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Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8831-8849页

作者： María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F troncoso Institute of Biological Chemistry and Biophysics "Prof. Alejandro C. Paladini" (UBA-CONICET) Department of Biological ChemistrySchool of Pharmacy and BiochemistryUniversity of Buenos AiresC1113AADBuenos AiresArgentina Institute of Biology and Experimental Medicine (CONICET) Department of Biological ChemistrySchool of Exact and Natural SciencesUniversity of Buenos AiresC1113AAD Buenos AiresArgentina

Hepatocellular carcinoma(HCC)represents a global health *** with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this *** of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced *** are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence ***,we summarize the current literature implicating galectins in the pathogenesis of *** of"proto-type"galectin-1,"chimera-type"galectin-3 and"tandem repeat-type"galectin-4 is up-regulated in HCC cells compared to their normal *** the other hand,the"tandemrepeat-type"lectins galectin-8 and galectin-9 are downregulated in tumor *** abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor ***,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take ***-based therapies have been proposed to attenuate liver *** functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC.

关键词： Galectins Hepatocellular carcinoma Inflammation-associated liver injury Hepatitis B or C virus infection-associated hepatocellular carcinoma Fibrosis-related liver pathologies

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A novel semantic segmentation approach based on U-Net,WU-Net,and U-Net++deep learning for predicting areas sensitive to pluvial flood at tropical area

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International Journal of Digital Earth 2023年第1期16卷 3661-3679页

作者： Laura Melgar-García Francisco Martínez-álvarez Dieu Tien Bui Alicia troncoso Data Science&Big Data Lab Pablo de Olavide UniversitySevilleSpain GIS Group Department of Business and ITUniversity of South-Eastern NorwayGullbringvegen 36B?i Telemark3800Norway

Floods remain one of the most devastating weather-induced disastersworldwide, resulting in numerous fatalities each year and severelyimpacting socio-economic development and the ***, the ability to predict flood-prone areas in advance is crucialfor effective risk management. The objective of this research is to assessand compare three convolutional neural networks, U-Net, WU-Net, andU-Net++, for spatial prediction of pluvial flood with a case study at atropical area in the north of Vietnam. They are relative new convolutionalgorithms developed based on U-shaped architectures. For this task, ageospatial database with 796 historical flood locations and 12 floodindicators was prepared. For training the models, the binary crossentropywas employed as the loss function, while the Adaptive momentestimation (ADAM) algorithm was used for the optimization of themodel parameters, whereas, F1-score and classification accuracy (Acc)were used to assess the performance of the models. The results unequivocally highlight the high performance of the three models,achieving an impressive accuracy rate of 96.01%. The flood susceptibility maps derived from this research possess considerable utility for local authorities, providing valuable insights and informationto enhance decision-making processes and facilitate the implementation of effective risk management strategies.

关键词： Flash-flood assessment convolutional networks climate change GIS

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Leishmaniasis in the knee area

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 330-331页

作者： Bava Amadeo Javier Rossi Maria Laura Seley Celeste troncoso Alcides Department of Micology La Plata University Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Leishmaniasis is a parasitic infection caused by species leishmaniae,which can produce two types of manifestations:visceral and *** south America cutaneous leishmaniasis is more common than visceral leishmaniasis.A case of primary cutaneous leishmaniasis from Bolivia is presented for its *** patient of our case showed an ulcerated lesion of the knee. Montenegro’s intradermal test was ***-stained touch preparation of the skin biopsy revealed amastigotes inside macrophages,consistent with *** patient was treated with meglumine antimoniate intramuscular(20 mg of Sb+/kg/day) three weeks,with complete cicatrization of the lesion.

关键词： Cutaneous leishmaniasis Skin ulcers Leishmania

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Chromoblastomycosis as a problem of the tropics

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 79-80页

作者： Bava Amadeo Javier Rodriguez Rios Elizabeth troncoso Alcides Department of Micology La Plata National UniversityBuenos Aires State Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Chromoblastomycosis can also cause severe but usually superficial lesions on the *** other deep mycosis, this chronic and disabling condition is seen in many tropical regions,including Argentina,where this man was ***... 详细信息

关键词： Chromoblastomycosis Verrucous Lesiones

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A case report of pulmonary coinfection of Strongyloides stercoralis and Pneumocystis jiroveci

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 334-336页

作者： Bava AJ Romero MM Prieto R troncoso A Laboratory of Parasitology Infectious Diseases HospitalBuenos AiresArgentina Respiratory Unit of Intensive Care Infectious Diseases HospitalBuenos AiresArgentina Department of Microbiology ParasitologyInfectious Diseases and Tropical MedicineSchool of MedicineBuenos Aires UniversityArgentina

A case of pulmonary coinfection by Strongyloides stercoralis and Pneumocystis jiroveci has been detected in an AIDS patient treated in the Respiratory Intensive Care Unit of the Muniz *** diagnosis,the patient presented cough with mucopurulent expectoration,dyspnea,fever,bilateral pulmonary infiltrates on the chest X-ray,negative bacilloscopy for acid fast bacteria and a CD4^+ T lymphocytes count of 52 cells/μ *** microbiological diagnosis was achieved by microscopic observation of the respiratory secretions obtained by bronchoalveolar lavage,while the wet mount examination revealed rhabditiform and filariform larvae of the nematode and foamy exudates,pathognomonic of the pulmonary *** was the unique case of this association among about 3 000 samples performed in our laboratory in the last 10 years and diagnosed by *** complementary stains(a rapid modification of Grocott,Kinyoun and Giemsa) were applied to the smears after the diagnosis of mycotic and parasitary infections achieved by fresh *** physicians and microbiologists should take into account the possible coexistence of respiratory pathogens in immunocompromised patients,such as those with AIDS.

关键词： Strongyloides stercoralis Pneumocystis jiroveci Pulmonary coinfection AIDS Bronchoalveolar lavage Wet mout examination Pulmonary pneumocystosis

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Recent surface marine sediments of Cocos Island in Costa Rica

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International Journal of Sediment Research 2014年第1期29卷 59-72页

作者： Jeffrey A.SIBAJA-CORDERO Jesús S.troncoso Eddy GóMEZ-RAMíREZ Escuela de Biología&Centro de Investigación en Ciencias del Mary Limnología (CIMAR) Universidad de Costa Rica Dr.grad.by Departamento de Ecología y Biología Animal Facultad de Ciencias del MarUniversidad de Vigo Departamento de Ecología y Biología Animal Facultad de Ciencias del MarUniversidad de VigoCampus Lagoas Marcosende Centro de Investigación en Ciencias del Mary Limnología(CIMAR) Universidad de Costa RicaSan Pedro 115012 060 San JoséCosta Rica Dr.(Cand).Departamento de Biología Facultad de Ciencias del Mary AmbientalesUniversidad de Cádiz

Subtidal sediments of Isla del Coco(Cocos Island),Costa Rica were described in their grain size,sorting,organic matter,and carbonates from 27 dredge samples(3-75 m),collected in April *** organic matter range between 1.37-3.31%and carbonates presented a mean of 74±17%.The sorting was moderately or *** grain size ranged between *** pattern is that sediment change from inner to mouth of *** and gravel fractions increased offshore and organic matter have high values inner the *** of vegetal debris and mud was from the rivers of this island covered with rain and cloud forest.

关键词： Sand bottom Sorting Organic matter Carbonates Isla del Coco

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Neurocysticercosis causing sudden death:a case report

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 669-670页

作者： Martinez Fernanda Seley Celeste Marchesi Liliana Fontanarossa Victoria Rodriguez Dominique troncoso Alcides Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

We report an acute case of a native man from Bolivia suffered from cephalalgia which rapidly worsened and ended in his sudden and unexpected *** resonance imaging(MRI) of the brain was *** demonstrated on brain MRI scan were consistent with a diagnosis of neurocysticercosis(NCC).An autopsy showed the presence of intraventricular Taenia solium(***) cysts which caused blockage of cerebrospinal fluid and secondary *** to the increasing travel movements of people neurocysticercosis must be considered as a cause of unexplained sudden death.

关键词： Neurocysticercosis Taenia solium Sudden death

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Documented outbreaks of botulism:the impact of foodborne transmission

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 71-75页

作者： Victoria Rebagliati Sabrina Chianelli Mariela Tornese Laura Rossi Alcides troncoso Department of Microbiology and Parasitology School of NutritionBuenos Aires Medical SchoolBuenos AiresArgentina

Botulism is a severe neuroparalytic disease caused by Clostridium botulinums *** the disease is uncommon,causes great concern due to its high rate of mortality;foodbome outbreaks of botulism occur worldwide and require immediate public health and acute care *** study had a review of outstanding outbreaks published;Journals articles related to the *** the outbreaks analysis we found the most involved food products were;fermented fish products in Alaska;home canning food,oil preservation and restaurant sauce in London and USA;home canned vegetables,food airtight packed with inappropriate refrigeration and aerosols in *** conclusion,the diagnosis is based only on clinical findings matching the disease and previous exposure to suspicious *** must be immediately identified as one case suggests an epidemic and should be treated as a public health *** the purpose of the following review is to recognize the associated risks with the consumption of potentially dangerous foods,to help work our way on prevention for every public health professional to be aware of the dangers of this potentially lethal disease.

关键词： foodborne botulism Clostridium botulinum

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Ophthalmic manifestations in patients with inflammatory bowel disease: a review

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World Journal of Gastroenterology 2017年第32期23卷 5836-5848页

作者： Leandro Lopes troncoso Ana Luiza Biancardi Haroldo Vieira de Moraes Jr Cyrla Zaltman Department of Ophthalmology Universidade Federal do Rio de Janeiro Department of Internal Medicine Gastroenterology DivisionUniversidade Federal do Rio de Janeiro

Clinical manifestations of inflammatory bowel disease(IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in Pub Med, was performed. Episcleritis, the most common ocular extraintestinal manifestation(EIM), seems to be more associated with IBD activity when compared with other ocular EIMs. In IBD patients, anterior uveitis has an insidious onset, it is longstanding and bilateral, and not related to the intestinal disease activity. Systemic steroids or immunosuppressants may be necessary in severe ocular inflammation cases, and control of the underlying bowel disease is important to prevent recurrence. Our review revealed that ocular involvement is more prevalent in Crohn's disease than ulcerative colitis, in active IBD, mainly in the presence of other EIMs. The ophthalmic symptoms in IBD are mainly nonspecific and their relevance may not be recognized by the clinician; most ophthalmic manifestations are treatable, and resolve without sequel upon prompt treatment. A collaborative clinical care team for management of IBD that includes ophthalmologists is central for improvement of quality care for these patients, and it is also cost-effective.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Ocular complications Eye manifestations

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Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy:prediction of"regression to the mean"using routine clinical features with correlating biochemical relapse rates

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Asian Journal of Andrology 2019年第6期21卷 598-604页

作者： Muammer Altok Patricia troncoso Mary F Achim Surena F Matin Graciela N Gonzalez John W Davis Department of Urology University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Pathology University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Biostatistics University of Texas MD Anderson Cancer CenterHoustonTX 77030USA.

Recommendations for managing clinically localized prostate cancer are structured around clinical risk criteria,with prostate biopsy(PB)Gleason score(GS)being the most important *** to radical prostatectomy(RP)specimen upgrading/downgrading is welldescribed,and is often the ratio nale for costly imaging or genomic *** prese nt simple,no-cost an a lyses of clinical parametersto predict which GS 6 and GS 8 patients will change to GS 7 at *** May 2006 to December 2012,1590 patientsunderwent robot-assisted radical prostatectomy(RARP).After exclusions,we identified a GS 6 cohort of 374 patients and a GS 8cohort of 91 *** this era,>1000 additional patients were enrolled in an active surveillanee(AS)*** GS 6,265(70.9%)of 374 patients were upgraded,and the cohort included 183(48.9%)patients eligible for AS by the Prostate Cancer ResearchInternational Active Surveillance Study(PRIAS)standards,of which 57.9%were *** features that predicted a>90%chanceof upgrading included≥7 cores positive,maximum foci length≥8 mm in any core,and total tumor involvement≥30%.For GS 8,downgrading occurred in 46(50.5%),which was significantly higher for single core versus multiple cores(80.4%vs 19.6%,P=0.011).Biochemical recurre nee(BCR)occurred in 3.4%of GS 6 upgraded versus 0%non upgraded,and in GS 8,19.6%downgraded versus42.2%nondown *** coun seling men with clin ically localized prostate can cer,the odds of GS cha nge should be presented,andcertain men with high-volume GS 6 or low-volume GS 8 can be counseled with GS 7-based recommendations.

关键词： biopsy down grade Gleas on score prostate cancer upgrade

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