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四川盆地中国石化探区天然气勘探开发领域与技术攻关方向

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天然气地球科学 2020年第9期31卷 1195-1203页

作者：龙胜祥刘娅昭许华明陈前程喆中国石化石油勘探开发研究院北京100083

四川盆地中国石化探区天然气勘探开发成果显著,自新场气田发现以来,勘探开发领域逐步扩大,储量和产量快速增长。地质理论认识深化与关键技术进步是推动天然气勘探开发大发展的主要动力。中国石化探区天然气资源丰富,有利目标类型多,常... 详细信息

四川盆地中国石化探区天然气勘探开发成果显著,自新场气田发现以来,勘探开发领域逐步扩大,储量和产量快速增长。地质理论认识深化与关键技术进步是推动天然气勘探开发大发展的主要动力。中国石化探区天然气资源丰富,有利目标类型多,常规天然气整体探明程度为16%,页岩气勘探尚处于初期阶段,根据HCZ模式预测,中国石化探区天然气(含页岩气)勘探开发仍将快速发展,具备年均新增探明天然气地质储量(1600~2000)×10^8 m^3的潜力。围绕页岩气、海相碳酸盐岩天然气、陆相致密砂岩气等领域的高效勘探开发,需要加强深层海相页岩气增产降本的钻完井、压裂技术攻关,以及陆相、海陆过渡相页岩气资源潜力评价和勘探开发适应性技术准备,加强深层超深层礁滩相碳酸盐岩储层、风化壳储层预测和超深井高效钻井、压裂测试技术攻关,加强陆相致密砂岩气地质—测井—地震一体化甜点预测和低成本直井多层压裂技术攻关。

关键词：四川盆地常规天然气页岩气勘探领域技术攻关

CRD-CGAN:category-consistent and relativistic constraints for diverse text-to-image generation

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Frontiers of Computer Science 2024年第1期18卷 61-75页

作者： Tao HU Chengjiang long Chunxia XIAO College of Intelligent Systems Science and Engineering Hubei Minzu UniversityEnshi 445000China School of Computer Science Wuhan UniversityWuhan 430072China Key Laboratory of Performing Art Equipment&System Technology Ministry of Culture and TourismBeijing 100007China Meta Reality Labs BurlingameCA94010USA

Generating photo-realistic images from a text description is a challenging problem in computer *** works have shown promising performance to generate synthetic images conditional on text by Generative Adversarial Networks(GANs).In this paper,we focus on the category-consistent and relativistic diverse constraints to optimize the diversity of synthetic *** on those constraints,a category-consistent and relativistic diverse conditional GAN(CRD-CGAN)is proposed to synthesize K photo-realistic images *** use the attention loss and diversity loss to improve the sensitivity of the GAN to word attention and ***,we employ the relativistic conditional loss to estimate the probability of relatively real or fake for synthetic images,which can improve the performance of basic conditional ***,we introduce a category-consistent loss to alleviate the over-category issues between K synthetic *** evaluate our approach using the Caltech-UCSD Birds-200-2011,Oxford 102 flower and MS COCO 2014 datasets,and the extensive experiments demonstrate superiority of the proposed method in comparison with state-of-the-art methods in terms of photorealistic and diversity of the generated synthetic images.

关键词： text-to-image diverse conditional GAN relativi-stic category-consistent

Clinical practice guideline for acupuncture and moxibustion: Female urinary incontinence

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Journal of Integrative Medicine 2024年第3期22卷 258-269页

作者： Chao Yang Shan-ze Wang sheng Chen Shuo Du Guan-qun Wang Wei Guo Xiao-long Xie Bi-hui Peng Shi-hao Du Ji-ping Zhao Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong provincial hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Urinary incontinence (UI) is a common problem *** has a major impact on physical and social activities and interpersonal *** is common in women,but is under-reported and *** affects the quality of life of female patients *** and moxibustion have been proposed as potentially effective interventions for female ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies initiated a project to develop a clinical practice guideline (CPG) for the use of acupuncture and moxibustion to treat female *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation (GRADE) methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group (GDG) played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by GDG using the modified Delphi *** CPG contains ten recommendations about the use of acupuncture and moxibustion interventions for ten clinical questions,which include nine conditional recommendations for the intervention and one conditional recommendation for either the intervention or the *** CPG also provides one protocol for conventional filiform needle therapy,two therapy protocols for deep needling stimulation on lumbosacral acupoints,and four moxibustion therapy protocols,based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Acupuncture Clinical practice guideline Female urinary incontinence Moxibustion GRADE

Clinical practice guideline for acupuncture and moxibustion:Allergic rhinitis

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Journal of Integrative Medicine 2024年第3期22卷 245-257页

作者： Shi-hao Du sheng Chen Shan-ze Wang Guan-qun Wang Shuo Du Wei Guo Xiao-long Xie Bi-hui Peng Chao Yang Ji-ping Zhao Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Traditional Chinese Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for ***,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group(GDG)played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi *** CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion *** include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of *** CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Clinical practice guideline Allergic rhinitis Acupuncture Moxibustion GRADE

Experimental Study on Wire Melting Control Ability of Twin-Body Plasma Arc

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 184-194页

作者： Ruiying Zhang Fan Jiang long Xue School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China Beijing Academy of Safety Engineering and Technology Beijing 102617China College of Mechanical and Energy Engineering Beijing University of TechnologyBeijing 100124China

The twin-body plasma arc has the decoupling control ability of heat transfer and mass transfer,which is beneficial to shape and property control in wire arc additive *** this paper,with the wire feeding speed as a characteristic quantity,the wire melting control ability of twin-body plasma arc was studied by adjusting the current separation ratio(under the condition of a constant total current),the wire current/main current and the position of the wire in the arc axial *** results showed that under the premise that the total current remains unchanged(100 A),as the current separation ratio increased,the middle and minimum melting amounts increased approximately synchronously under the effect of anode effect power,the first melting mass range remained constant;the maximum melting amount increased twice as fast as the middle melting amount under the effect of the wire feeding speed,and the second melting mass range was *** the wire current increased,the anode effect power and the plasma arc power were both factors causing the increase in the wire melting amount;however,when the main current increased,the plasma arc power was the only factor causing the increase in the wire melting *** average wire melting increment caused by the anode effect power was approximately 2.7 times that caused by the plasma arc *** minimum melting amount was not affected by the wire-torch distance under any current separation ratio *** the current separation ratio increased and reached a threshold,the middle melting amount remained constant with increasing wire-torch *** the current separation ratio continued to increase and reached the next threshold,the maximum melting amount remained constant with the increasing wire-torch *** effect of the wire-torch distance on the wire melting amount reduced with the increase in the current separation *** this study,the decoupling mechanism and ability of this innovative

关键词： Twin-body plasma arc Melting control ability Melting amount Current separation ratio

Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang Lou xiang Li School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

Acupoint Selection Standards of Auricular Therapy in the Treatment of Maintenance Hemodialysis Insomnia Based on Data Mining

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 53-64页

作者： Jun-Xin Wang Bing-Qian Zou Yu-Feng Chen Cheng-long Wang Wei-Hong Li Xue-Ling Ma xiang-Di Liu Department of TCM Nursing School of NursingBeijing University of Chinese MedicineBeijingChina Department of Healthcare Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesP.R.China Pharmacology of Integrated Chinese and Western Medicine School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Beijing Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineMinistry of EducationBeijingChina

Background:Insomnia is a high-incidence complication in patients undergoing maintenance hemodialysis(MHD).Auricular therapy can effectively improve sleep with few adverse *** selection affects the impact of auricular ***,there is currently a lack of analysis on the standards of acupoint *** study used data mining technology to investigate the acupoint selection principles and characteristics of auricular therapy for the treatment of MHD-related ***:The objective of the study is to explore the standards of acupoint selection in auricular therapy for the treatment of MHD-related insomnia through data mining *** and Methods:We searched three English(PubMed,WOS,and Embase)and four Chinese(CNKI,VIP,Wangfang,and CBM)databases for studies on auricular therapy for MHD-related insomnia from self-establishment to November 14,***:Eighty-one publications were involved,which included 33 *** most common auricular points in patients with MHD-related insomnia were the Shenmen,heart,and kidney *** applications involved the visceral,nervous system,and specific *** effective clusters and two clusters were obtained through cluster analysis,including specific auricular points for insomnia,such as the multi-dream area,neurasthenia area,deep sleep point,and anterior ear *** network analysis showed that the core auricular acupoint combinations for the intervention of MHD-related insomnia were Shenmen with kidney,Shenmen with heart,heart with kidney,heart with Shenmen,and heart and Shenmen with ***:The selection of auricular points for the treatment of MHD-related insomnia was guided by the heart theory of traditional Chinese *** treatment attaches importance to the use of the multi-dream area,neurasthenia area,and other acupoints.

关键词： Acupoint selection standards auricular therapy data mining insomnia maintenance hemodialysis

A new twist to the interplay between superconductivity and Kondo correlation

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 1-2页

作者： Gui-Lu long Department of Physics Tsinghua UniversityBeijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China

Recently,Deng et al.[1] found a new twist to the intriguing physics resulting from the interplay between Kondo correlation and *** correlation [2,3] and superconductivity [4,5] are two fundamental phenomena in condens... 详细信息

关键词： Kondo twist

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Design and commissioning of a wideband RF system for CSNS-Ⅱ rapid-cycling synchrotron

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Nuclear Science and Techniques 2024年第1期35卷 35-44页

作者： Jian Wu xiang Li Bin Wu Chun-Lin Zhang Yang Liu Wei long Xiao Li University of Chinese Academy of Sciences Beijing 100049China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China

The China Spallation Neutron Source(CSNS) upgrade project(CSNS-Ⅱ) aims to enhance the beam power from 100 to 500 kW. A dual-harmonic accelerating method has been adopted to alleviate the stronger space-charge effect in rapid-cycling synchrotrons owing to the increased beam intensity. To satisfy the requirements of dual-harmonic acceleration, a new radiofrequency(RF) system based on a magnetic alloy-loaded cavity is proposed. This paper presents design considerations and experimental results regarding the performance evaluation of the proposed RF system through high-power tests and beam commissioning. The test results demonstrate that the RF system satisfies the desired specifications and affords significant benefits for CSNS-Ⅱ.

关键词： Dual-harmonic acceleration Magnetic alloy-loaded cavity RF system