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AT1 receptor downregulation:A mechanism for improving glucose homeostasis

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World Journal of Diabetes 2023年第3期14卷 170-178页

作者： Diana l lopez Oscar E Casillas Hiram J Jaramillo Tatiana Romero-Garcia J.Gustavo Vazquez-Jimenez Department of Internal Medicine General Hospital of MexicaliMexicali 21000Baja CaliforniaMexico Faculty of Medicine Autonomous University of Baja CaliforniaMexicali 21000Baja CaliforniaMexico Faculty of Sports Autonomous University of Baja CaliforniaMexicali 21289Baja CaliforniaMexico

There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-Ⅱ enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the JNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1receptor could have beneficial effects in treating metabolic syndrome and type 2diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor.

关键词： Type 2 diabetes mellitus High blood pressure Insulin receptor Insulin signaling pathway AT1 receptor Angiotensin II signaling pathway

The importance of post-COVID condition phenotypes characterization to decipher the mechanisms underlying this post-viral syndrome

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World Journal of Pediatrics 2024年第6期20卷 633-634页

作者： Jon Izquierdo-Pujol Sara Moron-lopez IrsiCaixa and Institute for Health Science Research Germans Trias i Pujol(IGTP) Can Ruti CampusBadalonaSpain Biomedicine doctoral programme Faculty of BiologyUniversity of BarcelonaBarcelonaSpain CIBERINFEC MadridSpain

The coronavirus disease-19(COVID-19)outbreak,caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was declared a global pandemic in March *** has affected over 700 million people worldwide and resulted in almost 7 million deaths,equating to a 1%mortality *** present,the majority of COVID-19 cases are either asymptomatic or mild,typically resolving within two ***,between 1%and 10%of COVID-19 survivors do not fully recover and experience a post-viral syndrome referred to as"long COVID","post-acute COVID-19 syndrome"(PASC),or"post-COVID condition"(PCC).This post-viral syndrome affects both adult and pediatric ***,most of the studies published to date evaluate the adult population,leaving a gap in our understanding of its impact on children and adolescents.

关键词： acute mortality respiratory

Method and its application of the momentum model for debris flow risk zoning

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Chinese Science Bulletin 2003年第6期48卷 594-598页

作者： WEIFangqiang J.l.lopez 等 InstituteofMountainHzardsandEnvironment ChineseAcademyofSciencesChengdu610041China InstiuteofFluidMechanics CentralUniversityofVenczuelaCaracasVenezuela

In order to ascertain the distribution of flow depth and velocity of debris flow, the combination of nu-merical modeling and the GIS technology has been used to simulate the movement process of debris flow out of the out-let. The main model of momentum classification of risk zon-ing of debris flow is Z=Khv. Based on the distribution of the velocity and depth of debris flow, the distribution of mo-mentum can be ascertained. Thereby the classification of risk zoning of debris flow can be worked out. A case study of Chacaito Valley in Caracas, Venezuela, is presented to illus-trate the application of the method.

关键词：泥石流风险区划动量模型数值模拟应用 GIS

Temporal changes in nitrogen acquisition of Japanese black pine(Pinus thunbergii) associated with black locust(Robinia pseudoacacia)

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Journal of Forestry Research 2014年第3期25卷 585-589页

作者： M.l.lopez C. C.Mizota Y.Nobori T.Sasaki T.Yamanaka Faculty of Agriculture Yamagata University1-23 Wakabamachi Tsuruoka Yamagata 997-8555 Japan Faculty of Agriculture Iwate University Division of Earth Science Graduate School of Natural Science and Technology Okayama University1-1 Naka 3-chome Tsushima Okayama Japan

The alien woody legume, black locust （Robinia pseudoaca-cia）, has invaded Japanese black pine （Pinus thunbergii） forests located in Japan’s coastal plain and hill regions where gaps are formed in pine forests after nematode infestation. Nitrogen fixation by legumes acceler-ates N cycling in forest ecosystems. We studied temporal change in the annual tree-ring resolution N stable isotope composition （δ15N, a per mil deviation of δ15N/14N ratio, relative to atmospheric N2δ15N=0‰） at two natural locations of Japanese black pine forest with black locust that differed in the time since black locust establishment （Shohnai in north-east and Kita-Kyushu in southwest Japan）. Analyzed tree-rings covered the period from 1990/1992 to 2009. N acquisition by Japanese black pine from black locust N input to the soil was evidenced by temporal shifting of N stable isotope composition on the annual pine tree rings. With pro-gressive development of the forest stand,δ15N values of earlier tree-ringsδ15N of -5‰） from black pine associated with black locust shifted to-wards values similar to those of black locustδ15N values nearly to-1‰）, which suggests acquisition of N by N2 fixation （Shohnai site）. In con-trast, in a forest where black locust had settled for two or three genera-tions, in a black pine stand （Kita-Kyushu site）, longer periods of N en-richment in the soil were reflected in the elevated tree-ringδ15N values of newly established black pine trees. Based on tree-ringδ15N data from the Shohnai site, we determined that about 10 years after black locust establishment, soil N had already been enriched by black locust N, this, in turn, contributed to N fertilization of surrounding trees in mixed stands.

关键词： δ15N natural abundance Japanese black pine black locust,nitrogen acquisition tree-ring

Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVIllANO Javier PRECIADO-GARBAYO Jorge SEVIl Francisco GUTIERREZ Juan JMARTiNEZ Sonia MARTiN-lopez Miguel GONZAlEZ-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray Amelia Felipo-Benavent Cristian J.Antonelli Begona Balaguer Maria Pilar lopez-Gresa Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

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消耗性运载器的新生命

导弹与航天运载技术(中英文) 1988年第4期 74-79页

作者： Ramon l.lopez 陈炳芳

本文介绍了消耗性运载器怎样获得新生的,以及发展前景。着重叙述了大力神、德尔它、宇宙神-半人马座、阿里安、质子号、长征等运载器的近况及发射卫星的价格。

关键词：运载火箭大力神运载火箭德尔它运载火箭阿里安运载火箭质子号运载火箭

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人口普查遗漏的组合式估计方法

统计与信息论坛 2024年第2期39卷 3-14页

作者：胡桂华 lopez-CARR David 黄艳华吴笛重庆工商大学数学与统计学院重庆400067 重庆工商大学成渝地区双城经济圈建设研究院重庆400067 加州大学圣芭芭拉分校地理系加利福尼亚圣芭芭拉93106

以人口普查标准时点上的人口总体(全国、全国以下各行政区)为研究对象,研究如何利用对总体登记的普查人口名单和覆盖调查人口名单构造的组合式遗漏估计量估计人口普查遗漏人口数。目前各国政府统计部门在人口普查遗漏估计中主要使用单... 详细信息

以人口普查标准时点上的人口总体(全国、全国以下各行政区)为研究对象,研究如何利用对总体登记的普查人口名单和覆盖调查人口名单构造的组合式遗漏估计量估计人口普查遗漏人口数。目前各国政府统计部门在人口普查遗漏估计中主要使用单重遗漏估计量,但该方法未包括同时遗漏于这两份调查人口名单的双重遗漏人口,低估了总体普查遗漏人口数。组合式遗漏估计量除了包括单重遗漏人口外,还包括了双重遗漏人口,避免了单重遗漏估计量的缺陷。采取抽样估计和数理模型相结合的方法研究单重遗漏估计量、双重遗漏估计量和组合式遗漏估计量,理论和数据分析结果表明:组合式遗漏估计量在抽样估计精度和遗漏人口数估计上优于单重遗漏估计量,尤其是在分析双重遗漏人口特征和改进未来人口普查登记工作等方面;在使用刀切法近似计算总体的组合式遗漏估计量的抽样方差时,不能忽视等概率人口层之间的协方差,否则可能低估或高估其抽样方差;单重遗漏估计量和组合式遗漏估计量属于有偏估计量,要使用均方误差比较其估计精度。本文创新之处在于,利用原始数据全面演示了单重遗漏估计量、双重遗漏估计量和组合式遗漏估计量及其抽样方差估计量等的详细计算过程,同时讨论了其统计性质,尤其是利用设置的数据模拟了有偏性,有助于中国人口普查遗漏估计方案的科学制定及估计精度的提高。

关键词：政府统计人口普查质量评估单重遗漏估计量双重遗漏估计量组合式遗漏估计量不完整二维列联表

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念珠菌生物膜体外抗真菌药物敏感性研究

中华皮肤科杂志 2002年第5期35卷 409-410页

作者：孙秋宁 Gordon Ramage Jose l.lopez-Ribot 中国医学科学院中国协和医科大学北京协和医院皮肤科北京100730 Department of microbiology Division of Infectious DiseasesUniversity of Texas Health Science Center at San AntonioSan AntonioTexas U.S.A Department of Medicine Division of Infectious DiseasesUniversity of Texas Health Science Center at San AntonioSan AntonioTexas U.S.A

随着医疗技术的不断进步,各种体内装置的应用明显增加,如静脉插管、人工心脏瓣膜、关节置换术等。这些装置均可作为微生物的附着物而形成一种由单层或多层细胞粘附到这些生物材料基质的表面生长的生物膜结构 [1]。生长在生物膜中的念... 详细信息

随着医疗技术的不断进步,各种体内装置的应用明显增加,如静脉插管、人工心脏瓣膜、关节置换术等。这些装置均可作为微生物的附着物而形成一种由单层或多层细胞粘附到这些生物材料基质的表面生长的生物膜结构 [1]。生长在生物膜中的念珠菌在其表型上与悬浮的念珠菌有着很大的不同,其中最主要的特点是对许多抗真菌药物的敏感性降低甚至产生耐药 [2]。

关键词：念珠菌生物膜抗真菌药物药物敏感性悬浮菌粘附菌合理用药