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Deep brain stimulation for obsessive-compulsive disorder:A systematic review of worldwide experience after 20 years

World Journal of Psychiatry 2021年第9期11卷 659-680页

作者： lorea mar-barrutia Eva Real Cinto Segalas Sara Bertolin Jose Manuel Menchon Pino Alonso OCD Clinical and Research Unit Department of PsychiatryHospital de BellvitgeBarcelona 08907Spain Bellvitge Biomedical Research Institute-IDIBELL Barcelona 08907Spain CIBERSAM(Centro de Investigaci on en Red de Salud Mental) Carlos Ⅲ Health InstituteMadrid 28029Spain Department of Clinical Sciences Faculty of MedicineUniversity of BarcelonaBarcelona 08907Spain

BACKGROUND Twenty years after its first use in a patient with obsessive-compulsive disorder(OCD),the results confirm that deep brain stimulation(DBS)is a promising therapy for patients with severe and resistant forms of the ***,many unknowns remain,including the optimal anatomical targets,the best stimulation parameters,the long-term(LT)effects of the therapy,and the clinical or biological factors associated with *** systematic review of the articles published to date on DBS for OCD assesses the short and LT efficacy of the therapy and seeks to identify predictors of *** To summarize the existing knowledge on the efficacy and tolerability of DBS in treatment-resistant *** A comprehensive search was conducted in the PubMed,Cochrane,Scopus,and *** databases from inception to December 31,2020,using the following strategy:“(Obsessive-compulsive disorder OR OCD)AND(deep brain stimulation OR DBS).”Clinical trials and observational studies published in English and evaluating the effectiveness of DBS for OCD in humans were included and screened for relevant information using a standardized collection *** inclusion criteria were as follows:a main diagnosis of OCD,DBS conducted for therapeutic purposes and variation in symptoms of OCD measured by the Yale-Brown Obsessive-Compulsive scale(Y-BOCS)as primary *** were analyzed with descriptive *** Forty articles identified by the search strategy met the eligibility *** a follow-up threshold of 36 mo,29 studies(with 230 patients)provided information on short-term(ST)response to DBS in,while 11(with 155 patients)reported results on LT *** follow-up period was 18.5±8.0 mo for the ST studies and 63.7±20.7 mo for the LT ***,the percentage of reduction in Y-BOCS scores was similar in ST(47.4%)and LT responses(47.2%)to DBS,but more patients in the LT reports met the criteria for response(defined as a reduction in

关键词： Deep brain stimulation Obsessive-compulsive disorder Predictors of response Side effects Short-term Long-term

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A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy

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Chinese Journal of Cancer 2014年第4期33卷 204-210页

作者： Jon Cacicedo Francisco Casquero lorea martinez-Indart Olga del Hoyo Alfonso Gomez de Iturriaga Arturo Navarro Pedro Bilbao Department of Radiation Oncology Cruces University Hospital Department of Statistics and Epidemiology Cruces University Hospital Department of Radiation Oncology Catalan Institute of OncologyL'Hospitalet de Llobregat

Malnutrition occurs frequently in patients with ***,a variety of nutritional and tumorrelated factors must be taken into account in these *** this relationship,we aimed to prospectively evaluate the risk factors that influence weight loss in patients undergoing radiotherapy with oral nutritional supplementation and dietetic *** loss of 74 patients during radiotherapy and 1 month after treatment was *** such as age,gender,tumor location,tumor stage,Eastern Cooperative Oncology Group performance status(ECOG PS)score,and the use of chemotherapy were analyzed to evaluate their influence on weight *** patients underwent oral nutritional supplementation and dietetic ***-six(65.7%)patients lost weight,with a mean weight loss of(4.73±3.91)kg,during *** 1 month after treatment,45(66.2%)patients lost weight,presenting a mean weight loss of(4.96±4.04)kg,corresponding to a(6.84±5.24)%net reduction from their baseline *** and neck cancer patients had a mean weight loss of(3.25±5.30)kg,whereas the remaining patients had a mean weight loss of(0.64±2.39)kg(P=0.028)during *** the multivariate analysis,the head and neck tumor location(P=0.005),use of chemotherapy(P=0.011),and ECOG PS score of 2-3(P=0.026)were considered independent risk *** status and parameters,such as tumor location(especially the head and neck),the use of chemotherapy,and the ECOG PS score,should be evaluated before radiotherapy because these factors can influence weight loss during radiotherapy and 1 month after treatment.

关键词：癌症患者放疗减肥头颈部肿瘤平均体重营养不良危险因素营养补充

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Colorectal and interval cancers of the Colorectal Cancer Screening Program in the Basque Country (Spain)

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World Journal of Gastroenterology 2017年第15期23卷 2731-2742页

作者： Isabel Portillo Eunate Arana-Arri Isabel Idigoras Isabel Bilbao lorea martínez-Indart Luis Bujanda Inaki Gutierrez-Ibarluzea BioCruces Health Research Institute Colorectal Cancer Screening Programme OsakidetzaBasque Health Service Department of Gastroenterology Hospital Donostia/Instituto BiodonostiaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasUniversidad del País Vasco(UPV/EHU Basque Office for Health Technology Assessment Ministry for HealthBasque Government

AIM To assess proportions, related conditions and survival of interval cancer(IC).METHODS The programme has a linkage with different clinical databases and cancer registers to allow suitable evaluation. This evaluation involves the detection of ICs after a negative faecal inmunochemical test(FIT), interval cancer FIT(IC-FIT) prior to a subsequent invitation, and the detection of ICs after a positive FIT and confirmatory diagnosis without colorectal cancer(CRC) detected and before the following recommended c o l o n o s c o p y, I C-c o l o n o s c o p y. W e c o n d u c t e d a retrospective observational study analyzing from January 2009 to December 2015 1193602 invited people onto the Programme(participation rate of 68.6%).RESULTS Two thousand five hundred and eighteen cancers were diagnosed through the programme, 18 cases of IC-colonoscopy were found before the recommended follow-up(43542 colonoscopies performed) and 186 IC-FIT were identified before the following invitation of the 769200 negative FITs. There was no statistically significant relation between the predictor variables of ICs with sex, age and deprivation index, but there was relation between location and stage. Additionally, it was observed that there was less risk when the location was distal rather than proximal(OR = 0.28, 95%CI: 0.20-0.40, P < 0.0001), with no statistical significance when the location was in the rectum as opposed to proximal. When comparing the screen-detected cancers(SCs) with ICs, significant differences in survival were found(P < 0.001); being the 5-years survival for SCs 91.6% and IC-FIT 77.8%.CONCLUSION These findings in a Population Based CRC Screening Programme indicate the need of population-based studies that continue analyzing related factors to improve their detection and reducing harm.

关键词： Colorectal cancer Population Screening Programme Interval cancer Faecal immunochemical test Colonoscopy Diagnosis Mortality Survival

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基于文献检索的腰椎间盘突出症临床研究

基于文献检索的腰椎间盘突出症临床研究

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作者： lorea Fernandez Perez（罗小龙）南京中医药大学

学位级别：硕士

研究目的：通过收集和分析古代文献,现代文献和临床研究中关于腰椎间盘突出症的治疗方法和穴位选取（以下选取的穴位均来自古代文献）,我们可以观察不同历史时期针对该病不同的治法和穴位选择,并通过分析这三个不同来源对穴位的选取,可... 详细信息

研究目的：通过收集和分析古代文献,现代文献和临床研究中关于腰椎间盘突出症的治疗方法和穴位选取（以下选取的穴位均来自古代文献）,我们可以观察不同历史时期针对该病不同的治法和穴位选择,并通过分析这三个不同来源对穴位的选取,可以掌握理论和实践的差异。通过寻找腰椎间盘突出症和腰痛相似的体征和症状,来找到古代文献记载的治疗腰椎间盘突出症的穴位选取依据。本研究通过总结归纳临床常用治法和已不常用的治法,来为临床实践中腰椎间盘突出症的治疗提供理论依据。研究方法：阅读并调查文献,临床研究和古代文献中关于腰椎间盘突出症的诊治,并总结分析三个不同角度对该病的不同诊断和穴位选取.文献及现代和古代理论记载来源于南京中医药大学图书馆。收集和分析使用的临床研究来自中国期刊全文数据库（CNKI）,维普数据库（VIP）和万方数据库（WF）。数据处理使用软件包括Microsoft Access, Word和Excel。整理归纳文献资源和临床上方法的使用,治疗和多种方法的混合使用。本文总结了文献,临床研究和实际操作中不同鉴别诊断和穴位选取的差异。研究结果：发现下腰痛和腰椎间盘突出症的成因和诊断具有极大的相似性,因而穴位的选取也十分类似,最重要的几个穴位是委中穴,肾俞穴和环跳穴,尽管在阿是穴和阳陵泉的使用上有差异性,但这在古典文献中几乎也未提及。

关键词：腰椎间盘突出腰痛

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Early tacrolimus exposure does not impact long-term outcomes after liver transplantation

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World Journal of Hepatology 2021年第3期13卷 362-374页

作者： Mikel Gastaca Patricia Ruiz Javier Bustamante lorea martinez-Indart Alberto Ventoso JoséRamón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador maria Senosiain maria Jesus Suárez Andres Valdivieso Department of HPB Surgery and Liver Transplantation Unit Hospital Universitario CrucesBilbao 48903Spain Department of Hepatology Unit Hospital Universitario CrucesBilbao 48903Spain Department of Bioinformatics and Statistics Platform Biocruces Bizkaia Health Research InstituteHospital Universitario CrucesBilbao 48903Spain

BACKGROUND Tacrolimus trough levels(TTL)during the first weeks after liver transplantation(LT)have been related with long-term renal function and hepatocellular carcinoma ***,the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate AIM To evaluate the effect of TTL during the first month on the long-term outcomes after *** One hundred fifty-five LT recipients treated de novo with once-daily tacrolimus were retrospectively *** with repeated LT or combined transplantation were excluded as well as those who presented renal dysfunction prior to transplantation and/or those who needed induction *** were classified into 2 groups according to their mean TTL within the first month after transplantation:≤10(n=98)and>10 ng/mL(n=57).Multivariate analyses were performed to assess risk factors for patient *** Mean levels within the first month post-transplant were 7.4±1.7 and 12.6±2.2 ng/mL in the≤10 and>10 groups,*** age was higher in the high TTL group 62.9±16.8 years vs 45.7±17.5 years(P=0.002)whilst mycophenolate-mofetil was more frequently used in the low TTL group 32.7%vs 15.8%(P=0.02).Recipient features were generally similar across *** a median follow-up of 52.8 mo(range 2.8-81.1),no significant differences were observed in:Mean estimated glomerular filtration rate(P=0.69),hepatocellular carcinoma recurrence(P=0.44),de novo tumors(P=0.77),new-onset diabetes(P=0.13),or biopsy-proven acute rejection rate(12.2%and 8.8%,respectively;P=0.50).Eighteen patients died during the follow-up and were evenly distributed across groups(P=0.83).Five-year patient survival was 90.5%and 84.9%,respectively(P=0.44),while 5-year graft survival was 88.2%and 80.8%,respectively(P=0.42).Early TTL was not an independent factor for patient mortality in multivariate *** Differences in tacrolimus levels restricted to the fi

关键词： Liver transplantation Tacrolimus levels Prolonged released tacrolimus Oncedaily tacrolimus Renal function Survival Outcomes

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基于冷热水试验和头脉冲试验的梅尼埃病患者的前庭诱发肌源性电位检查

基于冷热水试验和头脉冲试验的梅尼埃病患者的前庭诱发肌源性电位...

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中国中西医结合学会眩晕病专业委员会第二次学术大会暨河南省中西医结合学会眩晕病专业委员会第三次学术大会暨眩晕高峰论坛

作者： Nicolas PEREZ Raquel MANRIQUE lorea ARBIZU maria Victoria UCAR 纳瓦拉大学耳鼻喉科

最近有假说认为,梅尼埃病(MD)患者冷热水试验(CAL)、视频-头脉冲试验(vHIT)之间的不一致提示水平半规管中内淋巴积水。在本研究中我们基于CAL和vHIT的结果将MD分类,评估了他们的前庭诱发肌源性电位(VEMP)改变。我们收集了诊断为单侧病...

最近有假说认为,梅尼埃病(MD)患者冷热水试验(CAL)、视频-头脉冲试验(vHIT)之间的不一致提示水平半规管中内淋巴积水。在本研究中我们基于CAL和vHIT的结果将MD分类,评估了他们的前庭诱发肌源性电位(VEMP)改变。我们收集了诊断为单侧病变的肯定的梅尼埃病患者,所有患者患耳和健侧耳的vHIT试验均正

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