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Therapeutic actions of terpenes in neurodegenera.i.e disorders and their correla.i.ns with the regula.i.n and remodeling of the extracellular matrix

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BiOCELL 2025年第1期49卷 109-125页

作者： RENATA DA SiLVA CARNEiRO MATEUS HENRiQUE DE ALMEiDA DA COSTA JOSÉZiLTON LiMA VERDE SANTOS VALDiLÉiA TEiXEiRA UCHÔA LUCiANO DA SiLVA lopes ANDERSON NOGUEiRA MENDES Laboratory of Science in innova.i.n and Technology-La.i.EC Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil Laboratory of Natural Products and Bioprospecting Natural Sciences CenterState University of PiauíTeresina64018Brazil Laboratory of Experimental Neurochemistry Research-LAPNEX Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil

Neurodegenera.i.e diseases are a major public health challenge,mainly affecting the elderly popula.i.n and compromising their cognitive,sensory,and motor ***,available thera.i.s focus on allevia.i.g symptoms and slowing the progression of these conditions,but they do not yet offer a definitive *** this scena.i.,terpenes emerge as promising natural alterna.i.es due to their neuroprotective *** compounds can reduce the forma.i.n of protein aggregates,neutra.i.e free ra.i.als,and inhibit pro-inflammatory enzymes,which are crucial factors in the development of neurodegenera.i.e *** addition,terpenes also play an important role in the regula.i.n and remodeling of the extracellular matrix,a key target for improving neuronal *** such as linalool,pinene,and eugenol,among others,have potential therapeutic effects by modula.i.g inflammatory and oxida.i.e stress processes,the main factors that contribute to the progression of these *** suggest that these compounds act on signa.i.g pathways that regulate the extracellular matrix,improving neuronal integrity and,consequently,cognitive and motor *** work aims to review the potential of terpenes in the treatment of neurodegenera.i.e disorders,with empha.i. on their a.i.ity to regulate oxida.i.e stress and inflamma.i.n,as well as to remodel the extracellular *** interaction between these mecha.i.ms points to the promising use of terpenes as an innova.i.e and natural therapeutic approach to combat these diseases.

关键词： Terpenes Neurodegenera.i.e Disorders Extracellular matrix

Hyperonic neutron stars: reconcilia.i.n between nuclear properties and NiCER and LiGO/ViRGO results

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Communica.i.ns in Theoretical Physics 2022年第1期74卷 57-63页

作者： Luiz L lopes Centro Federal de Educagao Tecnologica de Minas Gerais Campus Viii CEP 37.022-560Varginha-MG-Brasil

Using an extended version of quantum hadrodyna.i.s,i propose a new microscopic equa.i.n of state(EoS)that is able to correctly reproduce the main properties of symmetric nuclear matter at the satura.i.n density,as well as produce massive neutron stars and sa.i.factory results for the ra.i.s and the tidal parameter.i show that this EoS can reproduce at least a 2.00 solar mass neutron star,even when hyperons are *** constraints about the ra.i.s of a 2.00 M_(⊙) and the minimum mass that enables a direct Urea effect are also checked.

关键词： neutron star nuclear matter tidal deforma.i.ity DU process hyperons

Computer Vision in Augmented,Virtual,Mixed and Extended Rea.i.y environments-A bibliometric review

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Visual informa.i.s 2024年第4期8卷 13-22页

作者： Júlio Castro lopes Rui Pedro lopes Research Center in Digita.i.a.i.n and intelligent Robotics(CeDRi) Instituto Politécnico de Bragança(IPB)BragançaPortuga

This work describes a bibliometric analysis of the literature on the use of computer vision algorithms in Augmented Rea.i.y(AR),Virtual Rea.i.y(VR),Mixed Rea.i.y(MR),and Extended Rea.i.y(XR)*** analysis aims to highlight the evolution,trends,and effects of research in this *** review provides an overview of immersive technologies and their applica.i.ns,as well as the role of computer vision algorithms in enabling these technologies and the potential benefits of using such *** study identifies important authors,institutions,and research themes by using bibliometric indicators such as cita.i.n counts,co-cita.i.n analysis,and network *** analysis also identifies gaps and opportunities for additional research in this area,as well as a critical assessment of the qua.i.y and relevance of the publica.i.ns.

关键词： Augmented Rea.i.y Virtual Rea.i.y Deep Learning Computer Vision Machine Learning

A Differential Evolution Approach for Protein Folding Using a Lattice Model

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Journal of Computer Science & Technology 2007年第6期22卷 904-908页

作者： Heitor Silverio lopes Reginaldo Bitello Bioinforma.i.s Laboratory Federal University of Technology-ParanáAv.7 de setembro3165 80230-901 CuritibaBrazil

Protein folding is a relevant computa.i.nal problem in Bioinforma.i.s, for which many heuristic algorithms have been proposed. This work presents a methodology for the applica.i.n of differential evolution （DE） to the problem of protein folding, using the bi-dimensional hydrophobic-polar model. DE is a rela.i.ely recent evolutionary algorithm, and has been used successfully in several engineering optimiza.i.n problems, usually with continuous va.i.bles. We introduce the concept of genotype-phenotype mapping in DE in order to provide a mapping between the real-valued vector and an actual folding. The methodology is detailed and several experiments with benchmarks are done. We compared the results with other similar implementa.i.ns. The proposed DE has shown to be competitive, sta.i.tically consistent and very promising.

关键词： bioinforma.i.s differential evolution evolutionary computa.i.n protein folding

Endoscopic resection of superficial gastrointestinal tumors

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World Journal of Gastroenterology 2008年第29期14卷 4600-4606页

作者： Giovannini Marc Cesar Vivian lopes Endoscopic Unit Paoli-Calmettes Institute232 Bd St-Marguerite Cedex 13273 France

Therapeutic endoscopy plays a major role in the management of gastrointestinal (Gi) neopla.i.. its indica.i.ns can be genera.i.ed into four broad categories; to remove or obliterate neoplastic lesion, to palliate ma.i.nant obstruction, or to treat bleeding. Only endoscopic resection allows complete histological sta.i.g of the cancer, which is critical as it allows stra.i.ica.i.n and refinement for further treatment. Although other endoscopic techniques, such as abla.i.n therapy, may also cure early Gi cancer, they can not provide a definitive pathological specimen. Early stage lesions reveal low frequency of lymph node metasta.i. which allows for less inva.i.e treatments and thereby improving the qua.i.y of life when compared to surgery. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are now accepted worldwide as treatment moda.i.ies for early cancers of the Gi tract.

关键词： Superficial gastrointestinal cancers Endoscopic mucosal resection Endoscopic submucosaldissection Lymph node sprea.i.g Esophagus Stomach Colorectal

Cyst fluid glucose: An alterna.i.e to carcinoembryonic antigen for pancrea.i. mucinous cysts

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World Journal of Gastroenterology 2019年第19期25卷 2271-2278页

作者： César Vivian lopes Department of Gastroenterology and Digestive Endoscopy Santa Casa Hospital

Pancrea.i. cystic lesions(PCLs) have been increa.i.gly recognized in clinical practice. Although inflammatory cysts(pseudocysts) are the most common PCLs detected by cross-sectional ima.i.g moda.i.ies in symptoma.i. pa.i.nts in a setting of acute or chronic pancrea.i.is, incidental pancrea.i. cysts with no symptoms or history of pancrea.i.is are usually neoplastic cysts. For these lesions,it is impera.i.e to identify mucinous cysts(intraductal pa.i.lary mucinous neoplasms and mucinous cystic neoplasms) due to the risk of their progression to ma.i.nancy. However, no single ima.i.g moda.i.y alone is sufficient for a definitive diagnosis of all PCLs. The cyst fluid obtained by endoscopic ultrasound-guided fine needle aspira.i.n provides additional informa.i.n for the differential diagnosis of PCLs. Current recommenda.i.ns suggest sending cyst fluid for cytology evalua.i.n and measurement of carcinoembryonic antigen(CEA) levels. Unfortunately, the sensitivity of cytology is greatly limited, and cyst fluid CEA has demonstrated insufficient accuracy as a predictor of mucinous cysts. More recently, cyst fluid glucose has emerged as an alterna.i.e to CEA for distinguishing between mucinous and nonmucinous lesions. Herein, the clinical utility of cyst fluid glucose and CEA for the differential diagnosis of PCLs was evaluated.

关键词： Carcinoembryonic antigen Differential diagnosis Fine-needle biopsy Glucose Pancrea.i. cyst Tumor marker

Quantita.i.e Study on Nonmetallic inclusion Particles in Steels by Automa.i. image Analysis With Extreme Values Method

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Journal of iron and Steel Research interna.i.nal 2009年第4期16卷 18-21,32页

作者： Cássio Barbosa José Brant de Campos Jneo lopes do Nascimento iêda Ma.i. Vieira Ca.i.ha Na.i.nal institute of Technology

The presence of nonmetallic inclusion particles which appear during steelma.i.g process is harmful to the properties of steels, which is mainly as a function of some aspects such as size, volume fraction, shape, and distribution of these particles. The automa.i. image analysis technique is one of the most important tools for the quantita.i.e determina.i.n of these parameters. The classical Student approach and the Extreme Values Method （EVM） were used for the inclusion size and shape determina.i.n and the evalua.i.n of distance between the inclusion particles. The results thus obtained indicated that there were significant differences in the characteristics of the inclusion particles in the analyzed products. Both methods achieved results with some differences, indica.i.g that EVM could be used as a faster and more reliable sta.i.tical methodology.

关键词： image analysis steel microstructure nonmetallic inclusion

influence of PVD-duplex-treated, Bionic Surface Structures on the Wetting Beha.i.r for Sheet-Bulk Metal Forming Tools

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Journal of Bionic Engineering 2017年第3期14卷 520-531页

作者： Wolfgang Tiilmann Dominic Stangier Nelson Filipe lopes Dias institute of Materials Engineering TU Dortmund 44227 Dortmund Germany Leonhard-Euler-Strafle 2

Bionic surface structures, inspired by the flora, were developed for Sheet-Bulk Metal Forming （SBMF） in order to locally control the friction condition by adjusting the wetting beha.i.r. Five bionic structures were micromilled on ASP 2023 in annealed as well as hardened and tempered conditions. Subsequently, the structured surfaces were plasma-nitrided and coated with a CrA1N thin film. The influence of the treatment method on the structural geometry was investigated with the aid of a scanning electron microscope and 3D-profilometer. The wetting beha.i.rs of water and deep dra.i.g oil （Berufluid ST6007） on bionic surfaces were evaluated using contact angle measurements. The resulting micro-milled structures exhibit an almost identical shape as their bionic models. However, the roughness of the structured surfaces is influenced by the microstructure. The combina.i.n of plasma-nitriding and Physical Vapor Deposition （PVD） leads to an increase in roughness. All bionic struc- tures possess higher contact angles than that of the unstructured surfaces when wetted by water. This can be explained by the fact that the structural eleva.i.ns block the sprea.i.g. When the bionic surfaces are wetted by deep dra.i.g oil, the lubricant spreads in the structural ca.i.ies, lea.i.g to smaller contact angles. Furthermore, the a.i.otropy of the structure has an influence on the wetting beha.i.r.

关键词： bionic structures sheet-bulk metal forming CrA1N PVD-duplex treatment wetting beha.i.r

Biliary stone causing afferent loop syndrome and pancrea.i.is

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World Journal of Gastroenterology 2006年第38期12卷 6229-6231页

作者： André Roncon Dias Roberto iglesias lopes Department of General Surgery Hospital das Clínicas Faculdade de Medicina da Universidade de So Paulo So Paulo Brazil

We report the case of an 84-year-old female who had a partial gastrectomy with Billroth-Ⅱ anastomosis 24 years ago for a benign peptic ulcer who now presented an acute pancrea.i.is secondary to an afferent loop syndrome. The syndrome was caused by a gallstone that migrated through a cholecystoenteric fistula. This is the first description in the literature of a biliary stone causing afferent loop syndrome.

关键词： Afferent loop syndrome Biliary stone Acute pancrea.i.is Gallstone ileus