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Virologica Sinica 2018年第2期33卷 142-152页

作者： Lina Rustanti Hongping Jin Dongsheng Li mary lor Haran Sivakumaran David Harrich Faculty of medicine The University of Queensland Department of Cell and molecular Biology QIMR Berghofer Medical Research Institute National Institute of Health Research and Development the Ministry of Health of Republic of Indonesia Central Jakarta

Nullbasic is a mutant form of HIV-1 Tat that has strong ability to protect cells from HIV-1 replication by inhibiting three different steps of viral replication: reverse transcription, Rev export of viral m RNA from the nucleus to the cytoplasm and transcription of viral m RNA by RNA polymerase II. We previously showed that Nullbasic inhibits transduction of human cells including T cells by HIV-1-based lentiviral vectors. Here we investigated whether the Nullbasic antagonists huTat2(a Tat targeting intrabody), HIV-1 Tat or Rev proteins or cellular DDX1 protein could improve transduction by a HIV-1 lentiviral vector conveying Nullbasic-Zs Green1 to human T cells. We show that overexpression of huTat2, Tat-FLAG and DDX1-HA in virus-like particle(VLP) producer cells significantly improved transduction efficiency of VLPs that convey Nullbasic in Jurkat cells. Specifically, co-expression of Tat-FLAG and DDX1-HA in the VLP producer cell improved transduction efficiency better than if used individually. Transduction efficiencies could be further improved by including a spinoculation step. However, the same optimised protocol and using the same VLPs failed to transduce primary human CD4^+T cells. The results imply that the effects of Nullbasic on VLPs on early HIV-1 replication are robust in human CD4^+T cells. Given this significant block to lentiviral vector transduction by Nullbasic in primary CD4^+T cells, our data indicate that gammaretroviral, but not lentiviral, vectors are suitable for delivering Nullbasic to primary human T cells.

关键词： HIV-1 Transduction Lentiviral vector Nullbasic Tat Rev DDX1 lntrabody

In-situ study of the microstructure evolution during tension of a mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

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Journal of magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián máthis Péter Nagy Péter Jenei Zoltán Hegedus Andrea Farkas Jozef Vesely Shin-ichi Inoue Daria Drozdenko Yoshihito Kawamura Department of materials Physics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Physics of materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation(RSRC)technique exhibit an exceptional mechanical performance indicating promising application *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanoplates(CANaPs),or complete long period stacking ordered(LPSO)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial microstructure on the mechanical performance,additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation of the mechanical *** maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction profile analysis indicated that most dislocations formed during tension were of non-basal and pyramidal types,what was also in agreement with the Schmid factor values revealed independently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value,which was explained by a model of the interaction between prismatic dislocations and CANaPs/LPSO plates.

关键词： mg-Zn-Y-Al alloy Long period stacking ordered(LPSO)phase Cluster arranged nanoplates(CANaPs) Annealing Tension Dislocation density Hardening

The Soft X-ray Imager(SXI)on the SmILE mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer m.Guedel Y.Guo m.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-Y.Hsieh m.W.J.Hubbard H.Jeszenszky m.Jones T.Kennedy K.Koch-mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.martindale J.miguel mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.m.Read N.m.m.Roque m.E.Rostad C.Runciman S.Sachdev A.Samsonov m.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland m.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK mullard Space Science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weather National Space Science CentreBeijing 100190China University of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space GmbH CH-8157 DielsdorfSwitzerland Space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STm Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics Laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space Physics Boston UniversityBostonMA 02215USA Department of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind magnetosphere Ionosphere Link Explorer(SmILE)*** is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SmILE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SmILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Imaging micropore optics large area CCD

Enabling Technologies for Autonomous Robotic Systems in manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐS Gábor ABAI Kristóf BEREGI Richárd CSEmPESZ János CSERTEG Tamás GODÓGábor HAJÓS mátyás HÁY Borbála HORVÁTH Dániel HORVÁTH Gergely JUNIKIÁdám KEmÉNY Zsolt KOVÁCS András NACSA János PANITI Imre PEDONE Gianfranco TAKÁCS Emma TIPARY Bence ZAHORÁN László VÁNCZA József Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of manufacturing Science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC InnoLabs Nonprofit Ltd. BudapestHungary Eötvös loránd University(ELTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at HUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

CT结肠成像筛查检出意外的肠外病变:临床和经济影响

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国际医学放射学杂志 2008年第A6期31卷 499-500页

作者： P.J.Pickhardt m.E.Hanson D.J.Vanness J.Y.Lo D.H.Kim A.J.Tay-lor 冯洁玲 Department of Radiology University of Wisconsin School of medicine and Public Health E3/311 Clinical Science Center 600 Highland Ave Madison WI 53792-3252USA.

目的在大量筛查人群中,评价CT结肠成像发现结肠外病变的几率并评估额外检查费用。方法本回顾性研究通过机构审查委员会批准。

关键词： CT结肠成像无症状检查费用外科操作诊断检查超声检查相关费用影像检查年平均统计分析

Hazards and Landscape Changes(Degradations) on Hungarian Karst mountains Due to Natural and Human Effects

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Journal of mountain Science 2013年第1期10卷 16-28页

作者： móga JNOS Kiss KLAUDIA Szabó mRIA Kériné Borsodi ANDREA Kéri ANDRS mari LSZLó Knáb móNIKA Iván VERONIKA Geography and Earth Science Institute Etvs Loránd University Biology Institute Etvs Loránd University

In order to study the karstological processes within the karst ecological system,the geohazards and degradation of karst landscapes on the karst areas of the Bakony mountains(Hungary),we investigated the abiotic elements of the environment,soil and cover deposits,erosion soil decay;the changes in the quantity and quality of karst waters:contamination at swallow holes,contamination of karst springs;and the biogenic factors:surface vegetation coverage by the corine land cover method,plant-ecological examinations,qualification of surface waters with the help of biological water *** recognized that the increasing human activities during the past few centuries have had significant impact on the investigated landscapes of karst areas because of their spatial *** the scope of our research we concluded that the landscape changes due to natural and human effects can vary strongly on the different karst *** differences can arise from the climatic and geomorphologic situation,the coverlayer's qualities,etc.,but primarily from the different utilization of the investigated karst areas(*** intensity,characteristics and territorial extension of utilization).On the spot investigation we detected traces of new and fast geomorphological processes(gully formation,landslides,collapses,new sinkhole development) and landforms(sinkholes,gullies,swallow holes),which are clear evidences of the effect of climatic changes.

关键词： Karst landscape Geological hazards Soil erosion Limestone mountain

Performance of a No-Till Vegetable Transplanter for Transplanting Thai Round Eggplant (Solanum melongena L.) in Conservation Agriculture

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Journal of Environmental Science and Engineering(B) 2020年第6期9卷 236-247页

作者： Lyhour Hin Borarin Buntong manuel RReyes Lyda Hok Lytour lor Horace Clemmons Ted SKornecki Faculty of Agricultural Engineering Royal University of AgriculturePhnom Penh 12401Cambodia Division of Research and Extension Royal University of AgriculturePhnom Penh 12401Cambodia Faculty of Agronomy Royal University of AgriculturePhnom Penh 12401Cambodia Center of Excellence on Sustainable Agricultural Intensification and Nutrition Royal University of AgriculturePhnom Penh 12401Cambodia Department of Agronomy Kansas State UniversityKS 66506the United States of America Think Oggun Clebber LLCRaleighNC 27658the United States of America National Soil Dynamics Laboratory USDA-ARSAuburnAL 36832the United States of America

Vegetables are vital for human health and are consumed five days a week in ***,the production cannot meet domestic demands due to labor-intensive farming and production costs related to soil *** is needed along with soil quality and sustainability improvements by the adoption of CA(Conservation Agriculture).The research aimed to compare the performance of the no-till vegetable transplanter with punch-planter in CA and hand transplanting in CT(Conventional Tillage).The study was conducted at the Royal University of Agriculture,Cambodia,starting from January to September 2020,by firstly growing sunn hemp as a cover crop and then transplanting Thai round eggplant.A randomized complete block design was used with three treatments,replicated three *** plot was 2 m by 15 m,with 0.2-m row *** results showed that the transplanter speed was 0.54 km􀁸h^-1,almost two times the speed of punch planter and 9 times the speed of hand *** highest working capacity was also achieved with the ***,different transplanting did not affect plant spacing,or plant *** spacing was 1 m,and plant density varied from 10,300 to 11,500 plants􀁸*** growth and yield were also not influenced by the transplanter in CA,or hand transplanting in *** fruit diameter,fruit weight,fruit number,and yield were 38 mm,31.4 g􀁸fruit-1,15.7 fruits􀁸plant-1 and 3.9 t􀁸ha-1,*** maximum working area of the transplanter and its break-even area were 25.2 ha·y^-1 and 18.3 ha·y^-1,*** the no-till transplanter may save both time and labor,but its use in combination with CA was unlikely to affect plant growth and yield in the short term.

关键词： Break-even area CA (Conservation Agriculture) economic analysis plant growth roller/crimper working capacity

Numerical and experimental analysis for simulating fuel reactor in chemical looping combustor system

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International Journal of Coal Science & Technology 2020年第3期7卷 551-559页

作者： Tamer m.Ismail Lu Ding Khaled Ramzy mAbd El-Salam Department of mechanical Engineering Suez Canal UniversityIsmailiaEgypt Institute of Clean Coal Technology East China University of Science and TechnologyShanghai200237China Department of Basic Science Cairo UniversityGizaEgypt

The greenhouse problem has a significant effect on our communities such as,health and *** dioxide is one of the main gases that cause global ***,CO2 capture techniques have been the focus of attention these *** chemical looping combustion technique adopted the air reactor and fuel reactor to recycle heat *** study presents a numerical and experimental investigation on a fuel reactor in chemical looping combustor(CLC)*** present numerical model is introduced by the kinetic theory of granular flow and coupled with gas–solid flow with chemical reactions to simulate the combustion of solids in the *** k–εturbulent model was used to model the gas phase and the particle *** developed model simplify the prediction of flow patterns,particle velocities,gas velocities,and composition profiles of gas products and the distribution of heterogeneous reaction rates under the same operating *** predicted and experimental results were compared according to the basis of determination coefficient(R2).In addition the results showed that there is a good agreement between the predicted and experimental *** value of(R2)for CO,CO2 and CH4 was 0.959,0.925 and 0.969 *** shows that the present model is a promising simulation for solid particle combustion and gives the power direction for the design and optimization of the CLC systems.

关键词： Chemical looping combustion mathematical modeling Fluidized bed Coal Kinetic model

Symmetric carbon tetramers forming spin qubits in hexagonal boron nitride

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npj Computational materials 2023年第1期9卷 407-416页

作者： Zsolt Benedek Rohit Babar Ádám Ganyecz Tibor Szilvási Örs Legeza Gergely Barcza Viktor Ivády Strongly Correlated Systems Lendület Research Group Wigner Research Centre for PhysicsPO Box 49H-1525 BudapestHungary mTA-ELTE Lendület“momentum”NewQubit Research Group Pázmány PéterSétány 1/A1117 BudapestHungary Department of Chemical and Biological Engineering The University of AlabamaTuscaloosaAL 35487USA Institute for Advanced Study Technical University of MunichLichtenbergstrasse 2a85748 GarchingGermany Department of Physics of Complex Systems Eötvös Loránd UniversityEgyetem tér 1-3H-1053 BudapestHungary Department of Physics Chemistry and BiologyLinköping UniversitySE-58183 LinköpingSweden

Point defect quantum bits in semiconductors have the potential to revolutionize sensing at atomic ***,vacancy-related defects are at the forefront of high spatial resolution and low-dimensional *** the other hand,it is expected that impurity-related defect structures may give rise to new features that could further advance quantum sensing in low ***,we study the symmetric carbon tetramer clusters in hexagonal boron nitride and propose them as spin qubits for *** utilize periodic-DFT and quantum chemistry approaches to reliably and accurately predict the electronic,optical,and spin properties of the studied *** show that the nitrogen-centered symmetric carbon tetramer gives rise to spin state-dependent optical signals with strain-sensitive intersystem crossing ***,the weak hyperfine coupling of the defect to their spin environments results in a reduced electron spin resonance linewidth that can enhance sensitivity.

关键词： hexagonal boron quantum