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Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study

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World Journal of Gastroenterology 2017年第15期23卷 2696-2704页

作者： Marco Toscano Roberta De Grandi Laura Stronati Elena De Vecchi lorenzo drago Laboratory of Clinical Microbiology Department of Biomedical Science for HealthUniversity of Milan Department of Cellular Biotechnology and Hematology Laboratory of Clinical Chemistry and Microbiology IRCCS Galeazzi Orthopaedic InstituteUniversity of Milan

AIMTo evaluate the ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize the intestinal environment of healthy subjects and modify the gut microbiota *** healthy Italian volunteers, eight males and twelve females, participated in the study. Ten subjects took a sachet containing 4 × 109 colony-forming units (CFU) of Bifidobacterium longum BB536 and 109 CFU of Lactobacillus rhamnosus HN001, 30 min before breakfast (pre-prandial administration), while ten subjects took a sachet of probiotic product 30 min after breakfast (post-prandial administration). The ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize human gut microbiota was assessed by means of quantitative real-time PCR, while changes in gut microbiota composition were detected by using Ion Torrent Personal Genome *** after 1-mo of probiotic administration, B. longum BB536 and L. rhamnosus HN001 load was increased in the majority of subjects in both pre-prandial and post-prandial groups. This increase was found also 1 mo after the end of probiotic oral intake in both groups, if compared to samples collected before probiotic consumption. At phyla level a significant decrease in Firmicutes abundance was detected immediately after 1-mo of B. longum BB536 and L. rhamnosus HN001 oral intake. This reduction persisted up to 1 mo after the end of probiotic oral intake together with a significant decrease of Proteobacteria abundance if compared to samples collected before probiotic administration. Whereas, at species level, a higher abundance of Blautia producta, Blautia wexlerae and Haemophilus ducrey was observed, together with a reduction of Holdemania filiformis, Escherichia vulneris, Gemmiger formicilis and Streptococcus sinensis abundance. In addition, during follow-up period we observed a further reduction in Escherichia vulneris and Gemmiger formicilis, together with a decrease in

关键词： Probiotics Gut microbiota Bifidobacterium Lactobacillus Human health

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Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification

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世界骨科杂志：英文版 2017年第5期8卷 400-411页

作者： David A George lorenzo drago Sara Scarponi Enrico Gallazzi Fares S Haddad Carlo L Romano Department of Trauma and Orthopaedics University College London Hospitals Microbiological Laboratory Orthopaedic Re-search Institute Galeazzi Centre for Reconstructive Surgery and Osteoarticular Infections Orthopaedic Research Institute Galeazzi

AIM To undertook a systematic review to determine factors that increase a patient's risk of developing lower limb periprosthetic joint infections(PJI).METHODS This systematic review included full-text studies that reviewed risk factors of developing either a hip or knee PJI following a primary arthroplasty published from January 1998 to November 2016. A variety of keywords were used to identify studies through international databases referencing hip arthroplasty, knee arthroplasty, infection, and risk factors. Studies were only included if they included greater than 20 patients in their study cohort, and there was clear documentation of the statistical parameter used; specifically P-value, hazard ratio, relative risk, or/and odds ratio(OR). Furthermore a quality assessment criteria for the individual studies was undertaken to evaluate the presence of record and reporting bias. RESULTS Twenty-seven original studies reviewing risk factors relating to primary total hip and knee arthroplasty infections were included. Four studies(14.8%) reviewed PJI of the hip, 3(11.21%) of the knee, and 20(74.1%) reviewed both joints. Nineteen studies(70.4%) were retrospective and 8(29.6%) prospective. Record bias was identified in the majority of studies(66.7%). The definition of PJI varied amongst the studies but there was a general consensus to define infection by previously validated methods. The most significant risks were the use of preoperative high dose steroids(OR = 21.0, 95%CI: 3.5-127.2, P < 0.001), a BMI above 50(OR = 18.3, P < 0.001), tobacco use(OR = 12.76, 95%CI: 2.47-66.16, P= 0.017), body mass index below 20(OR = 6.00, 95%CI: 1.2-30.9, P = 0.033), diabetes(OR = 5.47, 95%CI: 1.77-16.97, P = 0.003), and coronary artery disease(OR = 5.10, 95%CI: 1.3-19.8, P = 0.017).CONCLUSION We have highlighted the need for the provider to optimise modifiable risk factors, and develop strategies to limit the impact of non-modifiable factors.

关键词： Periprosthetic joint infection Risk factor Predictive Hip arthroplasty Knee arthroplasty

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In vitro laboratory infection research in orthopaedics:Why,when,and how

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世界骨科杂志:英文版 2023年第8期14卷 598-603页

作者： Konstantinos Tsikopoulos lorenzo drago Gabriele Meroni Dimitrios Kitridis Byron Chalidis Fotios Papageorgiou Paraskevi Papaioannidou 1^(st)Department of Pharmacology School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical Sciences for Health School of MedicineUniversity of MilanMilan 20133Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20133Italy 1^(st)Department of Orthopaedic School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 57010Greece Department of Orthopaedic Surgery 404 General Army HospitalLarisa 41222Greece 1^(st)Department of Pharmacology Aristotle University of ThessalonikiThessaloniki 54124Greece

The musculoskeletal system involves multiple tissues which are constantly exposed to being exposed to various biological and mechanical *** such,isolating and studying a particular system from a complex human clinical environment is not always a realistic *** top of that,recruitment limitations,in addition to the nature of orthopaedic interventions and their associated cost,sometimes preclude consideration of human trials to answer a clinical ***,in this mini review,we sought to rationalize the rapid evolution of biomedical research at a basic scientific level and explain why the perception of orthopaedic conditions has fundamentally changed over the last *** more detail,we highlight that the number of orthopaedic in vitro publications has soared since *** but not least,we elaborated on the minimum requirements for conducting a scientifically sound infection-related laboratory experiment to offer valuable information to clinical *** also explained the rationale behind implementing molecular biology techniques,ex vivo experiments,and artificial intelligence in this type of laboratory research.

关键词： Biofilm In vitro Laboratory research Methodology

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Viral infections in orthopedics: A systematic review and classification proposal

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World Journal of Orthopedics 2022年第11期13卷 1015-1028页

作者： Konstantinos Sidiropoulos Savvas Ilias Christofilos Konstantinos Tsikopoulos Dimitrios Kitridis lorenzo drago Gabriele Meroni Carlo Luca Romanò Venu Kavarthapu General Hospital of Serres Serres 62100Greece Department of Genetics Evolution and EnvironmentUniversity College LondonLondon WC1E 6BTUnited Kingdom Department of Orthopaedics 404 Army General HospitalLarissa 41222Greece the First Department of Orthopaedics Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical Sciences for Health and Microbiome University of MilanMilan 20133Italy Department of Biomedical Surgicaland Dental SciencesOne Health UnitUniversity of MilanMilan 20133Italy Gruppo di Studio SIOT Infezioni-Clinica San Gaudenzio-Novara-Gruppo Policlinico di Monza University of MilanMilan 20100Italy Trauma and OrthopaedicsKings College Hospital LondonDenmark HillLondon SE59RSUnited Kingdom

BACKGROUND Although the impact of microbial infections on orthopedic clinical outcomes is well recognized,the influence of viral infections on the musculoskeletal system might have been *** To systematically review the available evidence on risk factors and musculoskeletal manifestations following viral infections and to propose a pertinent classification *** We searched MEDLINE,Cochrane Central Register of Controlled Trials(CENTRAL),the Reference Citation Analysis(RCA),and Scopus for completed studies published before January 30,2021,to evaluate risk factors and bone and joint manifestations of viral infection in animal models and patient *** assessment was performed using SYRCLE's risk of bias tool for animal studies,Moga score for case series,Wylde score for registry studies,and Newcastle-Ottawa Scale for case-control *** Six human and four animal studies were eligible for inclusion in the qualitative *** C virus was implicated in several peri-and post-operative complications in patients without cirrhosis after major orthopedic *** virus may affect the integrity of lumbar discs,whereas Ross River and Chikungunya viruses provoke viral arthritis and bone *** Evidence of moderate strength suggested that viruses can cause moderate to severe arthritis and *** factors such as pre-existing rheumatologic disease contributed to higher disease severity and duration of ***,based on our literature search,the proposed clinical and pathogenetic classification scheme is as follows:(1)Viral infections of bone or joint;(2)Active bone and joint inflammatory diseases secondary to viral infections in other organs or tissues;and(3)Viral infection as a risk factor for post-surgical bacterial infection.

关键词： Viral infection Musculoskeletal system Bone and joint manifestations Chikungunya Zika Hepatitis C virus Herpesviridae Ross River virus Cross-reactivity Classification

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Rationalising animal research synthesis in orthopaedic literature

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World Journal of Methodology 2021年第3期11卷 75-80页

作者： Konstantinos Tsikopoulos Konstantinos Sidiropoulos Dimitrios Kitridis lorenzo drago Rakesh Ebnezar David Lavalette Orthopaedic Department Harrogate and District Foundation TrustHarrogate HG27SXNorth YorkshireUnited Kingdom Orthopaedic Department General Hospital of SerresSerres 62120Greece First Orthopedic Department of Aristotle University G.Papanikolaou General HospitalThessaloniki 55210Greece Laboratory of Clinical Microbiology Department of Biochemical Sciences for HealthUniversity of MilanMilan 20164Italy

Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent *** top of that,high-quality randomized human evidence on crucial orthopaedic topics is more often than not *** this situation,pooling animal literature could offer an excellent insight into unanswered critical clinical questions,thus potentially improving *** this paper,we sought to present the rationale and basic principles governing meta-analysis of animal *** specifically,we elaborated on the available evidence-based methods to achieve a scientifically sound animal data *** addition,we discussed result interpretation,strength of recommendations and clinical implications based on the results of these meta-analytic modalities.

关键词： Meta-analysis Animal research Evidence synthesis in vivo Orthopaedics

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