake Forest Institute for Regenerative Medicine Regenerative Medicine Winston Salem USA

Tissue engineering has been used for the treatment of several skin diseases and lesions;however, tissue engineering and regenerative medicine also have a huge potential in cosmetology. They include skin substitutes, cell therapy and wound-healing treatments based on biomaterial-based replacements and 3D systems. This review focuses on the bioprinting technology and how it can improve skin functions, restoring pigmentation or helping hair follicles to develop.

关键词： 3D Bioprinting Skin Bioprinting Scaffolds Human Skin Cells Cosmetology

The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Padilla lourdes Sánchez-Salido Anne Baron-Van Evercooren Beatriz García-Díaz Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONAND) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain Departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain Sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and chronic condition widely found in the general *** reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in *** the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical ***,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies satellite glial cells sensory neurons

Identification of Rhizobia Isolated from Nodules of Mexican Commercial Soybean Varieties

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American Journal of Plant Sciences 2024年第1期15卷 29-45页

作者： Cecilia Vázquez Rodríguez lourdes Vital López Jesús Gerardo García Olivares Homar Rene Gill Langarica Laboratorio de Biotecnología Vegetal Centro de Biotecnología Genómica Instituto Politécnico Nacional Reynosa México Carrera de Mantenimiento Industrial Universidad Tecnológica de Tamaulipas Norte Universidad Tecnológica Reynosa México

Rhizobia, crucial for nitrogen fixation in leguminous plants, play a vital role in soybean cultivation. This study, conducted in Mexico, a major soybean importer, aimed to identify bacteria from nodules of five soybean varieties in high-production regions. Multilocus sequence analysis (MLSA) was employed for enhanced species resolution. The study identified six Bradyrhizobium species: Bradyrhizobium japonicum USDA 110, Bradyrhizobium japonicum USDA 6, Bradyrhizobium elkanii USDA 76, Bradyrhizobium neotropicale, Bradyrhizobium lablabi, and Bradyrhizobium icense. Bradyrhizobium japonicum USDA 110 predominated in the soils, displaying symbiotic preference for the Huasteca 400 variety. However, phylogenetic analysis didn't reveal a clear association between strains, soil, and soybean variety. This research sheds light on the diversity of rhizobia in Mexican soybean cultivation, contributing to the understanding of symbiotic relationships in soybean production systems.

关键词： Nodules Soybean Housekeeping Genes MLSA Rhizobia Bradyrhizobium Nitrogen Fixation Symbiosis Phylogenetic Analysis

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Computational screening of transition metal-doped CdS for photocatalytic hydrogen production

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npj Computational Materials 2022年第1期8卷 2190-2198页

作者： Yuting Li Daniel Bahamon Mutasem Sinnokrot lourdes F.Vega Research and Innovation Center on CO_(2) and Hydrogen(RICH) Khalifa UniversityPO Box 127788Abu DhabiUAE Chemical Engineering Department.Khalifa University PO Box 127788Abu DhabiUAE Chemistry Department Khalifa UniversityPO Box 127788Abu DhabiUAE

A novel computational screening study of single transition metal(TM),TM-doped,and dual TMs-doped on CdS(110)surfaces via DFT calculations is presented,focusing on their stability and catalytic activity,searching for efficient photocatalysts for hydrogen *** based on key performance descriptors allowed to fine-tune the *** indicate that TM dopants can reduce the energy band gap and enhance impurity ***,Rh,and Pd were found to be the best dopants in TM-doped CdS,since their|ΔG_(H)|is 80%smaller compared to the pristine CdS ***,TM1-TM2-co-doped CdS catalysts show better performance for the hydrogen evolution reaction(HER)due to synergistic effects of the two TMs,where Co-Pt,Pd-Pt and Co-Rh co-doping CdS significantly reduced|ΔGH|to less than 0.1 *** point out four promising novel co-catalysts(i.e.,Co,Co-Pt,Co-Rh,Rh-Ag)with very good performance in HER,to be further explored in experimental studies.

关键词： surface transition allowed

Origin of Traditional Chinese Medicine in Cuba in the 19th Century from Its Main Exponents and Some Notable Medical Descendants in the 20th Century

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Chinese Medicine and Culture 2023年第4期6卷 367-376页

作者： lourdes Bárbara Alpizar Caballero lourdes de la Caridad Borges Oquendo Endocrinology Institute Department of ScienceTechnology and InnovationHavana 10400Cuba Faculty of Medical Sciences“Calixto García” Department of ScienceTechnology and InnovationHavana 10400Cuba

The Cuban people are made up of three major migratory currents, the Chinese are one of them. They brought their culture, the methods, and procedures of traditional Chinese medicine(TCM) in the 19th century. Few were able to return and so they created families in Cuba;some of their descendants dedicated themselves to medicine. In order to investigate the practices that were predecessors of TCM in Cuba in the 19th century, a qualitative phenomenological research was carried out, reviewing what was published by various sources, applying documentary analysis, logical historical analysis, abstraction, synthesis, and systematization of the results on the regularities of the work and human behavior of Chinese doctors in the Cuban 19th and 20th centuries. This made it possible to identify six Chinese doctors in the 19th century in Cuba who gave rise to the beginning of some practices of TCM in Cuba, and five from the 20th century, descendants of coolies who dedicated themselves to other specialties of medicine. It was found that despite their geographical and time disperse, they were all notorious for their outstanding professional and human behavior, with a trail of accumulated successes in achieving “almost the impossible” with the patient. They have left their mark on Cuban culture.

关键词： Chinese doctor Coolies Popular phrase Immigrants Professional behavior Human behavior History

Frailty and acute coronary syndrome: does gender matter?

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Journal of Geriatric Cardiology 2019年第2期16卷 138-144页

作者： lourdes Vicent Manuel Martinez-Selles Servicio de Cardiologia Hospital General Universitario Gregorio MaraiionCIBERCVMadridSpain Universidad Europea Universidad ComplutenseMadridSpain

There are important sex-related differences in elderly patients with acute coronary syndrome(ACS).Women are older,more frequently frail,and present more comorbidities than *** symptoms at presentation are also more common in female patients,they are leaded to a delayed diagnosis and *** angiography and subsequent revascularization are frequently underused in elderly women and they tend to receive less guidelines-recommended *** prognosis in elderly frail women with ACS is poor,and it is with high mortality and readmissions *** is recurrent ischemic events in which it is more frequent in women than in *** time might be long,and a multidisciplinary approach is desirable to improve prognosis and quality of *** studies are needed in order to clarify the benefit of the different therapies in the group of frail women,and this is particularly true for revascularization,as scientific evidence in this group is very scarce.

关键词： Acute coronary syndrome Frailty The elderly Women

Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer:A systematic review of observational studies

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World Journal of Gastroenterology 2023年第7期29卷 1219-1234页

作者： lourdes Pilar Chávez-Hidalgo Silvia Martín-Fernández-de-Labastida Marian M de Pancorbo Marta Arroyo-Izaga Department of Pharmacy and Food Sciences Faculty of PharmacyUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain Department of Z.and Cellular Biology A. University of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain BIOMICs Research Group MICROFLUIDICs and BIOMICs Cluster UPV/EHULascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain

BACKGROUND Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer(CRC).However,whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still *** To improve the current understanding of the molecular basis of *** A literature search in the Medline database,Reference Citation Analysis(https://***/),and manual reference screening were performed to identify observational studies published from inception to May *** A total of fourteen case-control studies and five cohort studies were *** studies included information on dietary methyl donors,dietary components that potentially modulate the bioavailability of methyl groups,genetic variants of methyl metabolizing enzymes,and/or markers of CpG island methylator phenotype and/or microsatellite instability,and their possible interactions on CRC *** Several studies have suggested interactions between methylenetetrahydrofolate reductase polymorphisms,methyl donor nutrients(such as folate)and alcohol on CRC ***,vitamin B6,niacin,and alcohol may affect CRC risk through not only genetic but also epigenetic *** of specific mechanisms in these interactions associated with CRC may assist in developing targeted prevention strategies for individuals at the highest risk of developing CRC.

关键词： Colorectal cancer DNA methylation Epigenetics Methyl donors Microsatellite instability Nutrients

Species and Plant Community Reorganization in the Trans-Mexican Volcanic Belt under Climate Change Conditions

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Journal of Mountain Science 2013年第6期10卷 923-931页

作者： VILLERS-RUIZ lourdes CASTAEDA-AGUADO Diana Center of Atmospheric Sciences National Autonomous University of Mexico (UNAM) School of Science Biology Department National Autonomous University of Mexico (UNAM)

This study analyzes six vegetation communities in relation to current climatic parameters and eight climate change scenarios along an elevation gradient extending from 2,710 m to 4,210m in the Trans-Mexican Volcanic Belt. The projected movements of 25 plant species with the current restricted or wide altitudinal distributions were also modeled. To relate climatic parameters to the species and communities, a Precipitation/Temperature(P/T)index was used both for the current and the different climate-change scenarios. The temperatures are expected to increase by 1.1°C to 1.7°C by 2020 and by2°C to 3°C by 2050. A decrease of 4% to 13% in the annual precipitation is expected for the 2020 horizon,and a reduction between 3% and 20% is expected for2050. The reductions in water availability were projected for all altitude levels and plant *** most marked reduction was under the HADLEYA2 scenario, in which the lower limit of the altitudinal range increased from 2,710 to 3,310 m(2050 horizon)with reductions in the P/T index between 36% and39% compared to the current climate. Most plant species tended to shift their distribution from 200 to300 m upward in the 2020 temporal horizon scenarios. The Pinus hartwegii, Alnus jorullensis and Pinus montezumae communities would have a shorter altitudinal range as they move upward and merge with the remaining species at the higher altitudinal range. For the 2050 temporal horizon,30% of the species, primarily those from the higher altitudinal range, would disappear because their P/Tindex values would be above the limit of plant survival(>4,210 m).

关键词：气候变化植物群落火山带墨西哥海拔梯度植物种类重组品种