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三例基于5-(二甲基氨基)间苯二甲酸的锌(Ⅱ)/铜(Ⅱ)配合物的合成、晶体结构、Hirshfeld表面分析和荧光性质

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无机化学学报 2024年第7期40卷 1397-1408页

作者：王凯民顾雄邓娜于红梅叶艳青马钰璐云南民族大学化学与环境学院昆明650504 昆明医科大学药学院暨天然药物药理重点实验室昆明650500 昆明医科大学现代生物医药产业学院昆明650500

利用配体5-(二甲基氨基)间苯二甲酸(H_(2)dia)和咪唑(mdz)分别与锌(Ⅱ)和铜(Ⅱ)金属盐反应,制备了3例过渡金属配合物[Zn(dia)(mdz)_(2)]·2H_(2)O(1)、[Cu(dia)(mdz)_(2)(DMF)](2)和[Cu(dia)(mdz)_(2)]·H_(2)O(3)。利用单晶X射线衍射、元素分析、红外光谱、热重和Hirshfeld表面分析对其进行了结构表征。结果表明配合物1和2为一维线状链,1中每个四配位的Zn(Ⅱ)处于变形四面体中心,2中Cu(Ⅱ)中心拥有五配位的三角双锥几何构型。改变合成溶剂条件得到锯齿形一维链状配合物3,其四配位Cu(Ⅱ)中心展现出对称平面四边形构型。上述结果说明,金属离子几何构型以及合成溶剂可能对配合物结构具有重要影响。丰富的分子间氢键帮助3例配合物形成稳定的三维超分子结构。热重分析表明,3例配合物均具有良好的热稳定性。固体荧光分析表明配合物1具有较强荧光性,而配合物2和3荧光强度均远低于配体。

关键词：配合物过渡金属晶体结构 Hirshfeld表面分析荧光性质

Extended structural materials constructed from sulfate-centered Preyssler-type polyoxometalate with excellent electrocatalytic property

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Chinese Chemical Letters 2018年第9期29卷 1409-1412页

作者： na Zhang Luying Hong Aifang Geng Jinghui Yan Shuang Yao Zhiming Zhang College of Chemistry and Environmental Engineering Changchun University of Science and Technology Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical Engineering Tianjin University of Technology

Sulfate-centered Preyssler-type polyoxometalate was used as the precursor to react with transition metal cations and organic ligand for constructing inorganic-organic hybrid materials {H[Ni2（H2O）4（Htrz）3]2（KSsW30O110）}·18H2O （trz = 1,2,4-triazole）（1）, which was characterized by single crystal X-ray diffraction analysis, energy-dispersive X-ray （EDX）, power X-ray diffraction （PXRD）, ir spectra and thermogravimetric （TG） analyses. In 1, the cylindrical vacancy of the inorganic crown-type anion （SsW30Ouo） captures a K^＋ ion resulting in the anion {KS5W3oO110）^9-, which was further connected by dimeric [Ni2（H2O）4（Htrz）3]2 metal-organic units into an one-dimensional （1D） chain-like structure. These 1D chains are further packed to form a three-dimensional （3D） supramolecular structure via Hbonding interactions. Here, the sulfate-centered Preyssler-typepolyoxometalate was firstly used to coordinate with transition metal cations and introduced into the inorganic-organic hybrid materials. Electrocatalytic study indicates that compound I exhibits good electrocatalytic activity toward reduction of H2O2 and NO2^-.

关键词： Preyssler-type Polyoxometalate Transition metal Supramolecular structure Electrocatalytic activity

Synthesis, Antiproliferative Activity and Dna-Binding Properties of Nitrogen and Sulfur Heterocyclic Norcantharidin Acylamide Acid

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Chinese Journal of Chemistry 2011年第3期29卷 473-477页

作者： Wang, na Wang, Yunyun Wang, Xiaoxia Zheng, Xiaoliang Yan, Dongmei Lin, Qiuyue College of Chemical and Life Science Zhejiang Normal University Jinhua Zhejiang 321004 China Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces Zhejiang Normal University Jinhua Zhejiang 321004 China Institute ofMateria Medica of Zhejiang Academy of Medical Sciences Hangzhou Zhejiang 310013 China

Three novel norcantharidin acylamide acids （L1 =N-thiadiazole norcantharidin acylamide acid, CIoHIlN304S; L2=N-thiazole norcantharidin acylamide acid, CjIHI2N204S and L3=N-benzothiazole norcantharidin acylamide acid, C15H14N204S） were synthesized by the reactions of norcantharidin （NCTD=7-oxabicyclo[2,2,1 ]heptane-2,3- dicarboxylic acid anhydride, C8H8O4） with 2-amino-1,3,4-thiadiazole （C2H3N3S）, 2-aminothiazole （C3H4N2S） and 2-aminobenzothiazole （C7H6N2S）, respectively. Their structures were characterized by elemental analysis, ir, and NMR. The inhibition rates of L3 was much higher than those of Lj and L2 against human hepatoma cells SMMC7721 cell lines in vitro. The interaction between the compounds and Dna was studied by means of fluorescence quenching studies and viscosity measurements. The emission intensities decreased obviously with increasing concentration of the compounds in the fluorescence quenching experiments. The linear Stern-Volmer quenching constant Ksq values were 0.62 （Ll）, 0.55 （L2） and 1.08 （L3）, respectively. The binding abilities followed the trend from high to low were L3, L1 and L2, respectively. The results of viscosity measurements showed that L1 and L2 might bind to Dna via partial intercalation, while L3 bound mainly in intercalation.

关键词： norcantharidin Dna fluorescence spectroscopy antiproliferative activity

2型糖尿病患者血糖目标范围内时间与代谢相关脂肪性肝病及肝纤维化的相关性研究

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中华内分泌代谢杂志 2024年第3期40卷 198-203页

作者：王丹钰刘凯坤邓欣如史晓阳杨俊朋徐娜陈耀楠袁慧娟河南省人民医院(郑州大学人民医院)内分泌科郑州450003 河南省人民医院(郑州大学人民医院)老年医学科郑州450003

目的探讨2型糖尿病患者血糖目标范围内时间(time in range,Tir)与代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)及进展期肝纤维化的相关性。方法本研究为回顾性研究,选取2019年10月至2022年4月河南省人民医院内... 详细信息

目的探讨2型糖尿病患者血糖目标范围内时间(time in range,Tir)与代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)及进展期肝纤维化的相关性。方法本研究为回顾性研究,选取2019年10月至2022年4月河南省人民医院内分泌科494例2型糖尿病患者作为研究对象,Tir来自持续血糖监测数据,腹部超声诊断脂肪肝,瞬时弹性成像技术的肝脏硬度值评估肝纤维化。采用Pearson相关性分析及多元线性回归分析评估Tir与肝脏硬度值的相关性,采用logistic回归分析评估Tir与MAFLD及进展期肝纤维化患病风险的相关性。结果Pearson相关性分析显示,Tir与肝脏硬度值呈负相关(r=-0.86,Pir)与肝脏硬度值呈正相关(r=0.48,Pir负向预测肝脏硬度值(β=-0.75,Pir正向预测肝脏硬度值(β=0.21,P=0.025);调整混杂因素后,logistic回归分析显示,与Tir Q4患者相比,Tir Q1患者MAFLD(OR=1.96,95%CI 1.07~3.62,P=0.027)及进展期肝纤维化(OR=3.82,95%CI 1.17~12.50,P=0.027)患病风险增加,HOMA-ir是MAFLD(OR=1.22,95%CI 1.04~1.43,P=0.005)及进展期肝纤维化(OR=1.26,95%CI 1.03~1.54,P=0.025)的独立危险因素。结论2型糖尿病患者中,低水平Tir、胰岛素抵抗是MAFLD及进展期肝纤维化的独立危险因素,Tir对MAFLD及进展期肝纤维化发生有显著的预测价值。

关键词：目标范围内时间代谢相关脂肪性肝病进展期肝纤维化

The Improvement Effects of naH_(2)PO_(4) and KH_(2)PO_(4) on the Properties of Magnesium Oxysulfate Cement

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Journal of Wuhan University of Technology(Materials Science) 2021年第1期36卷 50-57页

作者： WANG nan YU Hongfa BI Wanli GUAN Yan GONG Wei ZHANG na WU Chengyou department of Civil Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Materials and Metallurgy Liaoning University of Science and TechnologyAnshan 114051China School of Civil Engineering Qinghai UniversityXinitig 810016China

Sodium dihydrogen phosphate (naH_(2)PO_(4)) and potassium dihydrogen phosphate (KH_(2)PO_(4)) were selected as additives for magnesium oxysulfate (MOS) *** phase composition and the microstructure of MOS cement were characterized using X-ray diffraction (XRD),thermogravimetric analysis (TG-DSC),Flourier transform infrared spectroscopy (FT-ir),mercury intrusion porosimetry (MIP) and scanning electron microscopy (SEM).It is found that both naH_(2)PO_(4) and KH_(2)PO_(4) lead to an increase in the compressive strength and an improvement in the volume stability of MOS *** XRD,MIP and SEM results show that the addition of naH_(2)PO_(4) or KH_(2)PO_(4) does not change the phase composition of MOS cement but promotes the formation of strength phase of 5Mg(OH)_(2)·MgSO_(4)·7H_(2)O (5·1·7 phase).This phase brings a considerable improvement in the microstructure of MOS cement,which has a positive effect on the properties of MOS cement.

关键词： magnesium oxysulfate cement phosphates compressive strength volume stability microstructure

Anti-fouling ultrafiltration membrane prepared from polysulfone-graft-methyl acrylate copolymers by UV-induced grafting method

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Journal of Environmental Sciences 2008年第5期20卷 565-570页

作者： HUA Helin LI na WU Linlin ZHONG Hui WU Guangxia YUAN Zonghuan LIN Xiangwei TANG Lianyi Research Center for Eco-Environmental Science Chinese Academy of Sciences Beijing 100085 China department of Environment and Chemistry Engineering Nanchang Hangkong University Nanchang 330034 China The Greatwall Pharmaceutical Factory of Beijing Beijing 100071 China

Membrane fouling is one of the most important challenges faced in membrane ultrafiltration operations. The copolymers of polysulfone-graft-methyl acrylate were synthesized by homogeneous photo-initiated graft copolymerization. The variables affecting the degree of grafting, such as the time of UV （Ultraviolet-visible） irradiation and the concentrations of the methyl acrylate and photoinitiator, were investigated. The graft copolymer membranes were prepared by the phase inversion method. The chemical and morphological changes were characterized by attenuated total reflection-Fourier transform infrared spectroscopy （ATR/FT-ir）, scanning electron microscopy, and water contact angles measurements. Results revealed that methyl acrylate groups were present on the membranes and the graft degree of methyl acrylate had remarkable effect on the performance of membranes. Pure water contact angle on the membrane surface decreases with the increase of methyl acrylate graft degree, which indicated that the hydrophilicity of graft copolymer membranes was improved. The permeation fluxes of pure water and bovine serum albumin solution were measured to evaluate the antifouling property of graft copolymer membranes, the results of which have shown an enhancement of antifouling property for graft copolymer membranes.

关键词： polysulfone methyl acrylate UV irradiation graft polymerization

Crystal Engineering of Multiple-component Organic Compound： Organic co-Crystals of the Functional Groups of Carboxyl and Amino with persistent Hydrogen Bonding Motifs

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Chemical Research in Chinese Universities 2013年第3期29卷 408-413页

作者： SONG Ge BAI Feng-ying XING na CHEN Chen SHAN Hui XING Yong-heng College of Chemistry and Chemical Engineering College of Life Science Liaoning Normal University Dalian 116029 P. R. China

Three small organic molecular co-crystal compounds （C3N6H6）·（C6H10O4）·H2O（I）, C3HsN2O（3） and （H4btec）2.（4,4＇-bipy）（4）（H4btec=1,2,4,5-benzenetetracarboxylic acid, 4,4＇-bipy=4,4＇-bipyridine） and one coordination supramolecular compound [Mn（CEO4）（HEO）E]＇C6HllNO2（2） were synthesized by hydrothermal reaction. They were characterized by elemental analysis, infrared（ir） spectroscopy and single crystal X-ray diffraction（XRD）. Structural analyses reveal that these 2D or 3D supramolecular networks of the compounds were formed by C--H…O, N--H…O, N--H…N, O--H…O and O-H…N hydrogen bonds. Therein, the functional groups of--COOH, --NH2 and --OH play important roles in constructing supramolecular architectures.

关键词： co-Crystal compound Hydrogen bond Hydrothermal reaction

Synthesis and NHE1 inhibitory activity of ligustrazine derivatives

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Chinese Chemical Letters 2007年第5期18卷 539-541页

作者： Mei Ren Yun Gen Xu na Wen Da Yong Zhang Wei Yi Hua Center of Drug Discovery China Pharmaceutical University Nanjing 210009 China department of Pharmacology China Pharmaceutical University Nanjing 210009 China

A series of novel derivatives of ligustrazine linked with substituted benzoyl guanidine were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by ir, ^1H NMR and MS. The results of NHE1 inhibitory activity test showed that compounds I2, I3, I4, I6, and I7 possess more potent NHE1 inhibitory activity than cariporide.

关键词： na^+/H^+ exchanger inhibitors Ligustrazine derivatives Benzoyl guanidine derivatives Synthesis

Cu_(2)O/Ag/g-C_(3)N_(4)复合材料制备及其光催化降解抗生素性能

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工业催化 2024年第7期32卷 43-48页

作者：林诗音张宇航谢继苗毛娜渭南师范学院陕西渭南714099

采用水热法和原位光还原法制备一系列Cu_(2)O/Ag/g-C_(3)N_(4)复合材料,采用XRD、ir、PL等对复合材料进行表征,并测试其光催化性能。结果表明,Ag和Cu_(2)O成功负载到g-C_(3)N_(4)表面,且没有破坏g-C_(3)N_(4)的结构;当溶液pH=6时,20 mg ... 详细信息

采用水热法和原位光还原法制备一系列Cu_(2)O/Ag/g-C_(3)N_(4)复合材料,采用XRD、ir、PL等对复合材料进行表征,并测试其光催化性能。结果表明,Ag和Cu_(2)O成功负载到g-C_(3)N_(4)表面,且没有破坏g-C_(3)N_(4)的结构;当溶液pH=6时,20 mg 15%-Cu_(2)O/Ag/g-C_(3)N_(4)对四环素降解率为94.3%。·OH、·O_(2)^(-)、h^(+)对Cu_(2)O/Ag/g-C_(3)N_(4)降解四环素起主要作用。光催化性能提升的原因可能是由于Ag和Cu_(2)O的加入形成异质结,增大g-C_(3)N_(4)的比表面积,降低其带隙能,使其在可见光区的吸收增强,抑制光生电子-空穴对的复合,提高了g-C_(3)N_(4)光催化性能。

关键词：催化化学 Cu_(2)O g-C_(3)N_(4) 四环素光-类Fenton催化